-
1
-
-
1542344435
-
Proteasomes and their kin: Proteases in the machine age
-
C.M. Pickart, and R.E. Cohen Proteasomes and their kin: proteases in the machine age Nat. Rev. Mol. Cell Biol. 5 2004 177 187
-
(2004)
Nat. Rev. Mol. Cell Biol.
, vol.5
, pp. 177-187
-
-
Pickart, C.M.1
Cohen, R.E.2
-
2
-
-
0035292759
-
Themes and variations on ubiquitylation
-
A.M. Weissman Themes and variations on ubiquitylation Nat. Rev. Mol. Cell Biol. 2 2001 169 178
-
(2001)
Nat. Rev. Mol. Cell Biol.
, vol.2
, pp. 169-178
-
-
Weissman, A.M.1
-
3
-
-
0036629253
-
Protein quality control: U-box-containing E3 ubiquitin ligases join the fold
-
D.M. Cyr Protein quality control: U-box-containing E3 ubiquitin ligases join the fold Trends Biochem. Sci. 27 2002 368 375
-
(2002)
Trends Biochem. Sci.
, vol.27
, pp. 368-375
-
-
Cyr, D.M.1
-
4
-
-
0033520987
-
Posttranslational quality control: Folding, refolding, and degrading proteins
-
S. Wickner Posttranslational quality control: folding, refolding, and degrading proteins Science 286 1999 1888 1893
-
(1999)
Science
, vol.286
, pp. 1888-1893
-
-
Wickner, S.1
-
5
-
-
0038375025
-
Regulation of apoptosis: The ubiquitous way
-
Y. Yang, and X. Yu Regulation of apoptosis: the ubiquitous way FASEB J. 17 2003 790 799
-
(2003)
FASEB J.
, vol.17
, pp. 790-799
-
-
Yang, Y.1
Yu, X.2
-
6
-
-
0036855056
-
Proteasome inhibitors as new anticancer drugs
-
J. Adams Proteasome inhibitors as new anticancer drugs Curr. Opin. Oncol. 14 2002 628 634
-
(2002)
Curr. Opin. Oncol.
, vol.14
, pp. 628-634
-
-
Adams, J.1
-
7
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
L.T. Vassilev In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 Science 303 2004 844 848
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
-
8
-
-
0038434056
-
A superfamily of protein tags: Ubiquitin, SUMO and related modifiers
-
D.C. Schwartz, and M. Hochstrasser A superfamily of protein tags: ubiquitin, SUMO and related modifiers Trends Biochem. Sci. 28 2003 321 328
-
(2003)
Trends Biochem. Sci.
, vol.28
, pp. 321-328
-
-
Schwartz, D.C.1
Hochstrasser, M.2
-
9
-
-
0032563319
-
Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway
-
P.R. Johnson Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway Cell 94 1998 217 227
-
(1998)
Cell
, vol.94
, pp. 217-227
-
-
Johnson, P.R.1
-
10
-
-
0037449572
-
Endoproteolytic activity of the proteasome
-
C.W. Liu Endoproteolytic activity of the proteasome Science 299 2003 408 411
-
(2003)
Science
, vol.299
, pp. 408-411
-
-
Liu, C.W.1
-
11
-
-
0035976835
-
Alpha-synuclein metabolism and aggregation is linked to ubiquitin- independent degradation by the proteasome
-
G.K. Tofaris Alpha-synuclein metabolism and aggregation is linked to ubiquitin- independent degradation by the proteasome FEBS Lett. 509 2001 22 26
-
(2001)
FEBS Lett.
, vol.509
, pp. 22-26
-
-
Tofaris, G.K.1
-
12
-
-
3142514201
-
Protein aggregation and neurodegenerative disease
-
C.A. Ross, and M.A. Poirier Protein aggregation and neurodegenerative disease Nat. Med. 10 2004 S10 S17
-
(2004)
Nat. Med.
, vol.10
-
-
Ross, C.A.1
Poirier, M.A.2
-
13
-
-
0038689039
-
Protein aggregation and the ubiquitin proteasome pathway: Gaining the UPPer hand on neurodegeneration
-
S.J. Berke, and H.L. Paulson Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration Curr. Opin. Genet. Dev. 13 2003 253 261
-
(2003)
Curr. Opin. Genet. Dev.
, vol.13
, pp. 253-261
-
-
Berke, S.J.1
Paulson, H.L.2
-
14
-
-
0032989712
-
Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease
-
J.L. Price, and J.C. Morris Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease Ann. Neurol. 45 1999 358 368
-
(1999)
Ann. Neurol.
