Neuroblastoma Cells expressing mature IL-18, but not proIL-18, induce a strong and immediate antitumor immune response

Journal of Immunotherapy

Volumn 22, Issue 4, 1999, Pages 324-335

  Heuer, Josef G ^a   Tucker McClung, Cheryl ^a   Hock, Randy A ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytokines; IFN ; IL 18; Immunotherapy; Neuroblastoma

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 18; PROTEIN PRECURSOR; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOGENICITY; CONTROLLED STUDY; FEMALE; HELPER CELL; IMMUNE RESPONSE; LYMPHOCYTE DEPLETION; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS;

EID: 0032996166     PISSN: 15249557     EISSN: 15374513     Source Type: Journal    
DOI: 10.1097/00002371-199907000-00006     Document Type: Article

References (45)

1. Prehn RT, JM Main. Immunity to methylcholanthrene-induced sarcomas. J Natl Cancer Inst 1957;18:769-78.
2. Klein G, Sjögren HO, Klein E, et al. Demonstration of resistance against methylcholanthrene-induced sarcomas in the primary autochthonous host. Cancer Res 1960;20:1561-72.
3. Shimuzi SK, Shen F-W. Role of different T cell sets in the rejection of syngeneic chemically induced tumors. J Immunol 1979;122:1162-5.
4. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-57.
5. Cher DJ, Mosmann TR. Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones. J Immunol 1987;138:3688-94.
6. Cherwinski HM, Schumacher JH, Brown KD, Mosmann TR. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Thl and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J Exp Med 1987;166:1229-44.
7. O’Garra A, Murphy K. Role of cytokines in determining Tlymphocyte function. Curr Opin Immunol 1994;6:458-66.
8. Watanabe Y, Kuribayashi K, Miyatake S, et al. Exogenous expression of mouse interferon gamma cDNA in mouse neuroblastoma C1300 cells results in reduced tumorigenicity by augmented antitumor immunity. Proc Natl Acad Sci USA 1989;86:9456-60.
9. Fearon EM, Pardoll DM, Itaya T, et al. IL-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell 1990;60:397-403.
10. Gansbacher B, Bannerji R, Daniels B, Zier K, Cronin K, Gilboa E. Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity. Cancer Res 1990;50:7820-5.
11. Dranoff G, Jaffee E, Lazenby A, et al. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and longlasting anti-tumor immunity. Proc Natl Acad Sci USA 1993;90: 3539-43.
12. Tahara H, Zeh HJ 3rd, Storkus WJ, et al. Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo. Cancer Res 1994;54:182-9.
13. Okamura H, Tsutsui H, Komatsu T, et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 1995;378:88-91.
14. Okamura H, Nagata K, Komatsu T, et al. A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock. Infect Immun 1995;63:3966-72.
15. Bazan JF, Timans JC, Kastelein RA. A newly defined interleukin-17 Nature 1996;379:591.
16. Gu Y, Kuida K, Tsutsui H, et al. Activation of interferon-gamma inducing factor mediated by interleukin-lb converting enzyme. Science 1997;275:206-9.
17. Micallef MJ, Yoshida K, Kawai S, et al. In vivo antitumor effects of murine interferon-gamma-inducing factor/interleukin-18 in mice bearing syngeneic Meth A sarcoma malignant ascites. Cancer Immunol Immunother 1997;43:361-7.
18. Finklestein JZ, Arima E, Byfield PE, Byfield JE, Fonkalsrud EW. Murine neuroblastoma: a model of human disease. Cancer Chemother Rep 1973;57:405-12.
19. Katsanis E, Xu Z, Bausero MA, et al. B7-1 expression decreases tumorigenicity and induces partial systemic immunity to murine neuroblastoma deficient in major histocompatibility complex and costimulatory molecules. Cancer Gene Ther 1995;2:39-46.
20. Heuer JG, Tucker-McClung CL, Hock RA. Retroviral mediated gene transfer of B7-1 and MHC class II converts a poorly immunogenic neuroblastoma into a highly immunogenic one. Hum Gene Ther 1996;7:2059-68.
21. Justila J, Weisner R, Evans C. Immunization of the A/Jax mouse with irradiated cells of its indigenous tumour, sarcoma 1. Nature 1962;195:301.
22. Markowitz D, Goff S, Bank A. Construction of a safe and efficient retrovirus packaging cell line. Virology 1988;167:400-6.
