Synergistic antitumor effects of interleukin-12 gene transfer and systemic administration of interleukin-18 in a mouse bladder cancer model

Cancer Immunology Immunotherapy

Volumn 48, Issue 6, 1999, Pages 297-302

  Yamanaka, Kazuki ^a   Hara, Isao ^a   Nagai, Hiroshi ^a   Miyake, Hideaki ^a   Gohji, Kazuo ^a   Micallef, Mark J ^b   Kurimoto, Masashi ^b   Arakawa, Soichi ^a   Kamidono, Sadao ^a  

^a KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b HAYASHIBARA BIOCHEMICAL LABORATORIES INC   (Japan)

Author keywords

Bladder cancer; Interleukin 12; Interleukin 18

Indexed keywords

GAMMA INTERFERON ANTIBODY; INTERLEUKIN 12; INTERLEUKIN 18;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLADDER CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENTIATION; GENE TRANSFER; GENETIC TRANSDUCTION; HELPER CELL; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TUMOR GROWTH;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTILYMPHOCYTE SERUM; BIOLOGICAL RESPONSE MODIFIERS; CARCINOMA; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COMBINED MODALITY THERAPY; FEMALE; GENE THERAPY; GRAFT REJECTION; IMMUNITY, CELLULAR; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-18; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, NUDE; NEOPLASM TRANSPLANTATION; RECOMBINANT FUSION PROTEINS; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS;

EID: 0032830013     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050578     Document Type: Article

References (19)

1. Ahn HJ, Maruo S, Tomura M, Mu J, Hamaoka T, Nakanishi K, Clark S, Kurimoto M, Okamura H (1997) A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma. J Immunol 159:2125
2. Brunda MJ, Luistro L, Warrier RR, Wright RB, Hbbard BR, Murphy M, Wolf SF, Gately MK (1993) Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med 178:1223
3. Chan SH, Perussia B, Gupta JW, Kobayashi M, Pospisil M, Young HA, Wolf SF, Young D, Clark SC, Trinchieri G (1991) Induction of interferon g production by natural killer cell stimulatory factor: characterization of the responding cells and synergy with other inducers. J Exp Med 173:869
4. Cohen J (1995) IL-12 death: explanation and a puzzle. Science 270:908
5. Dao T, Ohashi K, Kayano T, Kurimoto M, Okamura H (1996) Interferon-γ-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells. Cell Immunol 173:230
6. Gately MK (1992) Interleukin-12: a recently discovered cytokine with potential for enhancing cell-mediated immune responses to tumors. Cancer Invest 11:500
7. Gately MK, Desai B, Wolitzky AG, Quinn PM, Dwyer CM, Podlaski FJ, Familletti PC, Sinigaglia F, Chizonite R, Gublar U, Stern AS (1991) Regulation of human lymphocyte proliferation by a heterodinamic cytokine, IL-12 (cytotoxic lymphocyte maturation factor). J Immunol 147:874
8. Kobayashi M, Fitz L, Ryan M, Hewick RM, Clark SC, Chan S, Loudon R, Sherman F, Perussia B, Trinchieri G (1989) Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes. J Exp Med 170:827
9. Kohno K, Kataoka J, Ohtsuki T, Suemoto Y, Okamoto I, Usui M, Ikeda M, Kurimoto M (1997) IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts effect independently of IL-12. J Immunol 158:1541
10. Michallef MJ, Ohtsuki T, Kohno K, Tanabe F, Ushio S, Namba M, Tanimoto T, Torigoe K, Fujii M, Ikeda M, Fukuda S, Kurimoto M (1996) Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-γ production. Eur J Immunol 26:1647
11. Micallef MJ, Yoshida K, Kawai S, Hanaya T, Kohno K, Arai S, Tanimoto T, Torigae K, Fujii M, Ikeda M, Kurimoto M (1997) in vivo antitumor effects of murine interferon-γ-inducing factor/interleukin-18 in mice bearing syngeneic MethA sarcoma malignant ascites. Cancer Immunol Immunother 43:361
12. Okamura H, Tsutsui T, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K, Akita K, Namba M, Tanabe F, Konishi K, Fukuda S, Kurimoto M (1995) Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 378:88
13. Okamura H, Nakata K, Komatsu T, Tanimoto T, Nukada Y, Tanabe F, Akita K, Torigoe K, Okura T, Fukuda S, Kurimoto M (1995) A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock. Infect Immun 63:3966
14. Okayama H, Berg PA (1983) A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells. Mol Cell Biol 3:280
15. + T lymphocytes, and NK cells. J Immunol 149:3495
16. Robertson MJ, Soiffer RJ, Wolf SF, Manly TJ, Donahau C, Young D, Herrmann SH Ritz J (1992) Responses of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF. J Exp Med 175:779
17. Southern PJ, Berg S (1982) Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J Mol Appl Genet 1:327
18. Stern AS, Podlaski FJ, Hulmes JD, Pan YE, Quinn PM, Wolitzky AG, Familleti PC, Stremlo DL, Truitt T, Chizzonite R, Gately MK (1990) Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc Natl Acad Sci USA 87:6808
19. Tahara H, Zitvogel L, Storkus WJ, Zeh III HJ, McKinney TG, Schreiber RD, Gubler U, Robbins PD, Lotze ML (1995) Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector. J Immunol 154:6466