, vol.45
, pp. 358-368
-
-
Price, J.L.1
Morris, J.C.2
-
15
-
-
0033391428
-
Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice
-
C.J. Cummings Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice Neuron 24 1999 879 892
-
(1999)
Neuron
, vol.24
, pp. 879-892
-
-
Cummings, C.J.1
-
16
-
-
1042266624
-
CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival
-
H. Shimura CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival J. Biol. Chem. 279 2004 4869 4876
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 4869-4876
-
-
Shimura, H.1
-
17
-
-
11144356089
-
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation
-
L. Petrucelli CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation Hum. Mol. Genet. 13 2004 703 714
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 703-714
-
-
Petrucelli, L.1
-
18
-
-
0034578389
-
Aggresomes, inclusion bodies and protein aggregation
-
R.R. Kopito Aggresomes, inclusion bodies and protein aggregation Trends Cell Biol. 10 2000 524 530
-
(2000)
Trends Cell Biol.
, vol.10
, pp. 524-530
-
-
Kopito, R.R.1
-
19
-
-
0037154229
-
Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment
-
P.J. Muchowski Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment Proc. Natl. Acad. Sci. U. S. A. 99 2002 727 732
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 727-732
-
-
Muchowski, P.J.1
-
20
-
-
0042838303
-
Alzheimer's disease-affected brain: Presence of oligomeric a beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
-
Y. Gong Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss Proc. Natl. Acad. Sci. U. S. A. 100 2003 10417 10422
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 10417-10422
-
-
Gong, Y.1
-
21
-
-
0036669881
-
Amyloid-beta oligomers: Their production, toxicity and therapeutic inhibition
-
D.M. Walsh Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition Biochem. Soc. Trans. 30 2002 552 557
-
(2002)
Biochem. Soc. Trans.
, vol.30
, pp. 552-557
-
-
Walsh, D.M.1
-
22
-
-
0035834360
-
Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct
-
K.A. Conway Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct Science 294 2001 1346 1349
-
(2001)
Science
, vol.294
, pp. 1346-1349
-
-
Conway, K.A.1
-
23
-
-
0038386274
-
Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease
-
M.J. Volles, and P.T. Lansbury Jr Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease Biochemistry 42 2003 7871 7878
-
(2003)
Biochemistry
, vol.42
, pp. 7871-7878
-
-
Volles, M.J.1
Lansbury Jr., P.T.2
-
24
-
-
0037174879
-
Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization
-
M.A. Poirier Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization J. Biol. Chem. 277 2002 41032 41037
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 41032-41037
-
-
Poirier, M.A.1
-
25
-
-
0037461730
-
Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders
-
I. Sanchez Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders Nature 421 2003 373 379
-
(2003)
Nature
, vol.421
, pp. 373-379
-
-
Sanchez, I.1
-
26
-
-
0035947372
-
Impairment of the ubiquitin-proteasome system by protein aggregation
-
N.F. Bence Impairment of the ubiquitin-proteasome system by protein aggregation Science 292 2001 1552 1555
-
(2001)
Science
, vol.292
, pp. 1552-1555
-
-
Bence, N.F.1
-
27
-
-
1842766144
-
Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins
-
P. Venkatraman Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins Mol. Cell 14 2004 95 104
-
(2004)
Mol. Cell
, vol.14
, pp. 95-104
-
-
Venkatraman, P.1
-
28
-
-
2342485108
-
The proteasome degrades soluble expanded polyglutamine completely and efficiently
-
A. Michalik, and C. Van Broeckhoven The proteasome degrades soluble expanded polyglutamine completely and efficiently Neurobiol. Dis. 16 2004 202 211
-
(2004)
Neurobiol. Dis.
, vol.16
, pp. 202-211
-
-
Michalik, A.1
Van Broeckhoven, C.2
-
29
-
-
0037108725
-
Aggregate formation inhibits proteasomal degradation of polyglutamine proteins
-
L.G. Verhoef Aggregate formation inhibits proteasomal degradation of polyglutamine proteins Hum. Mol. Genet. 11 2002 2689 2700
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 2689-2700
-
-
Verhoef, L.G.1
-
30
-
-
0035870881
-
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis
-
Y. Tanaka Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis Hum. Mol. Genet. 10 2001 919 926
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 919-926
-
-
Tanaka, Y.1
-
31
-
-
3042794162
-
Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease
-
K.S. McNaught Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease Ann. Neurol. 56 2004 149 162
-
(2004)
Ann. Neurol.
