메뉴 건너뛰기




Volumn 8, Issue 8, 2016, Pages

Spices for prevention and treatment of cancers

Author keywords

Cancer; Capsaicin; Curcumin; Spice; Thymoquinone

Indexed keywords

BLACK PEPPER EXTRACT; CAPSAICIN; CROCUS SATIVUS EXTRACT; CURCUMA LONGA EXTRACT; CURCUMIN; GARLIC EXTRACT; GINGER EXTRACT; HYPOXIA INDUCIBLE FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE; NIGELLA SATIVA EXTRACT; PIPERINE; THYMOQUINONE; 1,3 BENZODIOXOLE DERIVATIVE; ALKALOID; AMIDE; ANTINEOPLASTIC AGENT; BENZOQUINONE DERIVATIVE; PIPERIDINE DERIVATIVE;

EID: 84982315626     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu8080495     Document Type: Review
Times cited : (253)

References (275)
  • 1
    • 84887938478 scopus 로고    scopus 로고
    • Antioxidant potential of spices and their active constituents. Crit. Rev
    • Srinivasan, K. Antioxidant potential of spices and their active constituents. Crit. Rev. Food Sci. Nutr. 2014, 54, 352–372.
    • (2014) Food Sci. Nutr , vol.54 , pp. 352-372
    • Srinivasan, K.1
  • 2
    • 84879514249 scopus 로고    scopus 로고
    • Recent advances in biologically active compounds in herbs and spices: A review of the most effective antioxidant and anti-inflammatory active principles
    • Rubio, L.; Motilva, M.J.; Romero, M.P. Recent advances in biologically active compounds in herbs and spices: A review of the most effective antioxidant and anti-inflammatory active principles. Crit. Rev. Food Sci. Nutr. 2013, 53, 943–953.
    • (2013) Crit. Rev. Food Sci. Nutr. , vol.53 , pp. 943-953
    • Rubio, L.1    Motilva, M.J.2    Romero, M.P.3
  • 3
    • 84919741025 scopus 로고    scopus 로고
    • Curcumin and chronic kidney disease (CKD): Major mode of action through stimulating endogenous intestinal alkaline phosphatase
    • Ghosh, S.S.; Gehr, T.W.; Ghosh, S. Curcumin and chronic kidney disease (CKD): Major mode of action through stimulating endogenous intestinal alkaline phosphatase. Molecules 2014, 19, 20139–20156.
    • (2014) Molecules , vol.19 , pp. 20139-20156
    • Ghosh, S.S.1    Gehr, T.W.2    Ghosh, S.3
  • 4
    • 84933036660 scopus 로고    scopus 로고
    • Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review
    • Majdalawieh, A.F.; Fayyad, M.W. Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review. Int. Immunopharmacol. 2015, 28, 295–304.
    • (2015) Int. Immunopharmacol , vol.28 , pp. 295-304
    • Majdalawieh, A.F.1    Fayyad, M.W.2
  • 5
    • 84941366815 scopus 로고    scopus 로고
    • Antibacterial effects of cinnamon: From farm to food, cosmetic and pharmaceutical industries
    • Nabavi, S.F.; di Lorenzo, A.; Izadi, M.; Sobarzo-Sanchez, E.; Daglia, M.; Nabavi, S.M. Antibacterial effects of cinnamon: From farm to food, cosmetic and pharmaceutical industries. Nutrients 2015, 7, 7729–7748.
    • (2015) Nutrients , vol.7 , pp. 7729-7748
    • Nabavi, S.F.1    Di Lorenzo, A.2    Izadi, M.3    Sobarzo-Sanchez, E.4    Daglia, M.5    Nabavi, S.M.6
  • 6
    • 84890121517 scopus 로고    scopus 로고
    • Spices: The savory and beneficial science of pungency
    • Nilius, B.; Appendino, G. Spices: The savory and beneficial science of pungency. Rev. Physiol. Biochem. Pharmacol. 2013, 164, 1–76.
