-
1
-
-
84864557192
-
Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1
-
Aarts M., Sharpe R., Garcia-Murillas I., Gevensleben H., Hurd M.S., Shumway S.D., Toniatti C., Ashworth A., Turner N.C. Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1. Cancer Discov. 2012, 2:524-539.
-
(2012)
Cancer Discov.
, vol.2
, pp. 524-539
-
-
Aarts, M.1
Sharpe, R.2
Garcia-Murillas, I.3
Gevensleben, H.4
Hurd, M.S.5
Shumway, S.D.6
Toniatti, C.7
Ashworth, A.8
Turner, N.C.9
-
2
-
-
84869079205
-
Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer
-
Abkevich V., Timms K.M., Hennessy B.T., Potter J., Carey M.S., Meyer L.A., Smith-McCune K., Broaddus R., Lu K.H., Chen J., et al. Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer. Br. J. Cancer 2012, 107:1776-1782.
-
(2012)
Br. J. Cancer
, vol.107
, pp. 1776-1782
-
-
Abkevich, V.1
Timms, K.M.2
Hennessy, B.T.3
Potter, J.4
Carey, M.S.5
Meyer, L.A.6
Smith-McCune, K.7
Broaddus, R.8
Lu, K.H.9
Chen, J.10
-
3
-
-
84906903083
-
Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy
-
Al-Ahmadie H., Iyer G., Hohl M., Asthana S., Inagaki A., Schultz N., Hanrahan A.J., Scott S.N., Brannon A.R., McDermott G.C., et al. Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy. Cancer Discov. 2014, 4:1014-1021.
-
(2014)
Cancer Discov.
, vol.4
, pp. 1014-1021
-
-
Al-Ahmadie, H.1
Iyer, G.2
Hohl, M.3
Asthana, S.4
Inagaki, A.5
Schultz, N.6
Hanrahan, A.J.7
Scott, S.N.8
Brannon, A.R.9
McDermott, G.C.10
-
4
-
-
84947755226
-
Role of MTH1 (NUTD1) in cancer cell survival
-
Alwan H., Eckersley K., Goodwin L., Lau A., Jones D., Kettle J., Nissink W.M., Read J., Scott J.S., Taylor B.J.M., Walker G.E., Foote K.M. Role of MTH1 (NUTD1) in cancer cell survival. Proceedings of the 2015 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics 2015, 45.
-
(2015)
Proceedings of the 2015 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
, pp. 45
-
-
Alwan, H.1
Eckersley, K.2
Goodwin, L.3
Lau, A.4
Jones, D.5
Kettle, J.6
Nissink, W.M.7
Read, J.8
Scott, J.S.9
Taylor, B.J.M.10
Walker, G.E.11
Foote, K.M.12
-
5
-
-
49249119415
-
A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair
-
Ashworth A. A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. J. Clin. Oncol. 2008, 26:3785-3790.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 3785-3790
-
-
Ashworth, A.1
-
6
-
-
84872044020
-
The clinical development of molecularly targeted agents in combination with radiation therapy: a pharmaceutical perspective
-
Ataman O.U., Sambrook S.J., Wilks C., Lloyd A., Taylor A.E., Wedge S.R. The clinical development of molecularly targeted agents in combination with radiation therapy: a pharmaceutical perspective. Int. J. Radiat. Oncol. Biol. Phys. 2012, 84:e447-e454.
-
(2012)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.84
, pp. e447-e454
-
-
Ataman, O.U.1
Sambrook, S.J.2
Wilks, C.3
Lloyd, A.4
Taylor, A.E.5
Wedge, S.R.6
-
7
-
-
77955039099
-
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial
-
Audeh M.W., Carmichael J., Penson R.T., Friedlander M., Powell B., Bell-McGuinn K.M., Scott C., Weitzel J.N., Oaknin A., Loman N., et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet 2010, 376:245-251.
-
(2010)
Lancet
, vol.376
, pp. 245-251
-
-
Audeh, M.W.1
Carmichael, J.2
Penson, R.T.3
Friedlander, M.4
Powell, B.5
Bell-McGuinn, K.M.6
Scott, C.7
Weitzel, J.N.8
Oaknin, A.9
Loman, N.10
-
8
-
-
18244385718
-
ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
-
Ball H.L., Myers J.S., Cortez D. ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Mol. Biol. Cell 2005, 16:2372-2381.
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 2372-2381
-
-
Ball, H.L.1
Myers, J.S.2
Cortez, D.3
-
9
-
-
84947795362
-
Randomized, Double-Blind Phase II Trial With Prospective Classification by ATM Protein Level to Evaluate the Efficacy and Tolerability of Olaparib Plus Paclitaxel in Patients With Recurrent or Metastatic Gastric Cancer
-
Published online August 17, 2015
-
Bang Y.J., Im S.A., Lee K.W., Cho J.Y., Song E.K., Lee K.H., Kim Y.H., Park J.O., Chun H.G., Zang D.Y., et al. Randomized, Double-Blind Phase II Trial With Prospective Classification by ATM Protein Level to Evaluate the Efficacy and Tolerability of Olaparib Plus Paclitaxel in Patients With Recurrent or Metastatic Gastric Cancer. J. Clin. Oncol. 2015, Published online August 17, 2015.
-
(2015)
J. Clin. Oncol.
-
-
Bang, Y.J.1
Im, S.A.2
Lee, K.W.3
Cho, J.Y.4
Song, E.K.5
Lee, K.H.6
Kim, Y.H.7
Park, J.O.8
Chun, H.G.9
Zang, D.Y.10
-
10
-
-
84875018599
-
Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma
-
Barazzuol L., Jena R., Burnet N.G., Meira L.B., Jeynes J.C., Kirkby K.J., Kirkby N.F. Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma. Radiat. Oncol. 2013, 8:65.
-
(2013)
Radiat. Oncol.
, vol.8
, pp. 65
-
-
Barazzuol, L.1
Jena, R.2
Burnet, N.G.3
Meira, L.B.4
Jeynes, J.C.5
Kirkby, K.J.6
Kirkby, N.F.7
-
11
-
-
17244367849
-
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
-
Bartkova J., Horejsí Z., Koed K., Krämer A., Tort F., Zieger K., Guldberg P., Sehested M., Nesland J.M., Lukas C., et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005, 434:864-870.
-
(2005)
Nature
, vol.434
, pp. 864-870
-
-
Bartkova, J.1
Horejsí, Z.2
Koed, K.3
Krämer, A.4
Tort, F.5
Zieger, K.6
Guldberg, P.7
Sehested, M.8
Nesland, J.M.9
Lukas, C.10
-
12
-
-
77956627442
-
Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas
-
Bartkova J., Hamerlik P., Stockhausen M.T., Ehrmann J., Hlobilkova A., Laursen H., Kalita O., Kolar Z., Poulsen H.S., Broholm H., et al. Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas. Oncogene 2010, 29:5095-5102.
-
(2010)
Oncogene
, vol.29
, pp. 5095-5102
-
-
Bartkova, J.1
Hamerlik, P.2
Stockhausen, M.T.3
Ehrmann, J.4
Hlobilkova, A.5
Laursen, H.6
Kalita, O.7
Kolar, Z.8
Poulsen, H.S.9
Broholm, H.10
-
13
-
-
84868689115
-
Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption
-
Beck H., Nähse-Kumpf V., Larsen M.S., O'Hanlon K.A., Patzke S., Holmberg C., Mejlvang J., Groth A., Nielsen O., Syljuåsen R.G., Sørensen C.S. Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption. Mol. Cell. Biol. 2012, 32:4226-4236.