23. Liang P, Pardee AB. Polymerase chain reaction. In: Ausubel FM, Brent R, Kingston RE, eds. Current protocols in molecular biology. New York: John Wiley, 1995:15.0.1-15.8.8.
24. Morris JC, Neven S, Bennett F, et al. Molecular cloning and characterization of murine interleukin-11. Exp Hematol 1996;24:1369-76.
25. Miller AD, Rosman GJ. Improved retroviral vectors for gene transfer and expression. Biotechniques 1989;7:980-90.
26. Hock RA, Miller AD, Osborne WRA. Expression of human adenosine deaminase from various strong promoters after gene transfer into human hematopoietic cell lines. Blood 1989;74:876-81.
27. Domann R, Martinez J. Alternative to cloning cylinders for isolation of adherent cell clones. Biotechniques 1995;18:594-5.
28. Van Zoelen EJ, van de Ven WJ, Franssen HJ, et al. Neuroblastoma cells express c-sis and produce a transforming growth factor antigenically related to the platelet-derived growth factor. Mol Cell Biol 1985:5:2289-97.
29. Li XF, Takiuchi H, Zou JP, et al. Transforming growth factor-beta (TGF-beta)-mediated immunosuppression in the tumor-bearing state: enhanced production of TGF-beta and a progressive increase in TGF-beta susceptibility of anti-tumor CD4+ T cell function. Jpn J Cancer Res 1993;84:315-25.
30. Schmitt E, Hoehn P, Huels C, et al. T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin- 12 and interferon-gamma and is inhibited by transforming growth factor-beta. Eur J Immunol 1994;24:793-8.
31. Barnard JA, Lyons RM, Moses HL. The cell biology of transforming growth factor beta. Biochim Biophys Acta 1990;1032:79-87.
32. Rook AH, Kehrl JH, Wakefield LM, et al. Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness. J Immunol 1986;136:3916-20.
33. Herberman RB. Natural cell-mediated cytotoxicity in nude mice. In: Fogh J, B.C. Giovanella, editors. The nude mouse in experimental and clinical research. Vol. 1, Ch. 8. New York: Academic Press, 1978:136-66.
34. Ushio S, Namba M, Okkura T, et al. Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J Immunol 1996;156:4274-9.
35. Katsanis E, Orchard PJ, Bausero MA, Gorden KB, Mclvor RS, Blazar BR. Interleukin-2 gene transfer into murine neuroblastoma decreases tumorigenicity and enhances systemic immunity causing regression of preestablished retroperitoneal tumors. J Immunother 1994;15:81-90.
36. Katsanis E, Bausero MA, Panoskaltsis-Mortari A, et al. Irradiation of singly and doubly transduced murine neuroblastoma cells expressing B7-1 and producing interferon-gamma reduces their capacity to induce systemic immunity. Cancer Gene Ther 1996;3:75-82.
37. Bausero MA, Panoskaltsis-Mortari A, Blazar BR, Katsanis E. Effective immunization against neuroblastoma using doubletransduced tumor cells secreting GM-CSF interferon-gamma. J Immunother 1996;19:113-24.
38. Fischer HG, Frosch S, Reske K, Reske-Kunz AB. Granulocyte-macrophage colony-stimulating factor activates macrophages derived from bone marrow cultures to synthesis of MHC class II molecules and to augmented antigen presentation function. J Immunol 1988;141:3882-8.
39. Kato T, Inaba K, Ogawa Y, et al. Granulocyte-macrophage colonystimulating factor enhances macrophage accessory function in Con A-stimulated T-cell proliferation. Cell Immunol 1990;130:490-500.
40. Smith PD, Lamerson CL, Wong HL, Wahl LM, Wahl SM. Granulocyte-macrophage colony-stimulating factor stimulates human monocyte accessory cell function. J Immunol 1990;144:3829-34.
41. Basham TY, Merigan TC. Recombinant interferon-gamma increases HLA-DR synthesis and expression. J Immunol 1983;130:1492-4.
42. Gajewski TF, Fitch FW. Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Thl murine helper T lymphocyte clones. J Immunol 1988;140:4245-52.
43. Freedman AS, Freeman GJ, Rhynhart K, Nadler LM. Selective induction of B7/BB-1 on interferon-gamma stimulated monocytes: a potential mechanism for amplification of T cell activation through the CD28 pathway. Cell Immunol 1991;137:429-37.
44. Hsieh CS, Macatonia SE, Tripp CS, Wolf SF, O’Garra A, Murphy KM. Development of THI CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 1993;260:547-9.
45. Belardelli F. Role of interferons and other cytokines in the regulation of the immune response. APM1S 1995;103:161-79.