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1
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0029954214
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Insulin-dependent diabetes mellitus
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Tisch R, McDevitt H. Insulin-dependent diabetes mellitus. Cell. 85:1996;291-297.
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(1996)
Cell
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Tisch, R.1
McDevitt, H.2
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3
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0028922437
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Genetic control of autoimmune diabetes in the NOD mouse
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Wicker LS, Todd JA, Peterson LB. Genetic control of autoimmune diabetes in the NOD mouse. Annu Rev Immunol. 13:1995;179-200.
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(1995)
Annu Rev Immunol
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, pp. 179-200
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Wicker, L.S.1
Todd, J.A.2
Peterson, L.B.3
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4
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15144356187
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Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene
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of outstanding interest. See annotation [6].
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Denny P, Lord CJ, Hill NJ, Goy JV, Levy ER, Podolin PL, Peterson LB, Wicker LS, Todd JA, Lyons PA. Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene. of outstanding interest Diabetes. 46:1997;695-700 See annotation [6].
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(1997)
Diabetes
, vol.46
, pp. 695-700
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Denny, P.1
Lord, C.J.2
Hill, N.J.3
Goy, J.V.4
Levy, E.R.5
Podolin, P.L.6
Peterson, L.B.7
Wicker, L.S.8
Todd, J.A.9
Lyons, P.A.10
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5
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7144263739
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Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse chromosome 3
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of outstanding interest. See annotation [6].
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Podolin PL, Denny P, Armitage N, Lord CJ, Hill NJ, Levt ER, Peterson LB, Todd JA, Wicker LS, Lyons PA. Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse chromosome 3. of outstanding interest Mamm Genome. 9:1998;283-286 See annotation [6].
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(1998)
Mamm Genome
, vol.9
, pp. 283-286
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Podolin, P.L.1
Denny, P.2
Armitage, N.3
Lord, C.J.4
Hill, N.J.5
Levt, E.R.6
Peterson, L.B.7
Todd, J.A.8
Wicker, L.S.9
Lyons, P.A.10
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6
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0031571223
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Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1
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of outstanding interest. Taken together, references [4-6] demonstrate the most careful dissection to date on the locations and functional relationships among susceptibility genes in the NOD mouse strain. Although the specific functions of the loci are not yet known, the recombinant congenic mouse strains that were used for this analysis should provide excellent tools for developing strategies for positional cloning of genes with subtle phenotypes.
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Podolin PL, Denny P, Lord CJ, Hill NJ, Todd JA, Peterson LB, Wicker LS, Lyons PA. Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1. of outstanding interest J Immunol. 159:1997;1835-1843 Taken together, references [4-6] demonstrate the most careful dissection to date on the locations and functional relationships among susceptibility genes in the NOD mouse strain. Although the specific functions of the loci are not yet known, the recombinant congenic mouse strains that were used for this analysis should provide excellent tools for developing strategies for positional cloning of genes with subtle phenotypes.
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(1997)
J Immunol
, vol.159
, pp. 1835-1843
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Podolin, P.L.1
Denny, P.2
Lord, C.J.3
Hill, N.J.4
Todd, J.A.5
Peterson, L.B.6
Wicker, L.S.7
Lyons, P.A.8
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7
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0031914643
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Subcongenic analysis of the Idd13 locus in NOD/Lt mice: Evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin
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of special interest. This study supports the hypothesis that the subtle gene effects demonstrated for the susceptibility loci on chromosome 3 are the rule, rather than the exception, for diabetogenic loci.
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Serreze DV, Bridgett M, Chapman HD, Chen E, Richard SD, Leiter EH. Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin. of special interest J Immunol. 160:1998;1472-1478 This study supports the hypothesis that the subtle gene effects demonstrated for the susceptibility loci on chromosome 3 are the rule, rather than the exception, for diabetogenic loci.
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(1998)
J Immunol
, vol.160
, pp. 1472-1478
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Serreze, D.V.1
Bridgett, M.2
Chapman, H.D.3
Chen, E.4
Richard, S.D.5
Leiter, E.H.6
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8
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0031406387
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Genetic control of diabetes progression
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of special interest. This report demonstrates the utility of simplified models, most notably those using transgenic expression of disease-related T cell receptor genes, in studying genetic control of disease.
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Gonzalez A, Katz JD, Mattei MG, Kikutani H, Benoist C, Mathis D. Genetic control of diabetes progression. of special interest Immunity. 7:1997;873-883 This report demonstrates the utility of simplified models, most notably those using transgenic expression of disease-related T cell receptor genes, in studying genetic control of disease.
