VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1α

EMBO Reports

Volumn 6, Issue 4, 2005, Pages 373-378

  Li, Zaibo ^a   Wang, Dakun ^a   Messing, Edward M ^a   Wu, Guan ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

HIF 1 ; Ubiquitin; VDU1; VDU2; VHL

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIGASE; LUCIFERASE; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE AMPLIFICATION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; UBIQUITINATION; WESTERN BLOTTING;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; ENDOPEPTIDASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOBLOTTING; LUCIFERASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 17644421091     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.embor.7400377     Document Type: Article

References (14)

1. Bruick RK, McKnight SL (2001) A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294: 1337-1340
2. Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC (2003) Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. J Clin Invest 112: 189-196
3. D'Andrea A, Pellman D (1998) Deubiquitinating enzymes: a new class of biological regulators. Crit Rev Biochem Mol Biol 33: 337-352
4. Epstein AD et al (2001) C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107: 43-54
5. Harris AL (2001) Hypoxia - a key regulatory factor in tumor growth. Nat Rev Cancer 2: 38-46
6. 2 sensing. Science 292: 464-468
7. 2-regulated prolyl hydroxylation. Science 292: 468-472
8. Kaelin Jr WG (2002) Molecular basis of the VHL hereditary cancer syndrome. Nat Rev Cancer 2: 673-682
9. Li M, Chen D, Shiloh A, Luo J, Nikolaev AY, Qin J, Gu W (2002) Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 416: 648-653
10. Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (2002a) Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J Biol Chem 277: 4656-4662
11. Li Z, Wang D, Na X, Messing EM, Schoen SR, Wu G (2002b) Identification of a ubiquitin specific processing protease subfamily as the downstream substrates of pVHL E3 ubiquitin ligase. Biochem Biophys Res Commun 294: 700-709
12. Li Z, Wang D, Na X, Messing EM, Schoen SR, Wu G (2003) The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1α transcriptional activity. EMBO J 22: 1857-1867
13. Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732
14. Wilkinson KD (2000) Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome. Semin Cell Dev Biol 11: 141-148