, vol.56
, pp. 149-162
-
-
McNaught, K.S.1
-
32
-
-
0037062561
-
Amyloid-like features of polyglutamine aggregates and their assembly kinetics
-
S. Chen Amyloid-like features of polyglutamine aggregates and their assembly kinetics Biochemistry 41 2002 7391 7399
-
(2002)
Biochemistry
, vol.41
, pp. 7391-7399
-
-
Chen, S.1
-
33
-
-
0035800572
-
Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity
-
S. Chen Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity J. Mol. Biol. 311 2001 173 182
-
(2001)
J. Mol. Biol.
, vol.311
, pp. 173-182
-
-
Chen, S.1
-
34
-
-
0031446233
-
Intranuclear neuronal inclusions: A common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?
-
C.A. Ross Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases? Neuron 19 1997 1147 1150
-
(1997)
Neuron
, vol.19
, pp. 1147-1150
-
-
Ross, C.A.1
-
35
-
-
0037194897
-
Polyglutamine pathogenesis. Emergence of unifying mechanisms for Huntington's disease and related disorders
-
C. Ross Polyglutamine pathogenesis. Emergence of unifying mechanisms for Huntington's disease and related disorders Neuron 35 2002 819 822
-
(2002)
Neuron
, vol.35
, pp. 819-822
-
-
Ross, C.1
-
36
-
-
1042289730
-
Decreased CRE-mediated transcription: An early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis
-
K.L. Sugars Decreased CRE-mediated transcription: an early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis J. Biol. Chem. 279 2003 4988 4999
-
(2003)
J. Biol. Chem.
, vol.279
, pp. 4988-4999
-
-
Sugars, K.L.1
-
37
-
-
0033613212
-
Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells
-
A. Kazantsev Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells Proc. Natl. Acad. Sci. U. S. A. 96 1999 11404 11409
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 11404-11409
-
-
Kazantsev, A.1
-
38
-
-
12944263711
-
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
-
J.S. Steffan The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription Proc. Natl. Acad. Sci. U. S. A. 97 2000 6763 6768
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 6763-6768
-
-
Steffan, J.S.1
-
39
-
-
0034285017
-
CREB-binding protein sequestration by expanded polyglutamine
-
A. McCampbell CREB-binding protein sequestration by expanded polyglutamine Hum. Mol. Genet. 9 2000 2197 2202
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 2197-2202
-
-
McCampbell, A.1
-
40
-
-
0035937523
-
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity
-
F.C. Nucifora Jr Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity Science 291 2001 2423 2428
-
(2001)
Science
, vol.291
, pp. 2423-2428
-
-
Nucifora Jr., F.C.1
-
41
-
-
3042717240
-
Cellular toxicity of polyglutamine expansion proteins: Mechanism of transcription factor deactivation
-
G. Schaffar Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation Mol. Cell 15 2004 95 105
-
(2004)
Mol. Cell
, vol.15
, pp. 95-105
-
-
Schaffar, G.1
-
42
-
-
12244298155
-
Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein
-
H. Jiang Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein Hum. Mol. Genet. 12 2003 1 12
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 1-12
-
-
Jiang, H.1
-
43
-
-
0035894855
-
Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death
-
L. Stefanis Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death J. Neurosci. 21 2001 9549 9560
-
(2001)
J. Neurosci.
, vol.21
, pp. 9549-9560
-
-
Stefanis, L.1
-
44
-
-
0038094427
-
Prion proteins meet protein quality control
-
D.E. Dimcheff Prion proteins meet protein quality control Trends Cell Biol. 13 2003 337 340
-
(2003)
Trends Cell Biol.
, vol.13
, pp. 337-340
-
-
Dimcheff, D.E.1
-
45
-
-
0035910069
-
Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation
-
J. Ma, and S. Lindquist Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation Proc. Natl. Acad. Sci. U. S. A. 98 2001 14955 14960
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 14955-14960
-
-
Ma, J.1
Lindquist, S.2
-
46
-
-
2242472974
-
Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions
-
M. Hasegawa Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions J. Biol. Chem. 277 2002 49071 49076
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 49071-49076
-
-
Hasegawa, M.1
-
47
-
-
0141891953
-
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons
-
M.S. Goldberg Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons J. Biol. Chem. 278 2003 43628 43635
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 43628-43635
-
-
Goldberg, M.S.1
-
48
-
-
0242300619
-
Alpha-Synuclein locus triplication causes Parkinson's disease
-
A.B. Singleton alpha-Synuclein locus triplication causes Parkinson's disease Science 302 2003 841
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
-
49
-
-
0033788434
-
Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex
-
M. Ghee Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex J. Neurochem. 75 2000 2221 2224
-
(2000)
