IFN-γ-Inducing Factor (IGIF) Is a Costimulatory Factor on the Activation of Th1 but not Th2 Cells and Exerts its Effect Independently of IL-12

Journal of Immunology

Volumn 158, Issue 4, 1997, Pages 1541-1550

  Kohno, Keizo ^a   Kataoka, Jun ^a   Ohtsuki, Takashi ^a   Suemoto, Yasuo ^a   Okamoto, Iwao ^a   Usui, Mitsuko ^a,b   Ikeda, Masao ^a   Kurimoto, Masashi ^a  

^a HAYASHIBARA BIOCHEMICAL LABORATORIES INC   (Japan)

^b Okinaka Memorial Institute for Medical Research   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERFERON INDUCING AGENT; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; OVALBUMIN;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; C3H MOUSE; C57BL MOUSE; CELL CLONE; CELL LINE; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; FEMALE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; PHYSIOLOGY; TH1 CELL; TH2 CELL;

ANIMALS; CELL LINE; CLONE CELLS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; DRUG SYNERGISM; FEMALE; INTERFERON INDUCERS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-18; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; OVALBUMIN; RECEPTORS, INTERLEUKIN-2; TH1 CELLS; TH2 CELLS;

EID: 0031568526     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Manetti, R., P. Parronchi, M. G. Giudizi, M.-P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177:1199.
2. Manetti, R., F. Gerosa, M. G. Giudizi, R. Biagiotti, P. Parronchi, M.-P. Piccinni, S. Sampognaro, E. Maggi, S. Romagnani, and G. Trinchieri. 1994. Interleukin 12 induces stable priming for interferon γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J. Exp. Med. 179:1273.
3. + T cells through IL-12 produced by Lisreria-induced macrophages. Science 260:547.
4. Macatonia, S. E., C.-S. Hsieh, K. M. Murphy, and A. O'Garra. 1993. Dendritic cells and macrophages are required for Th1 development of CD44+ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent. Int. Immunol. 5:1199.
5. Trinchieri, G. 1994. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84:4008.
6. Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827.
7. Chan, S. H., M. Kobayashi, D. Santoli, B. Perussia, and G. Trinchieri. 1992. Mechanisms of IFN-γ induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the syngeneic interaction between NKSF and IL-2. J. Immunol. 148:92.
8. Gazzinelli, R. T., S. Hieny, T. A. Wynn, S. Wolf, and A. Sher. 1993. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl. Acad. Sci. USA 90:6115.
9. D'Andrea A , M. Rengaraju, N. M. Valiante, J. Chehimi, M. Kubin, M. Aste, S. H. Chan, M. Kobayashi, D. Young, E. Nickbarg, R. Chizzonite, S. F. Wolf, and G. Trinchieri. 1992. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387.
10. Scott, P., and S. H. E. Kaufmann. 1991. The role of T-cell subsets and cytokines in the regulation of infection. Immunol. Today 12:346.
11. Okamura, H., H. Tsutsui, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, K. Torigoe, T. Okura, Y. Nukada, K. Hattori, K. Akita, M. Namba, F. Tanabe, K. Konishi, S. Fukuda, and M. Kurimoto. 1995. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 378:88.
12. Ushio, S., M. Namba, T. Okura, K. Hattori, Y. Nukada, K. Akita, F. Tanabe, K. Konishi, M. Micallef, M. Fujii, K. Torigoe, T. Tanimoto, S. Fukuda, M. Ikeda, H. Okamura, and M. Kurimoto. 1996. Cloning of the cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biological activities of the protein. J. Immunol. 156:4274.
13. Okamura, H., K. Nakata, T. Komatsu, T. Tanimoto, Y. Nukada, F. Tanabe, K. Akita, K. Torigoe, T. Okura, S. Fukuda, and M. Kurimoto. 1995. A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock. Infect. Immun. 63:3966.
14. Taniguchi, Y., H. Ikegami, M. Usui, S. Ando, M. Kurimoto, M. Sakaguchi, S Inoue, and T. Matuhasi. 1989. Biological and immunological properties of sugi basic protein-pullulan conjugate. I. Suppressive effect on IgE antibody production and on IgE-mediated reactions. Int. Arch. Allergy Appl. Immunol. 89:136.
15. Karasuyama, H., N. Tohyama, and T. Tada. 1989. Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene. J. Exp. Med. 169:13.
16. Zou, J. J., D. S. Schoenhaut, D. M. Carvajal, R. R. Warrier, D. H. Presky, M. K. Gately, and U. Gubler. 1995. Structure-function analysis of the p35 subunit of mouse interleukin 12. J. Biol. Chem. 270:5864.
17. Kohno, K., T. Ohtsuki, Y. Suemoto, T. Inoue, Y. Taniguchi, M. Usui, M. Ikeda and M. Kurimoto. 1996. Regulation of cytokine production by sugi allergen-pullulan conjugate. Cell. Immunol. 168:211.
18. Tamura, T., T. Yanagida, and H. Nariuchi. 1993. Difference in signal transduction pathway for IL-2 and IL-4 production in T helper 1 and T helper 2 cell clones in response to anti-CD3. J. Immunol. 151:6051.
