IL-18 and IL-12 induce intestinal inflammation and fatty liver in mice in an IFN-γ dependent manner

Gut

Volumn 47, Issue 6, 2000, Pages 779-786

  Chikano, S ^a   Sawada, K ^a   Shimoyama, T ^a   Kashiwamura, S I ^a   Sugihara, A ^a   Sekikawa, K ^a,b   Terada, N ^a   Nakanishi, K ^a   Okamura, H ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF ANIMAL HEALTH   (Japan)

Author keywords

Fatty liver; Interferon ; Interleukins; Intestinal inflammation; Mice

Indexed keywords

FAS LIGAND; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENTERITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FATTY LIVER; FEMALE; HISTOPATHOLOGY; INTESTINE MUCOSA; LIVER INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FATTY LIVER; FEMALE; INFLAMMATORY BOWEL DISEASES; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-18; INTESTINAL MUCOSA; LIVER; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II;

EID: 0033674358     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.47.6.779     Document Type: Article

References (47)

1. Th 1 and Th 2 cells: Different patterns of lymphokine secretion lead to different functional properties
2. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
3. + T cells
4. Cloning of a new cytokine that induces IFN-γ production by T cells
5. High serum IL-6 level reflects susceptible status of the host to endotoxin and IL-1/tumor necrosis factor
6. Importance of direct hepatocytolysis by liver macrophages in experimental fulminant hepatitis
7. Interleukin 1 potentiates the lethal effect of tumor necrosis-factor α/cachectin in mice
8. Interleukin 1 induces a shock-like state in rabbits
9. The biology of cachectin/TNF a primary mediator of the host response
10. Cloning of the cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein
11. Interleukin-18 (IL-18): A novel cytokine that augments both innate and acquired immunity
12. Defective NK cell activity and Th1 response in IL-18-deficient mice
13. + T cells but induces type1 T cells in the liver by induction of IL-12 and IL-18 production from kupffer cells
14. IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independantly of IL-12
15. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells
16. A mechanism underlying synergy between IL-12 and IFN-γ-inducing factor in enhanced production of IFN-γ
17. IL-12 up-regulates IL-18R expression on T cells, Th1 cells and B cells: Synergism with IL-18 for IFN-γ production
18. IL-18 accounts for both TNF-α-and Fas ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice
19. IFN-γ-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones
20. A pivotal role of IL-12 in Th-1 dependent mouse liver injury
21. Animal models of inflammatory bowel disease
22. + T cells induce or protect from chronic intestinal inflammation in CB-17 Scid mice
23. + T cells
24. + T cells
25. + T cells from IFN-γ knockout mice do not induce wasting disease
26. + T cells
27. Severe colitis in mice with aberrant thymic selection
28. Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation
29. Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4
30. Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines
31. T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat-4) pathway, but is not conditional on interferon γ expression by T cells
32. Suppression of concanavalin A-induced hepatitis in IFN-γ-/- mice, but not in TNF-α-/- mice: Role for IFN-γ in activating apoptosis of hepatocytes
33. Identification and purification of natural killer cell stimulatory factor (NKSF)
34. + T lymphocytes
35. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NF-κB
36. IL-18, although antiallergic when administered with IL-12 stimulates IL-4 and histamine release by basophils
37. IL-18 is a potent coinducer of IL-13 in NK and T cells: A new potential role for IL-18 in modulating the immune response
38. IFN-γ-inducing factor (IL-18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma
39. Interferon-γ. Biology and role in pathogenesis
40. Interactions between endogenous gamma interferon and tumor necrosis factor in host resistance against primary and secondary Listeria monocytogenes infections
41. TNF-α and IFN-γ stimulate a macrophage precursor cell line to kill Listeria monocytogenes in a nitric oxide-independent manner
42. Microbiostatic effect of murine-activated macrophages for Toxoplasmagondii
43. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells
44. Nitric oxide: Physiology, pathophysiology, and pharmacology
45. Nitric oxide induces apoptosis in mouse thymocytes
46. DNA damage and mutation in human cells exposed to nitric oxide in vitro
47. Nitric oxide protects against alkyl peroxide-mediated cytotoxicity: Further insights into the role nitric oxide plays in oxidative stress