    • (2013) Rev. Physiol. Biochem. Pharmacol , vol.164 , pp. 1-76
    • Nilius, B.1    Appendino, G.2
  • 7
    • 84960094148 scopus 로고    scopus 로고
    • Antiproliferation of Cryptocarya concinna-derived cryptocaryone against oral cancer cells involving apoptosis, oxidative stress, and DNA damage. BMC Complemt. Altern
    • Chang, H.S.; Tang, J.Y.; Yen, C.Y.; Huang, H.W.; Wu, C.Y.; Chung, Y.A.; Wang, H.R.; Chen, I.S.; Huang, M.Y.; Chang, H.W. Antiproliferation of Cryptocarya concinna-derived cryptocaryone against oral cancer cells involving apoptosis, oxidative stress, and DNA damage. BMC Complemt. Altern. Med. 2016, 16, 94.
    • (2016) Med , vol.16 , pp. 94
    • Chang, H.S.1    Tang, J.Y.2    Yen, C.Y.3    Huang, H.W.4    Wu, C.Y.5    Chung, Y.A.6    Wang, H.R.7    Chen, I.S.8    Huang, M.Y.9    Chang, H.W.10
  • 8
    • 79959918489 scopus 로고    scopus 로고
    • Antioxidant capacities and total phenolic contents of 62 fruits
    • Fu, L.; Xu, B.T.; Xu, X.R.; Gan, R.Y.; Zhang, Y.; Xia, E.Q.; Li, H.B. Antioxidant capacities and total phenolic contents of 62 fruits. Food Chem. 2011, 129, 345–350.
    • (2011) Food Chem , vol.129 , pp. 345-350
    • Fu, L.1    Xu, B.T.2    Xu, X.R.3    Gan, R.Y.4    Zhang, Y.5    Xia, E.Q.6    Li, H.B.7
  • 9
    • 84866179634 scopus 로고    scopus 로고
    • Determination of antioxidant property and their lipophilic and hydrophilic phenolic contents in cereal grains
    • Deng, G.F.; Xu, X.R.; Guo, Y.J.; Xia, E.Q.; Li, S.; Wu, S.; Chen, F.; Ling, W.H.; Li, H.B. Determination of antioxidant property and their lipophilic and hydrophilic phenolic contents in cereal grains. J. Funct. Foods 2012, 4, 906–914.
    • (2012) J. Funct. Foods , vol.4 , pp. 906-914
    • Deng, G.F.1    Xu, X.R.2    Guo, Y.J.3    Xia, E.Q.4    Li, S.5    Wu, S.6    Chen, F.7    Ling, W.H.8    Li, H.B.9
  • 10
    • 84956745362 scopus 로고    scopus 로고
    • Forced extinction of CD24 stem-like breast cancer marker alone promotes radiation resistance through the control of oxidative stress. Mol
    • Bensimon, J.; Biard, D.; Paget, V.; Goislard, M.; Morel-Altmeyer, S.; Konge, J.; Chevillard, S.; Lebeau, J. Forced extinction of CD24 stem-like breast cancer marker alone promotes radiation resistance through the control of oxidative stress. Mol. Carcinog. 2016, 55, 245–254.
    • (2016) Carcinog , vol.55 , pp. 245-254
    • Bensimon, J.1    Biard, D.2    Paget, V.3    Goislard, M.4    Morel-Altmeyer, S.5    Konge, J.6    Chevillard, S.7    Lebeau, J.8
  • 11
    • 84886292674 scopus 로고    scopus 로고
    • Antioxidant capacities and total phenolic contents of infusions from 223 medicinal plants
    • Li, S.; Li, S.K.; Gan, R.Y.; Song, F.L.; Kuang, L.; Li, H.B. Antioxidant capacities and total phenolic contents of infusions from 223 medicinal plants. Ind. Crop Prod. 2013, 51, 289–298.
    • (2013) Ind. Crop Prod , vol.51 , pp. 289-298
    • Li, S.1    Li, S.K.2    Gan, R.Y.3    Song, F.L.4    Kuang, L.5    Li, H.B.6
  • 12
    • 84872136233 scopus 로고    scopus 로고
    • Antioxidant capacities, phenolic compounds and polysaccharide contents of 49 edible macro-fungi
    • Guo, Y.J.; Deng, G.F.; Xu, X.R.; Wu, S.; Li, S.; Xia, E.Q.; Li, F.; Chen, F.; Ling, W.H.; Li, H.B. Antioxidant capacities, phenolic compounds and polysaccharide contents of 49 edible macro-fungi. Food Funct. 2012, 3, 1195–1205.