J. Neurochem.
, vol.75
, pp. 2221-2224
-
-
Ghee, M.1
-
50
-
-
0037129213
-
A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal
-
Y.A. Lam A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal Nature 416 2002 763 767
-
(2002)
Nature
, vol.416
, pp. 763-767
-
-
Lam, Y.A.1
-
51
-
-
0035854437
-
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: Implications for Parkinson's disease
-
H. Shimura Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease Science 293 2001 263 269
-
(2001)
Science
, vol.293
, pp. 263-269
-
-
Shimura, H.1
-
52
-
-
0034700158
-
Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
-
Y. Zhang Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1 Proc. Natl. Acad. Sci. U. S. A. 97 2000 13354 13359
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 13354-13359
-
-
Zhang, Y.1
-
53
-
-
0035959931
-
Parkin and the molecular pathways of Parkinson's disease
-
B.I. Giasson, and V.M. Lee Parkin and the molecular pathways of Parkinson's disease Neuron 31 2001 885 888
-
(2001)
Neuron
, vol.31
, pp. 885-888
-
-
Giasson, B.I.1
Lee, V.M.2
-
54
-
-
0037137702
-
Parkin protects against the toxicity associated with mutant alpha-synuclein: Proteasome dysfunction selectively affects catecholaminergic neurons
-
L. Petrucelli Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons Neuron 36 2002 1007 1019
-
(2002)
Neuron
, vol.36
, pp. 1007-1019
-
-
Petrucelli, L.1
-
55
-
-
2542534741
-
S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function
-
K.K. Chung S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function Science 304 2004 1328 1331
-
(2004)
Science
, vol.304
, pp. 1328-1331
-
-
Chung, K.K.1
-
56
-
-
0037307858
-
The von Hippel-Lindau tumor suppressor protein: New insights into oxygen sensing and cancer
-
W. Kim, and W.G. Kaelin Jr The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer Curr. Opin. Genet. Dev. 13 2003 55 60
-
(2003)
Curr. Opin. Genet. Dev.
, vol.13
, pp. 55-60
-
-
Kim, W.1
Kaelin Jr., W.G.2
-
57
-
-
0034776095
-
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: Implications for Lewy-body formation in Parkinson disease
-
K.K. Chung Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease Nat. Med. 7 2001 1144 1150
-
(2001)
Nat. Med.
, vol.7
, pp. 1144-1150
-
-
Chung, K.K.1
-
58
-
-
0034085796
-
Synphilin-1 is present in Lewy bodies in Parkinson's disease
-
K. Wakabayashi Synphilin-1 is present in Lewy bodies in Parkinson's disease Ann. Neurol. 47 2000 521 523
-
(2000)
Ann. Neurol.
, vol.47
, pp. 521-523
-
-
Wakabayashi, K.1
-
59
-
-
1642633757
-
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease
-
M. Tanaka Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease Nat. Med. 10 2004 148 154
-
(2004)
Nat. Med.
, vol.10
, pp. 148-154
-
-
Tanaka, M.1
-
60
-
-
11144358336
-
Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease
-
E. Liani Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease Proc. Natl. Acad. Sci. U. S. A. 101 2004 5500 5505
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 5500-5505
-
-
Liani, E.1
-
61
-
-
0036345454
-
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity
-
Y. Imai CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity Mol. Cell 10 2002 55 67
-
(2002)
Mol. Cell
, vol.10
, pp. 55-67
-
-
Imai, Y.1
-
62
-
-
0035967883
-
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin
-
Y. Imai An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin Cell 105 2001 891 902
-
(2001)
Cell
, vol.105
, pp. 891-902
-
-
Imai, Y.1
-
63
-
-
0038159253
-
Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function
-
Y.C. Tsai Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function J. Biol. Chem. 278 2003 22044 22055
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 22044-22055
-
-
Tsai, Y.C.1
-
64
-
-
2442481789
-
Mitochondrial dysfunction and oxidative damage in parkin-deficient mice
-
J.J. Palacino Mitochondrial dysfunction and oxidative damage in parkin-deficient mice J. Biol. Chem. 279 2004 18614 18622
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 18614-18622
-
-
Palacino, J.J.1
-
65
-
-
0037338634
-
Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death
-
F. Darios Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death Hum. Mol. Genet. 12 2003 517 526
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 517-526
-
-
Darios, F.1
-
66
-
-
0037131567
-
The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility
-
Y. Liu The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility Cell 111 2002 209 218
-
(2002)
Cell
, vol.111
, pp. 209-218
-
-
Liu, Y.1
-
67
-
-
0141704202
-
L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system
-
D.W. Miller L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system J. Biol. Chem. 278 2003 36588 36595
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 36588-36595
-
-
Miller, D.W.1
-
68
-
-
0142139305
-
Role for the ubiquitin-proteasome system in Parkinson's disease and other neurodegenerative brain amyloidoses
-
D.J. Moore Role for the ubiquitin-proteasome system in Parkinson's disease and other neurodegenerative brain amyloidoses Neuromolecular Med. 4 2003 95 108
-
(2003)
Neuromolecular Med.