19. Yanagida, T., T. Kato, O. Igarashi, T. Inoue, and H. Nariuchi. 1994. Second signal activity of IL-12 on the proliferation and IL-2R expression of T helper cell-1 clone. J. Immunol. 152:4919.
20. Lamont, A. G., and L. Adorini. 1996. IL-12: a key cytokine in immune regulation. Immunol. Today 17:214.
21. Germann, T., M. K. Gately, D. S. Schoenhaut, M. Lohoff, F. Mattner, S. Fischer, S.-C. Jin, E. Schmitt, and E. Rüde. 1993. Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells. Eur. J. Immunol. 23:1762.
22. Gajewski, T. F., M. Pinnas, T. Wong, and F. W. Fitch. 1991. Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations. J. Immunol. 146:1750.
23. Kakiuch, T., M. Matsui, S. Taira, H. Nariuchi, H. Osawa, and T. Diamantstein. 1987. B cells as antigen-presenting cells: antigen-specific IL-2 production by cloned T cells without expression of IL-2 receptors. Cell. Immunol. 108:150
24. Chang, T.-L., C. M. Shea, S. Urioste, R. C. Thompson, W. H. Boom, and A. K. Abbas. 1990. Heterogeneity of helper/inducer T lymphocytes. III. Responses of IL-2- and IL-4-producing (Th1 and Th2) clones to antigens presented by different accessory cells. J. Immunol. 145:2803.
25. Lichtman, A. H., J. Chin, J. A. Schmidt, and A. K. Abbas. 1988. Role of interleukin 1 in the activation of T lymphocytes. Prof. Natl. Acad. Sci. USA 85:9699.
26. + T cells through an effect on antigen-presenting cells. J. Immunol 154:2578.
27. + T lymphocytes, and NK cells. J. Immunol. 149:3495.
28. Taniguchi, T. 1995. Cytokine signaling through nonreceptor protein tyrosme kinases. Science 268:251.
29. Bacon, C. M., D. W. McVicar, J. R. Ortaldo, R. C. Rees, J. J. O'Shea., and J. A. Johnston. 1995. Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J. Exp. Med. 181:399.
30. Jacobson, N. G., S. J. Szabo, R. M. Weber-Nordt, Z. Zhong, R. D. Schreiber, J. E. Darnell, Jr., and K. M. Murphy. 1995. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp. Med. 181:1755.
31. Micallef, M. J., T. Ohtsuki, K. Kohno, F. Tanabe, S. Ushio, M. Namba, T. Tanimoto, K. Torigoe, M. Fujii, M. Ikeda, S. Fukuda, and M. Kurimoto. 1996. Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for Interferon-γ production. Eur. J. Immunol. 26:1647.
32. Dao, T., K. Ohashi, T. Kayano, M. Kurimoto, and H. Okamura. 1996. Interferon-γ-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells. Cell. Immunol 173:230.
33. Ramsdell, F., M. S. Seaman, R. E. Miller, T. W. Tough, M. R. Alderson, and D. H. Lynch. 1994. gld/gld mice are unable to express a functional ligand tor Fas. Eur. J. Immunol. 24:928.
34. Miyawaki, T., T. Uehara, R. Nibu, T. Tsuji, A. Yachie, S. Yonehara, and N. Taniguchi. 1992. Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood. J. Immunol. 149:3753.
35. Klas, C., K.-M. Debatin, R. R. Jonker, and P. H. Krammer. 1993. Activation interferes with the APO-1 pathway in mature human T cells. Int. Immunol. 5:625.
36. Kabelitz, D., T. Pohl, and K. Pechhold. 1993. Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes. Immunol. Today 14:338.
37. Ramsdell, F., M. S. Seaman, R. E. Miller, K. S. Picha, M. K. Kennedy and D. H. Lynch. 1994. Differential ability of Th1 and Th2 T cells to express Fas ligand and to undergo activation-induced cell death. Int. Immunol. 6:1545.
38. Alderson, M. R., T. W. Tough, T. Davis-Smith, S. Braddy, B. Falk, K. A. Schooley, R. G. Goodwin, C. A. Smith, F. Ramsdell, and D. H. Lynch. 1995. Fas ligand mediates activation-induced cell death in human T lymphocytes. J. Exp. Med. 181:71.
39. Chan, S. H., B. Perussia, J. W. Gupta, M. Kobayashi, M. Pospísil, H. A. Young, S. F. Wolf, D. Young, S. C. Clark, and G. Trinchieri. 1991. Induction of interferon γ production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J. Exp. Med. 173:869.
40. Bairoch, A. 1993. The PROSITE dictionary of sites and patterns in proteins, its current status. Nucleic Acids Res. 21:3097.
41. Wysocka, M., M. Kubin, L. Q. Vieira, L. Ozmen, G. Garotta, P. Scott, and G. Trinchieri. 1995. Interleukin-12 is required for Interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25:672.
42. Shu, U., M. Kiniwa, C. Y. Wu, C. Maliszewsky, N. Vezzio, J. Hakimi, M. Gately, and G. Delespesse. 1995. Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. Eur. J. Immunol. 25:1125.
43. Nastala, C., H. D. Edington, T. G. McKinney, H. Tahara, M. A. Nalesnik, M. J. Brunda, M. K. Gately, S. F. Wolf, R. D. Schreiber, W. J. Storkus, and M. T. Lotze. 1994. Recombinant IL-12 administration induces tumor regression in association with IFN-γ production. J. Immunol 153:1697.
44. Zou, J.-P., N. Yamamoto, T. Fujii, H. Takenaka, M. Kobayashi, S. H. Herrmann S. F. Wolf, H. Fujiwara, and T. Hamaoka. 1995. Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-γ production by anti-tumor T cells. Int. Immunol. 7:1135.