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(1997)
Immunity
, vol.7
, pp. 873-883
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Gonzalez, A.1
Katz, J.D.2
Mattei, M.G.3
Kikutani, H.4
Benoist, C.5
Mathis, D.6
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9
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0037896004
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Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat
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Kloting I, Schmidt S, Kovacs P. Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat. Biochem Biophys Res Comm. 245:1998;483-486.
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(1998)
Biochem Biophys Res Comm
, vol.245
, pp. 483-486
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Kloting, I.1
Schmidt, S.2
Kovacs, P.3
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10
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0031081321
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Segregation of autoimmune type 1 diabetes in a cross between diabetic BB and brown Norway rats
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Jackerott M, Hornum L, Andreasen BE, Markholst H. Segregation of autoimmune type 1 diabetes in a cross between diabetic BB and brown Norway rats. J Autoimmun. 10:1997;35-41.
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(1997)
J Autoimmun
, vol.10
, pp. 35-41
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Jackerott, M.1
Hornum, L.2
Andreasen, B.E.3
Markholst, H.4
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11
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0030776907
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A non-MHC locus essential for autoimmune type I diabetes in the Komeda diabetes-prone rat
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of special interest. Data presented in this report substantially corroborate the previous findings on genetic complexity of autoimmune diabetes in the NOD mouse model. This confirmation is important in providing a rationale for further study of this disease in rodent models.
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Yokoi N, Kanazawa M, Kitada K, Tanaka A, Kanazawa Y, Suda S, Ito H, Serikawa T, Komeda K. A non-MHC locus essential for autoimmune type I diabetes in the Komeda diabetes-prone rat. of special interest J Clin Invest. 100:1997;2015-2021 Data presented in this report substantially corroborate the previous findings on genetic complexity of autoimmune diabetes in the NOD mouse model. This confirmation is important in providing a rationale for further study of this disease in rodent models.
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(1997)
J Clin Invest
, vol.100
, pp. 2015-2021
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Yokoi, N.1
Kanazawa, M.2
Kitada, K.3
Tanaka, A.4
Kanazawa, Y.5
Suda, S.6
Ito, H.7
Serikawa, T.8
Komeda, K.9
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12
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0030873325
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Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region
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Colucci F, Bergman ML, Penha-Goncalves C, Cilio CM, Holmberg D. Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region. Proc Natl Acad Sci USA. 94:1997;8670-8674.
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(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 8670-8674
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Colucci, F.1
Bergman, M.L.2
Penha-Goncalves, C.3
Cilio, C.M.4
Holmberg, D.5
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13
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0030871949
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The lymphopenia (lyp) gene controls the intrathymic cytokine ratio in congenic BioBreeding rats
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Bieg S, Moller C, Olsson T, Lernmark A. The lymphopenia (lyp) gene controls the intrathymic cytokine ratio in congenic BioBreeding rats. Diabetologia. 40:1997;786-792.
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(1997)
Diabetologia
, vol.40
, pp. 786-792
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Bieg, S.1
Moller, C.2
Olsson, T.3
Lernmark, A.4
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14
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0031025193
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New insights into insulin dependent diabetes mellitus from studies with transgenic mouse models
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Grewal S, Flavell RA. New insights into insulin dependent diabetes mellitus from studies with transgenic mouse models. Lab Invest. 76:1997;3-10.
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(1997)
Lab Invest
, vol.76
, pp. 3-10
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Grewal, S.1
Flavell, R.A.2
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15
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0030779118
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A mechanism for the major histocompatibility complex-linked resistance to autoimmunity
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of special interest. This report demonstrates the utility of simplified models, most notably those using transgenic expression of disease-related T cell receptor genes, in studying genetic control of disease.
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Schmidt D, Verdaguer J, Averill N, Santamaria P. A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. of special interest J Exp Med. 186:1997;1059-1075 This report demonstrates the utility of simplified models, most notably those using transgenic expression of disease-related T cell receptor genes, in studying genetic control of disease.
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(1997)
J Exp Med
, vol.186
, pp. 1059-1075
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Schmidt, D.1
Verdaguer, J.2
Averill, N.3
Santamaria, P.4
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16
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2642655282
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Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes
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Luhder F, Hoglund P, Allison JP, Benoist C, Mathis D. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J Exp Med. 187:1998;427-432.
