De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

Nature

Volumn 430, Issue 7000, 2004, Pages 694-699

  Wartz, Ingrid E ^a,b   O'Rourke, Karen M ^a   Zhou, Honglin ^a   Eby, Michael ^a   Aravind, L ^c   Seshagiri, Somasekar ^a   Wu, Ping ^a   Wiesmann, Christian ^a   Baker, Rohan ^d   Boone, David L ^e   Ma, Averli ^e   Koonin, Eugene V ^c   Dixit, Vishva M ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d Australian National University   (Australia)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DEGRADATION; FUNCTIONS; SIGNALING;

CELL DEATH; INFLAMMATION;

ENZYMES;

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LYSINE; PROTEASOME; PROTEIN; PROTEIN A20; RECEPTOR INTERACTING PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; NUCLEAR PROTEIN; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK1 PROTEIN, HUMAN; SIGNAL PEPTIDE; SMALL INTERFERING RNA; TNFAIP3 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME;

CELLS AND CELL COMPONENTS; TUMOR;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DEATH; HUMAN; HUMAN CELL; INFLAMMATION; MOUSE; NONHUMAN; OVARY TUMOR; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; UBIQUITINATION; CELL LINE; CHEMISTRY; DOWN REGULATION; GENETICS; HELA CELL; METABOLISM; PROTEIN TERTIARY STRUCTURE;

CELL LINE; DOWN-REGULATION; HELA CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NF-KAPPA B; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 2; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES;

EID: 3943054838     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02794     Document Type: Article

References (30)

1. Dixit, V. & Mak, T. W. NF-kappaB signaling. Many roads lead to Madrid. Cell 111, 615-619 (2002).
2. Lee, E. G. et al. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 289, 2350-2354 (2000).
3. Makarova, K. S., Aravind, L. & Koonin, E. V. A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae. Trends Biochem. Sci. 25, 50-52 (2000).
4. Ting, A. T., Pimentel-Muinos, F. X. & Seed, B. RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis. EMBO J. 15, 6189-6196 (1996).
5. Kelliher, M. A. et al. The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. Immunity 8, 297-303 (1998).
6. Opipari, A. W. Jr, Boguski, M. S. & Dixit, V. M. The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J. Biol. Chem. 265, 14705-14708 (1990).
7. Aravind, L., Dixit, V. M. & Koonin, E. V. Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons. Science 291, 1279-1284 (2001).
8. Pickart, C. M. Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 70, 503-533 (2001).
9. Weissman, A. M. Themes and variations on ubiquitylation. Nature Rev. Mol. Cell Biol. 2, 169-178 (2001).
10. Yeh, W. C. et al. Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAP2-deficient mice. Immunity 7, 715-725 (1997).
11. Lee, S. Y. et al. TRAF2 is essential for INK but not NF-kappaB activation and regulates lymphocyte proliferation and survival. Immunity 7, 703-713 (1997).
12. Kieser, A., Kaiser, C. & Hammerschmidt, W. LMP1 signal transduction differs substantially from TNF receptor 1 signaling in the molecular functions of TRADD and TRAF2. EMBO J. 18, 2511-2521 (1999).
13. Tada, K. et al. Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death. J. Biol. Chem. 276, 36530-36534 (2001).
14. Hsu, H., Huang, J., Shu, H. B., Baichwal, V. & Goeddel, D. V. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4, 387-396 (1996).
15. Zhang, S. Q., Kovalenko, A., Cantarella, G. & Wallach, D. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. Immunity 12, 301-311 (2000).
16. Legler, D. F., Micheau, O., Doucey, M. A., Tschopp, J. & Bron, C. Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation. Immunity 18, 655-664 (2003).
17. Micheau, O. & Tschopp, J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114, 181-190 (2003).
18. Balakirev, M. Y., Tcherniuk, S. O., Jaquinod, M. & Chroboczek, J. Otubains; a new family of cysteine proteases in the ubiquitin pathway. EMBO Rep. 4, 517-522 (2003).
19. Borodovsky, A. et al. Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. Chem. Biol. 9, 1149-1159 (2002).
20. Evans, P. C. et al. A novel type of deubiquitinating enzyme. J. Biol. Chem. 278, 23180-23186 (2003).
21. Evans, P. C. et al. Zinc-finger protein A20, a regulator of inflammation and cell survival, has deubiquitinating activity. Biochem. J. 378, 727-734 (2004).
22. Deng, L. et al. Activation of the 1kappaB kinase complex by TRAT6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103, 351-361 (2000).
23. Wang, C. et al. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346-351 (2001).
24. Shi, C. S. & Kehr, J. H. Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2). J. Biol. Chem. 278, 15429-15434 (2003).
25. Wilkinson, K. D. Signal transduction: aspirin, ubiquitin and cancer. Nature 424, 738-739 (2003).
26. Zhou, H. et al. Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. Nature 427, 167-171 (2004).
27. Hsu, H., Shu, H. B., Pan, M. G. & Goeddel, D. V. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84, 299-308 (1996).
28. Devin, A. et al. The distinct roles of TRAF2 and RIP in IKK activation by TNF-RI: TRAT2 recruits IKK to TNF-R1 while RIP mediates IKK activation. Immunity 12, 419-429 (2000).
29. Poyet, J. L. et al. Activation of the Ikappa B kinases by RIP via IKKgamma/NEMO-mediated oligomerization. J. Biol. Chem. 275, 37966-37977 (2000).
30. Devin, A. et al. The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF. Mol. Cell. Biol. 21, 3986-3994 (2001).