메뉴 건너뛰기




Volumn 10, Issue 3, 1998, Pages 259-264

Regulation of interferon-γ production by IL-12 and IL-18

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERFERON INDUCING AGENT; INTERLEUKIN 12; INTERLEUKIN 18; UNCLASSIFIED DRUG;

EID: 0031860165     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(98)80163-5     Document Type: Article
Times cited : (479)

References (44)
  • 1
    • 0027411525 scopus 로고
    • The molecular cell biology of interferon-γ And its receptor
    • Farrar MA, Schreiber RD. The molecular cell biology of interferon-γ and its receptor. Annu Rev Immunol. 11:1993;571-611.
    • (1993) Annu Rev Immunol , vol.11 , pp. 571-611
    • Farrar, M.A.1    Schreiber, R.D.2
  • 2
    • 0030890586 scopus 로고    scopus 로고
    • Cellular responses to interferon-γ
    • A good review of recent IFN-γ studies.
    • Boehm U, Klamp T, Groot M, Howard JC. Cellular responses to interferon-γ Annu Rev Immunol. 15:1997;749-795 A good review of recent IFN-γ studies.
    • (1997) Annu Rev Immunol , vol.15 , pp. 749-795
    • Boehm, U.1    Klamp, T.2    Groot, M.3    Howard, J.C.4
  • 3
    • 0028970060 scopus 로고
    • Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol. 13:1995;251-276.
    • (1995) Annu Rev Immunol , vol.13 , pp. 251-276
    • Trinchieri, G.1
  • 4
    • 0026357870 scopus 로고
    • Natural immunity, a T cell-independent pathway of macrophage activation, defined in the SCID mouse
    • Bancroft GJ, Schreiber RD, Unanue ER. Natural immunity, a T cell-independent pathway of macrophage activation, defined in the SCID mouse. Immunol Rev. 124:1992;5-24.
    • (1992) Immunol Rev , vol.124 , pp. 5-24
    • Bancroft, G.J.1    Schreiber, R.D.2    Unanue, E.R.3
  • 6
    • 0030296747 scopus 로고    scopus 로고
    • Interferon-γ-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells
    • Dao T, Ohashi K, Kayano T, Kurimoto M, Okamura H. Interferon-γ-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells. Cell Immunol. 173:1996;230-235.
    • (1996) Cell Immunol , vol.173 , pp. 230-235
    • Dao, T.1    Ohashi, K.2    Kayano, T.3    Kurimoto, M.4    Okamura, H.5
  • 7
    • 0030293444 scopus 로고    scopus 로고
    • IFN-γ-inducing factor upregulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones
    • Tsutsui H, Nakanishi K, Matsui K, Higashino K, Okamura H, Miyazawa Y, Kaneda K. IFN-γ-inducing factor upregulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones. J Immunol. 156:1996;3967-3973.
    • (1996) J Immunol , vol.156 , pp. 3967-3973
    • Tsutsui, H.1    Nakanishi, K.2    Matsui, K.3    Higashino, K.4    Okamura, H.5    Miyazawa, Y.6    Kaneda, K.7
  • 8
    • 15844367093 scopus 로고    scopus 로고
    • Cloning of cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein
    • Ushio S, Namba M, Okura T, Hattori K, Nukada Y, Akita K, Tanabe F, Konishi K, Micallef M, Fjii M, et al. Cloning of cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J Immunol. 156:1996;4274-4279.
    • (1996) J Immunol , vol.156 , pp. 4274-4279
    • Ushio, S.1    Namba, M.2    Okura, T.3    Hattori, K.4    Nukada, Y.5    Akita, K.6    Tanabe, F.7    Konishi, K.8    Micallef, M.9    Fjii, M.10
  • 9
    • 8944226108 scopus 로고    scopus 로고
    • Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: Synergism with interleukin-12 for interferon-γ production
    • of special interest
    • Micallef MJ, Ohtsuki T, Kohno K, Tanabe F, Ushio S, Namba M, Tanimoto T, Torigoe K, Fujii M, Ikeda M, et al. Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-γ production. of special interest Eur J Immunol. 26:1996;1647-1651.
