Synthesis and structure-activity relationship studies of N -benzyl-2-phenylpyrimidin-4-amine derivatives as potent usp1/uaf1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer

Journal of Medicinal Chemistry

Volumn 57, Issue 19, 2014, Pages 8099-8110

  Dexheimer, Thomas S ^a   Rosenthal, Andrew S ^a   Luci, Diane K ^a   Liang, Qin ^b   Villamil, Mark A ^b   Chen, Junjun ^b   Sun, Hongmao ^a   Kerns, Edward H ^a   Simeonov, Anton ^a   Jadhav, Ajit ^a   Zhuang, Zhihao ^b   Maloney, David J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF DELAWARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEUBIQUITINASE; N BENZYL 2 PHENYLPYRIMIDIN 4 AMINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ARABIDOPSIS PROTEIN; CYCLINE; NUCLEAR PROTEIN; USP1 ASSOCIATED FACTOR 1, HUMAN; USP1 PROTEIN, HUMAN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC50; LIVER MICROSOME; NON SMALL CELL LUNG CANCER; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CARCINOMA, NON-SMALL-CELL LUNG; LUNG NEOPLASMS; METABOLISM; SYNTHESIS; TUMOR CELL LINE; UBIQUITINATION;

ANTINEOPLASTIC AGENTS; ARABIDOPSIS PROTEINS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; HUMANS; LUNG NEOPLASMS; NUCLEAR PROTEINS; PROLIFERATING CELL NUCLEAR ANTIGEN; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; UBIQUITIN-SPECIFIC PROTEASES; UBIQUITINATION;

EID: 84907886762     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5010495     Document Type: Article

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