    • (2012) Food Funct , vol.3 , pp. 1195-1205
    • Guo, Y.J.1    Deng, G.F.2    Xu, X.R.3    Wu, S.4    Li, S.5    Xia, E.Q.6    Li, F.7    Chen, F.8    Ling, W.H.9    Li, H.B.10
  • 14
    • 84960101252 scopus 로고    scopus 로고
    • Sodium channel gamma ENaC mediates IL-17 synergized high salt induced inflammatory stress in breast cancer cells
    • Amara, S.; Ivy, M.T.; Myles, E.L.; Tiriveedhi, V. Sodium channel gamma ENaC mediates IL-17 synergized high salt induced inflammatory stress in breast cancer cells. Cell Immunol. 2016, 302, 1–10.
    • (2016) Cell Immunol , vol.302 , pp. 1-10
    • Amara, S.1    Ivy, M.T.2    Myles, E.L.3    Tiriveedhi, V.4
  • 15
    • 84967321420 scopus 로고    scopus 로고
    • The where, the when, and the how of immune monitoring for cancer immunotherapies in the era of checkpoint inhibition. Clin
    • Hegde, P.S.; Karanikas, V.; Evers, S. The where, the when, and the how of immune monitoring for cancer immunotherapies in the era of checkpoint inhibition. Clin. Cancer Res. 2016, 22, 1865–1874.
    • (2016) Cancer Res , vol.22 , pp. 1865-1874
    • Hegde, P.S.1    Karanikas, V.2    Evers, S.3
  • 18
    • 84884179404 scopus 로고    scopus 로고
    • Antiproliferative activities of tea and herbal infusions
    • Li, F.; Li, S.; Li, H.B.; Deng, G.F.; Ling, W.H.; Xu, X.R. Antiproliferative activities of tea and herbal infusions. Food Funct. 2013, 4, 530–538.
    • (2013) Food Funct , vol.4 , pp. 530-538
    • Li, F.1    Li, S.2    Li, H.B.3    Deng, G.F.4    Ling, W.H.5    Xu, X.R.6
  • 19
    • 84960427651 scopus 로고    scopus 로고
    • Dietary natural products for prevention and treatment of liver cancer
    • Zhou, Y.; Li, Y.; Zhou, T.; Zheng, J.; Li, S.; Li, H.B. Dietary natural products for prevention and treatment of liver cancer. Nutrients 2016, 8, 156.
    • (2016) Nutrients , vol.8 , pp. 156
    • Zhou, Y.1    Li, Y.2    Zhou, T.3    Zheng, J.4    Li, S.5    Li, H.B.6
  • 20
    • 84942048168 scopus 로고    scopus 로고
    • Overview of gastrointestinal cancer prevention in Asia. Best Pract. Res. Clin
    • Park, J.M.; Lee, H.J.; Yoo, J.H.; Ko, W.J.; Cho, J.Y.; Hahm, K.B. Overview of gastrointestinal cancer prevention in Asia. Best Pract. Res. Clin. Gastroenterol. 2015, 29, 855–867.
    • (2015) Gastroenterol , vol.29 , pp. 855-867
    • Park, J.M.1    Lee, H.J.2    Yoo, J.H.3    Ko, W.J.4    Cho, J.Y.5    Hahm, K.B.6
  • 23
    • 84938961535 scopus 로고    scopus 로고
    • Pilot clinical study of the effects of ginger root extract on eicosanoids in colonic mucosa of subjects at increased risk for colorectal cancer. Mol
    • Zick, S.M.; Turgeon, D.K.; Ren, J.; Ruffin, M.T.; Wright, B.D.; Sen, A.; Djuric, Z.; Brenner, D.E. Pilot clinical study of the effects of ginger root extract on eicosanoids in colonic mucosa of subjects at increased risk for colorectal cancer. Mol. Carcinog. 2015, 54, 908–915.
    • (2015) Carcinog , vol.54 , pp. 908-915
    • Zick, S.M.1    Turgeon, D.K.2    Ren, J.3    Ruffin, M.T.4    Wright, B.D.5    Sen, A.6    Djuric, Z.7    Brenner, D.E.8
  • 24
    • 84982251869 scopus 로고    scopus 로고
    • WHO|Cancer. Aviliable online: http://www.who.int/mediacentre/factsheets/fs297/en/ (accessed on 17 May 2016).
