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A good review of recent IFN-γ studies.
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Boehm U, Klamp T, Groot M, Howard JC. Cellular responses to interferon-γ Annu Rev Immunol. 15:1997;749-795 A good review of recent IFN-γ studies.
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Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
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Cloning of a new cytokine that induces IFN-γ production by T cells
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Okamura H, Tsutsui H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K, et al. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature. 378:1995;88-91.
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Hattori, K.10
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0030296747
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Interferon-γ-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells
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Dao T, Ohashi K, Kayano T, Kurimoto M, Okamura H. Interferon-γ-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells. Cell Immunol. 173:1996;230-235.
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Dao, T.1
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7
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0030293444
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IFN-γ-inducing factor upregulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones
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Tsutsui H, Nakanishi K, Matsui K, Higashino K, Okamura H, Miyazawa Y, Kaneda K. IFN-γ-inducing factor upregulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones. J Immunol. 156:1996;3967-3973.
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Tsutsui, H.1
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Matsui, K.3
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Kaneda, K.7
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8
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15844367093
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Cloning of cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein
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Ushio S, Namba M, Okura T, Hattori K, Nukada Y, Akita K, Tanabe F, Konishi K, Micallef M, Fjii M, et al. Cloning of cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J Immunol. 156:1996;4274-4279.
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Ushio, S.1
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9
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Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: Synergism with interleukin-12 for interferon-γ production
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of special interest
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Micallef MJ, Ohtsuki T, Kohno K, Tanabe F, Ushio S, Namba M, Tanimoto T, Torigoe K, Fujii M, Ikeda M, et al. Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-γ production. of special interest Eur J Immunol. 26:1996;1647-1651.
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Eur J Immunol
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Micallef, M.J.1
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Namba, M.6
Tanimoto, T.7
Torigoe, K.8
Fujii, M.9
Ikeda, M.10
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10
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0031568526
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IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1, but not Th2 cells and exerts its effect independently of IL-12
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of special interest. This paper describes how IL-18 serves as a co-stimulatory factor in the activation of Th1 cells stimulated by antigens. It indicates that IL-18 exhibited this activity independently of IL-12 and suggested that IL-12 and IL-18 utilize different signal transduction pathways. It also indicates that these cytokines stimulated Th1 cells synergistically, and that the involvement of endogenous IL-18 as well as IL-12 should be taken into consideration in the activation of Th1 cells.
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Kohno K, Kataoka J, Otsuki T, Suemoto Y, Okamoto I, Usui M, Ikeda M, Kurimoto M. IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1, but not Th2 cells and exerts its effect independently of IL-12. of special interest J Immunol. 158:1997;1541-1550 This paper describes how IL-18 serves as a co-stimulatory factor in the activation of Th1 cells stimulated by antigens. It indicates that IL-18 exhibited this activity independently of IL-12 and suggested that IL-12 and IL-18 utilize different signal transduction pathways. It also indicates that these cytokines stimulated Th1 cells synergistically, and that the involvement of endogenous IL-18 as well as IL-12 should be taken into consideration in the activation of Th1 cells.
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(1997)
J Immunol
, vol.158
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Kohno, K.1
Kataoka, J.2
Otsuki, T.3
Suemoto, Y.4
Okamoto, I.5
Usui, M.6
Ikeda, M.7
Kurimoto, M.8
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11
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15644369352
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Activation of interferon-γ-inducing factor mediated by interleukin-1β converting enzyme
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of outstanding interest. This is the first published report that caspase 1 (IL-1β converting enzyme) processes the inactive IL-18 precursor to the active form. This was proved by immunoblotting of lysates of COS cells cotransfected with plasmids for pro-IL-18 and caspase 1. It was also proved that caspase-1 deficient mice failed to produce mature IL-18.
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Gu Y, Kuida K, Tsutsui H, Ku G, Hsiao K, Fleming MA, Hayashi N, Higashino K, Okamura H, Nakanishi K, et al. Activation of interferon-γ-inducing factor mediated by interleukin-1β converting enzyme. of outstanding interest Science. 275:1997;206-209 This is the first published report that caspase 1 (IL-1β converting enzyme) processes the inactive IL-18 precursor to the active form. This was proved by immunoblotting of lysates of COS cells cotransfected with plasmids for pro-IL-18 and caspase 1. It was also proved that caspase-1 deficient mice failed to produce mature IL-18.
