Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

Nature

Volumn 405, Issue 6785, 2000, Pages 458-462

  Borovikova, Lyudmila V ^a   Ivanova, Svetlana ^a   Zhang, Minghuang ^a   Yang, Huan ^a   Botchkina, Galina I ^a   Watkins, Linda R ^b   Wang, Halchao ^c   Abumrad, Naji ^c   Eaton, John W ^d   Tracey, Kevin J ^c  

^a PICOWER INST FOR MEDICAL RESEARCH   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c NORTH SHORE UNIVERSITY HOSPITAL   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNOREGULATION; INFLAMMATION; MACROPHAGE ACTIVATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; VAGUS NERVE STIMULATION;

ACETYLCHOLINE; ANIMALS; CELLS, CULTURED; CYTOKINES; ELECTRIC STIMULATION; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; NEUROGENIC INFLAMMATION; NEUROIMMUNOMODULATION; RATS; RATS, INBRED LEW; RECEPTORS, CHOLINERGIC; VAGUS NERVE;

EID: 0034713266     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35013070     Document Type: Article

References (28)

1. Tracey, K. J. et al. Shock and tissue injury induced by recombinant human cachectin. Science 234, 470-474 (1986).
2. Dinarello, C. A. The interleukin-1 family: 10 years of discovery. FASEB J. 8, 1314-1325 (1994).
3. Wang, H. et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science 285, 248-251 (1999).
4. Nathan, C. F. Secretory products of macrophages. J. Clin. Invest. 79, 319-326 (1987).
5. Besedovsky, H., Rey, D. A., Sorkin, E. & Dinarello, C. A. Immunoregulalory feedback between interleukin-1 and glucocorticoid hormones. Science 233, 652-654 (1986).
6. Woiciechowsky, C. et al. Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury. Nature Med. 4, 808-813 (1998).
7. Hu, X. X., Goldmuntz, E. A. & Brosnan, C. F. The effect of norepinephrine on endotoxin-mediated macrophage activation. J. Neuroimmunol. 31, 35-42 (1991).
8. Liplon, J. M. & Catania, A. Anti-inflammatory actions of the neuroimmunomodulator alpha-MSH. Immunol. Today 18, 140-145 (1997).
9. Watkins, L. R. & Maier, S. F. Implications of immune-to-brain communication for sickness and pain. Proc. Natl Acad. Sci. USA 96, 7710-7713 (1999).
10. Sternberg, E. M. Neural-immune interactions in health and disease. J. Clin. Invest. 100, 2641-2647 (1997).
11. Scheinman, R. I., Cogswell, P. C., Lofquist, A. K. & Baldwin, A. S. Jr Role of transcriptional activation of IkappaB alpha in mediation of immimosuppression by glucocorticoids. Science 270, 283-286 (1995).
12. Gaykema, R. P., Dijksita, I. & Tilders, F. J. Subdiaphragmatic vagotomy suppresses endotoxin-induced activation of hypothalamic corticotropin-releasing hormone neurons and ACTH secretion. Endocrinology 136, 4717-4720 (1995).
13. Fleshner, M. et al. Thermogenic and corticosterone responses to intravenous cytokines (IL-1beta and TNF-alpha) are attenuated by subdiaphragmatic vagotomy. J. Neuroimmunol. 86, 134-141 (1998).
14. Watkins, L. R. et al. Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication. Neurosci. Lett. 183, 27-31 (1995).
15. Romanovsky, A. A., Simons, C. T., Szekely, M. & Kulchitsky, V. A. The vagus nerve in the thermoregulatory response to systemic inflammation. Am J. Physiol. 273, R407-R413 (1997).
16. Antonica, A., Magni, F., Mearini, L. & Paolocci, N. Vagal control of lymphocyte release from rat thymus. J. Auton. Nerv. Syst. 48, 187-197 (1994)
17. Guslandi, M. Nicotine treatment for ulcerative colitis. Br. J. Clin. Pharmacol. 48, 481-484 (1999).
18. Sandborn, W. J. et al. Transdermal nicotine for mildly to moderately active ulcerative colitis. A randomized, double-blind, placebo-controlled trial Ann. Intern. Med. 126, 364-371 (1997).
19. Sher, M. E. et al. The influence of cigarette smoking on cytokine levels in patients with inflammatory bowel disease. Inflamm. Bowel Dis. 5, 73-78 (1999).
20. Sato, E., Koyama S., Okubo, Y., Kubo, K. & Sekigushi, M. Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity. Am. J. Physiol. 274, L970-L979 (1998).
21. Whaley, K., Lappin, D. & Barkas, T. C2 synthesis by human monocytes is modulated by a nicotinic cholinergic receptor. Nature 293, 580-583 (1981).
22. Sato, K. Z. et al. Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines. Neurosci. Lett. 266, 17-20 (1999).
23. Wathey, J. C., Nass, M. M. & Lester, H. A. Numerical reconstruction of the quantal event at nicotinic synapses. Biophys. J. 27, 145-164 (1979).
24. Kumins, N. H., Hunt, J., Gamelli, R. L. & Filkins, J. P. Partial hepatoectomy reduces the endotoxin-induced peak circulating level of tumor necrosis factor in rats. Shock 5, 385-388 (1996).
25. Gregory, S. H. & Wing, E. J. Neutrophil-Kupffer-cell interaction in host defenses to systemic infections. Immunol. Today 19, 507-510 (1998).
26. Tracey, K. J. et al. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 330, 662-664 (1987).
27. Madretsma, G. S. et al. Nicotine inhibits the in vitro production of interleukin 2 and tumour necrosis factor-alpha by human mononuclear cells. Immunopharmacology 35, 47-51 (1996).
28. van Dijk, A. P. et al. Transdermal nicotine inhibits interleukin 2 synthesis by mononuclear cells derived from healthy volunteers. Eur. J. Clin. Invest. 28, 664-671 (1998).