  • 26
    • 84921732567 scopus 로고    scopus 로고
    • Metallic taste in cancer patients treated with chemotherapy. Cancer Treat
    • IJpma, I.; Renken, R.J.; Ter Horst, G.J.; Reyners, A.K. Metallic taste in cancer patients treated with chemotherapy. Cancer Treat. Rev. 2015, 41, 179–186.
    • (2015) Rev , vol.41 , pp. 179-186
    • Ijpma, I.1    Renken, R.J.2    Ter Horst, G.J.3    Reyners, A.K.4
  • 27
    • 84908324338 scopus 로고    scopus 로고
    • Curcuma contra cancer? Curcumin and hodgkin’s lymphoma
    • Staege, M.; Kewitz, S.; Volkmer, I. Curcuma contra cancer? Curcumin and hodgkin’s lymphoma. Cancer Growth Metastasis 2013, 6, 35–52.
    • (2013) Cancer Growth Metastasis , vol.6 , pp. 35-52
    • Staege, M.1    Kewitz, S.2    Volkmer, I.3
  • 28
    • 84954200979 scopus 로고    scopus 로고
    • Curcumin and cancer: Barriers to obtaining a health claim. Nutr
    • Devassy, J.G.; Nwachukwu, I.D.; Jones, P. Curcumin and cancer: Barriers to obtaining a health claim. Nutr. Rev. 2015, 73, 155–165.
    • (2015) Rev , vol.73 , pp. 155-165
    • Devassy, J.G.1    Nwachukwu, I.D.2    Jones, P.3
  • 30
    • 79959923588 scopus 로고    scopus 로고
    • Apoptotic death in curcumin-treated NPC-TW 076 human nasopharyngeal carcinoma cells is mediated through the ROS, mitochondrial depolarization and caspase-3-dependent signaling responses
    • Kuo, C.L.; Wu, S.Y.; Ip, S.W.; Wu, P.P.; Yu, C.S.; Yang, J.S.; Chen, P.Y.; Wu, S.H.; Chung, J.G. Apoptotic death in curcumin-treated NPC-TW 076 human nasopharyngeal carcinoma cells is mediated through the ROS, mitochondrial depolarization and caspase-3-dependent signaling responses. Int. J. Oncol. 2011, 39, 319–328.
    • (2011) Int. J. Oncol. , vol.39 , pp. 319-328
    • Kuo, C.L.1    Wu, S.Y.2    Ip, S.W.3    Wu, P.P.4    Yu, C.S.5    Yang, J.S.6    Chen, P.Y.7    Wu, S.H.8    Chung, J.G.9
  • 31
    • 84896706363 scopus 로고    scopus 로고
    • Curcumin enhances the radiosensitivity in nasopharyngeal carcinoma cells involving the reversal of differentially expressed long non-coding RNAs
    • Wang, Q.R.; Fan, H.N.; Liu, Y.; Yin, Z.X.; Cai, H.B.; Liu, J.; Wang, Z.Y.; Shao, M.; Sun, X.G.; Diao, J.X.; et al. Curcumin enhances the radiosensitivity in nasopharyngeal carcinoma cells involving the reversal of differentially expressed long non-coding RNAs. Int. J. Oncol. 2013, 44, 858–864.
    • (2013) Int. J. Oncol. , vol.44 , pp. 858-864
    • Wang, Q.R.1    Fan, H.N.2    Liu, Y.3    Yin, Z.X.4    Cai, H.B.5    Liu, J.6    Wang, Z.Y.7    Shao, M.8    Sun, X.G.9    Diao, J.X.10
  • 32
    • 84907207714 scopus 로고    scopus 로고
    • Curcumin exerts inhibitory effects on undifferentiated nasopharyngeal carcinoma by inhibiting the expression ofmiR-125a-5p. Clin
    • Gao, W.; Chan, J.Y.; Wong, T. Curcumin exerts inhibitory effects on undifferentiated nasopharyngeal carcinoma by inhibiting the expression ofmiR-125a-5p. Clin. Sci. 2014, 127, 571–579.