    • (1996) Eur J Immunol , vol.26 , pp. 1647-1651
    • Micallef, M.J.1    Ohtsuki, T.2    Kohno, K.3    Tanabe, F.4    Ushio, S.5    Namba, M.6    Tanimoto, T.7    Torigoe, K.8    Fujii, M.9    Ikeda, M.10
  • 10
    • 0031568526 scopus 로고    scopus 로고
    • IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1, but not Th2 cells and exerts its effect independently of IL-12
    • of special interest. This paper describes how IL-18 serves as a co-stimulatory factor in the activation of Th1 cells stimulated by antigens. It indicates that IL-18 exhibited this activity independently of IL-12 and suggested that IL-12 and IL-18 utilize different signal transduction pathways. It also indicates that these cytokines stimulated Th1 cells synergistically, and that the involvement of endogenous IL-18 as well as IL-12 should be taken into consideration in the activation of Th1 cells.
    • Kohno K, Kataoka J, Otsuki T, Suemoto Y, Okamoto I, Usui M, Ikeda M, Kurimoto M. IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1, but not Th2 cells and exerts its effect independently of IL-12. of special interest J Immunol. 158:1997;1541-1550 This paper describes how IL-18 serves as a co-stimulatory factor in the activation of Th1 cells stimulated by antigens. It indicates that IL-18 exhibited this activity independently of IL-12 and suggested that IL-12 and IL-18 utilize different signal transduction pathways. It also indicates that these cytokines stimulated Th1 cells synergistically, and that the involvement of endogenous IL-18 as well as IL-12 should be taken into consideration in the activation of Th1 cells.
    • (1997) J Immunol , vol.158 , pp. 1541-1550
    • Kohno, K.1    Kataoka, J.2    Otsuki, T.3    Suemoto, Y.4    Okamoto, I.5    Usui, M.6    Ikeda, M.7    Kurimoto, M.8
  • 11
    • 15644369352 scopus 로고    scopus 로고
    • Activation of interferon-γ-inducing factor mediated by interleukin-1β converting enzyme
    • of outstanding interest. This is the first published report that caspase 1 (IL-1β converting enzyme) processes the inactive IL-18 precursor to the active form. This was proved by immunoblotting of lysates of COS cells cotransfected with plasmids for pro-IL-18 and caspase 1. It was also proved that caspase-1 deficient mice failed to produce mature IL-18.
    • Gu Y, Kuida K, Tsutsui H, Ku G, Hsiao K, Fleming MA, Hayashi N, Higashino K, Okamura H, Nakanishi K, et al. Activation of interferon-γ-inducing factor mediated by interleukin-1β converting enzyme. of outstanding interest Science. 275:1997;206-209 This is the first published report that caspase 1 (IL-1β converting enzyme) processes the inactive IL-18 precursor to the active form. This was proved by immunoblotting of lysates of COS cells cotransfected with plasmids for pro-IL-18 and caspase 1. It was also proved that caspase-1 deficient mice failed to produce mature IL-18.
    • (1997) Science , vol.275 , pp. 206-209
    • Gu, Y.1    Kuida, K.2    Tsutsui, H.3    Ku, G.4    Hsiao, K.5    Fleming, M.A.6    Hayashi, N.7    Higashino, K.8    Okamura, H.9    Nakanishi, K.10
  • 12
    • 0031004174 scopus 로고    scopus 로고
    • Caspase 1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production
    • of special interest. Another report clearly showing that IL-18 is processed by caspase 1.
    • Ghayur T, Banerjee S, Hugunin M, Butler D, Herzog L, Carter A, Quintal L, Sekut L, Taianian R, Paskind M, et al. Caspase 1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production. of special interest Nature. 386:1997;619-623 Another report clearly showing that IL-18 is processed by caspase 1.
    • (1997) Nature , vol.386 , pp. 619-623
    • Ghayur, T.1    Banerjee, S.2    Hugunin, M.3    Butler, D.4    Herzog, L.5    Carter, A.6    Quintal, L.7    Sekut, L.8    Taianian, R.9    Paskind, M.10
  • 13
    • 0025787766 scopus 로고
    • Hypercytokinemia in familial hemophagocytic lymphohistocytosis
    • Henter J-I, Elinder G, Soder O, Hansson B, Andersson U. Hypercytokinemia in familial hemophagocytic lymphohistocytosis. Blood. 78:1991;2918-2922.
