A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30

Cell Research

Volumn 24, Issue 4, 2014, Pages 482-496

  Yue, Wen ^a,b   Chen, Ziheng ^a,b   Liu, Haiyang ^c   Yan, Chen ^c   Chen, Ming ^a,b   Feng, Du ^d   Yan, Chaojun ^f   Wu, Hao ^a,b   Du, Lei ^a,b   Wang, Yueying ^a,b   Liu, Jinhua ^d   Huang, Xiaohu ^e   Xia, Laixin ^a   Liu, Lei ^a   Wang, Xiaohui ^a   Jin, Haijing ^a   Wang, Jun ^a   Song, Zhiyin ^f   Hao, Xiaojiang ^c   Chen, Quan ^a,b,d  

^a INSTITUTE OF ZOOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c KUNMING INSTITUTE OF BOTANY   (China)

^d NANKAI UNIVERSITY   (China)

^e Peking University   (China)

^f WUHAN UNIVERSITY   (China)

Author keywords

15 Oxospiramilactone; deubiquitinase USP30; mitochondrial fusion; mitofusin1 2

Indexed keywords

15-OXOSPIRAMILACTONE; CARRIER PROTEIN; DEUBIQUITINASE; DITERPENE; ENZYME INHIBITOR; GUANOSINE TRIPHOSPHATASE; MFN1 PROTEIN, HUMAN; MFN2 PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; THIOL ESTER HYDROLASE; USP30 PROTEIN, HUMAN;

ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; DRUG EFFECTS; GENE INACTIVATION; GENETICS; HELA CELL LINE; HUMAN; METABOLISM; MITOCHONDRIAL DYNAMICS; MITOCHONDRION; MOUSE; OXIDATIVE PHOSPHORYLATION;

ANIMALS; CELLS, CULTURED; DITERPENES; ENZYME INHIBITORS; GENE KNOCKOUT TECHNIQUES; GTP PHOSPHOHYDROLASES; HELA CELLS; HUMANS; MICE; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL PROTEINS; OXIDATIVE PHOSPHORYLATION; THIOLESTER HYDROLASES; UBIQUITIN-SPECIFIC PROTEASES;

EID: 84898025574     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2014.20     Document Type: Article

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