Deubiquitinase inhibition as a cancer therapeutic strategy

Pharmacology and Therapeutics

Volumn 147, Issue , 2015, Pages 32-54

  D'Arcy, Padraig ^a,b   Wang, Xin ^a,b   Linder, Stig ^a,b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Apoptosis; Cancer therapeutics; Deubiquitinase; Proteasome; Small molecule inhibitors; unsaturated ketones

Indexed keywords

ALPHA,BETA DIENONE DERIVATIVE; ALPHA,BETA UNSATURATED KETONE DERIVATIVE; ANTINEOPLASTIC AGENT; CHALCONE DERIVATIVE; CYCLOPENTENONE DERIVATIVE; DEUBIQUITINASE; DEUBIQUITINASE INHIBITOR; KETONE DERIVATIVE; NATURAL PRODUCT; PROSTAGLANDIN DERIVATIVE; PROTEASOME; PROTEASOME INHIBITOR; PROTEINASE INHIBITOR; SMALL MOLECULE TRANSPORT AGENT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CELL FUNCTION; DRUG SELECTIVITY; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME REGULATION; GENE MUTATION; GENETIC ASSOCIATION; HUMAN; MICHAEL ADDITION; MOLECULAR WEIGHT; MOLECULARLY TARGETED THERAPY; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEINASE INHIBITION; REVIEW; ANIMAL; ANTAGONISTS AND INHIBITORS; ENZYMOLOGY; METABOLISM; NEOPLASMS;

ANIMALS; ANTINEOPLASTIC AGENTS; HUMANS; NEOPLASMS; PROTEASE INHIBITORS; UBIQUITIN-SPECIFIC PROTEASES;

EID: 84922605325     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2014.11.002     Document Type: Review

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