IL-18 promotes type 1 cytokine production from NK cells and T cells in human intracellular infection

Journal of Immunology

Volumn 162, Issue 10, 1999, Pages 6114-6121

  García, Verónica E ^a   Uyemura, Koichi ^a   Sieling, Peter A ^a   Ochoa, María T ^a   Morita, Craig T ^b   Okamura, Haruki ^c   Kurimoto, Masashi ^d   Rea, Thomas H ^e   Modlin, Robert L ^a,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HYOGO COLLEGE OF MEDICINE   (Japan)

^d HAYASHIBARA BIOCHEMICAL LABORATORIES INC   (Japan)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 4; MESSENGER RNA; RECOMBINANT CYTOKINE; RECOMBINANT INTERLEUKIN 18; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; LEPROMATOUS LEPROSY; LEPROSY; MONOCYTE; MYCOBACTERIUM LEPRAE; NATURAL KILLER CELL; PRIORITY JOURNAL; T LYMPHOCYTE; TUBERCULOID LEPROSY;

CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-18; KILLER CELLS, NATURAL; LEPROSY; MONOCYTES; T-LYMPHOCYTES; TUBERCULOSIS, PULMONARY;

EID: 0033563009     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Heinzel, F. P., M. D. Sadick, B. J. Holaday, R. L. Coffman, and R. M. Locksley. 1989. Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis: evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 169:59.
2. Salgame, P., J. S. Abrams, C. Clayberger, H. Goldstein, J. Convit, R. L. Modlin, and B. R. Bloom. 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 254:279.
3. Yamamura, M., K. Uyemura, R. J. Deans, K. Weinberg, T. H. Rea, B. R. Bloom, and R. L. Modlin. 1991. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 254:277.
4. Libraty, D. H., L. E. Airan, K. Uyemura, D. Jullien, B. Spellberg, T. H. Rea, and R. L. Modlin. 1997. Interferon-γ differentially regulates interleukin-12 and interleukin-10 production in leprosy. J. Clin. Invest. 99:336.
5. Manetti, R., F. Gerosa, M. G. Giudizi, R. Biagiotti, P. Parronchi, M. P. Piccinni, S. Sampognaro, E. Maggi, S. Romagnani, and G. Trinchieri. 1994. Interleukin 12 induces stable priming for interferon γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J. Exp. Med. 179:1273.
6. + T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent. Int. Immunol. 5:1119.
7. Trinchieri, G. 1994. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1. Blood 84:4008.
8. Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. H. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827.
9. Chan, S. H., M. Kobayashi, D. Santoli, B. Perussia, and G. Trinchieri. 1992. Mechanisms of IFN-γ induction by natural killer cell stimulatory factor (NKSF/ IL-12): role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2. J. Immunol. 148:92.
10. Zhang, T., K. Kawakami, M. H. Qureshi, H. Okamura, M. Kurimoto, and A. Saito. 1997. Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of γ interferon by natural killer cells. Infect. Immun. 65:3594.
11. Micallef, M. J., T. Ohtsuki, K. Kohno, F. Tanabe, S. Ushio, M. Namba, T. Tanimoto, K. Torigoe, M. Fujii, M. Ikeda, S. Fukuda, and M. Kurimoto. 1996. Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-γ production. Eur. J. Immunol. 26:1647.
12. Ushio, S., M. Namba, T. Okura, K. Hattori, Y. Nukada, K. Akita, F. Tanabe, K. Konishi, M. Micallef, M. Fujii, K. Torigoe, T. Tanimoto, S. Fukuda, M. Ikeda, H. Okamura, and M. Kurimoto. 1996. Cloning of the cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J. Immunol. 156:4274.
13. Okamura, H., H. Tsutsi, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, K. Torigoe, T. Okura, Y. Nukada, and K. Hattori. 1995. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 378:88.
14. Kohno, K., J. Kataoka, T. Ohtsuki, Y. Suemoto, I. Okamoto, M. Usui, M. Ikeda, and M. Kurimoto. 1997. IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. J. Immunol. 158:1541.
15. Yoshimoto, T., H. Okamura, Y. I. Tagawa, Y. Iwakura, and K. Nakanishi. 1997. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells. Proc. Natl. Acad. Sci. USA 94:3948.
16. Kawakami, K., M. H. Qureshi, T. Zhang, H. Okamura, M. Kurimoto, and A. Saito. 1997. IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-γ production. J. Immunol. 159: 5528.
17. Meyer Zum Buschenfelde, C., S. Cramer, C. Trumpfheller, B. Fleischer, and S. Frosch. 1997. Trypanosoma cruzi induces strong IL-12 and IL-18 gene. Clin. Exp. Immunol. 110:378.
18. Bohn, E., A. Sing, R. Zumbihl, C. Bielfeldt, H. Okamura, M. Kurimoto, J. Heesemann, and I. B. Autenrieth. 1998. IL-18 (IFN-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice. J. Immunol. 160:299.
