Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes

Chemistry and Biology

Volumn 18, Issue 11, 2011, Pages 1401-1412

  Altun, Mikael ^a   Kramer, Holger B ^a   Willems, Lianne I ^a   McDermott, Jeffrey L ^c   Leach, Craig A ^c   Goldenberg, Seth J ^c   Kumar, K G Suresh ^c   Konietzny, Rebecca ^a   Fischer, Roman ^a   Kogan, Edward ^a   MacKeen, Mukram M ^a   McGouran, Joanna ^a   Khoronenkova, Svetlana V ^b   Parsons, Jason L ^b   Dianov, Grigory L ^b   Nicholson, Benjamin ^c   Kessler, Benedikt M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c Progenra Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 ((2,4 DIFLUOROPHENYL)THIO) 4 NITROTHIOPHEN 2 YL)ETHANONE; 1-(5-((2,4-DIFLUOROPHENYL)THIO)-4-NITROTHIOPHEN-2-YL)ETHANONE; 2,6 DIAMINOPYRIDINE 3,5 BIS(THIOCYANATE); 2,6-DIAMINOPYRIDINE-3,5-BIS(THIOCYANATE); AMINOPYRIDINE DERIVATIVE; ANTIBODY; ENZYME INHIBITOR; THIOCYANIC ACID DERIVATIVE; THIOPHENE DERIVATIVE; UBIQUITIN THIOLESTERASE; USP7 PROTEIN, HUMAN;

ARTICLE; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOLOGY; METABOLISM; PROTEOMICS; RNA INTERFERENCE; TANDEM MASS SPECTROMETRY;

AMINOPYRIDINES; ANTIBODIES; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; PROTEOMICS; RNA INTERFERENCE; TANDEM MASS SPECTROMETRY; THIOCYANATES; THIOPHENES; UBIQUITIN THIOLESTERASE;

EID: 82255181181     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2011.08.018     Document Type: Article

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