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(1998)
J Exp Med
, vol.187
, pp. 427-432
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Luhder, F.1
Hoglund, P.2
Allison, J.P.3
Benoist, C.4
Mathis, D.5
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17
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0031964808
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MHC class II Ab diabetogenic residue 57 Asp/non-Asp dimorphism influences T-cell recognition and selection
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Antoniou AN, Elliott J, Rosmarakis E, Dyson PJ. MHC class II Ab diabetogenic residue 57 Asp/non-Asp dimorphism influences T-cell recognition and selection. Immunogenetics. 47:1998;218-225.
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(1998)
Immunogenetics
, vol.47
, pp. 218-225
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Antoniou, A.N.1
Elliott, J.2
Rosmarakis, E.3
Dyson, P.J.4
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18
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0032584240
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T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin
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of outstanding interest. This report describes a carefully constructed system for studying T cell responses to human MHC restriction elements. If such systems can be validated, in that they are associated with the development of disease, they will provide an exceptionally useful tool for investigating the generation of self-reactivity and the regulation of disease-related autoimmune responses.
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Congia M, Patel S, Cope AP, De Virgilis S, Sønderstrup G. T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin. of outstanding interest Proc Natl Acad Sci USA. 95:1998;3833-3838 This report describes a carefully constructed system for studying T cell responses to human MHC restriction elements. If such systems can be validated, in that they are associated with the development of disease, they will provide an exceptionally useful tool for investigating the generation of self-reactivity and the regulation of disease-related autoimmune responses.
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(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 3833-3838
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Congia, M.1
Patel, S.2
Cope, A.P.3
De Virgilis, S.4
Sønderstrup, G.5
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19
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0031025574
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Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice
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French MB, Allison J, Cram DS, Thomas HE, Dempsey-Collier M, Silva A, Georgiou HM, Kay TW, Harrison LC, Lew AM. Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice. Diabetes. 46:1997;34-39.
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(1997)
Diabetes
, vol.46
, pp. 34-39
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French, M.B.1
Allison, J.2
Cram, D.S.3
Thomas, H.E.4
Dempsey-Collier, M.5
Silva, A.6
Georgiou, H.M.7
Kay, T.W.8
Harrison, L.C.9
Lew, A.M.10
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20
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0030827384
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Reduction in diabetes incidence in an I-Ag7 transgenic nonobese diabetic mouse line
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Wherrett DK, Singer SM, McDevitt HO. Reduction in diabetes incidence in an I-Ag7 transgenic nonobese diabetic mouse line. Diabetes. 46:1997;1970-1974.
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(1997)
Diabetes
, vol.46
, pp. 1970-1974
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Wherrett, D.K.1
Singer, S.M.2
McDevitt, H.O.3
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21
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0027367830
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Major histocompatibility complex class I molecules are required for the development of insulitis in NOD mice
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Katz J, Benoist C, Mathis D. Major histocompatibility complex class I molecules are required for the development of insulitis in NOD mice. J Immunol. 23:1993;3358-3360.
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Katz, J.1
Benoist, C.2
Mathis, D.3
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22
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0031569582
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Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent
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of special interest. This report clearly demonstrates the need for islet-associated class I MHC expression in the disease process of NOD mice and provides a possible model for studying the role of CD8+ T cells in pathogenesis of diabetes.
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Serreze DV, Chapman HD, Varnum DS, Gerling I, Leiter EH, Shultz LD. Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent. of special interest J Immunol. 158:1997;3978-3986 This report clearly demonstrates the need for islet-associated class I MHC expression in the disease process of NOD mice and provides a possible model for studying the role of CD8+ T cells in pathogenesis of diabetes.
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(1997)
J Immunol
, vol.158
, pp. 3978-3986
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Serreze, D.V.1
Chapman, H.D.2
Varnum, D.S.3
Gerling, I.4
Leiter, E.H.5
Shultz, L.D.6
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23
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0028921986
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Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse
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Wong S, Guerder S, Visintin I, Reich EP, Swenson KE, Flavell RA, Janeway C Jr. Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse. Diabetes. 44:1995;326-329.
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(1995)
Diabetes
, vol.44
, pp. 326-329
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Wong, S.1
Guerder, S.2
Visintin, I.3
Reich, E.P.4
Swenson, K.E.5
Flavell, R.A.6
Janeway C., Jr.7
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24
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0031906622
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The threshold for autoimmune T cell killing is influenced by B7-1
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Allison J, Stephens LA, Kay TW, Kurts C, Heath WR, Miller JF, Krummel MF. The threshold for autoimmune T cell killing is influenced by B7-1. Eur J Immunol. 28:1998;949-960.
