T lymphocyte differentiation in the periphery

Current Opinion in Immunology

Volumn 10, Issue 2, 1998, Pages 226-232

  Murphy, Kenneth M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 18; INTERLEUKIN 4; UNCLASSIFIED DRUG;

GENE EXPRESSION; GENE LOCUS; GENETIC SUSCEPTIBILITY; HELPER CELL; HUMAN; IMMUNE RESPONSE; LEISHMANIASIS; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; REVIEW; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

EID: 0031976574     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(98)80253-7     Document Type: Article

References (65)

1. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature. 383:1996;787-793.
2. + T cell responses - the alternative approaches. Annu Rev Immunol. 15:1997;297-322.
3. of special interest Thierfelder WE, Vandeursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, Sangster MY, Vignali DAA, Doherty PC, Grosveld GC, Ihle JN. Requirement for STAT4 in interleukin-12-mediated responses of natural killer and T cells. Nature. 382:1996;171-174 This paper and [4-7] comprise clear demonstrations that Stat4 and Stat6 play direct roles in the early signaling mechanism initiating Th1 and Th2 development.
4. of special interest Kaplan MH, Sun YL, Hoey T, Grusby MJ. Impaired IL-12 responses and enhanced development of TH2 cells in STAT4-deficient mice. Nature. 382:1996;174-177 This paper and [3,5-7] demonstrate that Stat4 and Stat6 play direct roles in the early signaling mechanism initiating Th1 and Th2 development.
5. of special interest Shimoda K, Vandeursen J, Sangster MY, Sarawar SR, Carson RT, Tripp RA, Chu C, Quelle FW, Nosaka T, Vignali DAA, et al. Lack of IL-4-induced TH2 response and IgE class switching in mice with disrupted STAT6 gene. Nature. 380:1996;630-633 This paper and [3,4,6,7] comprise clear demonstrations that Stat4 and Stat6 play direct roles in the early signaling mechanism initiating Th1 and Th2 development.
6. of special interest Kaplan MH, Schindler U, Smiley ST, Grusby MJ. STAT6 is required for mediating responses to IL-4 and for the development of TH2 cells. Immunity. 4:1996;313-319 This paper and [3-5,7] comprise clear demonstrations that Stat4 and Stat6 play direct roles in the early signaling mechanism initiating Th1 and Th2 development.
7. of special interest Takeda K, Tanaka T, Shi W, Matsumoto M, Minami M, Kashiwamura S, Nakanishi K, Yoshida N, Kishimoto T, Akira S. Essential role of STAT6 in IL-4 signalling. Nature. 380:1996;627-630 This paper and [3-6] comprise clear demonstrations that Stat4 and Stat6 play direct roles in the early signaling mechanism initiating Th1 and Th2 development.
8. Nakamura T, Kamogawa Y, Bottomly K, Flavell RA. Polarization of IL-4- and IFN-gamma-producing CD4(+) T cells following activation on naive CD4(+) T cells. J Immunol. 158:1997;1085-1094.
9. Rincon M, Anguita J, Nakamura T, Fikrig E, Flavell RA. Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4(+) T cells. J Exp Med. 185:1997;461-469.
10. Coffman RL, Vonderweid T. Multiple pathways for the initiation of T helper 2 (TH2) responses. J Exp Med. 185:1997;373-375.
11. Yoshimoto T, Bendelac A, Watson C, Huli J, Paul WE. Role of NK1.1(+) T cells in a T(H)2 response and in immunoglobulin E production. Science. 270:1995;1845-1847.
12. Yoshimoto T, Bendelac A, Huli J, Paul WE. Defective IGE production by SJL mice is linked to the absence of CD4(+), NK1.1(+) T cells that promptly produce interleukin-4. Proc Natl Acad Sci USA. 92:1995;11931-11934.