    • (2014) Sci , vol.127 , pp. 571-579
    • Gao, W.1    Chan, J.Y.2    Wong, T.3
  • 33
    • 84892604628 scopus 로고    scopus 로고
    • Curcumin treatment alters ERK-1/2 signaling in vitro and inhibits nasopharyngeal carcinoma proliferation in mouse xenografts
    • Xie, Y.Q.; Wu, X.B.; Tang, S.Q. Curcumin treatment alters ERK-1/2 signaling in vitro and inhibits nasopharyngeal carcinoma proliferation in mouse xenografts. Int. J. Clin. Exp. Med. 2014, 7, 108–114.
    • (2014) Int. J. Clin. Exp. Med , vol.7 , pp. 108-114
    • Xie, Y.Q.1    Wu, X.B.2    Tang, S.Q.3
  • 34
    • 84863011324 scopus 로고    scopus 로고
    • Curcumin induces small cell lung cancer NCI-H446 cell apoptosis via the reactive oxygen species-mediated mitochondrial pathway and not the cell death receptor pathway
    • Yang, C.L.; Ma, Y.G.; Xue, Y.X.; Liu, Y.Y.; Xie, H.; Qiu, G.R. Curcumin induces small cell lung cancer NCI-H446 cell apoptosis via the reactive oxygen species-mediated mitochondrial pathway and not the cell death receptor pathway. DNA Cell Biol. 2012, 31, 139–150.
    • (2012) DNA Cell Biol , vol.31 , pp. 139-150
    • Yang, C.L.1    Ma, Y.G.2    Xue, Y.X.3    Liu, Y.Y.4    Xie, H.5    Qiu, G.R.6
  • 36
    • 84923186838 scopus 로고    scopus 로고
    • Shi, J.G. Curcumin inhibits proliferation-migration of NSCLC by steering crosstalk between a Wnt signaling pathway and an adherens junction via EGR-1. Mol
    • Chen, Q.Y.; Jiao, D.M.; Wang, L.F.; Wang, L.; Hu, H.Z.; Song, J.; Yan, J.; Wu, L.J.; Shi, J.G. Curcumin inhibits proliferation-migration of NSCLC by steering crosstalk between a Wnt signaling pathway and an adherens junction via EGR-1. Mol. Biosyst. 2015, 11, 859–868.
    • (2015) Biosyst , vol.11 , pp. 859-868
    • Chen, Q.Y.1    Jiao, D.M.2    Wang, L.F.3    Wang, L.4    Hu, H.Z.5    Song, J.6    Yan, J.7    Wu, L.J.8
  • 37
    • 84979856668 scopus 로고    scopus 로고
    • PIAS3 expression in squamous cell lung cancer is low and predicts overall survival
    • Abbas, R.; McColl, K.S.; Kresak, A.; Yang, M.; Chen, Y.; Fu, P.; Wildey, G.; Dowlati, A. PIAS3 expression in squamous cell lung cancer is low and predicts overall survival. Cancer Med. 2015, 4, 325–332.
    • (2015) Cancer Med , vol.4 , pp. 325-332
    • Abbas, R.1    McColl, K.S.2    Kresak, A.3    Yang, M.4    Chen, Y.5    Fu, P.6    Wildey, G.7    Dowlati, A.8
  • 38
    • 84920478874 scopus 로고    scopus 로고
    • Curcumin promotes apoptosis by activating the p53-miR-192–5p/215-XIAP pathway in non-small cell lung cancer
    • Ye, M.; Zhang, J.; Zhang, J.; Miao, Q.; Yao, L.; Zhang, J. Curcumin promotes apoptosis by activating the p53-miR-192–5p/215-XIAP pathway in non-small cell lung cancer. Cancer Lett. 2015, 357, 196–205.
    • (2015) Cancer Lett , vol.357 , pp. 196-205
    • Ye, M.1    Zhang, J.2    Zhang, J.3    Miao, Q.4    Yao, L.5    Zhang, J.6
  • 39
    • 84937109884 scopus 로고    scopus 로고
    • Curcumin triggers DNA damage and inhibits expression of DNA repair proteins in human lung cancer cells
    • Ting, C.Y.; Wang, H.E.; Yu, C.C.; Liu, H.C.; Liu, Y.C.; Chiang, I.T. Curcumin triggers DNA damage and inhibits expression of DNA repair proteins in human lung cancer cells. Anticancer Res. 2015, 35, 3867–3873.
