Deubiquitination of dishevelled by usp14 is required for wnt signaling

Oncogenesis

Volumn 2, Issue , 2013, Pages

  Jung, H ^a   Kim, B G ^b   Han, W H ^c   Lee, J H ^d   Cho, J Y ^e   Park, W S ^f   Maurice, M M ^g   Han, J K ^c   Lee, M J ^d   Finley, D ^h   Jho, E H ^a  

^a University of Seoul   (South Korea)

^b Seoul National University   (South Korea)

^c Pohang University of Science and Technology (POSTECH)   (South Korea)

^d Kyung Hee University   (South Korea)

^e Seoul National University   (South Korea)

^f The Catholic University of Korea   (South Korea)

^g UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^h HARVARD MEDICAL SCHOOL   (United States)

Author keywords

deubiquitinase; dishevelled; ubiquitination; Usp14; Wnt

Indexed keywords

BETA CATENIN; DISHEVELLED PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; USP14 PROTEIN; WNT PROTEIN;

ARTICLE; COLON CANCER; DEUBIQUITINATION; EMBRYO; HUMAN; HUMAN CELL; MUTATION; PRIORITY JOURNAL; TISSUE MICROARRAY; UBIQUITINATION; WNT SIGNALING PATHWAY;

EID: 84883185607     PISSN: None     EISSN: 21579024     Source Type: Journal    
DOI: 10.1038/oncsis.2013.28     Document Type: Article

References (34)

1. Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004; 20: 781-810. (Pubitemid 39488658)
2. Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006; 127: 469-480.
3. Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005; 434: 843-850. (Pubitemid 40558990)
4. MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 2009; 17: 9-26.
5. Clevers H, Nusse R. Wnt/beta-catenin signaling and disease. Cell 2012; 149: 1192-1205.
6. Wallingford JB, Habas R. The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity. Development 2005; 132: 4421-4436. (Pubitemid 41632222)
7. Zeng X, Tamai K, Doble B, Li S, Huang H, Habas R et al. A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 2005; 438: 873-877. (Pubitemid 41753071)
8. Pan W, Choi SC, Wang H, Qin Y, Volpicelli-Daley L, Swan L et al. Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. Science 2008; 321: 1350-1353.
9. Veeman MT, Axelrod JD, Moon RT. A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell 2003; 5: 367-377. (Pubitemid 37107667)
10. Gao C, Chen YG. Dishevelled: The hub of Wnt signaling. Cell Signal 2010; 22: 717-727.
11. Tauriello DV, Maurice MM. The various roles of ubiquitin in Wnt pathway regulation. Cell Cycle 2010; 9: 3700-3709.
12. Jung H, Kim HJ, Lee SK, Kim R, Kopachik W, Han JK et al. Negative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of Dishevelled. Exp Mol Med 2009; 41: 695-706.
13. Zhang L, Gao X, Wen J, Ning Y, Chen YG. Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. J Biol Chem 2006; 281: 8607-8612. (Pubitemid 43847964)
14. Gao C, Cao W, Bao L, Zuo W, Xie G, Cai T et al. Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat Cell Biol 2010; 12: 781-790.
15. Tauriello DV, Haegebarth A, Kuper I, Edelmann MJ, Henraat M, Canninga-van Dijk MR et al. Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. Mol Cell 2010; 37: 607-619.
16. Tauriello DV, Jordens I, Kirchner K, Slootstra JW, Kruitwagen T, Bouwman BA et al. Wnt/beta-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled. Proc Natl Acad Sci USA 2012; 109: E812-E820.
17. Heessen S, Masucci MG, Dantuma NP. The UBA2 domain functions as an intrinsic stabilization signal that protects Rad23 from proteasomal degradation. Mol Cell 2005; 18: 225-235.
18. Pickart CM. Ubiquitin enters the new millennium. Mol Cell 2001; 8: 499-504.
19. Komander D, Rape M. The ubiquitin code. Annu Rev Biochem 2012; 81: 203-229.
20. Beal RE, Toscano-Cantaffa D, Young P, Rechsteiner M, Pickart CM. The hydrophobic effect contributes to polyubiquitin chain recognition. Biochemistry 1998; 37: 2925-2934. (Pubitemid 28145745)
21. Kozlov G, Nguyen L, Lin T, De Crescenzo G, Park M, Gehring K. Structural basis of ubiquitin recognition by the ubiquitin-associated (UBA) domain of the ubiquitin ligase EDD. J Biol Chem 2007; 282: 35787-35795. (Pubitemid 350277104)
22. Bryja V, Schulte G, Rawal N, Grahn A, Arenas E. Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism. J Cell Sci 2007; 120(Pt 4): 586-595. (Pubitemid 46437893)
23. Price MA. CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling. Genes Dev 2006; 20: 399-410.
24. Lee BH, Lee MJ, Park S, Oh DC, Elsasser S, Chen PC et al. Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature 2010; 467: 179-184.
25. Lee MJ, Lee BH, Hanna J, King RW, Finley D. Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Mol Cell Proteomics 2011; 10: R110 003871.
26. Leggett DS, Hanna J, Borodovsky A, Crosas B, Schmidt M, Baker RT et al. Multiple associated proteins regulate proteasome structure and function. Mol Cell 2002; 10: 495-507. (Pubitemid 35284170)
27. Rosenzweig R, Bronner V, Zhang D, Fushman D, Glickman MH. Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome. J Biol Chem 2012; 287: 14659-14671.
28. Crimmins S, Sutovsky M, Chen PC, Huffman A, Wheeler C, Swing DA et al. Transgenic rescue of ataxia mice reveals a male-specific sterility defect. Dev Biol 2009; 325: 33-42.
29. Medema JP, Vermeulen L. Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. Nature 2011; 474: 318-326.
30. Kim CJ, Cho YG, Park YG, Nam SW, Kim SY, Lee SH et al. Pin1 overexpression in colorectal cancer and its correlation with aberrant beta-catenin expression. World J Gastroenterol 2005; 11: 5006-5009.
31. Long J, Gallagher TR, Cavey JR, Sheppard PW, Ralston SH, Layfield R et al. Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switch. J Biol Chem 2008; 283: 5427-5440.
32. Wooten MW, Geetha T, Babu JR, Seibenhener ML, Peng J, Cox N et al. Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins. J Biol Chem 2008; 283: 6783-6789.
33. Shinji S, Naito Z, Ishiwata S, Ishiwata T, Tanaka N, Furukawa K et al. Ubiquitinspecific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases. Oncol Rep 2006; 15: 539-543.
34. Endo A, Matsumoto M, Inada T, Yamamoto A, Nakayama KI, Kitamura N et al. Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36. J Cell Sci 2009; 122(Pt 5): 678-686.