13. + T cells as a source of IL-4 in response to certain pathogens.
14. + T cells as a source of IL-4 in response to certain pathogens.
15. + T cells and showed that Th2 development was still possible in vivo.
16. + T cells and showed that Th2 development was still possible in vivo.
17. + T cells and showed that Th2 development was still possible in vivo.
18. Chen HJ, Paul WE. Cultured NK1.1(+)CD4(+) T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1. J Immunol. 159:1997;2240-2249.
19. Chen HJ, Huang H, Paul WE. NK1.1(+)CD4(+) T cells lose NK1.1 expression upon in vitro activation. J Immunol. 158:1997;5112-5119.
20. of special interest Fowell DJ, Magram J, Turck CW, Killeen N, Locksley RM. Impaired TH2 subset development in the absence of CD4. Immunity. 6:1997;559-569 A provocative study suggesting that CD4 is required for IL-4 induction of Th2 development.
21. Brown DR, Swier K, Moskowitz NH, Naujokas MF, Locksley RM, Reiner SL. T helper subset differentiation in the absence of invariant chain. J Exp Med. 185:1997;31-41.
22. of outstanding interest Julia V, Rassoulzadegan M, Glaichenhaus N. Resistance to Leishmania major induced by tolerance to a single antigen. Science. 274:1996;421-423 An interesting experiment! Preventing the early T-cell response to the LACK antigen and delaying T-cell responses allow BALB/c mice to generate a curative Th1 response to L. major.
23. Mattner F, Magram J, Ferrante J, Launois P, Dipadova K, Behin R, Gately MK, Louis JA, Alber G. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized TH2 cell response. Eur J Immunol. 26:1996;1553-1559.
24. of outstanding interest Launois P, Maillard I, Pingel S, Swihart KG, Xenarios I, Achaorbea H, Diggelmann H, Locksley RM, MacDonald HR, Louis JA. IL-4 rapidly produced by V-beta-4 V-alpha-8 (CD4(+) T cells instructs the development and susceptibility to Leishmania major in Balb/C mice. of special interest Immunity. 6:1997;541-549 Related to [22] and perhaps [27], this study sets the stage suggesting that initial IL-4 that instructs Th2 development in Balb/c to L. major is produced by a memory phenotype population.
25. Mocci S, Coffman RL. The mechanism of in vitro T helper cell type 1 to T helper cell type 2 switching in highly polarized Leishmania major-specific T cell populations. J Immunol. 158:1997;1559-1564.
26. Launois P, Swihart KG, Milon G, Louis JA. Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-2 unresponsiveness. J Immunol. 158:1997;3317-3324.
27. Guler ML, Gorham JD, Hsieh CS, Mackey AJ, Steen RG, Dietrich WF, Murphy KM. Genetic susceptibility to Leishmania - IL-12 responsiveness in T(H)1 cell development. Science. 271:1996;984-987.
28. of special interest Kopf M, Brombacher F, Kohler G, Kienzle G, Widmann KH, Lefrang K, Humborg C, Ledermann B, Solbach W. IL-4-deficient Balb/c mice resist infection with Leishmania major. [see comments] J Exp Med. 184:1996;1127-1136 This, together with [29] battles to determine whether IL-4 is required for Th2 development in L. major infection in BALB/c.
29. of special interest Noben-Trauth N, Kropf P, Muller I. Susceptibility to Leishmania major infection in interleukin-4-deficient mice. Science. 271:1996;987-990 This, together with [28] battles to determine whether IL-4 is required for Th2 development in L. major infection in BALB/c.
30. Gorham JD, Guler ML, Steen RG, Mackey AJ, Daly MJ, Frederick K, Dietrich WF, Murphy KM. Genetic mapping of a murine locus controlling development of T helper 1 T helper 2 type responses. Proc Natl Acad Sci USA. 93:1996;12467-12472.