    • (2015) Anticancer Res , vol.35 , pp. 3867-3873
    • Ting, C.Y.1    Wang, H.E.2    Yu, C.C.3    Liu, H.C.4    Liu, Y.C.5    Chiang, I.T.6
  • 42
    • 84943783395 scopus 로고    scopus 로고
    • Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway. Oncol
    • Wu, L.; Guo, L.; Liang, Y.; Liu, X.; Jiang, L.; Wang, L. Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway. Oncol. Rep. 2015, 34, 3311–3317.
    • (2015) Rep , vol.34 , pp. 3311-3317
    • Wu, L.1    Guo, L.2    Liang, Y.3    Liu, X.4    Jiang, L.5    Wang, L.6
  • 43
    • 80052089527 scopus 로고    scopus 로고
    • Depping, R. Curcumin decreases survival of Hep3B liver and MCF-7 breast cancer cells. Strahlenther
    • Strofer, M.; Jelkmann, W.; Depping, R. Curcumin decreases survival of Hep3B liver and MCF-7 breast cancer cells. Strahlenther. Onkol. 2011, 187, 393–400.
    • (2011) Onkol , vol.187 , pp. 393-400
    • Strofer, M.1    Jelkmann, W.2
  • 44
    • 84924263718 scopus 로고    scopus 로고
    • Hepatoprotective effects of curcumin against diethyl nitrosamine induced hepatotoxicity in albino rats. Asian Pac
    • Kadasa, N.M.; Abdallah, H.; Afifi, M.; and Gowayed, S. Hepatoprotective effects of curcumin against diethyl nitrosamine induced hepatotoxicity in albino rats. Asian Pac. J. Cancer Prev. 2015, 16, 103–108.
    • (2015) J. Cancer Prev , vol.16 , pp. 103-108
    • Kadasa, N.M.1    Abdallah, H.2    Afifi, M.3    Gowayed, S.4
  • 48
    • 84940208364 scopus 로고    scopus 로고
    • Curcumin-mediated regulation of Notch1/hairy and enhancer of split-1/survivin: Molecular targeting in cholangiocarcinoma
    • Koprowski, S.; Sokolowski, K.; Kunnimalaiyaan, S.; Gamblin, T.C.; Kunnimalaiyaan, M. Curcumin-mediated regulation of Notch1/hairy and enhancer of split-1/survivin: Molecular targeting in cholangiocarcinoma. J. Surg. Res. 2015, 198, 434–440.
    • (2015) J. Surg. Res. , vol.198 , pp. 434-440
    • Koprowski, S.1    Sokolowski, K.2    Kunnimalaiyaan, S.3    Gamblin, T.C.4    Kunnimalaiyaan, M.5
  • 49
    • 84866394314 scopus 로고    scopus 로고
    • Curcumin suppresses the TPA-induced invasion through inhibition of PKC alpha-dependent MMP-expression in MCF-7 human breast cancer cells
    • Kim, J.M.; Noh, E.M.; Kwon, K.B.; Kim, J.S.; You, Y.O.; Hwang, J.K.; Hwang, B.M.; Kim, B.S.; Lee, S.H.; Lee, S.J.; et al. Curcumin suppresses the TPA-induced invasion through inhibition of PKC alpha-dependent MMP-expression in MCF-7 human breast cancer cells. Phytomedicine 2012, 19, 1085–1092.
    • (2012) Phytomedicine , vol.19 , pp. 1085-1092
    • Kim, J.M.1    Noh, E.M.2    Kwon, K.B.3    Kim, J.S.4    You, Y.O.5    Hwang, J.K.6    Hwang, B.M.7    Kim, B.S.8    Lee, S.H.9    Lee, S.J.10
  • 51
    • 84868577510 scopus 로고    scopus 로고
    • Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression. Mol. Med
    • Sun, X.D.; Liu, X.E.; Huang, D.S. Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression. Mol. Med. Rep. 2012, 6, 1267–1270.