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(1998)
Eur J Immunol
, vol.28
, pp. 949-960
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Allison, J.1
Stephens, L.A.2
Kay, T.W.3
Kurts, C.4
Heath, W.R.5
Miller, J.F.6
Krummel, M.F.7
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25
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1842289172
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Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice
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Kagi D, Odermatt B, Seiler P, Zinkernagel RM, Mak TW, Hengartner H. Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice. J Exp Med. 186:1997;989-997.
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(1997)
J Exp Med
, vol.186
, pp. 989-997
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Kagi, D.1
Odermatt, B.2
Seiler, P.3
Zinkernagel, R.M.4
Mak, T.W.5
Hengartner, H.6
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26
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0030890721
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The role of Fas in autoimmune diabetes
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Chervonsky AV, Wang Y, Wong FS, Visintin I, Flavell RA, Janeway CA Jr, Matis LA. The role of Fas in autoimmune diabetes. Cell. 89:1997;17-24.
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(1997)
Cell
, vol.89
, pp. 17-24
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Chervonsky, A.V.1
Wang, Y.2
Wong, F.S.3
Visintin, I.4
Flavell, R.A.5
Janeway C.A., Jr.6
Matis, L.A.7
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27
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0030800122
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Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice
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Itoh N, Imagawa A, Hanafusa T, Waguri M, Yamamoto K, Iwahashi H, Moriwaki M, Nakajima H, Miyagawa J, Namba M, et al. Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice. J Exp Med. 186:1997;613-618.
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(1997)
J Exp Med
, vol.186
, pp. 613-618
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Itoh, N.1
Imagawa, A.2
Hanafusa, T.3
Waguri, M.4
Yamamoto, K.5
Iwahashi, H.6
Moriwaki, M.7
Nakajima, H.8
Miyagawa, J.9
Namba, M.10
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28
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0031423760
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The nonobese diabetic mouse as a model of autoimmune diabetes: Immune dysregulation gets the NOD
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Delovitch TL, Singh B. The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity. 7:1997;727-738.
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(1997)
Immunity
, vol.7
, pp. 727-738
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Delovitch, T.L.1
Singh, B.2
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29
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0031051747
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Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitus
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von Herrath MG, Oldstone MB. Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitus. J Exp Med. 185:1997;531-539.
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(1997)
J Exp Med
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Von Herrath, M.G.1
Oldstone, M.B.2
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30
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0029948898
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Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice
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Hultgren B, Huang X, Dybdal N, Stewart TA. Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice. Diabetes. 45:1996;812-817.
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(1996)
Diabetes
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Hultgren, B.1
Huang, X.2
Dybdal, N.3
Stewart, T.A.4
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31
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0031456802
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Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes
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Wang B, Andre I, Gonzalez A, Katz JD, Aguet M, Benoist C, Mathis D. Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes. Proc Natl Acad Sci USA. 94:1997;13844-13849.
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(1997)
Proc Natl Acad Sci USA
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, pp. 13844-13849
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Wang, B.1
Andre, I.2
Gonzalez, A.3
Katz, J.D.4
Aguet, M.5
Benoist, C.6
Mathis, D.7
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32
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0030742237
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T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice
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Pakala SV, Kurrer MO, Katz JD. T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice. J Exp Med. 186:1997;299-306.
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(1997)
J Exp Med
, vol.186
, pp. 299-306
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Pakala, S.V.1
Kurrer, M.O.2
Katz, J.D.3
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33
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0030879734
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Mechanism underlying counterregulation of autoimmune diabetes by IL-4
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Mueller R, Bradley LM, Krahl T, Sarvetnick N. Mechanism underlying counterregulation of autoimmune diabetes by IL-4. Immunity. 7:1997;411-418.
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(1997)
Immunity
, vol.7
, pp. 411-418
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Mueller, R.1
Bradley, L.M.2
Krahl, T.3
Sarvetnick, N.4
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34
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0031017990
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Tissue-specific expression of interleukin-4 induces extracellular matrix accumulation and extravasation of B cells
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Mueller R, Krahl T, Sarvetnick N. Tissue-specific expression of interleukin-4 induces extracellular matrix accumulation and extravasation of B cells. Lab Invest. 76:1997;117-128.
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Lab Invest
, vol.76
, pp. 117-128
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Mueller, R.1
Krahl, T.2
Sarvetnick, N.3
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