A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination

Cellular Signalling

Volumn 23, Issue 12, 2011, Pages 2076-2085

  Kapuria, Vaibhav ^a,e   Levitzki, Alexander ^b   Bornmann, William G ^c   Maxwell, David ^c   Priebe, Waldemar ^c   Sorenson, Roderick J ^d   Showalter, Hollis D ^d   Talpaz, Moshe ^a   Donato, Nicholas J ^a  

^a UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c UNIVERSITY OF TEXAS   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

^e UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Aggresome; Deubiquitination; Jak Stat inhibitor; Signal transduction

Indexed keywords

HISTONE DEACETYLASE 6; JANUS KINASE 2; JANUS KINASE 2 INHIBITOR; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; SUPPRESSOR OF CYTOKINE SIGNALING 1; UNCLASSIFIED DRUG; WP 1130;

AGGRESOME; ARTICLE; CELL ASSAY; CELL STIMULATION; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; HUMAN; HUMAN CELL; MICHAEL ADDITION; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; UBIQUITINATION;

AMINO ACID SUBSTITUTION; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG EVALUATION, PRECLINICAL; ENDOPEPTIDASES; ENZYME ASSAYS; HISTONE DEACETYLASES; HSP90 HEAT-SHOCK PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; INTERLEUKIN-6; JANUS KINASE 2; MUTANT PROTEINS; NITRILES; PHOSPHORYLATION; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN TRANSPORT; PROTEOLYSIS; PYRIDINES; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; TYRPHOSTINS; UBIQUITIN; UBIQUITINATION;

ANIMALIA;

EID: 80053244315     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2011.08.002     Document Type: Article

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