    • (2012) Rep , vol.6 , pp. 1267-1270
    • Sun, X.D.1    Liu, X.E.2    Huang, D.S.3
  • 53
    • 84926482434 scopus 로고    scopus 로고
    • Curcumin reduces cytotoxicity of 5-Fluorouracil treatment in human breast cancer cells
    • Ferguson, J.E.; Orlando, R.A. Curcumin reduces cytotoxicity of 5-Fluorouracil treatment in human breast cancer cells. J. Med. Food 2015, 18, 497–502.
    • (2015) J. Med. Food , vol.18 , pp. 497-502
    • Ferguson, J.E.1    Orlando, R.A.2
  • 54
    • 84908090280 scopus 로고    scopus 로고
    • Curcumin restores sensitivity to retinoic acid in triple negative breast cancer cells
    • Thulasiraman, P.; McAndrews, D.J.; Mohiudddin, I.Q. Curcumin restores sensitivity to retinoic acid in triple negative breast cancer cells. BMC Cancer 2014, 14, 724.
    • (2014) BMC Cancer , vol.14 , pp. 724
    • Thulasiraman, P.1    McAndrews, D.J.2    Mohiudddin, I.Q.3
  • 55
    • 84927144570 scopus 로고    scopus 로고
    • Izzo, F. Dissecting the role of curcumin in tumour growth and angiogenesis in mouse model of human breast cancer. BioMed Res
    • Bimonte, S.; Barbieri, A.; Palma, G.; Rea, D.; Luciano, A.; D Aiuto, M.; Arra, C.; Izzo, F. Dissecting the role of curcumin in tumour growth and angiogenesis in mouse model of human breast cancer. BioMed Res. Int. 2015, 2015, 1–7.
    • (2015) Int , vol.2015 , pp. 1-7
    • Bimonte, S.1    Barbieri, A.2    Palma, G.3    Rea, D.4    Luciano, A.5    D Aiuto, M.6    Arra, C.7
  • 58
    • 84880532170 scopus 로고    scopus 로고
    • Curcumin for radiation dermatitis: A randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiat
    • Ryan, J.L.; Heckler, C.E.; Ling, M.; Katz, A.; Williams, J.P.; Pentland, A.P.; Morrow, G.R. Curcumin for radiation dermatitis: A randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiat. Res. 2013, 180, 34–43.
    • (2013) Res , vol.180 , pp. 34-43
    • Ryan, J.L.1    Heckler, C.E.2    Ling, M.3    Katz, A.4    Williams, J.P.5    Pentland, A.P.6    Morrow, G.R.7
  • 59
    • 84863195735 scopus 로고    scopus 로고
    • Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP. Br
    • Kusuhara, H.; Furuie, H.; Inano, A.; Sunagawa, A.; Yamada, S.; Wu, C.; Fukizawa, S.; Morimoto, N.; Ieiri, I.; Morishita, M.; et al. Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP. Br. J. Pharmacol. 2012, 166, 1793–1803.
    • (2012) J. Pharmacol. , vol.166 , pp. 1793-1803
    • Kusuhara, H.1    Furuie, H.2    Inano, A.3    Sunagawa, A.4    Yamada, S.5    Wu, C.6    Fukizawa, S.7    Morimoto, N.8    Ieiri, I.9    Morishita, M.10
  • 61
    • 84927582439 scopus 로고    scopus 로고
    • Curcumin inhibits proliferation of gastric cancer cells by impairing ATP-sensitive potassium channel opening. World
    • Liu, X.; Sun, K.; Chen, H.; Song, A.; Zhang, X.; Zhang, X.; He, X. Curcumin inhibits proliferation of gastric cancer cells by impairing ATP-sensitive potassium channel opening. World J. Surg. Oncol. 2014, 12, 389.
    • (2014) J. Surg. Oncol , vol.12 , pp. 389
    • Liu, X.1    Sun, K.2    Chen, H.3    Song, A.4    Zhang, X.5    Zhang, X.6    He, X.7
  • 62
    • 84908043135 scopus 로고    scopus 로고
    • Synergistic anti-tumor effect of KLF4 and curcumin in human gastric carcinoma cell line. Asian Pac
    • Ji, J.; Wang, H.S.; Gao, Y.Y.; Sang, L.M.; Zhang, L. Synergistic anti-tumor effect of KLF4 and curcumin in human gastric carcinoma cell line. Asian Pac. J. Cancer Prev. 2014, 15, 7747–7752.