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(1997)
Science
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Gu, Y.1
Kuida, K.2
Tsutsui, H.3
Ku, G.4
Hsiao, K.5
Fleming, M.A.6
Hayashi, N.7
Higashino, K.8
Okamura, H.9
Nakanishi, K.10
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12
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0031004174
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Caspase 1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production
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of special interest. Another report clearly showing that IL-18 is processed by caspase 1.
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Ghayur T, Banerjee S, Hugunin M, Butler D, Herzog L, Carter A, Quintal L, Sekut L, Taianian R, Paskind M, et al. Caspase 1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production. of special interest Nature. 386:1997;619-623 Another report clearly showing that IL-18 is processed by caspase 1.
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(1997)
Nature
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Ghayur, T.1
Banerjee, S.2
Hugunin, M.3
Butler, D.4
Herzog, L.5
Carter, A.6
Quintal, L.7
Sekut, L.8
Taianian, R.9
Paskind, M.10
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Lay JD, Tsao C-J, Chen J-Y, Kadin ME, Su I-J. Upregulation of tumor necrosis factor-α gene by Epstein-Barr virus and activation of macrophages in Epstein-Barr virus-infected T cells in the pathogenesis of hemophagocytic syndrome. J Clin Invest. 100:1997;1969-1979.
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Lay, J.D.1
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Tamura, T.6
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17
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A novel costimulatory factor for gamma interferon induction found in the liver of mice caused endotoxic shock
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Okamura H, Nagata K, Komatsu T, Tanimoto T, Nukata Y, Tanabe F, Akita K, Torigoe K, Okura T, Fukuda S, Kurimoto M. A novel costimulatory factor for gamma interferon induction found in the liver of mice caused endotoxic shock. Infect Immun. 63:1995;3966-3972.
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Okamura, H.1
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18
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0031181474
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Production of IL-18 (IFN-γ-inducing factor) mRNA and functional protein by murine keratinocytes
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Stoll S, Muller G, Kurimoto M, Saloga J, Tanimoto T, Yamauchi H, Okamura H, Knop J, Enk AH. Production of IL-18 (IFN-γ-inducing factor) mRNA and functional protein by murine keratinocytes. J Immunol. 159:1997;298-302.
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Stoll, S.1
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Yamauchi, H.6
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Knop, J.8
Enk, A.H.9
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19
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17544389276
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Interleukin-18 (interferon-γ-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-γ To inhibit osteoclast formation
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Udagawa N, Horwood NJ, Elliott J, Mackay A, Owens J, Okamura H, Kurimoto M, Chambers TJ, Martin TJ, Gillespie MT. Interleukin-18 (interferon-γ-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-γ to inhibit osteoclast formation. J Exp Med. 185:1997;1005-1012.
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Udagawa, N.1
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Okamura, H.6
Kurimoto, M.7
Chambers, T.J.8
Martin, T.J.9
Gillespie, M.T.10
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Conti B, Jahng JW, Tinti C, Son JH, Joh TH. Induction of interferon-γ-inducing factor in the adrenal cortex. J Biol Chem. 272:1997;2035-2037.
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Conti, B.1
Jahng, J.W.2
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Son, J.H.4
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21
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0030798384
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Immunohistochemical and immune-electroscopic detection of interferon-γ-inducing factor (interleukin 18) in mouse intestinal epithelial cells
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Takeuchi M, Nishizaki Y, Sano O, Ohta T, Ikeda M, Kurimoto M. Immunohistochemical and immune-electroscopic detection of interferon-γ-inducing factor (interleukin 18) in mouse intestinal epithelial cells. Cell Tissue Res. 289:1997;499-503.
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Takeuchi, M.1
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Ikeda, M.5
Kurimoto, M.6
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22
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0030693371
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Involvement of caspase 1 and caspase 3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells
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of outstanding interest. This demonstrates that human inactive precursor IL-18 is cleaved by two-step proteolysis, first by caspase 1 to give the active IL-18, and second by caspase 3 to generate inactive products. Caspase 3 was shown to cleave both inactive precursor and active mature protein at Asp71 - Ser72 and Asp76 - Asn77.
