USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin

EMBO Journal

Volumn 33, Issue 21, 2014, Pages 2473-2491

  Durcan, Thomas M ^a   Tang, Matthew Y ^a   Pérusse, Joëlle R ^b   Dashti, Eman A ^a   Aguileta, Miguel A ^a   McLelland, Gian Luca ^a   Gros, Priti ^a   Shaler, Thomas A ^c   Faubert, Denis ^b   Coulombe, Benoit ^b,d   Fon, Edward A ^a  

^a MCGILL UNIVERSITY   (Canada)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^c SRI INTERNATIONAL   (United States)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

deubiquitination; mitophagy; parkin; ubiquitin; USP8

Indexed keywords

DEUBIQUITINASE; PARKIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; USP8 PROTEIN; ESCRT PROTEIN; PROTEINASE; UBIQUITIN PROTEIN LIGASE; UBIQUITIN THIOLESTERASE; USP8 PROTEIN, HUMAN;

AFFINITY CHROMATOGRAPHY; ARTICLE; CONJUGATE; CONJUGATION; CONTROLLED STUDY; DEPOLARIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; FEMALE; FLUORESCENCE; GENETIC TRANSFECTION; HEK293 CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MASS SPECTROMETRY; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MITOPHAGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REGULATORY MECHANISM; STEADY STATE; TURNOVER TIME; U2OS CELL LINE; UBIQUITINATION; GENETICS; METABOLISM; PHYSIOLOGY;

ENDOPEPTIDASES; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; HEK293 CELLS; HELA CELLS; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; UBIQUITIN THIOLESTERASE; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84920892842     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201489729     Document Type: Article

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