    • (1991) Blood , vol.78 , pp. 2918-2922
    • Henter J-I1    Elinder, G.2    Soder, O.3    Hansson, B.4    Andersson, U.5
  • 14
    • 0028134785 scopus 로고
    • Haemophagocytic lymphohistiocytosis, interferon-gammanemia and Epstein-Barr virus involvement
    • Imashuku S, Hibi S, Fujiwara F, Ikushima S, Todo S. Haemophagocytic lymphohistiocytosis, interferon-gammanemia and Epstein-Barr virus involvement. Br J Haematol. 88:1994;656-658.
    • (1994) Br J Haematol , vol.88 , pp. 656-658
    • Imashuku, S.1    Hibi, S.2    Fujiwara, F.3    Ikushima, S.4    Todo, S.5
  • 15
    • 0030770948 scopus 로고    scopus 로고
    • Upregulation of tumor necrosis factor-α gene by Epstein-Barr virus and activation of macrophages in Epstein-Barr virus-infected T cells in the pathogenesis of hemophagocytic syndrome
    • Lay JD, Tsao C-J, Chen J-Y, Kadin ME, Su I-J. Upregulation of tumor necrosis factor-α gene by Epstein-Barr virus and activation of macrophages in Epstein-Barr virus-infected T cells in the pathogenesis of hemophagocytic syndrome. J Clin Invest. 100:1997;1969-1979.
    • (1997) J Clin Invest , vol.100 , pp. 1969-1979
    • Lay, J.D.1    Tsao C-J2    Chen J-Y3    Kadin, M.E.4    Su I-J5
  • 19
    • 17544389276 scopus 로고    scopus 로고
    • Interleukin-18 (interferon-γ-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-γ To inhibit osteoclast formation
    • Udagawa N, Horwood NJ, Elliott J, Mackay A, Owens J, Okamura H, Kurimoto M, Chambers TJ, Martin TJ, Gillespie MT. Interleukin-18 (interferon-γ-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-γ to inhibit osteoclast formation. J Exp Med. 185:1997;1005-1012.
    • (1997) J Exp Med , vol.185 , pp. 1005-1012
    • Udagawa, N.1    Horwood, N.J.2    Elliott, J.3    MacKay, A.4    Owens, J.5    Okamura, H.6    Kurimoto, M.7    Chambers, T.J.8    Martin, T.J.9    Gillespie, M.T.10
  • 20
    • 15144344777 scopus 로고    scopus 로고
    • Induction of interferon-γ-inducing factor in the adrenal cortex
    • Conti B, Jahng JW, Tinti C, Son JH, Joh TH. Induction of interferon-γ-inducing factor in the adrenal cortex. J Biol Chem. 272:1997;2035-2037.
    • (1997) J Biol Chem , vol.272 , pp. 2035-2037
    • Conti, B.1    Jahng, J.W.2    Tinti, C.3    Son, J.H.4    Joh, T.H.5
  • 21
    • 0030798384 scopus 로고    scopus 로고
    • Immunohistochemical and immune-electroscopic detection of interferon-γ-inducing factor (interleukin 18) in mouse intestinal epithelial cells
    • Takeuchi M, Nishizaki Y, Sano O, Ohta T, Ikeda M, Kurimoto M. Immunohistochemical and immune-electroscopic detection of interferon-γ-inducing factor (interleukin 18) in mouse intestinal epithelial cells. Cell Tissue Res. 289:1997;499-503.
    • (1997) Cell Tissue Res , vol.289 , pp. 499-503
    • Takeuchi, M.1    Nishizaki, Y.2    Sano, O.3    Ohta, T.4    Ikeda, M.5    Kurimoto, M.6
  • 22
    • 0030693371 scopus 로고    scopus 로고
    • Involvement of caspase 1 and caspase 3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells
    • of outstanding interest. This demonstrates that human inactive precursor IL-18 is cleaved by two-step proteolysis, first by caspase 1 to give the active IL-18, and second by caspase 3 to generate inactive products. Caspase 3 was shown to cleave both inactive precursor and active mature protein at Asp71 - Ser72 and Asp76 - Asn77.
    • Akita K, Ohtsuki T, Nukada Y, Tanimoto T, Namba M, Okura T, Takakura-Yamamoto R, Torigoe K, Gu Y, Su M S-S, Fujii M, et al. Involvement of caspase 1 and caspase 3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells. of outstanding interest J Biol Chem. 272:1997;26595-26603 This demonstrates that human inactive precursor IL-18 is cleaved by two-step proteolysis, first by caspase 1 to give the active IL-18, and second by caspase 3 to generate inactive products. Caspase 3 was shown to cleave both inactive precursor and active mature protein at Asp71 - Ser72 and Asp76 - Asn77.