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Akita K, Ohtsuki T, Nukada Y, Tanimoto T, Namba M, Okura T, Takakura-Yamamoto R, Torigoe K, Gu Y, Su M S-S, Fujii M, et al. Involvement of caspase 1 and caspase 3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells. of outstanding interest J Biol Chem. 272:1997;26595-26603 This demonstrates that human inactive precursor IL-18 is cleaved by two-step proteolysis, first by caspase 1 to give the active IL-18, and second by caspase 3 to generate inactive products. Caspase 3 was shown to cleave both inactive precursor and active mature protein at Asp71 - Ser72 and Asp76 - Asn77.
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(1997)
J Biol Chem
, vol.272
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Akita, K.1
Ohtsuki, T.2
Nukada, Y.3
Tanimoto, T.4
Namba, M.5
Okura, T.6
Takakura-Yamamoto, R.7
Torigoe, K.8
Gu, Y.9
Su M. S-S10
Fujii, M.11
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23
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0030931876
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Caspases: The executioners of apoptosis
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of special interest. This review covers the different usage of substrates for caspases, cell apoptosis and cytokine processing.
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Cohen GM. Caspases: the executioners of apoptosis. of special interest Biochem J. 326:1997;1-16 This review covers the different usage of substrates for caspases, cell apoptosis and cytokine processing.
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Cohen, G.M.1
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24
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Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
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Kuida K, Zheng T, Na S, Kuan C, Yang D, Karasuyama H, Rakic P, Flavell RA. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature. 384:1996;368-372.
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Kuida, K.1
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Kuan, C.4
Yang, D.5
Karasuyama, H.6
Rakic, P.7
Flavell, R.A.8
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25
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0029732843
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The proximal regulatory element of the interferon-γ promoter mediates selective expression in T cells
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Penix LA, Sweetser MY, Weaver WM, Hoeffler JP, Kerppola TK, Wilson CB. The proximal regulatory element of the interferon-γ promoter mediates selective expression in T cells. J Biol Chem. 271:1996;31964-31972.
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Penix, L.A.1
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Kerppola, T.K.5
Wilson, C.B.6
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27
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0030851728
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Purification and characterization of human interleukin-18 receptor
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of outstanding interest. In this report the human IL-18 receptor was purified and identified as the interleukin-1 receptor related protein (IL-1Rrp), which was previously reported as a member of the IL-1 receptor family. When IL-1Rrp cDNA was expressed in COS cells, it conferred IL-18-binding properties on the cells and the capacity for signal transduction.
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Torigoe K, Ushio S, Okura T, Kobayashi S, Taniai M, Kunikata T, Murakami T, Sanou O, Kojima H, Fujii M, et al. Purification and characterization of human interleukin-18 receptor. of outstanding interest J Biol Chem. 272:1997;25737-25742 In this report the human IL-18 receptor was purified and identified as the interleukin-1 receptor related protein (IL-1Rrp), which was previously reported as a member of the IL-1 receptor family. When IL-1Rrp cDNA was expressed in COS cells, it conferred IL-18-binding properties on the cells and the capacity for signal transduction.
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J Biol Chem
, vol.272
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Torigoe, K.1
Ushio, S.2
Okura, T.3
Kobayashi, S.4
Taniai, M.5
Kunikata, T.6
Murakami, T.7
Sanou, O.8
Kojima, H.9
Fujii, M.10
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28
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0029989325
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IL-1RrP is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologous T1/T2 and IL-1R AcP
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Parnet P, Garka KE, Bonnert TP, Dower SK, Sims JE. IL-1RrP is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologous T1/T2 and IL-1R AcP. J Biol Chem. 271:1996;3967-3970.
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Parnet, P.1
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Dower, S.K.4
Sims, J.E.5
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29
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Interleukin 18 activates NF-κB in murine T helper type 1 cells
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of special interest. The authors show that co-stimulation of cloned Th1 cells with IL-18 and anti-CD3 antibody induces the disappearance of IκB from the cytoplasm and the subsequent accumulation of NF-κB in the nucleus.
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Matsumoto S, Tsuji-Takayama K, Aizawa Y, Koide K, Takeuchi M, Ohta T, Kurimoto M. Interleukin 18 activates NF-κB in murine T helper type 1 cells. of special interest Biochem Biophys Res Commun. 234:1997;454-457 The authors show that co-stimulation of cloned Th1 cells with IL-18 and anti-CD3 antibody induces the disappearance of IκB from the cytoplasm and the subsequent accumulation of NF-κB in the nucleus.
