Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades

International Immunology

Volumn 12, Issue 1, 2000, Pages 113-117

  Takeuchi, Osamu ^a,b   Takeda, Kiyoshi ^a,b   Hoshino, Katsuaki ^a,b   Adachi, Osamu ^a,b   Ogawa, Tomohiko ^c   Akira, Shizuo ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c ASAHI UNIVERSITY   (Japan)

Author keywords

Gram positive bacteria; Innate immunity; Lipopolysaccharide; Macrophage; Toll like receptor

Indexed keywords

ADAPTOR PROTEIN; INTERLEUKIN 1 RECEPTOR; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; PEPTIDOGLYCAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL CELL WALL; CELLULAR IMMUNITY; CONTROLLED STUDY; GRAM POSITIVE BACTERIUM; IMMUNE RESPONSE; KNOCKOUT MOUSE; MACROPHAGE; MOUSE; MYCOBACTERIUM; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SPLEEN CELL;

EID: 0033968625     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/12.1.113     Document Type: Article

References (30)

1. Medzhitov, R. and Janeway, C. A., Jr. 1997. Innate immunity: the virtues of a nonclonal system of recognition. Cell 91:295.
2. Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J. M. and Hoffmann, J. A. 1996. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86:973.
3. Hashimoto, C., Hudson, K. L. and Anderson, K. V. 1988. The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell 52:269.
4. O'Neill, L. A. and Greene, C. 1998. Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants. J. Leuk. Biol. 63:650.
5. Williams, M. J., Rodriguez, A., Kimbrell, D. A. and Eldon, E. D. 1997. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense. EMBO J. 16:6120.
6. Lemaitre, B., Reichhart, J. M. and Hoffmann, J. A. 1997. Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc. Natl Acad. Sci. USA 94:14614.
7. Medzhitov, R., Preston-Hurlburt, P. and Janeway, C. A., Jr. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388:394.
8. Rock, F. L., Hardiman, G., Timans, J. C., Kastelein, R. A. and Bazan, J. F. 1998. A family of human receptors structurally related to Drosophila Toll. Proc. Natl Acad. Sci. USA 95:588.
9. Takeuchi, O., Kawai, T., Sanjo, H., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Takeda, K. and Akira, S. 1999. TLR6: a novel member of an expanding Toll-like receptor family. Gene 231:59.
10. Yang, R. B., Mark, M. R., Gray, A., Huang, A., Xie, M. H., Zhang, M., Goddard, A., Wood, W. I., Gurney, A. L. and Godowski, P. J. 1998. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature 395:284.
11. Kirschning, C. J., Wesche, H., Merrill Ayres, T. and Rothe, M. 1998. Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J. Exp. Med. 188:2091.
12. Poltorak, A., He, X., Smirnova, L. Liu, M. Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B. and Beutler, B. 1998. Defective LPS signaling in C3H/HeJ and C57B/10ScCr mice: mutations in Tlr4 gene. Science 282:2085.
13. Qureshi, S. T., Lariviere, L., Leveque, G., Clermont, S., Moore, K. J., Gros, P. and Malo, D. 1999. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J. Exp. Med. 189:615.
14. Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K. and Akira, S. 1999. Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162:3749.
15. Muzio, M., Ni, J., Feng, P. and Dixit, V. M. 1997. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278:1612.
16. Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S. and Cao, Z. 1997. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7:837.
17. Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K. and Akira, S. 1998. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9:143.
18. Muzio, M., Natoli, G., Saccani, S., Levrero, M. and Mantovani, A. 1998. The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J. Exp. Med. 187:2097.
19. Medzhitov, R., Preston-Hurlburt, P., Kopp, E., Stadlen, A., Chen, C., Ghosh, S. and Janeway, C. A., Jr. 1998. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell 2:253.
20. Kawai, T., Adachi, O., Ogawa, T., Takeda, K. and Akira, S. 1999. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11:115.
21. Schwandner, R., Dziarski, R., Wesche, H., Rothe, M. and Kirschning, C. J. 1999. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J. Biol. Chem. 274:17406.
22. Yoshimura, A., Lien, E., Ingalls, R. R., Tuomanen, E., Dziarski, R. and Golenbock, D. 1999. Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J. Immunol. 163:1.
23. Brightbill, H. D., Libraty, D. H., Krutzik, S. R., Yang, R. B., Belisle, J. T., Bleharski, J. R., Maitland, M., Norgard, M. V., Plevy, S. E., Smale, S. T., Brennan, P. J., Bloom, B. R., Godowski, P. J. and Modlin, R. L. 1999. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 285:732.
24. Aliprantis, A. O., Yang, R. B., Mark, M. R., Suggett, S., Devaux, B., Radolf, J. D., Klimpel, G. R., Godowski, P. and Zychlinsky, A. 1999. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 285:736.
25. Ogawa, T. 1993. Chemical structure of lipid A from 271 Porphyromonas (Bacteroides) gingivalis lipopolysaccharide. FEBS Lett. 332:197.
26. Pugin, J., Heumann, I. D., Tomasz, A., Kravchenko, V. V., Akamatsu, Y., Nishijima, M., Glauser, M. P., Tobias, P. S. and Ulevitch, R. J. 1994. CD14 is a pattern recognition receptor. Immunity 1:509.
27. Barnes, P. F., Chatterjee, D., Abrams, J. S., Lu, S., Wang, E., Yamamura, M., Brennan, P. J. and Modlin, R. L. 1992. Cytokine production induced by Mycobacterium tuberculosis lipoarabinomannan. Relationship to chemical structure. J. Immunol. 149:541.
28. Rietschel, E. T., Kirikae, T., Schade, F. U., Mamat, U., Schmidt, G., Loppnow, H., Ulmer, A. J., Zahringer, U., Seydel, U., Di Padova, F., et al. 1994. Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J. 8:217.
29. Saito-Taki, T., Tanabe, M. J., Mochizuki, H., Nakano, M., Tsujimoto, M., Kotani, S., Yokogawa, K. and Kawata, S. 1980. Mitogenicity of cell wall preparations of gram-positive bacteria on cultured spleen cells obtained from immunologically abnormal C3H/HeJ and CBA/N-defect mice. Microbiol. Immunol. 24:249.
30. Ogawa, T., Kotani, S., Fukuda, K., Tsukamoto, Y., Mori, M., Kusumoto, S. and Shiba, T. 1982. Stimulation of migration of human monocytes by bacterial cell walls and muramyl peptides. Infect. Immun. 38:817.