    • (1997) J Biol Chem , vol.272 , pp. 26595-26603
    • Akita, K.1    Ohtsuki, T.2    Nukada, Y.3    Tanimoto, T.4    Namba, M.5    Okura, T.6    Takakura-Yamamoto, R.7    Torigoe, K.8    Gu, Y.9    Su M. S-S10    Fujii, M.11
  • 23
    • 0030931876 scopus 로고    scopus 로고
    • Caspases: The executioners of apoptosis
    • of special interest. This review covers the different usage of substrates for caspases, cell apoptosis and cytokine processing.
    • Cohen GM. Caspases: the executioners of apoptosis. of special interest Biochem J. 326:1997;1-16 This review covers the different usage of substrates for caspases, cell apoptosis and cytokine processing.
    • (1997) Biochem J , vol.326 , pp. 1-16
    • Cohen, G.M.1
  • 25
    • 0029732843 scopus 로고    scopus 로고
    • The proximal regulatory element of the interferon-γ promoter mediates selective expression in T cells
    • Penix LA, Sweetser MY, Weaver WM, Hoeffler JP, Kerppola TK, Wilson CB. The proximal regulatory element of the interferon-γ promoter mediates selective expression in T cells. J Biol Chem. 271:1996;31964-31972.
    • (1996) J Biol Chem , vol.271 , pp. 31964-31972
    • Penix, L.A.1    Sweetser, M.Y.2    Weaver, W.M.3    Hoeffler, J.P.4    Kerppola, T.K.5    Wilson, C.B.6
  • 27
    • 0030851728 scopus 로고    scopus 로고
    • Purification and characterization of human interleukin-18 receptor
    • of outstanding interest. In this report the human IL-18 receptor was purified and identified as the interleukin-1 receptor related protein (IL-1Rrp), which was previously reported as a member of the IL-1 receptor family. When IL-1Rrp cDNA was expressed in COS cells, it conferred IL-18-binding properties on the cells and the capacity for signal transduction.
    • Torigoe K, Ushio S, Okura T, Kobayashi S, Taniai M, Kunikata T, Murakami T, Sanou O, Kojima H, Fujii M, et al. Purification and characterization of human interleukin-18 receptor. of outstanding interest J Biol Chem. 272:1997;25737-25742 In this report the human IL-18 receptor was purified and identified as the interleukin-1 receptor related protein (IL-1Rrp), which was previously reported as a member of the IL-1 receptor family. When IL-1Rrp cDNA was expressed in COS cells, it conferred IL-18-binding properties on the cells and the capacity for signal transduction.
    • (1997) J Biol Chem , vol.272 , pp. 25737-25742
    • Torigoe, K.1    Ushio, S.2    Okura, T.3    Kobayashi, S.4    Taniai, M.5    Kunikata, T.6    Murakami, T.7    Sanou, O.8    Kojima, H.9    Fujii, M.10
  • 28
    • 0029989325 scopus 로고    scopus 로고
    • IL-1RrP is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologous T1/T2 and IL-1R AcP
    • Parnet P, Garka KE, Bonnert TP, Dower SK, Sims JE. IL-1RrP is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologous T1/T2 and IL-1R AcP. J Biol Chem. 271:1996;3967-3970.
    • (1996) J Biol Chem , vol.271 , pp. 3967-3970
    • Parnet, P.1    Garka, K.E.2    Bonnert, T.P.3    Dower, S.K.4    Sims, J.E.5
  • 29
    • 0031578229 scopus 로고    scopus 로고
    • Interleukin 18 activates NF-κB in murine T helper type 1 cells
    • of special interest. The authors show that co-stimulation of cloned Th1 cells with IL-18 and anti-CD3 antibody induces the disappearance of IκB from the cytoplasm and the subsequent accumulation of NF-κB in the nucleus.