-
(2012)
Mol. Cell. Biol.
, vol.32
, pp. 4226-4236
-
-
Beck, H.1
Nähse-Kumpf, V.2
Larsen, M.S.3
O'Hanlon, K.A.4
Patzke, S.5
Holmberg, C.6
Mejlvang, J.7
Groth, A.8
Nielsen, O.9
Syljuåsen, R.G.10
Sørensen, C.S.11
-
14
-
-
79953054421
-
Strategies to improve radiotherapy with targeted drugs
-
Begg A.C., Stewart F.A., Vens C. Strategies to improve radiotherapy with targeted drugs. Nat. Rev. Cancer 2011, 11:239-253.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 239-253
-
-
Begg, A.C.1
Stewart, F.A.2
Vens, C.3
-
15
-
-
79955525482
-
Nucleotide deficiency promotes genomic instability in early stages of cancer development
-
Bester A.C., Roniger M., Oren Y.S., Im M.M., Sarni D., Chaoat M., Bensimon A., Zamir G., Shewach D.S., Kerem B. Nucleotide deficiency promotes genomic instability in early stages of cancer development. Cell 2011, 145:435-446.
-
(2011)
Cell
, vol.145
, pp. 435-446
-
-
Bester, A.C.1
Roniger, M.2
Oren, Y.S.3
Im, M.M.4
Sarni, D.5
Chaoat, M.6
Bensimon, A.7
Zamir, G.8
Shewach, D.S.9
Kerem, B.10
-
16
-
-
84922819486
-
High-affinity DNA-binding domains of replication protein A (RPA) direct SMARCAL1-dependent replication fork remodeling
-
Bhat K.P., Bétous R., Cortez D. High-affinity DNA-binding domains of replication protein A (RPA) direct SMARCAL1-dependent replication fork remodeling. J. Biol. Chem. 2015, 290:4110-4117.
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 4110-4117
-
-
Bhat, K.P.1
Bétous, R.2
Cortez, D.3
-
17
-
-
84888190793
-
PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication
-
Bianchi J., Rudd S.G., Jozwiakowski S.K., Bailey L.J., Soura V., Taylor E., Stevanovic I., Green A.J., Stracker T.H., Lindsay H.D., Doherty A.J. PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication. Mol. Cell 2013, 52:566-573.
-
(2013)
Mol. Cell
, vol.52
, pp. 566-573
-
-
Bianchi, J.1
Rudd, S.G.2
Jozwiakowski, S.K.3
Bailey, L.J.4
Soura, V.5
Taylor, E.6
Stevanovic, I.7
Green, A.J.8
Stracker, T.H.9
Lindsay, H.D.10
Doherty, A.J.11
-
18
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
Bryant H.E., Schultz N., Thomas H.D., Parker K.M., Flower D., Lopez E., Kyle S., Meuth M., Curtin N.J., Helleday T. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 2005, 434:913-917.
-
(2005)
Nature
, vol.434
, pp. 913-917
-
-
Bryant, H.E.1
Schultz, N.2
Thomas, H.D.3
Parker, K.M.4
Flower, D.5
Lopez, E.6
Kyle, S.7
Meuth, M.8
Curtin, N.J.9
Helleday, T.10
-
19
-
-
84941805396
-
Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase
-
Buisson R., Boisvert J.L., Benes C.H., Zou L. Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase. Mol. Cell 2015, 59:1011-1024.
-
(2015)
Mol. Cell
, vol.59
, pp. 1011-1024
-
-
Buisson, R.1
Boisvert, J.L.2
Benes, C.H.3
Zou, L.4
-
20
-
-
18244371925
-
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
-
Byun T.S., Pacek M., Yee M.C., Walter J.C., Cimprich K.A. Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev. 2005, 19:1040-1052.
-
(2005)
Genes Dev.
, vol.19
, pp. 1040-1052
-
-
Byun, T.S.1
Pacek, M.2
Yee, M.C.3
Walter, J.C.4
Cimprich, K.A.5
-
21
-
-
84908593807
-
DNA single-strand break repair
-
Caldecott K.W. DNA single-strand break repair. Exp. Cell Res. 2014, 329:2-8.
-
(2014)
Exp. Cell Res.
, vol.329
, pp. 2-8
-
-
Caldecott, K.W.1
-
22
-
-
2342635919
-
Cell death by mitotic catastrophe: a molecular definition
-
Castedo M., Perfettini J.L., Roumier T., Andreau K., Medema R., Kroemer G. Cell death by mitotic catastrophe: a molecular definition. Oncogene 2004, 23:2825-2837.
-
(2004)
Oncogene
, vol.23
, pp. 2825-2837
-
-
Castedo, M.1
Perfettini, J.L.2
Roumier, T.3
Andreau, K.4
Medema, R.5
Kroemer, G.6
-
23
-
-
84955360632
-
Repair Pathway Choices and Consequences at the Double-Strand Break
-
Ceccaldi R., Rondinelli B., D'Andrea A.D. Repair Pathway Choices and Consequences at the Double-Strand Break. Trends Cell Biol. 2015, 10.1016/j.tcb.2015.07.009.
-
(2015)
Trends Cell Biol.
-
-
Ceccaldi, R.1
Rondinelli, B.2
D'Andrea, A.D.3
-
24
-
-
78649336706
-
The DNA damage response: making it safe to play with knives
-
Ciccia A., Elledge S.J. The DNA damage response: making it safe to play with knives. Mol. Cell 2010, 40:179-204.
-
(2010)
Mol. Cell
, vol.40
, pp. 179-204
-
-
Ciccia, A.1
Elledge, S.J.2
-
25
-
-
47749141560
-
ATR: an essential regulator of genome integrity
-
Cimprich K.A., Cortez D. ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol. 2008, 9:616-627.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 616-627
-
-
Cimprich, K.A.1
Cortez, D.2
-
26
-
-
84880440332
-
ATR phosphorylates SMARCAL1 to prevent replication fork collapse
-
Couch F.B., Bansbach C.E., Driscoll R., Luzwick J.W., Glick G.G., Bétous R., Carroll C.M., Jung S.Y., Qin J., Cimprich K.A., Cortez D. ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Genes Dev. 2013, 27:1610-1623.
-
(2013)
Genes Dev.
, vol.27
, pp. 1610-1623
-
-
Couch, F.B.1
Bansbach, C.E.2
Driscoll, R.3
Luzwick, J.W.4
Glick, G.G.5
Bétous, R.6
Carroll, C.M.7
Jung, S.Y.8
Qin, J.9
Cimprich, K.A.10
Cortez, D.11
-
27
-
-
84870218588
-
DNA repair dysregulation from cancer driver to therapeutic target
-
Curtin N.J. DNA repair dysregulation from cancer driver to therapeutic target. Nat. Rev. Cancer 2012, 12:801-817.
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 801-817
-
-
Curtin, N.J.1
-
28
-
-
10744233628
-
Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells
-
Curtin N.J., Wang L.Z., Yiakouvaki A., Kyle S., Arris C.A., Canan-Koch S., Webber S.E., Durkacz B.W., Calvert H.A., Hostomsky Z., Newell D.R. Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells. Clin. Cancer Res. 2004, 10:881-889.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 881-889
-
-
Curtin, N.J.1
Wang, L.Z.2
Yiakouvaki, A.3
Kyle, S.4
Arris, C.A.5
Canan-Koch, S.6
Webber, S.E.7
Durkacz, B.W.8
Calvert, H.A.9
Hostomsky, Z.10
Newell, D.R.11
-
29
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
d'Adda di Fagagna F., Reaper P.M., Clay-Farrace L., Fiegler H., Carr P., Von Zglinicki T., Saretzki G., Carter N.P., Jackson S.P. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003, 426:194-198.