19. Kobayashi, K., M. Kai, M. Gidoh, N. Nakata, M. Endoh, R. P. Singh, T. Kasama, and H. Saito. 1998. The possible role of interleukin (IL)-12 and interferon-γ-inducing factor/IL-18 in protection against experimental Mycobacterium leprae infection in mice. Clin. Immunol. Immunopathol. 88:226.
20. Miettinen, M., S. Matikainen, J. Vuopio-Vakila, J. Pirhonen, K. Varkila, M. Kurimoto, and I. Julkunen. 1998. Lactobacilli and Streptococci induce interleukin-12 (JL-12), IL-18, and IFN-γ production in human peripheral blood mononuclear cells. Infect. Immun. 66:6058.
21. Sareneva, T., S. Matikainen, M. Kurimoto, and I. Julkunen. 1998. Influenza A virus-induced IFN-α/β and IL-18 synergistically enhance IFN-γ gene expression in human T cells. J. Immunol. 160:6032.
22. Ridley, D. S., and W. H. Jopling. 1966. Classification of leprosy according to immunity: a five-group system. Int. J. Lepr. 34:255.
23. Sieling, P. A., X.-H. Wang, M. K. Gately, J. L. Oliveros, T. McHugh, P. F. Barnes, S. F. Wolf, L. Golkar, M. Yamamura, Y. Yogi, K. Uyemura, T. H. Rea, and R. L. Modlin. 1994. IL-12 regulates T helper Type 1 cytokine responses in human infectious disease. J. Immunol. 153:3639.
24. Mehra, V., B. R. Bloom, A. C. Bajardi, C. L. Grisso, P. A. Sieling, D. Alland, J. Convit, X. D. Fan, S. W. Hunter, P. J. Brennan, T. H. Rea, and R. L. Modlin. 1992. A major T cell antigen of Mycobacterium leprae is a 10-kD heat-shock cognate protein. J. Exp. Med. 175:275.
25. Fogelman, A. M., F. Elahi, K. Sykes, B. J. Van Lenten, M. C. Territo, and J. A. Berliner. 1988. Modification of the Recalde method for the isolation of human monocytes. J. Lipid Res. 29:1243.
26. Sieling, P. A., J. S. Abrams, M. Yamamura, P. Salgame, B. R. Bloom, T. H. Rea, and R. L. Modlin. 1993. Immunosuppressive roles for interleukin-10 and interleukin-4 in human infection: in vitro modulation of T cell responses in leprosy. J. Immunol. 150:5501.
27. Yamamura, M., X.-H. Wang, J. D. Ohmen, K. Uyemura, T. H. Rea, B. R. Bloom, and R. L. Modlin. 1992. Cytokine patterns of immunologically mediated tissue damage. J. Immunol. 149:1470.
28. Morita, C. T., S. Verma, P. Aparicio, C. Martinez, H. Spits, and M. B. Brenner. 1991. Functionally distinct subsets of human γ/δ T cells. Eur. J. Immunol. 21: 2999.
29. Sieling, P. A., D. Chatterjee, S. A. Porcelli, T. I. Prigozy, T. Soriano, M. B. Brenner, M. Kronenberg, P. J. Brennan, and R. L. Modlin. 1995. CD1-restricted T cell recognition of microbial lipoglycans. Science 269:227.
30. Tanaka, Y., C. T. Monta, E. Nieves, M. B. Brenner, and B. R. Bloom. 1995. Natural and synthetic nonpeptide antigens recognized by human γ/δ T cells. Nature 375:155.
31. Taniguchi, M., K. Nagaoka, T. Kunikata, T. Kayano, H. Yamauchi, S. Nakamura, M. Ikeda, K. Orita, and M. Kurimoto. 1997. Characterization of anti-human interleukin-18 (IL-18)/interferon-γ-inducing factor (IGIF) monoclonal antibodies. J. Immunol. Methods 206:107.
32. Garcia, V. E., P. A. Sieling, J. Gong, P. F. Barnes, K. Uyemura, Y. Tanaka, B. R. Bloom, C. T. Morita, and R. L. Modlin. 1997. Single-cell cytokine analysis of γδ T cell responses to nonpeptide mycobacterial antigens. J. Immunol. 159: 1128.
33. Akita, K., T. Ohtsuki, Y. Nukada, T. Tanimoto, M. Namba, T. Okura, R. Takakura-Yamamoto, K. Torigoe, Y. Gu, M. S. S. Su, M. Fujii, M. Satoh-Itoh, K. Yamamoto, K. Kohno, M. Ikeda, and M. Kurimoto. 1997. Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells. J. Biol. Chem. 272:26595.
34. Meyer, Z. B., S. Cramer, C. Trumpfheller, B. Fleischer, and S. Frosch. 1997. Trypanosoma cruzi induces strong IL-12 and IL-18 gene expression in. Clin. Exp. Immunol. 110:378.
35. Garcia, V. E., D. Jullien, M. Song, K. Uyemura, K. Shuai, C. T. Monta, and R. L. Modlin. 1998. IL-15 enhances the response of human γδ T cells to non-peptide microbial antigens. J. Immunol. 160:4322.
36. + T lymphocytes. J. Immunol. 160:3642.
37. Takeda, K., H. Tsutsi, T. Yoshimoto, O. Adachi, N. Yoshida, T. Kishimoto, H. Okamura, K. Nakanishi, and S. Akira. 1998. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 8:383.
38. Robinson, D., K. Shibuya, A. Mui, F. Zonin, E. Murphy, T. Sana, S. B. Hartley, S. Menon, R. Kastelein, F. Bazan, and A. O'Garra. 1997. IGIF does not drive ThI development but synergizes with IL-12 for interferon-γ production and activates IRAK and NFκB. Immunity 7:571.