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Biochem Biophys Res Commun
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Matsumoto, S.1
Tsuji-Takayama, K.2
Aizawa, Y.3
Koide, K.4
Takeuchi, M.5
Ohta, T.6
Kurimoto, M.7
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30
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0031559577
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Interleukin-18 induces activation and association of p56lck and MAPK in a murine TH1 clone
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Tsuji-Takayama K, Matsumoto S, Koide K, Takeuchi M, Ikeda M, Ohta T, Kurimoto M. Interleukin-18 induces activation and association of p56lck and MAPK in a murine TH1 clone. Biochem Biophys Res Commun. 237:1997;126-130.
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Tsuji-Takayama, K.1
Matsumoto, S.2
Koide, K.3
Takeuchi, M.4
Ikeda, M.5
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Kurimoto, M.7
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Baldwin AS Jr. The NF-κB and IκB proteins: new discovery and insights. Annu Rev Immunol. 14:1996;649-681.
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Baldwin A.S., Jr.1
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0030694235
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IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NF-κB
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of outstanding interest. This paper reports the roles of IL-18 in the induction of Th1 cells using naive T cells from mice transgenic for the T cell receptor. IL-18, unlike IL-12, does not drive the development of Th1 cells by itself, but synergized with IL-12 for IFN-γ induction in Th1 cells. IL-18 was shown to signal through the IL-1 receptor associated kinase (IRAK) to induce the accumulation of NF-κB in the nucleus. As IL-1 activated Th2 cells but failed to activate Th1 cells, Th1 and Th2 cells were inferred to differ in responsiveness and in expression of receptors for the IL-1 family.
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Robinson D, Shibuya K, Mui A, Zonin F, Murphy E, Sana T, Hartley SB, Menon S, Kastelein R, Bazan F, O'Garra A. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NF-κB. of outstanding interest Immunity. 7:1997;571-581 This paper reports the roles of IL-18 in the induction of Th1 cells using naive T cells from mice transgenic for the T cell receptor. IL-18, unlike IL-12, does not drive the development of Th1 cells by itself, but synergized with IL-12 for IFN-γ induction in Th1 cells. IL-18 was shown to signal through the IL-1 receptor associated kinase (IRAK) to induce the accumulation of NF-κB in the nucleus. As IL-1 activated Th2 cells but failed to activate Th1 cells, Th1 and Th2 cells were inferred to differ in responsiveness and in expression of receptors for the IL-1 family.
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(1997)
Immunity
, vol.7
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Robinson, D.1
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Hartley, S.B.7
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Kastelein, R.9
Bazan, F.10
O'Garra, A.11
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Activation of γδ T cells for production of IFN-γ is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12
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35
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Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activation of transcription (STAT) 3 and STAT 4
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Jacobson NG, Szabo SJ, Weber-Nordt RM, Zhong Z, Schreiber RD, Darnell JE Jr, Murphy K. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activation of transcription (STAT) 3 and STAT 4. J Exp Med. 181:1995;1755-1762.
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Jacobson, N.G.1
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Weber-Nordt, R.M.3
Zhong, Z.4
Schreiber, R.D.5
Darnell J.E., Jr.6
Murphy, K.7
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36
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0031230444
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A mechanism underlying synergy between IL-12 and IFN-γ-inducing factor in enhanced production of IFN-γ
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of outstanding interest. This paper reported the first analysis of the underlying mechanism for the synergistic effect of IL-12 and IL-18 on interferon (IFN)-γ induction, using a T-cell clone responsive to IL-12. This clone grew equally in response to IL-12 and IL-2. However, these cells produced high levels of IFN-γ in response to IL-18 only when they were grown with IL-12, whereas they did not when grown with IL-2. It was shown by a binding assay for IL-18 that IL-12 upregulated the expression of IL-18 receptor, but that IL-2 reduced it. Naive T cells stimulated with anti-CD3 antibody plus anti-CD28 antibody and subsequently cultured with IL-12 were also shown to express the IL-18 receptor and to respond to the ligand.