-
(2003)
Nature
, vol.426
, pp. 194-198
-
-
d'Adda di Fagagna, F.1
Reaper, P.M.2
Clay-Farrace, L.3
Fiegler, H.4
Carr, P.5
Von Zglinicki, T.6
Saretzki, G.7
Carter, N.P.8
Jackson, S.P.9
-
30
-
-
84886644238
-
Wee1 kinase as a target for cancer therapy
-
Do K., Doroshow J.H., Kummar S. Wee1 kinase as a target for cancer therapy. Cell Cycle 2013, 12:3159-3164.
-
(2013)
Cell Cycle
, vol.12
, pp. 3159-3164
-
-
Do, K.1
Doroshow, J.H.2
Kummar, S.3
-
32
-
-
84921718845
-
Purification of proteins on newly synthesized DNA using iPOND
-
Dungrawala H., Cortez D. Purification of proteins on newly synthesized DNA using iPOND. Methods Mol. Biol. 2015, 1228:123-131.
-
(2015)
Methods Mol. Biol.
, vol.1228
, pp. 123-131
-
-
Dungrawala, H.1
Cortez, D.2
-
33
-
-
84941809696
-
The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability
-
Dungrawala H., Rose K.L., Bhat K.P., Mohni K.N., Glick G.G., Couch F.B., Cortez D. The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability. Mol. Cell 2015, 59:998-1010.
-
(2015)
Mol. Cell
, vol.59
, pp. 998-1010
-
-
Dungrawala, H.1
Rose, K.L.2
Bhat, K.P.3
Mohni, K.N.4
Glick, G.G.5
Couch, F.B.6
Cortez, D.7
-
35
-
-
84947795771
-
Lynparza recommended for approval in ovarian cancer
-
EMA (2014). Lynparza recommended for approval in ovarian cancer. http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2014/10/news_detail_002196.jsp&mid=WC0b01ac058004d5c1.
-
(2014)
-
-
-
36
-
-
84942096774
-
MGMT Expression Predicts PARP-Mediated Resistance to Temozolomide
-
Erice O., Smith M.P., White R., Goicoechea I., Barriuso J., Jones C., Margison G.P., Acosta J.C., Wellbrock C., Arozarena I. MGMT Expression Predicts PARP-Mediated Resistance to Temozolomide. Mol. Cancer Ther. 2015, 14:1236-1246.
-
(2015)
Mol. Cancer Ther.
, vol.14
, pp. 1236-1246
-
-
Erice, O.1
Smith, M.P.2
White, R.3
Goicoechea, I.4
Barriuso, J.5
Jones, C.6
Margison, G.P.7
Acosta, J.C.8
Wellbrock, C.9
Arozarena, I.10
-
37
-
-
54949098894
-
Nucleoside analogs: molecular mechanisms signaling cell death
-
Ewald B., Sampath D., Plunkett W. Nucleoside analogs: molecular mechanisms signaling cell death. Oncogene 2008, 27:6522-6537.
-
(2008)
Oncogene
, vol.27
, pp. 6522-6537
-
-
Ewald, B.1
Sampath, D.2
Plunkett, W.3
-
38
-
-
33749134033
-
A dynamic model for replication protein A (RPA) function in DNA processing pathways
-
Fanning E., Klimovich V., Nager A.R. A dynamic model for replication protein A (RPA) function in DNA processing pathways. Nucleic Acids Res. 2006, 34:4126-4137.
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 4126-4137
-
-
Fanning, E.1
Klimovich, V.2
Nager, A.R.3
-
39
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
Farmer H., McCabe N., Lord C.J., Tutt A.N., Johnson D.A., Richardson T.B., Santarosa M., Dillon K.J., Hickson I., Knights C., et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005, 434:917-921.
-
(2005)
Nature
, vol.434
, pp. 917-921
-
-
Farmer, H.1
McCabe, N.2
Lord, C.J.3
Tutt, A.N.4
Johnson, D.A.5
Richardson, T.B.6
Santarosa, M.7
Dillon, K.J.8
Hickson, I.9
Knights, C.10
-
40
-
-
84947765804
-
FDA approves Lynparza to treat advanced ovarian cancer
-
FDA (2015). FDA approves Lynparza to treat advanced ovarian cancer. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427554.htm.
-
(2015)
-
-
-
41
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong P.C., Boss D.S., Yap T.A., Tutt A., Wu P., Mergui-Roelvink M., Mortimer P., Swaisland H., Lau A., O'Connor M.J., et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N. Engl. J. Med. 2009, 361:123-134.
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
Tutt, A.4
Wu, P.5
Mergui-Roelvink, M.6
Mortimer, P.7
Swaisland, H.8
Lau, A.9
O'Connor, M.J.10
-
42
-
-
77952105389
-
Inflammatory networks during cellular senescence: causes and consequences
-
Freund A., Orjalo A.V., Desprez P.Y., Campisi J. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol. Med. 2010, 16:238-246.
-
(2010)
Trends Mol. Med.
, vol.16
, pp. 238-246
-
-
Freund, A.1
Orjalo, A.V.2
Desprez, P.Y.3
Campisi, J.4
-
43
-
-
0031734148
-
Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma
-
Friedman H.S., Kokkinakis D.M., Pluda J., Friedman A.H., Cokgor I., Haglund M.M., Ashley D.M., Rich J., Dolan M.E., Pegg A.E., et al. Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma. J. Clin. Oncol. 1998, 16:3570-3575.
-
(1998)
J. Clin. Oncol.
, vol.16
, pp. 3570-3575
-
-
Friedman, H.S.1
Kokkinakis, D.M.2
Pluda, J.3
Friedman, A.H.4
Cokgor, I.5
Haglund, M.M.6
Ashley, D.M.7
Rich, J.8
Dolan, M.E.9
Pegg, A.E.10
-
45
-
-
17244366865
-
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
-
Gorgoulis V.G., Vassiliou L.V., Karakaidos P., Zacharatos P., Kotsinas A., Liloglou T., Venere M., Ditullio R.A., Kastrinakis N.G., Levy B., et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005, 434:907-913.
-
(2005)
Nature
, vol.434
, pp. 907-913
-
-
Gorgoulis, V.G.1
Vassiliou, L.V.2
Karakaidos, P.3
Zacharatos, P.4
Kotsinas, A.5
Liloglou, T.6
Venere, M.7
Ditullio, R.A.8
Kastrinakis, N.G.9
Levy, B.10
-
46
-
-
0033614998
-
Creation of human tumour cells with defined genetic elements
-
Hahn W.C., Counter C.M., Lundberg A.S., Beijersbergen R.L., Brooks M.W., Weinberg R.A. Creation of human tumour cells with defined genetic elements. Nature 1999, 400:464-468.
-
(1999)
Nature
, vol.400
, pp. 464-468
-
-
Hahn, W.C.1
Counter, C.M.2
Lundberg, A.S.3
Beijersbergen, R.L.4
Brooks, M.W.5
Weinberg, R.A.6
-
47
-
-
40449120350
-
An oncogene-induced DNA damage model for cancer development
-
Halazonetis T.D., Gorgoulis V.G., Bartek J. An oncogene-induced DNA damage model for cancer development. Science 2008, 319:1352-1355.
