Human keratinocytes constitutively express interleukin-18 and secrete biologically active interleukin-18 after treatment with pro-inflammatory mediators and dinitrochlorobenzene

Journal of Investigative Dermatology

Volumn 113, Issue 5, 1999, Pages 766-772

  Naik, Shubhada M ^a   Cannon, Georgetta ^a   Burbach, Guido J ^a   Singh, Sarceta R ^a   Swerlick, Robert A ^a   Wilcox, Josiah N ^a   Ansel, John C ^a   Caughman, S Wright ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytokines; Inflammation; Skin; Th1; Th2

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; LIPOPOLYSACCHARIDE; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INTERFERON PRODUCTION; KERATINOCYTE; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN SECRETION; PSORIASIS; SKIN INFLAMMATION;

EID: 0032709099     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.1999.00750.x     Document Type: Article

References (40)

1. Akita K, Ohtsuki T, Nukada Y, et al: Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells. J Biol Chem 272(42):26595-26603, 1997
2. Barker JN, Mitra RS, Griffiths CE, Dixit VM, Nickloff BJ: Keratinocytes as initiators of inflammation. Lancet 337:211-214, 1991
3. Bazan JF, Timans JC, Kaselein RA: A newly defined interleukin-1? Nature 379:591-, 1996
4. Boehm KD, Yun JK, Strohl KP, Elmets CA: In-situ changes in the relative abundance of human epidermal cytokine messenger RNAs following exposure to the poison ivy/oak contact allergen, urushiol. Exp Dermatol 5(3):150-160, 1996
5. Boyce ST, Ham RG: Cultivation, frozen storage, and clonal growth of normal human epidermal keratinocytes in serum free media. J Tissue Culture Methods 9:83-93, 1985
6. Breathnach SM: The skin system and psoriasis. Clin Exp Immunol 91:343-345, 1993
7. Caruccio N, Ross J: Purification of a human polyribosome-associated 3′ to 5′ exoribonuclease. J Biol Chem 269(50):31814-31821, 1994
8. Cooper KD, Hammerberg C, Baadsgaard O, et al: IL-1 activity is reduced in psoriatic skin: decreased IL-1 alpha and increased nonfunctional IL-1 beta. J Immunol 144(12):4593-4603, 1990
9. Dinarello CA, Novick D, Puren AJ, et al: Overview of interleukin-18: more than an IFN-γ-inducing factor. J Leuk Biol 63(6):658-664, 1998
10. Ebnet K, Kaldijian EP, Anderson AO, Shaw S: Orchestrated information transfer underlying leukocyte endothelial interactions. Annu Rev Immunol 14:155-177, 1996
11. Farrar MA, Schreiber RD: The molecular cell biology of interferon-gamma and its receptor. Annu Rev Immunol 11:571-611, 1993
12. Ghayur T, Banerjee S, Hugunin M, et al: Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production. Nature 386:619-623, 1997
13. Gu Y, Kuida K, Tsutsui H, et al. Activation of interferon-γ inducing factor mediated by interleukin-1β converting enzyme. Science 275:206-209, 1997
14. Jaffe ES, Raffeld M: Identification of cells in tissue sections. In: Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W (eds). Current Protocols in Immunology New York: John Wiley, 1996, pp. 5.8.1-5.8.8
15. Kalish RS: Poison ivy dermatitis: pathogenesis of allergic contact dermatitis to urushiol. Prog Dermatol 29(3):1-7, 1995
16. Kanof ME, Smith PD, Zola H: Preparation of human mononuclear cell populations and subpopulations. In: Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W (eds). Current Protocols in Immunology. New York: John Wiley, 1991, pp. 7.1.1-7.1.7
17. Kubota Y, Kleinman H, Martin GR, Lawley TJ: Role of laminin and basement membrane in the differentiation of human endothelial cells into capillary-like structures. J Cell Biol 107(4):1589-1598, 1988