    • Matsumoto S, Tsuji-Takayama K, Aizawa Y, Koide K, Takeuchi M, Ohta T, Kurimoto M. Interleukin 18 activates NF-κB in murine T helper type 1 cells. of special interest Biochem Biophys Res Commun. 234:1997;454-457 The authors show that co-stimulation of cloned Th1 cells with IL-18 and anti-CD3 antibody induces the disappearance of IκB from the cytoplasm and the subsequent accumulation of NF-κB in the nucleus.
    • (1997) Biochem Biophys Res Commun , vol.234 , pp. 454-457
    • Matsumoto, S.1    Tsuji-Takayama, K.2    Aizawa, Y.3    Koide, K.4    Takeuchi, M.5    Ohta, T.6    Kurimoto, M.7
  • 31
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discovery and insights
    • Baldwin AS Jr. The NF-κB and IκB proteins: new discovery and insights. Annu Rev Immunol. 14:1996;649-681.
    • (1996) Annu Rev Immunol , vol.14 , pp. 649-681
    • Baldwin A.S., Jr.1
  • 32
    • 0030694235 scopus 로고    scopus 로고
    • IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NF-κB
    • of outstanding interest. This paper reports the roles of IL-18 in the induction of Th1 cells using naive T cells from mice transgenic for the T cell receptor. IL-18, unlike IL-12, does not drive the development of Th1 cells by itself, but synergized with IL-12 for IFN-γ induction in Th1 cells. IL-18 was shown to signal through the IL-1 receptor associated kinase (IRAK) to induce the accumulation of NF-κB in the nucleus. As IL-1 activated Th2 cells but failed to activate Th1 cells, Th1 and Th2 cells were inferred to differ in responsiveness and in expression of receptors for the IL-1 family.
    • Robinson D, Shibuya K, Mui A, Zonin F, Murphy E, Sana T, Hartley SB, Menon S, Kastelein R, Bazan F, O'Garra A. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NF-κB. of outstanding interest Immunity. 7:1997;571-581 This paper reports the roles of IL-18 in the induction of Th1 cells using naive T cells from mice transgenic for the T cell receptor. IL-18, unlike IL-12, does not drive the development of Th1 cells by itself, but synergized with IL-12 for IFN-γ induction in Th1 cells. IL-18 was shown to signal through the IL-1 receptor associated kinase (IRAK) to induce the accumulation of NF-κB in the nucleus. As IL-1 activated Th2 cells but failed to activate Th1 cells, Th1 and Th2 cells were inferred to differ in responsiveness and in expression of receptors for the IL-1 family.
    • (1997) Immunity , vol.7 , pp. 571-581
    • Robinson, D.1    Shibuya, K.2    Mui, A.3    Zonin, F.4    Murphy, E.5    Sana, T.6    Hartley, S.B.7    Menon, S.8    Kastelein, R.9    Bazan, F.10    O'Garra, A.11
  • 33
    • 0029031029 scopus 로고
    • Activation of γδ T cells for production of IFN-γ is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12
    • Skeen MJ, Ziegler HK. Activation of γδ T cells for production of IFN-γ is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12. J Immunol. 154:1995;5832-5841.
    • (1995) J Immunol , vol.154 , pp. 5832-5841
    • Skeen, M.J.1    Ziegler, H.K.2
  • 34
    • 0028973003 scopus 로고
    • IL-1b is required for IL-12 to induce production of IFN-γ By NK cells
    • Hunter CA, Chizzonite R, Remington JS. IL-1b is required for IL-12 to induce production of IFN-γ by NK cells. J Immunol. 155:1995;4347-4354.
    • (1995) J Immunol , vol.155 , pp. 4347-4354
    • Hunter, C.A.1    Chizzonite, R.2    Remington, J.S.3
  • 35
    • 0028943484 scopus 로고
    • Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activation of transcription (STAT) 3 and STAT 4
    • Jacobson NG, Szabo SJ, Weber-Nordt RM, Zhong Z, Schreiber RD, Darnell JE Jr, Murphy K. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activation of transcription (STAT) 3 and STAT 4. J Exp Med. 181:1995;1755-1762.