-
(2008)
Science
, vol.319
, pp. 1352-1355
-
-
Halazonetis, T.D.1
Gorgoulis, V.G.2
Bartek, J.3
-
48
-
-
84899644661
-
Investigation of radiosensitivity gene signatures in cancer cell lines
-
Hall J.S., Iype R., Senra J., Taylor J., Armenoult L., Oguejiofor K., Li Y., Stratford I., Stern P.L., O'Connor M.J., et al. Investigation of radiosensitivity gene signatures in cancer cell lines. PLoS ONE 2014, 9:e86329.
-
(2014)
PLoS ONE
, vol.9
, pp. e86329
-
-
Hall, J.S.1
Iype, R.2
Senra, J.3
Taylor, J.4
Armenoult, L.5
Oguejiofor, K.6
Li, Y.7
Stratford, I.8
Stern, P.L.9
O'Connor, M.J.10
-
49
-
-
0030667434
-
Integrating genetic approaches into the discovery of anticancer drugs
-
Hartwell L.H., Szankasi P., Roberts C.J., Murray A.W., Friend S.H. Integrating genetic approaches into the discovery of anticancer drugs. Science 1997, 278:1064-1068.
-
(1997)
Science
, vol.278
, pp. 1064-1068
-
-
Hartwell, L.H.1
Szankasi, P.2
Roberts, C.J.3
Murray, A.W.4
Friend, S.H.5
-
50
-
-
80052168685
-
The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings
-
Helleday T. The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings. Mol. Oncol. 2011, 5:387-393.
-
(2011)
Mol. Oncol.
, vol.5
, pp. 387-393
-
-
Helleday, T.1
-
51
-
-
31844456472
-
Replication fork reactivation downstream of a blocked nascent leading strand
-
Heller R.C., Marians K.J. Replication fork reactivation downstream of a blocked nascent leading strand. Nature 2006, 439:557-562.
-
(2006)
Nature
, vol.439
, pp. 557-562
-
-
Heller, R.C.1
Marians, K.J.2
-
52
-
-
9744271049
-
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
-
Hickson I., Zhao Y., Richardson C.J., Green S.J., Martin N.M., Orr A.I., Reaper P.M., Jackson S.P., Curtin N.J., Smith G.C. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 2004, 64:9152-9159.
-
(2004)
Cancer Res.
, vol.64
, pp. 9152-9159
-
-
Hickson, I.1
Zhao, Y.2
Richardson, C.J.3
Green, S.J.4
Martin, N.M.5
Orr, A.I.6
Reaper, P.M.7
Jackson, S.P.8
Curtin, N.J.9
Smith, G.C.10
-
53
-
-
84947767135
-
Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes
-
Hodgson D.R., Dougherty B., Lai Z., Grinsted L., Spencer S., O'Connor M.J., Ho T.W., Robertson J.D., Lanchbury J., Timms K., et al. Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes. Eur. J. Cancer 2015, 51. abstr 435.
-
(2015)
Eur. J. Cancer
, vol.51
-
-
Hodgson, D.R.1
Dougherty, B.2
Lai, Z.3
Grinsted, L.4
Spencer, S.5
O'Connor, M.J.6
Ho, T.W.7
Robertson, J.D.8
Lanchbury, J.9
Timms, K.10
-
54
-
-
0035902108
-
Genome maintenance mechanisms for preventing cancer
-
Hoeijmakers J.H. Genome maintenance mechanisms for preventing cancer. Nature 2001, 411:366-374.
-
(2001)
Nature
, vol.411
, pp. 366-374
-
-
Hoeijmakers, J.H.1
-
55
-
-
70349859881
-
DNA damage, aging, and cancer
-
Hoeijmakers J.H. DNA damage, aging, and cancer. N. Engl. J. Med. 2009, 361:1475-1485.
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 1475-1485
-
-
Hoeijmakers, J.H.1
-
56
-
-
70350504453
-
The DNA-damage response in human biology and disease
-
Jackson S.P., Bartek J. The DNA-damage response in human biology and disease. Nature 2009, 461:1071-1078.
-
(2009)
Nature
, vol.461
, pp. 1071-1078
-
-
Jackson, S.P.1
Bartek, J.2
-
57
-
-
33646187811
-
The multifaceted mismatch-repair system
-
Jiricny J. The multifaceted mismatch-repair system. Nat. Rev. Mol. Cell Biol. 2006, 7:335-346.
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 335-346
-
-
Jiricny, J.1
-
58
-
-
84881480253
-
Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress
-
Jones R.M., Mortusewicz O., Afzal I., Lorvellec M., García P., Helleday T., Petermann E. Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress. Oncogene 2013, 32:3744-3753.
-
(2013)
Oncogene
, vol.32
, pp. 3744-3753
-
-
Jones, R.M.1
Mortusewicz, O.2
Afzal, I.3
Lorvellec, M.4
García, P.5
Helleday, T.6
Petermann, E.7
-
59
-
-
84917706821
-
ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses
-
Jossé R., Martin S.E., Guha R., Ormanoglu P., Pfister T.D., Reaper P.M., Barnes C.S., Jones J., Charlton P., Pollard J.R., et al. ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses. Cancer Res. 2014, 74:6968-6979.
-
(2014)
Cancer Res.
, vol.74
, pp. 6968-6979
-
-
Jossé, R.1
Martin, S.E.2
Guha, R.3
Ormanoglu, P.4
Pfister, T.D.5
Reaper, P.M.6
Barnes, C.S.7
Jones, J.8
Charlton, P.9
Pollard, J.R.10
-
60
-
-
34249900982
-
Direct cellular responses to platinum-induced DNA damage
-
Jung Y., Lippard S.J. Direct cellular responses to platinum-induced DNA damage. Chem. Rev. 2007, 107:1387-1407.
-
(2007)
Chem. Rev.
, vol.107
, pp. 1387-1407
-
-
Jung, Y.1
Lippard, S.J.2
-
61
-
-
25444497278
-
The concept of synthetic lethality in the context of anticancer therapy
-
Kaelin W.G. The concept of synthetic lethality in the context of anticancer therapy. Nat. Rev. Cancer 2005, 5:689-698.
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 689-698
-
-
Kaelin, W.G.1
-
62
-
-
84942456107
-
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
-
aaa5612
-
Kang C., Xu Q., Martin T.D., Li M.Z., Demaria M., Aron L., Lu T., Yankner B.A., Campisi J., Elledge S.J. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science 2015, 349:aaa5612.
-
(2015)
Science
, vol.349
-
-
Kang, C.1
Xu, Q.2
Martin, T.D.3
Li, M.Z.4
Demaria, M.5
Aron, L.6
Lu, T.7
Yankner, B.A.8
Campisi, J.9
Elledge, S.J.10
-
63
-
-
77955889790
-
Expanded roles of the Fanconi anemia pathway in preserving genomic stability
-
Kee Y., D'Andrea A.D. Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev. 2010, 24:1680-1694.
-
(2010)
Genes Dev.
, vol.24
, pp. 1680-1694
-
-
Kee, Y.1
D'Andrea, A.D.2
-
64
-
-
84932628341
-
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
-
Le D.T., Uram J.N., Wang H., Bartlett B.R., Kemberling H., Eyring A.D., Skora A.D., Luber B.S., Azad N.S., Laheru D., et al. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N. Engl. J. Med. 2015, 372:2509-2520.