18. Kupper TS: The role of epidermal cytokines in immunophysiology. In: Shevach E, Oppenheim J (eds). The Role of Cells and Cytokines in Immunity and Inflammation. New York: Oxford University Press, 1990, pp. 285-305
19. Luger TA, Schwarz T: Evidence of an epidermal cytokine network. J Invest Dermatol 95(Suppl. 6):100S-104S, 1990
20. Matsumoto S, Tsuji-Takayama K, Aizawa Y, Koide K, Takeuchi M, Ohta, T, Kurimoto M: Interleukin-18 activates NF-κB in murine T helper type 1 cells. Biochem Biophys Res Commun 234(2):454-457, 1997
21. Murzin AG, Lesk AM, Chothia CJ: beta-trefoil fold: Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors. J Mol Biol 223(2):531-543, 1992
22. Okamura H, Tsutsui H, Komatsu T, et al: Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 378(6552):88-91, 1995
23. Parnet P, Garka KE, Bonnert TP, Dower SK, Sims JE: IL-1 Rrp is a novel receptor-like molecule similar to the type 1 interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. J Biol Chem 271(8):3967-3970, 1996
24. + human blood mononuclear cells. J Clin Invest 101(3):711-721, 1998
25. Robinson D, Shibuya K, Mui A, et al: IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NF-κB. Immunity 7(4):571-581, 1997
26. Rogers J, Munro H: Translation of ferritin light and heavy subunit mRNAS is regulated by intracellular chelatable iron levels in rat hepatoma cells. Proc Natl Acad Sci USA 84(8):2277-22981, 1987
27. Romagnani S: Lymphokine production by human T cells in disease states. Annu Rev Immunol 12:227-257, 1994
28. Schalinske KL, Chen OS, Eisenstein KS: Iron differentially stimulates translation of mitochondrial aconitase and ferritin mRNAs in mammalian cells. Implications for iron regulatory proteins as regulators of mitochondrial citrate utilization. J Biol Chem 273(6):3740-3746, 1998
29. Springer TA: Traffic signals on the endothelium for lymphocyte recirculation and leukocyte emigration. Annu Rev Physiol 57:827-872, 1995
30. Stoll S, Mueller G, Kurimoro M, et al: Production of IL-18 (IFN-γ-inducing factor) messenger RNA and functional protein by murine keratinocytes. J Immunol 159(1):298-302, 1997
31. Stoll S, Jonulcit H, Schmitt E, et al: Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-12-dependent TH1 development. Eur J Immunol 28(10):3231-3239, 1998
32. Takeda K, Tsutsui H, Yoshimoto T, et al: Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 8(3):383-390, 1998
33. Thornberry NA, Bull HG, Calaycay JR, et al: A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356:768-774, 1992
34. Torigoe K, Ushio S, Okura T, et al: Purification and characterization of the human interleukin-18 receptor. J Biol Chem 272(41):25737-25742, 1997
35. Tsutsui H, Nakanishi K, Matsui K, Higashino K, Okamura H, Miyazawa Y, Kaneda K: IFN-gamma inducing factor (IGIF) up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones. J Immunol 157(9):3967-3973, 1996
36. Udagawa N, Horwood NJ, Elliot J, et al. Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation. J Exp Med 185(6):1005-1012, 1997
37. Ushio S, Namba M, Okura T, et al: Cloning of the cDNA for human IFN-γ inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J Immunol 156(11):4274-4279, 1996
38. Wood LC, Jackson SM, Elias PM, Grunfeld C, Feingold KR: Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice. J Clin Invest 90(2):482-487, 1992
39. Xu D, Chan WL, Leung BP, et al: Selective expression; and functions of interleukin 18 receptor on T helper (Th) type 1 but not type 2 cells. J Exp Med 188(8):1485-1492, 1998
40. Zepter K, Haeffner A, Soohoo LF, et al: Induction of biologically active IL-1β-converting enzyme and mature IL-1β in human keratinocytes by inflammatory and immunologic stimuli. J Immunol 159(12):6203-6208, 1997