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Ahn H-J, Maruo S, Tomura M, Mu J, Hamaoka T, Nakanishi K, Clark S, Kurimoto M, Okamura H, Fujiwara H. A mechanism underlying synergy between IL-12 and IFN-γ-inducing factor in enhanced production of IFN-γ of outstanding interest J Immunol. 159:1997;2125-2131 This paper reported the first analysis of the underlying mechanism for the synergistic effect of IL-12 and IL-18 on interferon (IFN)-γ induction, using a T-cell clone responsive to IL-12. This clone grew equally in response to IL-12 and IL-2. However, these cells produced high levels of IFN-γ in response to IL-18 only when they were grown with IL-12, whereas they did not when grown with IL-2. It was shown by a binding assay for IL-18 that IL-12 upregulated the expression of IL-18 receptor, but that IL-2 reduced it. Naive T cells stimulated with anti-CD3 antibody plus anti-CD28 antibody and subsequently cultured with IL-12 were also shown to express the IL-18 receptor and to respond to the ligand.
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(1997)
J Immunol
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Ahn H-J1
Maruo, S.2
Tomura, M.3
Mu, J.4
Hamaoka, T.5
Nakanishi, K.6
Clark, S.7
Kurimoto, M.8
Okamura, H.9
Fujiwara, H.10
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37
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16044363695
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IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses
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Magram J, Connaughton SE, Warrier RR, Carvajal DM, Wu C-Y, Ferrante J, Stewart C, Sarmiento U, Faherty DA, Gately MK. IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses. Immunity. 4:1996;471-481.
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Immunity
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Magram, J.1
Connaughton, S.E.2
Warrier, R.R.3
Carvajal, D.M.4
Wu C-Y5
Ferrante, J.6
Stewart, C.7
Sarmiento, U.8
Faherty, D.A.9
Gately, M.K.10
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38
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0022586803
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In vitro production of interleukin 1 by normal and malignant human B lymphocytes
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Pistoia V, Cozzolino F, Rubartelli A, Torcia M, Roncella S, Ferrarini M. In vitro production of interleukin 1 by normal and malignant human B lymphocytes. J Immunol. 136:1986;1688-1692.
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Pistoia, V.1
Cozzolino, F.2
Rubartelli, A.3
Torcia, M.4
Roncella, S.5
Ferrarini, M.6
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39
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0024454176
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Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes
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Smeland EB, Blomhoff HK, Funderud S, Shalaby MR, Espevik T. Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes. J Exp Med. 170:1989;1463-1468.
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Smeland, E.B.1
Blomhoff, H.K.2
Funderud, S.3
Shalaby, M.R.4
Espevik, T.5
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40
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0027478367
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Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia
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Gerard C, Bruyns C, Marchant A, Abramowicz D, Vanderabeele P, Delvaux A, Fiers W, Goldmann M, Velu T. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med. 177:1993;547-550.
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Gerard, C.1
Bruyns, C.2
Marchant, A.3
Abramowicz, D.4
Vanderabeele, P.5
Delvaux, A.6
Fiers, W.7
Goldmann, M.8
Velu, T.9
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42
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0030933144
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Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells
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Yoshimoto T, Okamura H, Tagawa YI, Iwakura Y, Nakanishi K. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells. Proc Natl Acad Sci USA. 94:1997;3948-3953.
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Yoshimoto, T.1
Okamura, H.2
Tagawa, Y.I.3
Iwakura, Y.4
Nakanishi, K.5
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43
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0030885123
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Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells
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of special interest. In this report, IL-12 and IL-18 were shown to synergistically induce interferon-γ production by peritoneal exudate cells and to endow these cells with anticryptococcal activity via production of nitric oxide. Depletion of NK cells from the cell population suppressed these activities.
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Zhang T, Kawakami K, Qureshi MH, Okamura H, Kurimoto M, Satoh A. Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells. of special interest Infect Immun. 65:1997;3594-3599 In this report, IL-12 and IL-18 were shown to synergistically induce interferon-γ production by peritoneal exudate cells and to endow these cells with anticryptococcal activity via production of nitric oxide. Depletion of NK cells from the cell population suppressed these activities.
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(1997)
Infect Immun
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Zhang, T.1
Kawakami, K.2
Qureshi, M.H.3
Okamura, H.4
Kurimoto, M.5
Satoh, A.6
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44
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0027255749
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Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon-γ And bacterial lipopolysaccharide
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Xie QW, Whisnant R, Nathan C. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon-γ and bacterial lipopolysaccharide. J Exp Med. 177:1993;1779-1784.
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J Exp Med
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Xie, Q.W.1
Whisnant, R.2
Nathan, C.3
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