The role of MHC class II molecules in susceptibility and resistance to autoimmunity

Current Opinion in Immunology

Volumn 10, Issue 6, 1998, Pages 677-681

  McDevitt, Hugh O ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ALLELE; AUTOIMMUNITY; CELL SELECTION; DISEASE PREDISPOSITION; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; REVIEW; T LYMPHOCYTE; TRANSGENE;

EID: 0032403094     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(98)80088-5     Document Type: Article

References (31)

1. McDevitt HO, Tyan ML. Genetic control of the antibody response in inbred mice. Transfer of response by spleen cells and linkage to the major histocompatibility (H-2) locus. J Exp Med. 128:1968;1-11.
2. Grumet FC, Coukell A, Bodmer JG, Bodmer WF, McDevitt HO. Histocompatibility (HL-A) antigens associated with systemic lupus erythematosus. A possible genetic predisposition to disease. New Engl J Med. 285:1971;193-196.
3. Svejgaard A, Platz P, Ryder LP, Nielsen S, Thomsen M. HLA and disease associations - a survey. Transplantation Rev. 22:1975;3-43.
4. O'Dell JR, Nepom BS, Haire C, Gersuk VH, Gaur L, Moore GF, Drymalski W, Palmer W, Eckhoff PJ, Klassen LW, et al. HLA-DRB1 typing in rheumatoid arthritis: predicting response to specific treatments. Ann Rheum Dis. 57:1998;209-213.
5. Todd JA, Bell JI, McDevitt HO. HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature. 329:1987;599-604.
6. Tisch R, McDevitt H. Insulin-dependent diabetes mellitus. Cell. 85:1996;291-297.
7. Gregersen PK, Shen M, Song Q, Merryman P, Degar S, Seki T, Maccari J, Goldberg D, Murphy H, Schwenzer J, et al. Molecular diversity of HLA-DR4 haplotypes. Proc Natl Acad Sci USA. 83:1986;2642-2646.
8. Acha-Orbea H, McDevitt HO. The first external domain of the non-obese diabetic mouse class II I - Aβ chain is unique. Proc Natl Acad Sci USA. 84:1987;2435-2439.
9. Morel PA, Dorman JS, Todd JA, McDevitt HO, Trucco M. Aspartic acid at position 57 of the HLA-DQ B chain protects against type I diabetes. A family study. Proc Natl Acad Sci USA. 85:1998;8111-8115.
10. Winchester R. The molecular basis of susceptibility to rheumatoid arthritis. Adv Immunol. 56:1994;389-466.
11. Cope AP, Sonderstrup G: Evaluating candidate autoantigens in rheumatoid arthritis. Springer Semin Immunopath, in press.
12. Brewerton DA, Hart FD, Nicholls A, Caffrey M, James DCO, Sturrock RD. Ankylosing spondylitis and HLA 27. Lancet. 809:1973;904-907.
13. d transgene prevents diabetes in non-obese diabetic mice by inducing regulatory T-cells. Proc Natl Acad Sci USA. 90:1993;9566-9570.
14. Katz JD, Benoist C, Mathis D. T-helper cell subsets in insulin dependent diabetes. Science. 268:1995;1185-1188.
15. Nishimoto H, Kikutani H, Yamamura KI, Kishimoto T. Prevention of autoimmune insulitis by expression of I - E molecules in NOD mice. Nature. 328:1987;432-434.
16. k NOD transgenic mice. Int Immunol. 1:1989;209-213.
17. Uno M, Miyazaki T, Uehira M, Nishimoto H, Kimoto M, Miyazaki J, Yamamura K. Complete prevention of diabetes in transgenic NOD mice expressing I - E molecules. Immunol Lett. 31:1991;47-52.
18. Lund T, O'Reilly L, Hutchings P, Kanagawa O, Simpson E, Gravely R, Chandler P, Dyson J, Picard J, Edwards A, et al. Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I - A β-chain or normal I - E α-chain. Nature. 345:1990;727-729.
19. NOD to the development of insulitis in non-obese diabetic mice. Nature. 345:1990;722-724.
20. k transgenic mice. Nature. 345:1990;724-726.
21. g7 β-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus. J Immunol. 154:1995;5567-5575.
22. Reich EP, Sherwin RS, Kanagawa O, Janeway CA Jr. An explanation for the protective effect of the MHC class II I - E molecule in murine diabetes. Nature. 341:1989;326-328.
23. Schmidt D, Verdaguer J, Averill N, Santamaria P. Thymocyte selection and the major histocompatibility complex linked susceptibility and resistance to spontaneous autoimmune diabetes [abstract]. Diabetes. 46:1997;197A.
24. Slattery RM, Miller JFAP, Heath WR, Charlton B. Failure of a protective major histocompatibility complex class II molecule to delete autoreactive T-cells in autoimmune diabetes. Proc Natl Acad Sci USA. 90:1993;10808-10810.
25. Katz JD, Wang B, Haskins K, Benoist C, Mathis D. Following a diabetogenic T-cell from genesis through pathogenesis. Cell. 74:1993;1089-1100.
26. Takacs K, Douek DC, Altmann DM. Exacerbated autoimmunity associated with a T-helper-1 cytokine profile shift in H-2E-transgenic mice. Eur J Immunol. 25:1995;3134-3141.
27. Nepom GT. A unified hypothesis for the complex genetics of HLA associations with IDDM. Diabetes. 39:1990;1153-1157.
28. Deng H, Apple R, Clare-Salzler M, Trembleau S, Mathis D, Adorini L, Sercarz E. Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease. J Exp Med. 178:1993;1675-1680.
29. Luhder J, Katz J, Benoist C, Mathis D. Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T-cells with additional specificities. of outstanding interest J Exp Med. 187:1998;379-387 In this study, the authors show that resistant MHC alleles induce the development of T cell populations that are restricted to the resistant allele and capable of suppressing the diabetic process. Evidence is presented that this is not simply a gene dose effect but is in fact a direct or indirect effect of the population of T cells that is restricted to the resistant MHC class II allele.
30. Bohme J, Schuhbaur B, Kanagawa O, Benoist C, Mathis D. MHC-linked protection from diabetes dissociated from clonal deletion of T-cells. Science. 249:1990;293-295.
31. Schmidt D, Verdaguer J, Averill N, Santamaria P. A mechanism for the major histocompatibility linked resistance to autoimmunity. of outstanding interest J Exp Med. 186:1997;1059-1075 In this study, the authors show that introduction of a resistant MHC class II allele into a mouse transgenic for the TCR and expressing diabetogenic T cells results in negative selection of the diabetogenic TCR, thus offering a second possible mechanism for resistance to the development of type I diabetes (see [29]).