Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

Nature Communications

Volumn 5, Issue , 2014, Pages

  Ritorto, Maria Stella ^a   Ewan, Richard ^a   Perez Oliva, Ana B ^a   Knebel, Axel ^a   Buhrlage, Sara J ^b,c   Wightman, Melanie ^a   Kelly, Sharon M ^d   Wood, Nicola T ^a   Virdee, Satpal ^a   Gray, Nathanael S ^b,c   Morrice, Nicholas A ^e   Alessi, Dario R ^a   Trost, Matthias ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; DEUBIQUITINASE; ENZYME INHIBITOR; FEBUXOSTAT; HBX 41 108; L 434078; LIGASE INHIBITOR; NSC 697923; PIMOZIDE; POLYUBIQUITIN; PR 619; SJB 3 019A; UBIQUITIN THIOLESTERASE; UNCLASSIFIED DRUG; WP 1130; 2-((4-METHYLPHENYL)SULFONYL)-5-NITROFURAN; 3-(4-METHYLPHENYLSULFONYL)-2-PROPENENITRILE; NITRILE; NITROFURAN DERIVATIVE; PROTEINASE INHIBITOR; SULFONE; UBIQUITIN; USP7 PROTEIN, HUMAN;

BIOASSAY; DRUG; ENZYME ACTIVITY; MASS SPECTROMETRY;

AMINO ACID SEQUENCE; ARTICLE; CELL SCREENING; DIAGNOSTIC ACCURACY; DRUG POTENCY; DRUG SPECIFICITY; ENZYME ACTIVITY; FLUORESCENCE ANALYSIS; HUMAN; IC 50; IN VITRO STUDY; LIMIT OF QUANTITATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; QUALITY CONTROL; SCREENING; SENSITIVITY AND SPECIFICITY; ANTAGONISTS AND INHIBITORS; ENZYME SPECIFICITY; GENETICS; IC50; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; METABOLISM; PROCEDURES; REPRODUCIBILITY;

HUMANS; INHIBITORY CONCENTRATION 50; NITRILES; NITROFURANS; PROTEASE INHIBITORS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY; SULFONES; UBIQUITIN; UBIQUITIN THIOLESTERASE; UBIQUITIN-SPECIFIC PROTEASES;

EID: 84907358982     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5763     Document Type: Article

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