Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-12-dependent Th1 development

European Journal of Immunology

Volumn 28, Issue 10, 1998, Pages 3231-3239

  Stoll, Sabine ^a   Jonuleit, Helmut ^a   Schmitt, Edgar ^a   Müller, Gabriele ^a   Yamauchi, Hiroshi ^b   Kurimoto, Masashi ^b   Knop, Jürgen ^a   Enk, Alexander H ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b HAYASHIBARA BIOCHEMICAL LABORATORIES INC   (Japan)

Author keywords

Cytokine; Dendritic cell; IL 18; Th1 development

Indexed keywords

CONCANAVALIN A; CYTOKINE; INTERLEUKIN 12; MESSENGER RNA; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; HELPER CELL; HUMAN; HUMAN CELL; LANGERHANS CELL; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; NORTHERN BLOTTING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUPERNATANT; T LYMPHOCYTE ACTIVATION;

ANIMALS; BLOTTING, NORTHERN; CELL DIFFERENTIATION; CELL LINE; CULTURE MEDIA; DENDRITIC CELLS; HUMANS; INTERLEUKIN-12; INTERLEUKIN-18; LANGERHANS CELLS; MICE; MICE, TRANSGENIC; RNA, MESSENGER; TH1 CELLS;

EID: 0031705349     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199810)28:10<3231::AID-IMMU3231>3.0.CO;2-Q     Document Type: Article

References (25)

1. Steinman, R. M., The dendritic cell system and its role in immunogenicity. Anna. Rev. Immunol. 1991. 9: 271-296.
2. Austyn, J. M., Kupiec Weglinksi, J.W. and Morris, P. J., Migration patterns of dendritic cells in the mouse. Adv. Exp. Med. Biol. 1988. 237: 583-589.
3. Austyn, J. M., Kupiec Weglinski, J. W., Hankins, D. F. and Morris, P. J., Migration patterns of dendritic cells in the mouse. Homing to T cell-dependent areas of spleen, and binding within marginal zone. J. Exp. Med. 1988. 167: 646-651.
4. Kupiec Weglinski, J. W., Austyn, J. M. and Morris, P. J., Migration patterns of dendritic cells in the mouse. Traffic from the blood, and T cell-dependent and -independent entry to lymphoid tissues. J. Exp. Med. 1988. 167: 632-645.
5. Romani, N. and Schuler, G., The immunologic properties of epidermal Langerhans cells as a part of the dendritic cell system. Springer Semin. Immunopathol. 1992. 13: 265-279.
6. Sallusto, F. and Lanzavecchia, A., Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 1994. 179: 1109-1118.
7. Steinman, R. M. and Young, J. W., Signals arising from antigen-presenting cells. Curr. Opin. Immunol. 1991. 3: 361-372.
8. + T lymphocytes by human blood dendritic cells in vitro [published erratum appears in J. Clin. Invest. 1993. 91: 1853]. J. Clin. Invest. 1992. 90: 229-237.
9. + T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent. Int. Immunol. 1993. 5: 1119-1128.
10. + T cells. J. Immunol. 1995. 154: 5071-5079.
11. + T cells through IL-12 produced by Listeria-induced macrophages [see comments]. Science 1993. 260: 547-549.
12. Micallef, M. J., Ohtsuki, T., Kohno, K., Tanabe, F., Ushio, S., Namba, M., Tanimoto, T., Torigoe, K., Fujii, M., Ikeda, M., Fukuda, S. and Kurimoto, M., Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-γ production. Eur. J. Immunol. 1996. 26: 1647-1651.
13. Okamura, H., Tsutsi, H., Komatsu, T. et al., Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 1995. 378: 88-91.
14. Bazan, J. F., Timans, J. C. and Kastelein, R. A., A newly defined interleukin-1? [letter]. Nature 1996. 379: 591.
15. Udagawa, N., Horwood, N. J., Elliott, J., Mackay, A., Owens, J., Okamura, H., Kurimoto, M., Chambers, T. J., Martin, T. J. and Gillespie, M. T., Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation. J. Exp. Med. 1997. 185: 1005-1012.
16. Stoll, S., Müller, G., Kurimoto, M., Saloga, J., Tanimoto, T., Yamauchi, H., Okamura, H., Knop, J. and Enk, A. H., Production of IL-18 (IFN-gamma-inducing factor) messenger RNA and functional protein by murine keratinocytes. J. Immunol. 1997. 159: 298-302.
17. Ushio, S., Namba, M., Okura, T., Hattori, K., Nukada, Y., Akita, K., Tanabe, F., Konishi, K., Micallef, M., Fujii, M., Torigoe, K., Tanimoto, T., Fukuda, S., Ikeda, M., Okamura, H. and Kurimoto, M., Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J. Immunol. 1996. 156: 4274-4279.
18. Kohno, K., Kataoka, J., Ohtsuki, T., Suemoto, Y., Okamoto, I., Usui, M., Ikeda, M. and Kurimoto, M., IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts is effect independently of IL-12. J. Immunol. 1997. 158: 1541-1550.
19. Robinson, D., Shibuya, K., Mui, A., Zonin, F., Murphy, E., Sana, T., Hartley, S. B., Menon, S., Kastelein, R., Bazan, F. and O'Garra, A., IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkB. Immunity 1997. 7: 571-581.
20. Koch, F., Stanzl, U., Jennewein, P., Janke, K., Heufler, C., Kampgen, E., Romani, N. and Schuler, G., High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and down-regulation by IL-4 and IL-10. J. Exp. Med. 1996. 184: 741-746.
21. Xu, S., Ariizumi, K., Caceres Dittmar, G., Edelbaum, D., Hashimoto, K., Bergstresser, P. R. and Takashima, A., Successive generation of antigen-presenting, dendritic cell lines from murine epidermis. J. Immunol. 1995. 154: 2697-2705.
22. Tamaki, K., Stingl, G., Gullino, M., Sachs, D. H. and Katz, S. I., Ia antigens in mouse skin are predominantly expressed on Langerhans cells. J. Immunol. 1979. 123: 784-787.
23. Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S. and Steinman, R. M., Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/ macrophage colony-stimulating factor. J. Exp. Med. 1992. 176: 1693-1702.
24. Steinman, R. M., Kaplan, G., Witmer, M. D. and Cohn, Z. A., Identification of a novel cell type in peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro. J. Exp. Med. 1979. 149: 1-16.
25. Romani, N., Gruner, S., Brang, D., Kampgen, E., Lenz, A., Trockenbacher, B., Konwalinka, G., Fritsch, P. O., Steinman, R. M. and Schuler, G., Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 1994. 180: 83-93.