31. Demant P, Lipoldova M, Svobodova M. Resistance to Leishmania major in mice. Science. 274:1996;1392-1393.
32. Beebe AM, Mauze S, Schork NJ, Coffman RL. Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice. Immunity. 6:1997;551-557.
33. Roberts LJ, Baldwin TM, Curtis JM, Handman E, Foote SJ. Resistance to Leishmania major is linked to the H2 region on chromosome 17 and to chromosome 9. J Exp Med. 185:1997;1705-1710.
34. Wenner CA, Szabo SJ, Murphy KM. Identification of IL-4 promoter elements conferring TH2-restricted expression during T helper cell subset development. J Immunol. 158:1997;765-773.
35. Aune TM, Flavell RA. Differential expression of transcription directed by a discrete NF-AT binding element from the IL-4 promoter in naive and effector CD4 T cells. J Immunol. 159:1997;36-43.
36. Rincon M, Flavell RA. Transcription mediated by NFAT is highly inducible in effector CD4(+) T helper 2 (TH2) cells but not in TH1 cells. Mol Cell Biol. 17:1997;1522-1534.
37. Luo C, Burgeon E, Rao A. Mechanisms of transactivation by nuclear factor of activated T cells .1. J Exp Med. 184:1996;141-147.
38. Loh C, Carew JA, Kim J, Hogan PG, Rao A. T-cell receptor stimulation elicits an early phase of activation and a later phase of deactivation of the transcription factor NFAT1. Mol Cell Biol. 16:1996;3945-3954.
39. Luo C, Burgeon E, Carew JA, McCaffrey PG, Badalian TM, Lane WS, Hogan PG, Rao A. Recombinant NFAT1 (NFATP) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes. Mol Cell Biol. 16:1996;3955-3966.
40. Hodge MR, Ranger AM, Delabrousse FC, Hoey T, Grusby MJ, Glimcher LH. Hyperproliferation and dysregulation of IL-4 expression in NF-ATP-deficient mice. Immunity. 4:1996;397-405.
41. Xanthoudakis S, Viola JPB, Shaw KTY, Luo C, Wallace JD, Bozza PT, Curran T, Rao A. An enhanced immune response in mice lacking the transcription factor NFAT1. Science. 272:1996;892-895.
42. Lederer JA, Perez VL, Desroches L, Kim SM, Abbas AK, Lichtman AH. Cytokine transcriptional events during helper T cell subset differentiation. J Exp Med. 184:1996;397-406.
43. Huli J, Huang H, Ryan J, Paul WE. In differentiated CD4(+) T cells, interleukin 4 production is cytokine-autonomous, whereas interferon gamma production is cytokine-dependent. Proc Natl Acad Sci USA. 94:1997;3189-3194.
44. of outstanding interest Ho IC, Hodge MR, Rooney JW, Glimcher LH. The proto-oncogene C-Maf is responsible for tissue-specific expression of interleukin-4. Cell. 85:1996;973-983 A first! Identifies c-Maf as a Th2-specific transcription factor that can act on the proximal IL-4 promoter.
45. Hodge MR, Chun HJ, Rengarajan J, Alt A, Lieberson R, Glimcher LH. NF-AT-driven interleukin-4 transcription potentiated by NIP45. Science. 274:1996;1903-1905.
46. of special interest Zheng WP, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for TH2 cytokine gene expression in CD4 T cells. Cell. 89:1997;587-596 Identifies GATA3 as a Th2-specific transcription factor that acts to promote general Th2-selective cytokine expression.
47. Hattori N, Kawamoto H, Fujimoto S, Kuno K, Katsura Y. Involvement of transcription factors TCF-1 and GATA-3 in the initiation of the earliest step of T cell development in the thymus. J Exp Med. 184:1996;1137-1147.
48. Kubo M, Ransom J, Webb D, Hashimoto Y, Tada T, Nakayama T. Interleukin-4, Promoter, silencer, STAT6. T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6. EMBO J. 16:1997;4007-4020.
