IL-I 8 induction of IgE: Dependence on CD4+ T cells, IL-4 and STAT6

Nature Immunology

Volumn 1, Issue 2, 2000, Pages 132-137

  Yoshimoto, Tomohiro ^a,e   Mizutani, Hitoshi ^b   Tsutsui, Hiroko ^a   Noben Trauth, Nancy ^d   Yamanaka, Kei Ichi ^b   Tanaka, Minoru ^b   Izumi, Shinzo ^c   Okamura, Haruki ^a   Paul, William E ^d   Nakanishi, Kenji ^a,e  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b MIE UNIVERSITY   (Japan)

^c National Leprosarium   (Japan)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 LIGAND; IMMUNOGLOBULIN E; INTERLEUKIN 18; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; STAT6 PROTEIN; STAT6 PROTEIN, HUMAN; STAT6 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; C57BL MOUSE; CD4+ T LYMPHOCYTE; FEMALE; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOLOGY; LEPROMATOUS LEPROSY; MOUSE; MOUSE MUTANT; PHYSIOLOGY; TH2 CELL; TRANSGENIC MOUSE; TUBERCULOID LEPROSY;

ANIMALS; CASPASE 1; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-18; INTERLEUKIN-4; LEPROSY, LEPROMATOUS; LEPROSY, TUBERCULOID; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; RECEPTORS, INTERLEUKIN-4; STAT6 TRANSCRIPTION FACTOR; TH2 CELLS; TRANS-ACTIVATORS;

EID: 5844310778     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/77811     Document Type: Article

References (34)

1. Coffman, R.L. et al. The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol. Rev. 102, 5-28 (1988).
2. Finkelman, F.D. et al. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8, 303-333 (1990).
3. Punnonen, J. et al. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc. Natl Acad. Sci. USA 90, 3730-3734 (1993).
4. Zurawski, G. & de Vries, J.E.J. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol. Today. 15, 19-26 (1994).
5. Wills, K.M. et at. Interleukin-13: central mediator of allergic asthma. Science 282, 2258-2261 (1998).
6. Grunig, G. et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282, 2261-2263 (1998).
7. Hilton, D.J. et al. Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc. Natl Acad. Sci. USA 93, 497-501 (1996).
8. Okamura, H. et al. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 378, 88-91 (1995).
9. Gu, Y. et al. Activation of interferon-γ inducing factor mediated by interleukin-1β converting enzyme. Science 275, 206-209 (1997).
10. Okamura, H., Tsutsui, H., Kashiwamura, S., Yoshimoto, T. & Nakanishi, K. Interleukin-18: A novel cytokine that augments both innate and acquired immunity. Adv. Immunol. 70, 281-312 (1998).
11. Dinarello, C.A. et al. Overview of interleukin-18: more than an interferon-γ inducing factor. J. Leukoc.Biol. 63, 658-464 (1998).
12. Kohno, K. et al. IFN-γ-inducing factor (IGIF) Is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. J. Immunol. 158, 1541-1550 (1997).
13. Robinson, D. et al. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NFκB. Immunity 7, 571-581 (1997).
14. Yoshimoto, T. et al. IL-12 up-regulates IL-18 receptor expression on T cells. Th1 cells, and B cells: synergism with IL-18 for IFN-γ production. J. Immunol. 161, 3400-3407 (1998).
15. Xu, D. et al. Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells. J. Exp. Med. 188, 1485-1492 (1998).
16. Tsutsui, H. et al. IL-18 accounts for both TNF - and FasL-mediated hepatotoxic pathways in endotoxin-induced liver injury. J. Immunol. 159, 3961-3967 (1997).
17. Yoshimoto, T., Okamura, H., Tagawa, Y.I., Iwakura, Y. & Nakanishi, K. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells. Proc. Natl Acad. Sci. USA 94, 3948-3953 (1997).
18. Yoshimoto, T. et al. IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils. Proc. Natl Acad. Sci. USA 96, 13962-13966 (1999).
19. Kumano, K. et al. Interleukin-18 enhances antigen-induced eosinophil recruitment into the mouse airways. Am. J. Respir. Crit. Care. Med. 160, 873-878 (1999).
20. Hoshino, T., Wiltrout, R.H. & Young, H.A. IL-18 is a potent coinducer of IL-13 in NK and T cells: A new potential role for IL-18 in modulating the immune response. J. Immunol. 162, 5070-5077 (1999).
21. Yamanaka, K. et al. Skin-specific caspase-1 transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18. J. Immunol. (2000) (in the press).
22. + T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc. Natl Acad. Sci. USA 94, 10838-10843 (1997).
23. Noben-Trauth, N., Kohler, G., Burki, K. & Ledermann, B. Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line. Transgenic Res. 5, 487-491 (1996).
24. Urban, J.J. et al. IL-13, IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity 8, 255-264 (1998).
25. Takeda, K. et al. Essential role of Stat6 in IL-4 signalling. Nature 380, 627-630 (1996).
26. Takeda, K. et al. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 8, 583-590 (1998).
27. lo thymocytes in vivo. Science 250, 1720-1723 (1990).
28. Salgame, P. et al. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 254, 279-282 (1991).
29. Stoll, S. et al. Production of IL-18 (IFN-γ-inducing factor) messenger RNA and functional protein by murine keratinocytes. J. Immunol. 159, 298-302 (1997).
30. Ghayur, T. et al. Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production. Nature 386, 619-623 (1997).
31. + cells. Adv. Immunol. 53, 1-29 (1993).
32. Cameron, L.A. et al. Airway epithelium expresses interleukin-18. Eur. Respir. J. 14, 553-559 (1999).
33. Ohara, J. & Paul, W.E. Production of monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature 315, 333-336 (1985).
34. LeGros, G.G., Ben-Sasson, S.S., Seder, R.A., Finkelman, F.D. & Paul, W.E. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172, 921-929 (1990).