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 2509-2520
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
Bartlett, B.R.4
Kemberling, H.5
Eyring, A.D.6
Skora, A.D.7
Luber, B.S.8
Azad, N.S.9
Laheru, D.10
-
65
-
-
84919361106
-
Replication stress and cancer: it takes two to tango
-
Lecona E., Fernández-Capetillo O. Replication stress and cancer: it takes two to tango. Exp. Cell Res. 2014, 329:26-34.
-
(2014)
Exp. Cell Res.
, vol.329
, pp. 26-34
-
-
Lecona, E.1
Fernández-Capetillo, O.2
-
66
-
-
84859523588
-
Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer
-
Ledermann J., Harter P., Gourley C., Friedlander M., Vergote I., Rustin G., Scott C., Meier W., Shapira-Frommer R., Safra T., et al. Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer. N. Engl. J. Med. 2012, 366:1382-1392.
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 1382-1392
-
-
Ledermann, J.1
Harter, P.2
Gourley, C.3
Friedlander, M.4
Vergote, I.5
Rustin, G.6
Scott, C.7
Meier, W.8
Shapira-Frommer, R.9
Safra, T.10
-
67
-
-
84903547236
-
Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial
-
Ledermann J., Harter P., Gourley C., Friedlander M., Vergote I., Rustin G., Scott C.L., Meier W., Shapira-Frommer R., Safra T., et al. Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial. Lancet Oncol. 2014, 15:852-861.
-
(2014)
Lancet Oncol.
, vol.15
, pp. 852-861
-
-
Ledermann, J.1
Harter, P.2
Gourley, C.3
Friedlander, M.4
Vergote, I.5
Rustin, G.6
Scott, C.L.7
Meier, W.8
Shapira-Frommer, R.9
Safra, T.10
-
68
-
-
85007146303
-
Phase II study with Wee1 inhibitor AZD1775 plus carboplatin in patients with p53 mutated ovarian cancer refractory or resistant (<3 months) to standard first line therapy
-
Leijen S., van Geel R., Sonke G.S., de Jong D., Rosenberg E.H., Marchetti S., Pluim D., van Werkhoven E.D., Rose S., Lee M.A., et al. Phase II study with Wee1 inhibitor AZD1775 plus carboplatin in patients with p53 mutated ovarian cancer refractory or resistant (<3 months) to standard first line therapy. J. Clin. Oncol. 2015, 33. abstr2507.
-
(2015)
J. Clin. Oncol.
, vol.33
-
-
Leijen, S.1
van Geel, R.2
Sonke, G.S.3
de Jong, D.4
Rosenberg, E.H.5
Marchetti, S.6
Pluim, D.7
van Werkhoven, E.D.8
Rose, S.9
Lee, M.A.10
-
69
-
-
77953229115
-
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
-
Lieber M.R. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu. Rev. Biochem. 2010, 79:181-211.
-
(2010)
Annu. Rev. Biochem.
, vol.79
, pp. 181-211
-
-
Lieber, M.R.1
-
70
-
-
0028865245
-
Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks
-
Lindahl T., Satoh M.S., Poirier G.G., Klungland A. Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem. Sci. 1995, 20:405-411.
-
(1995)
Trends Biochem. Sci.
, vol.20
, pp. 405-411
-
-
Lindahl, T.1
Satoh, M.S.2
Poirier, G.G.3
Klungland, A.4
-
71
-
-
84908134454
-
Combination cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: a randomised phase 2 study
-
Liu J.F., Barry W.T., Birrer M., Lee J.M., Buckanovich R.J., Fleming G.F., Rimel B., Buss M.K., Nattam S., Hurteau J., et al. Combination cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: a randomised phase 2 study. Lancet Oncol. 2014, 15:1207-1214.
-
(2014)
Lancet Oncol.
, vol.15
, pp. 1207-1214
-
-
Liu, J.F.1
Barry, W.T.2
Birrer, M.3
Lee, J.M.4
Buckanovich, R.J.5
Fleming, G.F.6
Rimel, B.7
Buss, M.K.8
Nattam, S.9
Hurteau, J.10
-
72
-
-
84856019858
-
The DNA damage response and cancer therapy
-
Lord C.J., Ashworth A. The DNA damage response and cancer therapy. Nature 2012, 481:287-294.
-
(2012)
Nature
, vol.481
, pp. 287-294
-
-
Lord, C.J.1
Ashworth, A.2
-
73
-
-
0014285011
-
Synthetic lethality and semi-lethality among functionally related mutants of Drosophila melanfgaster
-
Lucchesi J.C. Synthetic lethality and semi-lethality among functionally related mutants of Drosophila melanfgaster. Genetics 1968, 59:37-44.
-
(1968)
Genetics
, vol.59
, pp. 37-44
-
-
Lucchesi, J.C.1
-
74
-
-
79952281751
-
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress
-
Lukas C., Savic V., Bekker-Jensen S., Doil C., Neumann B., Pedersen R.S., Grøfte M., Chan K.L., Hickson I.D., Bartek J., Lukas J. 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat. Cell Biol. 2011, 13:243-253.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 243-253
-
-
Lukas, C.1
Savic, V.2
Bekker-Jensen, S.3
Doil, C.4
Neumann, B.5
Pedersen, R.S.6
Grøfte, M.7
Chan, K.L.8
Hickson, I.D.9
Bartek, J.10
Lukas, J.11
-
75
-
-
84921932554
-
DNA replication stress as a hallmark of cancer
-
Macheret M., Halazonetis T.D. DNA replication stress as a hallmark of cancer. Annu. Rev. Pathol. 2015, 10:425-448.
-
(2015)
Annu. Rev. Pathol.
, vol.10
, pp. 425-448
-
-
Macheret, M.1
Halazonetis, T.D.2
-
76
-
-
77953658106
-
Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2
-
Martin S.A., McCarthy A., Barber L.J., Burgess D.J., Parry S., Lord C.J., Ashworth A. Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2. EMBO Mol. Med. 2009, 1:323-337.
-
(2009)
EMBO Mol. Med.
, vol.1
, pp. 323-337
-
-
Martin, S.A.1
McCarthy, A.2
Barber, L.J.3
Burgess, D.J.4
Parry, S.5
Lord, C.J.6
Ashworth, A.7
-
77
-
-
84923090502
-
Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination
-
Mateos-Gomez P.A., Gong F., Nair N., Miller K.M., Lazzerini-Denchi E., Sfeir A. Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination. Nature 2015, 518:254-257.
-
(2015)
Nature
, vol.518
, pp. 254-257
-
-
Mateos-Gomez, P.A.1
Gong, F.2
Nair, N.3
Miller, K.M.4
Lazzerini-Denchi, E.5
Sfeir, A.6
-
78
-
-
34250010317
-
Chk1 regulates the density of active replication origins during the vertebrate S phase
-
Maya-Mendoza A., Petermann E., Gillespie D.A., Caldecott K.W., Jackson D.A. Chk1 regulates the density of active replication origins during the vertebrate S phase. EMBO J. 2007, 26:2719-2731.
-
(2007)
EMBO J.
, vol.26
, pp. 2719-2731
-
-
Maya-Mendoza, A.1
Petermann, E.2
Gillespie, D.A.3
Caldecott, K.W.4
Jackson, D.A.5
-
79
-
-
0028113345
-
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
-
Miki Y., Swensen J., Shattuck-Eidens D., Futreal P.A., Harshman K., Tavtigian S., Liu Q., Cochran C., Bennett L.M., Ding W., et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994, 266:66-71.