, vol.4
, pp. 95-108
-
-
Moore, D.J.1
-
69
-
-
0036900880
-
Mechanisms of enveloped RNA virus budding
-
O. Pornillos Mechanisms of enveloped RNA virus budding Trends Cell Biol. 12 2002 569 579
-
(2002)
Trends Cell Biol.
, vol.12
, pp. 569-579
-
-
Pornillos, O.1
-
70
-
-
0345189365
-
Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein
-
S. Willingham Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein Science 302 2003 1769 1772
-
(2003)
Science
, vol.302
, pp. 1769-1772
-
-
Willingham, S.1
-
71
-
-
11144353613
-
Modification of huntingtin and Huntington's disease pathology
-
J.S. Steffan Modification of huntingtin and Huntington's disease pathology Science 304 2004 100 104
-
(2004)
Science
, vol.304
, pp. 100-104
-
-
Steffan, J.S.1
-
72
-
-
0036296111
-
Enhanced SUMOylation in polyglutamine diseases
-
H. Ueda Enhanced SUMOylation in polyglutamine diseases Biochem. Biophys. Res. Commun. 293 2002 307 313
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.293
, pp. 307-313
-
-
Ueda, H.1
-
73
-
-
18544410106
-
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
-
S.W. Davies Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation Cell 90 1997 537 548
-
(1997)
Cell
, vol.90
, pp. 537-548
-
-
Davies, S.W.1
-
74
-
-
0034754875
-
Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation
-
S. Waelter Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation Mol. Biol. Cell 12 2001 1393 1407
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 1393-1407
-
-
Waelter, S.1
-
75
-
-
0942287194
-
Poly-ubiquitin binding by the polyglutamine disease protein ataxin-3 links its normal function to protein surveillance pathways
-
Y. Chai Poly-ubiquitin binding by the polyglutamine disease protein ataxin-3 links its normal function to protein surveillance pathways J. Biol. Chem. 279 2004 3605 3611
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 3605-3611
-
-
Chai, Y.1
-
76
-
-
0242524455
-
Copper-binding-site-null SOD1 causes ALS in transgenic mice: Aggregates of non-native SOD1 delineate a common feature
-
J. Wang Copper-binding-site-null SOD1 causes ALS in transgenic mice: aggregates of non-native SOD1 delineate a common feature Hum. Mol. Genet. 12 2003 2753 2764
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 2753-2764
-
-
Wang, J.1
-
77
-
-
0034848395
-
Lewy bodies and parkinsonism in families with parkin mutations
-
M. Farrer Lewy bodies and parkinsonism in families with parkin mutations Ann. Neurol. 50 2001 293 300
-
(2001)
Ann. Neurol.
, vol.50
, pp. 293-300
-
-
Farrer, M.1
-
78
-
-
0035977006
-
Geldanamycin restores a defective heat shock response in vivo
-
K.F. Winklhofer Geldanamycin restores a defective heat shock response in vivo J. Biol. Chem. 276 2001 45160 45167
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 45160-45167
-
-
Winklhofer, K.F.1
-
79
-
-
0035176758
-
The Hsp90 chaperone as a promising drug target
-
P.W. Piper The Hsp90 chaperone as a promising drug target Curr. Opin. Investig. Drugs 2 2001 1606 1610
-
(2001)
Curr. Opin. Investig. Drugs
, vol.2
, pp. 1606-1610
-
-
Piper, P.W.1
-
80
-
-
1542301571
-
Diseases of protein conformation: What do in vitro experiments tell us about in vivo diseases?
