Crystal structure of the middle east respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression

Journal of Biological Chemistry

Volumn 289, Issue 50, 2014, Pages 34667-34682

  Bailey Elkin, Ben A ^a   Knaap, Robert C M ^b   Johnson, Garrett G ^a   Dalebout, Tim J ^b   Ninaber, Dennis K ^b   Van Kasteren, Puck B ^b   Bredenbeek, Peter J ^b   Snijder, Eric J ^b   Kikkert, Marjolein ^b   Mark, Brian L ^b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ACTIVITY; PAPAIN; VIRUSES;

ANTIVIRAL RESPONSE; DE-UBIQUITINATING ACTIVITY; DEUBIQUITINATING ENZYMES; INNATE IMMUNE RESPONSE; PROMOTER ACTIVITIES; PROTEOLYTIC ACTIVITIES; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS; VIRAL POLYPROTEIN;

CRYSTAL STRUCTURE;

BETA INTERFERON; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4; PAPAIN LIKE PROTEASE; UBIQUITIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; PAPAIN;

ARTICLE; CONTROLLED STUDY; CORONAVIRUS; CRYSTAL STRUCTURE; DEUBIQUITINATION; HUMAN; HUMAN CELL; INNATE IMMUNITY; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MUTATION; NONHUMAN; PROMOTER REGION; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN MODIFICATION; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; HEK293 CELL LINE; IMMUNOLOGICAL TOLERANCE; METABOLISM; MUTAGENESIS; PROTEIN MOTIF; UBIQUITINATION; X RAY CRYSTALLOGRAPHY;

CORONAVIRUS; SARS CORONAVIRUS;

AMINO ACID MOTIFS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HEK293 CELLS; HUMANS; IMMUNE TOLERANCE; IMMUNITY, INNATE; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MODELS, MOLECULAR; MUTAGENESIS; MUTATION; PAPAIN; UBIQUITIN; UBIQUITINATION;

EID: 84918528852     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.609644     Document Type: Article

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