-
(1994)
Science
, vol.266
, pp. 66-71
-
-
Miki, Y.1
Swensen, J.2
Shattuck-Eidens, D.3
Futreal, P.A.4
Harshman, K.5
Tavtigian, S.6
Liu, Q.7
Cochran, C.8
Bennett, L.M.9
Ding, W.10
-
80
-
-
77649131406
-
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
-
Moynahan M.E., Jasin M. Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat. Rev. Mol. Cell Biol. 2010, 11:196-207.
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 196-207
-
-
Moynahan, M.E.1
Jasin, M.2
-
81
-
-
84868221110
-
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
-
Murai J., Huang S.Y., Das B.B., Renaud A., Zhang Y., Doroshow J.H., Ji J., Takeda S., Pommier Y. Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors. Cancer Res. 2012, 72:5588-5599.
-
(2012)
Cancer Res.
, vol.72
, pp. 5588-5599
-
-
Murai, J.1
Huang, S.Y.2
Das, B.B.3
Renaud, A.4
Zhang, Y.5
Doroshow, J.H.6
Ji, J.7
Takeda, S.8
Pommier, Y.9
-
82
-
-
84901218339
-
Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition
-
Murai J., Zhang Y., Morris J., Ji J., Takeda S., Doroshow J.H., Pommier Y. Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition. J. Pharmacol. Exp. Ther. 2014, 349:408-416.
-
(2014)
J. Pharmacol. Exp. Ther.
, vol.349
, pp. 408-416
-
-
Murai, J.1
Zhang, Y.2
Morris, J.3
Ji, J.4
Takeda, S.5
Doroshow, J.H.6
Pommier, Y.7
-
83
-
-
36949012288
-
Targeted cancer therapies based on the inhibition of DNA strand break repair
-
O'Connor M.J., Martin N.M., Smith G.C. Targeted cancer therapies based on the inhibition of DNA strand break repair. Oncogene 2007, 26:7816-7824.
-
(2007)
Oncogene
, vol.26
, pp. 7816-7824
-
-
O'Connor, M.J.1
Martin, N.M.2
Smith, G.C.3
-
84
-
-
84947779778
-
Generating preclinical models to assess bone marrow toxicity induced by the PARP inhibitor olaparib in combination with chemotherapy
-
O'Connor M.J., Mason H., Horner S., Slater I., Lau A., Cadogan E., Oplustilova L. Generating preclinical models to assess bone marrow toxicity induced by the PARP inhibitor olaparib in combination with chemotherapy. Cancer Res. 2013, 73. 10.1158/1538-7445.AM2013-4420.
-
(2013)
Cancer Res.
, vol.73
-
-
O'Connor, M.J.1
Mason, H.2
Horner, S.3
Slater, I.4
Lau, A.5
Cadogan, E.6
Oplustilova, L.7
-
85
-
-
84906283789
-
The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2'-deoxycytidine lesions
-
Orta M.L., Höglund A., Calderón-Montaño J.M., Domínguez I., Burgos-Morón E., Visnes T., Pastor N., Ström C., López-lázaro M., Helleday T. The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2'-deoxycytidine lesions. Nucleic Acids Res. 2014, 42:9108-9120.
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. 9108-9120
-
-
Orta, M.L.1
Höglund, A.2
Calderón-Montaño, J.M.3
Domínguez, I.4
Burgos-Morón, E.5
Visnes, T.6
Pastor, N.7
Ström, C.8
López-lázaro, M.9
Helleday, T.10
-
86
-
-
79952747328
-
Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells
-
Patel A.G., Sarkaria J.N., Kaufmann S.H. Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells. Proc. Natl. Acad. Sci. USA 2011, 108:3406-3411.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 3406-3411
-
-
Patel, A.G.1
Sarkaria, J.N.2
Kaufmann, S.H.3
-
87
-
-
84923397599
-
Therapeutic opportunities within the DNA damage response
-
Pearl L.H., Schierz A.C., Ward S.E., Al-Lazikani B., Pearl F.M. Therapeutic opportunities within the DNA damage response. Nat. Rev. Cancer 2015, 15:166-180.
-
(2015)
Nat. Rev. Cancer
, vol.15
, pp. 166-180
-
-
Pearl, L.H.1
Schierz, A.C.2
Ward, S.E.3
Al-Lazikani, B.4
Pearl, F.M.5
-
88
-
-
84906899772
-
RADical response puts an exceptional responder in CHKmate: a synthetic lethal curative response to DNA-damaging chemotherapy?
-
Peng G., Woodman S.E., Mills G.B. RADical response puts an exceptional responder in CHKmate: a synthetic lethal curative response to DNA-damaging chemotherapy?. Cancer Discov. 2014, 4:988-990.
-
(2014)
Cancer Discov.
, vol.4
, pp. 988-990
-
-
Peng, G.1
Woodman, S.E.2
Mills, G.B.3
-
89
-
-
77957982422
-
Chk1 promotes replication fork progression by controlling replication initiation
-
Petermann E., Woodcock M., Helleday T. Chk1 promotes replication fork progression by controlling replication initiation. Proc. Natl. Acad. Sci. USA 2010, 107:16090-16095.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 16090-16095
-
-
Petermann, E.1
Woodcock, M.2
Helleday, T.3
-
90
-
-
59449085305
-
Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors
-
Plummer R., Jones C., Middleton M., Wilson R., Evans J., Olsen A., Curtin N., Boddy A., McHugh P., Newell D., et al. Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors. Clin. Cancer Res. 2008, 14:7917-7923.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 7917-7923
-
-
Plummer, R.1
Jones, C.2
Middleton, M.3
Wilson, R.4
Evans, J.5
Olsen, A.6
Curtin, N.7
Boddy, A.8
McHugh, P.9
Newell, D.10
-
91
-
-
77954187741
-
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
-
Pommier Y., Leo E., Zhang H., Marchand C. DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem. Biol. 2010, 17:421-433.
-
(2010)
Chem. Biol.
, vol.17
, pp. 421-433
-
-
Pommier, Y.1
Leo, E.2
Zhang, H.3
Marchand, C.4
-
92
-
-
84926432359
-
Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins
-
Prakash R., Zhang Y., Feng W., Jasin M. Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins. Cold Spring Harb. Perspect. Biol. 2015, 7:a016600.
-
(2015)
Cold Spring Harb. Perspect. Biol.
, vol.7
, pp. a016600
-
-
Prakash, R.1
Zhang, Y.2
Feng, W.3
Jasin, M.4
-
94
-
-
84885899930
-
RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells
-
Ragland R.L., Patel S., Rivard R.S., Smith K., Peters A.A., Bielinsky A.K., Brown E.J. RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells. Genes Dev. 2013, 27:2259-2273.
-
(2013)
Genes Dev.
, vol.27
, pp. 2259-2273
-
-
Ragland, R.L.1
Patel, S.2
Rivard, R.S.3
Smith, K.4
Peters, A.A.5
Bielinsky, A.K.6
Brown, E.J.7
-
95
-
-
79959376888
-
Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR
-
Reaper P.M., Griffiths M.R., Long J.M., Charrier J.D., Maccormick S., Charlton P.A., Golec J.M., Pollard J.R. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. Nat. Chem. Biol. 2011, 7:428-430.