-
J.N. Buxbaum Diseases of protein conformation: what do in vitro experiments tell us about in vivo diseases? Trends Biochem. Sci. 28 2003 585 592
-
(2003)
Trends Biochem. Sci.
, vol.28
, pp. 585-592
-
-
Buxbaum, J.N.1
-
81
-
-
0034615932
-
Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening
-
Y. Nagai Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening J. Biol. Chem. 275 2000 10437 10442
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 10437-10442
-
-
Nagai, Y.1
-
82
-
-
12444292683
-
Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila
-
Y. Nagai Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila Hum. Mol. Genet. 12 2003 1253 1259
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 1253-1259
-
-
Nagai, Y.1
-
83
-
-
0036547110
-
Peptide inhibitors of beta amyloid aggregation
-
M.A. Findeis Peptide inhibitors of beta amyloid aggregation Curr. Top. Med. Chem. 2 2002 417 423
-
(2002)
Curr. Top. Med. Chem.
, vol.2
, pp. 417-423
-
-
Findeis, M.A.1
-
84
-
-
0035836675
-
Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease
-
J.M. Lecerf Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease Proc. Natl. Acad. Sci. U. S. A. 98 2001 4764 4769
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 4764-4769
-
-
Lecerf, J.M.1
-
85
-
-
0345862278
-
Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy
-
J. Legleiter Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy J. Mol. Biol. 335 2004 997 1006
-
(2004)
J. Mol. Biol.
, vol.335
, pp. 997-1006
-
-
Legleiter, J.1
-
86
-
-
0037180511
-
Chemical chaperones increase the cellular activity of N370S beta-glucosidase: A therapeutic strategy for Gaucher disease
-
A.R. Sawkar Chemical chaperones increase the cellular activity of N370S beta-glucosidase: a therapeutic strategy for Gaucher disease Proc. Natl. Acad. Sci. U. S. A. 99 2002 15428 15433
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 15428-15433
-
-
Sawkar, A.R.1
-
87
-
-
0035955743
-
Chemical chaperones regulate molecular chaperones in vitro and in cells under combined salt and heat stresses
-
S. Diamant Chemical chaperones regulate molecular chaperones in vitro and in cells under combined salt and heat stresses J. Biol. Chem. 276 2001 39586 39591
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 39586-39591
-
-
Diamant, S.1
-
88
-
-
1042266326
-
Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective
-
M. Tanaka Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective J. Biol. Chem. 279 2004 4625 4631
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 4625-4631
-
-
Tanaka, M.1
-
89
-
-
1642285590
-
Development of Protacs to target cancer-promoting proteins for ubiquitination and degradation
-
K.M. Sakamoto Development of Protacs to target cancer-promoting proteins for ubiquitination and degradation Mol. Cell. Proteomics 2 2003 1350 1358
-
(2003)
Mol. Cell. Proteomics
, vol.2
, pp. 1350-1358
-
-
Sakamoto, K.M.1
-
90
-
-
0035411641
-
Beta-amyloid aggregation inhibitors for the treatment of Alzheimer's disease: Dream or reality?
-
P. Talaga Beta-amyloid aggregation inhibitors for the treatment of Alzheimer's disease: dream or reality? Mini Rev. Med. Chem. 1 2001 175 186
-
(2001)
Mini Rev. Med. Chem.
, vol.1
, pp. 175-186
-
-
Talaga, P.1
-
91
-
-
0029664613
-
Selective inhibition of Abeta fibril formation
-
S.J. Wood Selective inhibition of Abeta fibril formation J. Biol. Chem. 271 1996 4086 4092
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 4086-4092
-
-
Wood, S.J.1
-
92
-
-
0033849749
-
Inhibition of beta-amyloid-induced neurotoxicity by imidazopyridoindoles derived from a synthetic combinatorial library
-
N. Reixach Inhibition of beta-amyloid-induced neurotoxicity by imidazopyridoindoles derived from a synthetic combinatorial library J. Struct. Biol. 130 2000 247 258
-
(2000)
J. Struct. Biol.
, vol.130
, pp. 247-258
-
-
Reixach, N.1
-
93
-
-
18744369020
-
Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay
-
V. Heiser Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay Proc. Natl. Acad. Sci. U. S. A. 99 2002 16400 16406
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 16400-16406
-
-
Heiser, V.1
|