Deubiquitylating enzymes and drug discovery: Emerging opportunities

Nature Reviews Drug Discovery

Volumn 17, Issue 1, 2018, Pages 57-77

  Harrigan, Jeanine A ^a   Jacq, Xavier ^a   Martin, Niall M ^a,b   Jackson, Stephen P ^a,c  

^a Babraham Research Campus Babraham   (United Kingdom)

^b Artios Pharma Limited   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

15 OXOSPIRAMILACTONE; 8 MERCAPTO N [(TETRAHYDRO 3 FURANYL)METHYL] 4 QUINOLINECARBOXAMIDE; 9 (ETHOXYIMINO) 9H INDENO[1,2 B]PYRAZINE 2,3 DICARBONITRILE; ADC 01; ADC 03; AMIDE; ANTINEOPLASTIC AGENT; DEUBIQUITINASE; DNA; GSK 2643943A; HBX 19818; HBX 41108; IU 1; IU 1 DERIVATIVE; LDN 57444; MITOXANTRONE; ML 323; ML 364; NEUROPROTECTIVE AGENT; P 22077; P 5091; PROTEASOME; PROTEIN P53; PYRAZINE DERIVATIVE; QUINOLINE DERIVATIVE; SPAUTIN 1; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIALININ A; VLX 1570; WP 1130; NEW DRUG; UBIQUITIN;

CHEMICAL STRUCTURE; DNA REPAIR; DOWN SYNDROME; DRUG RESEARCH; DRUG STRUCTURE; DRUG TARGETING; ENZYME ANALYSIS; EPIGENETICS; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOLOGY; INFLAMMATION; MALIGNANT NEOPLASM; NERVE DEGENERATION; NONHUMAN; ONCOGENE; ONCOLOGY; PRIORITY JOURNAL; PROTEIN TARGETING; REVIEW; TUMOR SUPPRESSOR GENE; ANTAGONISTS AND INHIBITORS; DEGENERATIVE DISEASE; DRUG DEVELOPMENT; DRUG INDUSTRY; ENZYMOLOGY; METABOLISM; MOLECULARLY TARGETED THERAPY; NEOPLASM; PROCEDURES; TRENDS;

DEUBIQUITINATING ENZYMES; DRUG DISCOVERY; DRUG INDUSTRY; DRUGS, INVESTIGATIONAL; HUMANS; MOLECULAR TARGETED THERAPY; NEOPLASMS; NEURODEGENERATIVE DISEASES; PROTEASOME ENDOPEPTIDASE COMPLEX; UBIQUITIN;

EID: 85039776215     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd.2017.152     Document Type: Review

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