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 428-430
-
-
Reaper, P.M.1
Griffiths, M.R.2
Long, J.M.3
Charrier, J.D.4
Maccormick, S.5
Charlton, P.A.6
Golec, J.M.7
Pollard, J.R.8
-
96
-
-
84861578543
-
Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development
-
Reijns M.A., Rabe B., Rigby R.E., Mill P., Astell K.R., Lettice L.A., Boyle S., Leitch A., Keighren M., Kilanowski F., et al. Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development. Cell 2012, 149:1008-1022.
-
(2012)
Cell
, vol.149
, pp. 1008-1022
-
-
Reijns, M.A.1
Rabe, B.2
Rigby, R.E.3
Mill, P.4
Astell, K.R.5
Lettice, L.A.6
Boyle, S.7
Leitch, A.8
Keighren, M.9
Kilanowski, F.10
-
97
-
-
84899035081
-
Myc induced replicative stress response: How to cope with it and exploit it
-
Rohban S., Campaner S. Myc induced replicative stress response: How to cope with it and exploit it. Biochim. Biophys. Acta 2015, 1849:517-524.
-
(2015)
Biochim. Biophys. Acta
, vol.1849
, pp. 517-524
-
-
Rohban, S.1
Campaner, S.2
-
98
-
-
0037884963
-
Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
-
Rothkamm K., Löbrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc. Natl. Acad. Sci. USA 2003, 100:5057-5062.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 5057-5062
-
-
Rothkamm, K.1
Löbrich, M.2
-
99
-
-
84908213474
-
Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?
-
Sabharwal S.S., Schumacker P.T. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?. Nat. Rev. Cancer 2014, 14:709-721.
-
(2014)
Nat. Rev. Cancer
, vol.14
, pp. 709-721
-
-
Sabharwal, S.S.1
Schumacker, P.T.2
-
100
-
-
84866564290
-
Safety and tolerability of the poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib (AZD2281) in combination with topotecan for the treatment of patients with advanced solid tumors: a phase I study
-
Samol J., Ranson M., Scott E., Macpherson E., Carmichael J., Thomas A., Cassidy J. Safety and tolerability of the poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib (AZD2281) in combination with topotecan for the treatment of patients with advanced solid tumors: a phase I study. Invest. New Drugs 2012, 30:1493-1500.
-
(2012)
Invest. New Drugs
, vol.30
, pp. 1493-1500
-
-
Samol, J.1
Ranson, M.2
Scott, E.3
Macpherson, E.4
Carmichael, J.5
Thomas, A.6
Cassidy, J.7
-
101
-
-
83355174034
-
Targeting radiation-induced G(2) checkpoint activation with the Wee-1 inhibitor MK-1775 in glioblastoma cell lines
-
Sarcar B., Kahali S., Prabhu A.H., Shumway S.D., Xu Y., Demuth T., Chinnaiyan P. Targeting radiation-induced G(2) checkpoint activation with the Wee-1 inhibitor MK-1775 in glioblastoma cell lines. Mol. Cancer Ther. 2011, 10:2405-2414.
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 2405-2414
-
-
Sarcar, B.1
Kahali, S.2
Prabhu, A.H.3
Shumway, S.D.4
Xu, Y.5
Demuth, T.6
Chinnaiyan, P.7
-
102
-
-
33847688859
-
Repair of alkylated DNA: recent advances
-
Sedgwick B., Bates P.A., Paik J., Jacobs S.C., Lindahl T. Repair of alkylated DNA: recent advances. DNA Repair (Amst.) 2007, 6:429-442.
-
(2007)
DNA Repair (Amst.)
, vol.6
, pp. 429-442
-
-
Sedgwick, B.1
Bates, P.A.2
Paik, J.3
Jacobs, S.C.4
Lindahl, T.5
-
103
-
-
80053947757
-
Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft
-
Senra J.M., Telfer B.A., Cherry K.E., McCrudden C.M., Hirst D.G., O'Connor M.J., Wedge S.R., Stratford I.J. Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft. Mol. Cancer Ther. 2011, 10:1949-1958.
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 1949-1958
-
-
Senra, J.M.1
Telfer, B.A.2
Cherry, K.E.3
McCrudden, C.M.4
Hirst, D.G.5
O'Connor, M.J.6
Wedge, S.R.7
Stratford, I.J.8
-
104
-
-
3242670803
-
ATR and ATM regulate the timing of DNA replication origin firing
-
Shechter D., Costanzo V., Gautier J. ATR and ATM regulate the timing of DNA replication origin firing. Nat. Cell Biol. 2004, 6:648-655.
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 648-655
-
-
Shechter, D.1
Costanzo, V.2
Gautier, J.3
-
105
-
-
84898035920
-
DNA double-strand break repair in a cellular context
-
Shibata A., Jeggo P.A. DNA double-strand break repair in a cellular context. Clin. Oncol. (R Coll Radiol) 2014, 26:243-249.
-
(2014)
Clin. Oncol. (R Coll Radiol)
, vol.26
, pp. 243-249
-
-
Shibata, A.1
Jeggo, P.A.2
-
106
-
-
0011511768
-
Mechanisms of action of cancer chemotherapeutic agents: DNA-interactive alkylating agents and antitumour platinum-based drugs
-
John Wiley and Sons, Ltd. M.R. Alison (Ed.)
-
Siddik Z.H. Mechanisms of action of cancer chemotherapeutic agents: DNA-interactive alkylating agents and antitumour platinum-based drugs. The Cancer Handbook 2002, John Wiley and Sons, Ltd. M.R. Alison (Ed.).
-
(2002)
The Cancer Handbook
-
-
Siddik, Z.H.1
-
107
-
-
84897573804
-
Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide
-
Tentori L., Ricci-Vitiani L., Muzi A., Ciccarone F., Pelacchi F., Calabrese R., Runci D., Pallini R., Caiafa P., Graziani G. Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide. BMC Cancer 2014, 14:151.
-
(2014)
BMC Cancer
, vol.14
, pp. 151
-
-
Tentori, L.1
Ricci-Vitiani, L.2
Muzi, A.3
Ciccarone, F.4
Pelacchi, F.5
Calabrese, R.6
Runci, D.7
Pallini, R.8
Caiafa, P.9
Graziani, G.10
-
108
-
-
79958865837
-
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
-
Toledo L.I., Murga M., Zur R., Soria R., Rodriguez A., Martinez S., Oyarzabal J., Pastor J., Bischoff J.R., Fernandez-Capetillo O. A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nat. Struct. Mol. Biol. 2011, 18:721-727.
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 721-727
-
-
Toledo, L.I.1
Murga, M.2
Zur, R.3
Soria, R.4
Rodriguez, A.5
Martinez, S.6
Oyarzabal, J.7
Pastor, J.8
Bischoff, J.R.9
Fernandez-Capetillo, O.10
-
109
-
-
84889563685
-
ATR prohibits replication catastrophe by preventing global exhaustion of RPA
-
Toledo L.I., Altmeyer M., Rask M.B., Lukas C., Larsen D.H., Povlsen L.K., Bekker-Jensen S., Mailand N., Bartek J., Lukas J. ATR prohibits replication catastrophe by preventing global exhaustion of RPA. Cell 2013, 155:1088-1103.
-
(2013)
Cell
, vol.155
, pp. 1088-1103
-
-
Toledo, L.I.1
Altmeyer, M.2
Rask, M.B.3
Lukas, C.4
Larsen, D.H.5
Povlsen, L.K.6
Bekker-Jensen, S.7
Mailand, N.8
Bartek, J.9
Lukas, J.10
-
110
-
-
77955019276
-
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial
-
Tutt A., Robson M., Garber J.E., Domchek S.M., Audeh M.W., Weitzel J.N., Friedlander M., Arun B., Loman N., Schmutzler R.K., et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet 2010, 376:235-244.