49. Zhang DH, Cohn L, Ray P, Bottomly K, Ray A. Transcription factor GATA-3 is differentially expressed in murine TH1 and TH2 cells and controls TH2-specific expression of the interleukin-5 gene. J Biol Chem. 272:1997;21597-21603.
50. Young HA. Regulation of interferon-gamma gene expression. J Interferon Cytokine Res. 16:1996;563-568.
51. Ye JP, Cippitelli M, Dorman L, Ortaldo JR, Young HA. The nuclear factor YY1 suppresses the human gamma interferon promoter through two mechanisms - inhibition of AP1 binding and activation of a silencer element. Mol Cell Biol. 16:1996;4744-4753.
52. Penix LA, Sweetser MT, Weaver WM, Hoeffler JP, Kerppola TK, Wilson CB. The proximal regulatory element of the interferon-gamma promoter mediates selective expression in T cells. J Biol Chem. 271:1996;31964-31972.
53. Aune TM, Penix LA, Rincon MR, Flavell RA. Differential transcription directed by discrete gamma interferon promoter elements in naive and memory (effector) CD4 T cells and CD8 T cells. Mol Cell Biol. 17:1997;199-208.
54. Wenner CA, Guler ML, Macatonia SE, Ogarra A, Murphy KM. Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development. J Immunol. 156:1996;1442-1447.
55. Szabo SJ, Jacobson NG, Dighe AS, Gubler U, Murphy KM. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity. 2:1995;665-675.
56. Presky DH, Yang H, Minetti LJ, Chua AO, Nabavi N, Wu CY, Gately MK, Gubler U. A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci USA. 93:1996;14002-14007.
57. Szabo SJ, Dighe AS, Gubler U, Murphy KM. Regulation of the interleukin (IL)-12R beta-2 subunit expression in developing T helper 1 (TH1) and TH2 cells. J Exp Med. 185:1997;817-824.
58. Rogge L, Barberis-Maino L, Biffi M, Passini N, Presky DH, Gubler U, Sinigaglia F. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J Exp Med. 185:1997;825-831.
59. Nakamura T, Lee RK, Nam SY, Podack ER, Bottomly K, Flavell RA. Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype. J Immunol. 158:1997;2648-2653.
60. Cho SS, Bacon CM, Sudarshan C, Rees RC, Finbloom D, Pine R, Oshea JJ. Activation of STAT4 by IL-12 and IFN-alpha - evidence for the involvement of ligand-induced tyrosine and serine phosphorylation. J Immunol. 157:1996;4781-4789.
61. Hilkens CMU, Messer G, Tesselaar K, Vanrietschofen AGI, Kapsenberg ML, Wierenga EA. Lack of IL-12 signaling in human allergen-specific TH2 cells. J Immunol. 157:1996;4316-4321.
62. Kohno K, Kataoka J, Ohtsuki T, Suemoto Y, Okamoto I, Usui M, Ikeda M, Kurimoto M. IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of TH1 but not TH2 cells and exerts its effect independently of IL-12. J Immunol. 158:1997;1541-1550.
63. Ghayur T, Banerjee S, Hugunin M, Butler D, Herzog L, Carter A, Quintal L, Sekut L, Talanian R, Paskind M, et al. CASPASE-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature. 386:1997;619-623.
64. Ahn HJ, Maruo S, Tomura M, Mu J, Hamaoka T, Nakanishi K, Clark S, Kurimoto M, Okamura H, Fujiwara H. A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma. J Immunol. 159:1997;2125-2131.
65. of special interest Robinson D, Shibuya K, Mui A, Zonin F, Murphy E, Sana T, Hartley SB, Menon S, Kastelein R, Bazan F, O'Garra A. IGIF does not drive Th1 development but synergizes with IL-12 for interferon gamma production and activates IRAK and NF-kappa B. Immunity. 7:1997;571-581 An important paper that clarifies how IL-18 acts in phenotype development.