Usp16 contributes to somatic stem-cell defects in Down's syndrome

Nature

Volumn 501, Issue 7467, 2013, Pages 380-384

  Adorno, Maddalena ^a   Sikandar, Shaheen ^a   Mitra, Siddhartha S ^a   Kuo, Angera ^a   Di Robilant, Benedetta Nicolis ^a,b   Haro Acosta, Veronica ^a   Ouadah, Youcef ^a   Quarta, Marco ^a   Rodriguez, Jacqueline ^a   Qian, Dalong ^a   Reddy, Vadiyala M ^a   Cheshier, Samuel ^a   Garner, Craig C ^a   Clarke, Michael F ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; GREEN FLUORESCENT PROTEIN; HISTONE H2A; LYSINE; PEPTIDASE; SMALL INTERFERING RNA; UBIQUITIN SPECIFIC PEPTIDASE 16; UNCLASSIFIED DRUG;

ADULT; ALLELE; CHROMOSOME; MUTATION; RANGE EXPANSION; SENESCENCE;

ALLELE; ARTICLE; BREAST EPITHELIUM; CELL AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; CHROMOSOME 21; COLONY FORMATION; DOWN REGULATION; DOWN SYNDROME; FIBROBLAST; GENE EXPRESSION; GENE MUTATION; HEMATOPOIETIC STEM CELL; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; STEM CELL EXPANSION; SUBVENTRICULAR ZONE; UBIQUITINATION;

ADULT STEM CELLS; ANIMALS; CELL AGING; CELL PROLIFERATION; CHROMOSOMES, HUMAN, PAIR 21; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE MODELS, ANIMAL; DOWN SYNDROME; EPITHELIUM; FEMALE; FIBROBLASTS; GENE DOSAGE; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; HUMANS; MAMMARY GLANDS, ANIMAL; MICE; MOLECULAR TARGETED THERAPY; NEURAL STEM CELLS; TRISOMY; UBIQUITIN THIOLESTERASE; UBIQUITINATION;

MUS;

EID: 84884412859     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12530     Document Type: Article

References (39)