-
(2010)
Lancet
, vol.376
, pp. 235-244
-
-
Tutt, A.1
Robson, M.2
Garber, J.E.3
Domchek, S.M.4
Audeh, M.W.5
Weitzel, J.N.6
Friedlander, M.7
Arun, B.8
Loman, N.9
Schmutzler, R.K.10
-
111
-
-
84926525215
-
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
-
Twyman-Saint Victor C., Rech A.J., Maity A., Rengan R., Pauken K.E., Stelekati E., Benci J.L., Xu B., Dada H., Odorizzi P.M., et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature 2015, 520:373-377.
-
(2015)
Nature
, vol.520
, pp. 373-377
-
-
Twyman-Saint Victor, C.1
Rech, A.J.2
Maity, A.3
Rengan, R.4
Pauken, K.E.5
Stelekati, E.6
Benci, J.L.7
Xu, B.8
Dada, H.9
Odorizzi, P.M.10
-
112
-
-
0036285034
-
C-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability
-
Vafa O., Wade M., Kern S., Beeche M., Pandita T.K., Hampton G.M., Wahl G.M. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol. Cell 2002, 9:1031-1044.
-
(2002)
Mol. Cell
, vol.9
, pp. 1031-1044
-
-
Vafa, O.1
Wade, M.2
Kern, S.3
Beeche, M.4
Pandita, T.K.5
Hampton, G.M.6
Wahl, G.M.7
-
113
-
-
84896940791
-
Cancer suppression by the chromosome custodians, BRCA1 and BRCA2
-
Venkitaraman A.R. Cancer suppression by the chromosome custodians, BRCA1 and BRCA2. Science 2014, 343:1470-1475.
-
(2014)
Science
, vol.343
, pp. 1470-1475
-
-
Venkitaraman, A.R.1
-
114
-
-
84944150577
-
Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells
-
Verhagen C.V., de Haan R., Hageman F., Oostendorp T.P., Carli A.L., O'Connor M.J., Jonkers J., Verheij M., van den Brekel M.W., Vens C. Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells. Radiother. Oncol. 2015, 116:358-365.
-
(2015)
Radiother. Oncol.
, vol.116
, pp. 358-365
-
-
Verhagen, C.V.1
de Haan, R.2
Hageman, F.3
Oostendorp, T.P.4
Carli, A.L.5
O'Connor, M.J.6
Jonkers, J.7
Verheij, M.8
van den Brekel, M.W.9
Vens, C.10
-
115
-
-
0002747511
-
Nature of lesions formed by ionizing radiation
-
Humana Press, J.A. Nickoloff, M.F. Hoekstra (Eds.)
-
Ward J.F. Nature of lesions formed by ionizing radiation. DNA Damage and Repair 1998, 265-284. Humana Press. J.A. Nickoloff, M.F. Hoekstra (Eds.).
-
(1998)
DNA Damage and Repair
, pp. 265-284
-
-
Ward, J.F.1
-
116
-
-
63849131910
-
Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance
-
Waters L.S., Minesinger B.K., Wiltrout M.E., D'Souza S., Woodruff R.V., Walker G.C. Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance. Microbiol. Mol. Biol. Rev. 2009, 73:134-154.
-
(2009)
Microbiol. Mol. Biol. Rev.
, vol.73
, pp. 134-154
-
-
Waters, L.S.1
Minesinger, B.K.2
Wiltrout, M.E.3
D'Souza, S.4
Woodruff, R.V.5
Walker, G.C.6
-
117
-
-
84880917692
-
First-in-human phase 1/2a trial of CRLX101, a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies
-
Weiss G.J., Chao J., Neidhart J.D., Ramanathan R.K., Bassett D., Neidhart J.A., Choi C.H., Chow W., Chung V., Forman S.J., et al. First-in-human phase 1/2a trial of CRLX101, a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies. Invest. New Drugs 2013, 31:986-1000.
-
(2013)
Invest. New Drugs
, vol.31
, pp. 986-1000
-
-
Weiss, G.J.1
Chao, J.2
Neidhart, J.D.3
Ramanathan, R.K.4
Bassett, D.5
Neidhart, J.A.6
Choi, C.H.7
Chow, W.8
Chung, V.9
Forman, S.J.10
-
118
-
-
78149469632
-
Base excision repair and design of small molecule inhibitors of human DNA polymerase β
-
Wilson S.H., Beard W.A., Shock D.D., Batra V.K., Cavanaugh N.A., Prasad R., Hou E.W., Liu Y., Asagoshi K., Horton J.K., et al. Base excision repair and design of small molecule inhibitors of human DNA polymerase β. Cell. Mol. Life Sci. 2010, 67:3633-3647.
-
(2010)
Cell. Mol. Life Sci.
, vol.67
, pp. 3633-3647
-
-
Wilson, S.H.1
Beard, W.A.2
Shock, D.D.3
Batra, V.K.4
Cavanaugh, N.A.5
Prasad, R.6
Hou, E.W.7
Liu, Y.8
Asagoshi, K.9
Horton, J.K.10
-
119
-
-
0006713602
-
Identification of the breast cancer susceptibility gene BRCA2
-
Wooster R., Bignell G., Lancaster J., Swift S., Seal S., Mangion J., Collins N., Gregory S., Gumbs C., Micklem G. Identification of the breast cancer susceptibility gene BRCA2. Nature 1995, 378:789-792.
-
(1995)
Nature
, vol.378
, pp. 789-792
-
-
Wooster, R.1
Bignell, G.2
Lancaster, J.3
Swift, S.4
Seal, S.5
Mangion, J.6
Collins, N.7
Gregory, S.8
Gumbs, C.9
Micklem, G.10
-
120
-
-
84937426961
-
Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage
-
Wu W., Nishikawa H., Fukuda T., Vittal V., Asano M., Miyoshi Y., Klevit R.E., Ohta T. Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage. Cancer Res. 2015, 75:1311-1321.
-
(2015)
Cancer Res.
, vol.75
, pp. 1311-1321
-
-
Wu, W.1
Nishikawa, H.2
Fukuda, T.3
Vittal, V.4
Asano, M.5
Miyoshi, Y.6
Klevit, R.E.7
Ohta, T.8
-
121
-
-
79953839433
-
CRLX101 (formerly IT-101)-A Novel Nanopharmaceutical of Camptothecin in Clinical Development
-
Young C., Schluep T., Hwang J., Eliasof S. CRLX101 (formerly IT-101)-A Novel Nanopharmaceutical of Camptothecin in Clinical Development. Curr. Bioact. Compd. 2011, 7:8-14.
-
(2011)
Curr. Bioact. Compd.
, vol.7
, pp. 8-14
-
-
Young, C.1
Schluep, T.2
Hwang, J.3
Eliasof, S.4
-
122
-
-
84891301320
-
Causes and consequences of replication stress
-
Zeman M.K., Cimprich K.A. Causes and consequences of replication stress. Nat. Cell Biol. 2014, 16:2-9.
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 2-9
-
-
Zeman, M.K.1
Cimprich, K.A.2
-
123
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
-
Zou L., Elledge S.J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003, 300:1542-1548.
-
(2003)
Science
, vol.300
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
|