Murine macrophages secrete interferon γ upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation

Journal of Experimental Medicine

Volumn 187, Issue 12, 1998, Pages 2103-2108

  Munder, Markus ^a   Mallo, Moisés ^a   Eichmann, Klaus ^a   Modolell, Manuel ^a  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

Innate immunity; Interferon ; Interleukin 12; Interleukin 18; Macrophage

Indexed keywords

CD40 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CYTOKINE RELEASE; IMMUNITY; IN SITU HYBRIDIZATION; INTERFERON PRODUCTION; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; AUTOCRINE COMMUNICATION; BONE MARROW CELLS; CYTOKINES; DRUG SYNERGISM; FEEDBACK; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-18; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED AKR; MICE, INBRED C57BL; RNA, MESSENGER;

EID: 0032526840     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.12.2103     Document Type: Article

References (20)

1. Boehm, U., T. Klamp, M. Groot, and J.C. Howard. 1997. Cellular responses to interferon-γ. Annu. Rev. Immunol. 15: 749-795.
2. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251-276.
3. Okamura, H., K. Nagata, T. Komatsu, T. Tanimoto, Y. Nukata, F. Tanabe, K. Akita, K. Torigoe, T. Okura, S. Fukuda, and M. Kurimoto. 1995. A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock. Infect. Immun. 63:3966-3972.
4. Okamura, H., H. Tsutsui, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, K. Torigoe, T. Okura, Y. Nukada, K. Hattori, et al. 1995. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature. 378:88-91.
5. Micallef, M., T. Ohtsuki, K. Kohno, F. Tanabe, S. Ushio, M. Namba, T. Tanimoto, K. Torigoe, M. Fujii, M. Ikeda, et al. 1996. Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-γ production. Eur. J. Immunol. 26:1647-1651.
6. Robinson, D., K. Shibuya, A. Mui, F. Zonin, E. Murphy, T. Sana, S.B. Hartley, S. Menon, K. Kastelein, F. Bazan, and A. O'Garra. 1997. IGIF does not drive TH1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NFκB. Immunity. 7:571-581.
7. Zhang, T.T., K. Kawakami, M.H. Qureshi, H. Okamura, M. Kurimoto, and A. Saito. 1997. Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neuformans through production of gamma interferon by natural killer cells. Infect. Immun. 65:3594-3599.
8. Di Marzio, P., P. Puddu, L. Conti, F. Belardelli, and S. Gessani. 1994. Interferon-γ upregulates its own gene expression in mouse peritoneal macrophages. J. Exp. Med. 179:1731-1736.
9. Puddu, P., L. Fantuzzi, P. Borghi, B. Varano, G. Rainaldi, E. Guillemard, W. Malorni, P. Nicaise, S.F. Wolf, F. Belardelli, and S. Gessani. 1997. IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophages. J. Immunol. 159:3490-3497.
10. Fenton, M.J., M.W. Vermeulen, S. Kim, M. Burdick, R.M. Strieter, and H. Kornfeld. 1997. Induction of gamma interferon production in human alveolar macrophages by Mycobacterium tuberculosis. Infect. Immun. 65:5149-5156.
11. Yoshimoto, T., H. Okamura, Y. Tagawa, Y. Iwakura, and K. Nakanishi. 1997. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells. Proc. Natl. Acad. Sci. USA. 94: 3948-3953.
12. Huang, S., W. Hendriks, A. Althage, S. Hemmi, H. Bluethmann, R. Kamijo, J. Vilcek, R.M. Zinkernagel, and M. Aguet. 1993. Immune response in mice that lack the interferon-γ receptor. Science. 259:1742-1745.
13. Modolell, M., I.M. Corraliza, F. Link, G. Soler, and K. Eichmann. 1995. Reciprocal regulation of nitric oxide synthase/ arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines. Eur. J. Immunol. 25:1101-1104.
14. Chomczynski, P., and L. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal. Biochem. 162:156-159.
15. Vignaud, J.M., N. Martinet, Y. Martinet, and F. Plenat. 1994. In situ hybridization for localization of mRNAs in mononuclear phagocytes in cell culture and tissue sections. J. Immunol. Methods. 174:281-296.
16. MacMicking, J., Q.-W. Xie, and C. Nathan. 1997. Nitric oxide and macrophage function. Annu. Rev. Immunol. 15: 323-350.
17. Lambert, L.E., and D.M. Paulnock. 1989. Differential induction of activation markers in macrophage cell lines by interferon-γ. Cell. Immunol. 120:401-418.
18. Fultz, M.J., S.A. Barber, C.W. Dieffenbach, and S.N. Vogel. 1993. Induction of IFN-γ in macrophages by lipopolysaccharide. Int. Immunol. 5:1383-1392.
19. Tripp, C., S. Wolf, and E.R. Unanue. 1993. Interleukin 12 and tumor necrosis factor α are costimulators of interteron-γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA. 90:3725-3729.
20. Rothe, H., N.A. Jenkins, N.G. Copeland, and H. Kolb. 1997. Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2. J. Clin. Invest. 99:469-474.