    • (1995) J Exp Med , vol.181 , pp. 1755-1762
    • Jacobson, N.G.1    Szabo, S.J.2    Weber-Nordt, R.M.3    Zhong, Z.4    Schreiber, R.D.5    Darnell J.E., Jr.6    Murphy, K.7
  • 36
    • 0031230444 scopus 로고    scopus 로고
    • A mechanism underlying synergy between IL-12 and IFN-γ-inducing factor in enhanced production of IFN-γ
    • of outstanding interest. This paper reported the first analysis of the underlying mechanism for the synergistic effect of IL-12 and IL-18 on interferon (IFN)-γ induction, using a T-cell clone responsive to IL-12. This clone grew equally in response to IL-12 and IL-2. However, these cells produced high levels of IFN-γ in response to IL-18 only when they were grown with IL-12, whereas they did not when grown with IL-2. It was shown by a binding assay for IL-18 that IL-12 upregulated the expression of IL-18 receptor, but that IL-2 reduced it. Naive T cells stimulated with anti-CD3 antibody plus anti-CD28 antibody and subsequently cultured with IL-12 were also shown to express the IL-18 receptor and to respond to the ligand.
    • Ahn H-J, Maruo S, Tomura M, Mu J, Hamaoka T, Nakanishi K, Clark S, Kurimoto M, Okamura H, Fujiwara H. A mechanism underlying synergy between IL-12 and IFN-γ-inducing factor in enhanced production of IFN-γ of outstanding interest J Immunol. 159:1997;2125-2131 This paper reported the first analysis of the underlying mechanism for the synergistic effect of IL-12 and IL-18 on interferon (IFN)-γ induction, using a T-cell clone responsive to IL-12. This clone grew equally in response to IL-12 and IL-2. However, these cells produced high levels of IFN-γ in response to IL-18 only when they were grown with IL-12, whereas they did not when grown with IL-2. It was shown by a binding assay for IL-18 that IL-12 upregulated the expression of IL-18 receptor, but that IL-2 reduced it. Naive T cells stimulated with anti-CD3 antibody plus anti-CD28 antibody and subsequently cultured with IL-12 were also shown to express the IL-18 receptor and to respond to the ligand.
    • (1997) J Immunol , vol.159 , pp. 2125-2131
    • Ahn H-J1    Maruo, S.2    Tomura, M.3    Mu, J.4    Hamaoka, T.5    Nakanishi, K.6    Clark, S.7    Kurimoto, M.8    Okamura, H.9    Fujiwara, H.10
  • 39
    • 0024454176 scopus 로고
    • Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes
    • Smeland EB, Blomhoff HK, Funderud S, Shalaby MR, Espevik T. Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes. J Exp Med. 170:1989;1463-1468.
    • (1989) J Exp Med , vol.170 , pp. 1463-1468
    • Smeland, E.B.1    Blomhoff, H.K.2    Funderud, S.3    Shalaby, M.R.4    Espevik, T.5
  • 42
    • 0030933144 scopus 로고    scopus 로고
    • Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells
    • Yoshimoto T, Okamura H, Tagawa YI, Iwakura Y, Nakanishi K. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells. Proc Natl Acad Sci USA. 94:1997;3948-3953.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3948-3953
    • Yoshimoto, T.1    Okamura, H.2    Tagawa, Y.I.3    Iwakura, Y.4    Nakanishi, K.5
  • 43
    • 0030885123 scopus 로고    scopus 로고
    • Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells
    • of special interest. In this report, IL-12 and IL-18 were shown to synergistically induce interferon-γ production by peritoneal exudate cells and to endow these cells with anticryptococcal activity via production of nitric oxide. Depletion of NK cells from the cell population suppressed these activities.
    • Zhang T, Kawakami K, Qureshi MH, Okamura H, Kurimoto M, Satoh A. Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells. of special interest Infect Immun. 65:1997;3594-3599 In this report, IL-12 and IL-18 were shown to synergistically induce interferon-γ production by peritoneal exudate cells and to endow these cells with anticryptococcal activity via production of nitric oxide. Depletion of NK cells from the cell population suppressed these activities.
    • (1997) Infect Immun , vol.65 , pp. 3594-3599
    • Zhang, T.1    Kawakami, K.2    Qureshi, M.H.3    Okamura, H.4    Kurimoto, M.5    Satoh, A.6
  • 44
    • 0027255749 scopus 로고
    • Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon-γ And bacterial lipopolysaccharide
    • Xie QW, Whisnant R, Nathan C. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon-γ and bacterial lipopolysaccharide. J Exp Med. 177:1993;1779-1784.
    • (1993) J Exp Med , vol.177 , pp. 1779-1784
    • Xie, Q.W.1    Whisnant, R.2    Nathan, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.