Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3

Journal of Biological Chemistry

Volumn 285, Issue 9, 2010, Pages 6857-6866

  Artavanis Tsakonas, Katerina ^a,d   Weihofen, Wilhelm A ^b   Antos, John M ^a   Coleman, Bradley I ^c   Comeaux, Christy A ^c   Duraisingh, Manoj T ^c   Gaudet, Rachelle ^b   Ploegh, Hidde L ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b HARVARD UNIVERSITY   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVE SITE ARCHITECTURE; DEUBIQUITINATING ENZYMES; HUMAN ENZYMES; HYDROLASES; MOLECULAR DYNAMICS SIMULATIONS; PARASITE-; PLASMODIUM FALCIPARUM; STRUCTURAL STUDIES; UBIQUITIN; UBIQUITIN-PROTEASOME SYSTEM;

COMPLEXATION; ENZYME ACTIVITY; ENZYMES; MOLECULAR DYNAMICS; SUBSTRATES;

RIGID STRUCTURES;

NEDD8 PROTEIN; UBIQUITIN; UBIQUITIN THIOLESTERASE; UBIQUITIN THIOLESTERASE L3; UNCLASSIFIED DRUG; CYSTEINE PROTEINASE; HYDROLASE; PROTEASOME; PROTOZOAL PROTEIN; UCHL3 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME SPECIFICITY; MOLECULAR DYNAMICS; NONHUMAN; PARASITE SURVIVAL; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SIMULATION; STRUCTURE ANALYSIS; UBIQUITINATION; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; HUMAN; X RAY CRYSTALLOGRAPHY;

PLASMODIUM FALCIPARUM;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; HUMANS; HYDROLASES; MOLECULAR DYNAMICS SIMULATION; PLASMODIUM FALCIPARUM; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTOZOAN PROTEINS; UBIQUITIN;

EID: 77949901727     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.072405     Document Type: Article

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