1. Antonarakis, S. E., Lyle, R., Dermitzakis, E. T., Reymond, A. & Deutsch, S. Chromosome21andDownsyndrome:fromgenomics to pathophysiology. Nature Rev. Genet. 5, 725-738 (2004)
2. Yang, Q., Rasmussen, S. A. & Friedman, J. M. Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study. Lancet 359, 1019-1025 (2002)
3. Roth, G. M., Sun, B., Greensite, F. S., Lott, I. T. & Dietrich, R. B. Premature aging in persons with Down syndrome: MR findings. Am. J. Neuroradiol. 17, 1283-1289 (1996)
4. Zigman, W. B. & Lott, I. T. Alzheimer's disease in Down syndrome: neurobiology and risk. Ment. Retard. Dev. Disabil. Res. Rev. 13, 237-246 (2007)
5. Liu, L.&Rando, T. A.Manifestations andmechanismsof stemcell aging. J. Cell Biol. 193, 257-266 (2011)
6. Reeves, R. H. et al. A mouse model for Down syndrome exhibits learning and behaviour deficits. Nature Genet. 11, 177-184 (1995)
7. Sago, H. et al. Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome. Pediatr. Res. 48, 606-613 (2000)
8. Sago, H. et al. Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Proc. Natl Acad. Sci. USA 95, 6256-6261 (1998)
9. Joo, H.-Y. et al. Regulation of cell cycle progression and gene expression by H2A deubiquitination. Nature 449, 1068-1072 (2007)
10. Lorenzo, L. P. E. et al. Defective hematopoietic stem cell and lymphoid progenitor development in the Ts65Dn mouse model of Down syndrome: potential role of oxidative stress. Antioxid. Redox Signal. 15, 2083-2094 (2011)
11. Chao, M. P., Seita, J.&Weissman, I. L. Establishment of a normalhematopoietic and leukemia stem cell hierarchy. Cold Spring Harb. Symp. Quant. Biol. 73, 439-449 (2008)
12. Akala, O. O. et al. Long-term haematopoietic reconstitution by Trp532/2 p16Ink4a2/2 p19Arf2/2 multipotent progenitors. Nature 453, 228-232 (2008)
13. Park, I.-K. et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423, 302-305 (2003)
14. Pietersen, A. M. et al. Bmi1 regulates stem cells and proliferation and differentiation of committed cells in mammary epithelium. Curr. Biol. 18, 1094-1099 (2008)
15. Molofsky, A. V. et al.Bmi-1 dependence distinguishes neural stemcell self-renewal from progenitor proliferation. Nature 425, 962-967 (2003)
16. Cao, G. et al. Bmi-1 absence causes premature brain degeneration. PLoS ONE 7, e32015 (2012)
17. Lorenzi, H. A. & Reeves, R. H. Hippocampal hypocellularity in the Ts65Dn mouse originates early in development. Brain Res. 1104, 153-159 (2006)
18. Ellis, P. et al.SOX2, a persistent marker formultipotential neural stemcells derived from embryonic stem cells, the embryo or the adult. Dev. Neurosci. 26, 148-165 (2004)
19. Fischer, J. et al. Prospective isolation of adult neural stem cells from the mouse subependymal zone. Nature Protocols 6, 1981-1989 (2011)
20. Pastrana, E., Cheng, L.-C. & Doetsch, F. Simultaneous prospective purification of adult subventricular zone neural stemcells and their progeny. Proc. Natl Acad. Sci. USA 106, 6387-6392 (2009)
21. Stingl, J. et al. Purification andunique properties ofmammary epithelial stemcells. Nature 439, 993-997 (2006)
22. Shackleton, M. et al.Generation of a functionalmammary gland froma single stem cell. Nature 439, 84-88 (2006)
23. Jacobs, J. J., Kieboom, K., Marino, S., DePinho, R. A. & van Lohuizen, M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397, 164-168 (1999)
24. Liu, Y. et al. Expression of p16INK4a in peripheral blood T-cells is a biomarker of human aging. Aging Cell 8, 439-448 (2009)
25. Krishnamurthy, J. et al. Ink4a/Arf expression is a biomarker of aging. J. Clin. Invest. 114, 1299-1307 (2004)
26. Janzen, V. et al. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443, 421-426 (2006)
27. Kimura, M. et al. Proliferation dynamics in cultured skin fibroblasts from Down syndrome subjects. Free Radic. Biol. Med. 39, 374-380 (2005)
28. Carmeliet, G., David, G.&Cassiman, J. J. Cellular ageing of Alzheimer's disease and Down syndrome cells in culture. Mutat. Res. 256, 221-231 (1991)
29. Arron, J. R. et al. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature 441, 595-600 (2006)
30. Roy, A. et al. Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21. Proc. Natl Acad. Sci. USA 109, 17579-17584 (2012)
31. Reinholdt, L. G. et al. Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn. Mamm. Genome 22, 685-691 (2011)
32. Hu, Y. & Smyth, G. K. ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. J. Immunol. Methods 347, 70-78 (2009)
33. Dalerba, P. et al. Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nature Biotechnol. 29, 1120-1127 (2011)
34. Zeng, Y. A. & Nusse, R. Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell 6, 568-577 (2010)
35. Negishi, M. et al. A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1. PLoS ONE 5, e12373 (2010)
36. Ventura, A. et al. Cre-lox-regulated conditionalRNAinterference fromtransgenes. Proc. Natl Acad. Sci. USA 101, 10380-10385 (2004)
37. Shimono, Y. et al. Downregulation of miRNA-200c links breast cancer stemcells with normal stem cells. Cell 138, 592-603 (2009)
38. Tiscornia, G., Singer, O. & Verma, I. M. Production and purification of lentiviral vectors. Nature Protocols 1, 241-245 (2006)
39. Majeti, R., Park, C. Y. & Weissman, I. L. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell. 1, 635-645 (2007).