    • (2014) J. Cancer Prev , vol.15 , pp. 7747-7752
    • Ji, J.1    Wang, H.S.2    Gao, Y.Y.3    Sang, L.M.4    Zhang, L.5
  • 63
    • 84938202584 scopus 로고    scopus 로고
    • Curcumin suppresses lymphatic vessel density in an in vivo human gastric cancer model
    • Da, W.; Zhu, J.; Wang, L.; Sun, Q. Curcumin suppresses lymphatic vessel density in an in vivo human gastric cancer model. Tumor Biol. 2015, 36, 5215–5223.
    • (2015) Tumor Biol , vol.36 , pp. 5215-5223
    • Da, W.1    Zhu, J.2    Wang, L.3    Sun, Q.4
  • 64
    • 84934954073 scopus 로고    scopus 로고
    • Curcumin inhibits Ec109 cell growth via an AMPK-mediated metabolic switch
    • Zhang, F.; Zhang, H.; Liu, Y.; Huang, Y. Curcumin inhibits Ec109 cell growth via an AMPK-mediated metabolic switch. Life Sci. 2015, 134, 49–55.
    • (2015) Life Sci , vol.134 , pp. 49-55
    • Zhang, F.1    Zhang, H.2    Liu, Y.3    Huang, Y.4
  • 65
    • 84955489737 scopus 로고    scopus 로고
    • Curcumin enhances the effects of 5-Fluorouracil and oxaliplatin in inducing gastric cancer cell apoptosis both in vitro and in vivo. Oncol
    • Zhou, X.; Wang, W.; Li, P.; Zheng, Z.; Tu, Y.; Zhang, Y.; You, T. Curcumin enhances the effects of 5-Fluorouracil and oxaliplatin in inducing gastric cancer cell apoptosis both in vitro and in vivo. Oncol. Res. 2016, 23, 29–34.
    • (2016) Res , vol.23 , pp. 29-34
    • Zhou, X.1    Wang, W.2    Li, P.3    Zheng, Z.4    Tu, Y.5    Zhang, Y.6    You, T.7
  • 67
    • 84948764154 scopus 로고    scopus 로고
    • Prostaglandin e2 reverses curcumin-induced inhibition of survival signal pathways in human colorectal carcinoma (HCT-15) cell lines. Mol
    • Shehzad, A.; Islam, S.U.; Lee, J.; Lee, Y.S. Prostaglandin e2 reverses curcumin-induced inhibition of survival signal pathways in human colorectal carcinoma (HCT-15) cell lines. Mol. Cells 2014, 37, 899–906.
    • (2014) Cells , vol.37 , pp. 899-906
    • Shehzad, A.1    Islam, S.U.2    Lee, J.3    Lee, Y.S.4
  • 68
    • 84855986278 scopus 로고    scopus 로고
    • Prabhu, N.M. Synergistic anticancer activity of curcumin and catechin: An in vitro study using human cancer cell lines. Microsc. Res
    • Manikandan, R.; Beulaja, M.; Arulvasu, C.; Sellamuthu, S.; Dinesh, D.; Prabhu, D.; Babu, G.; Vaseeharan, B.; Prabhu, N.M. Synergistic anticancer activity of curcumin and catechin: An in vitro study using human cancer cell lines. Microsc. Res. Tech. 2012, 75, 112–116.
    • (2012) Tech , vol.75 , pp. 112-116
    • Manikandan, R.1    Beulaja, M.2    Arulvasu, C.3    Sellamuthu, S.4    Dinesh, D.5    Prabhu, D.6    Babu, G.7    Vaseeharan, B.8
  • 69
    • 84925483974 scopus 로고    scopus 로고
    • Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro
    • Wang, K.; Fan, H.; Chen, Q.S.; Ma, G.J.; Zhu, M.; Zhang, X.M.; Zhang, Y.Y.; Yu, J. Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro. Anti-Cancer Drugs 2015, 26, 15–24.
    • (2015) Anti-Cancer Drugs , vol.26 , pp. 15-24
    • Wang, K.1    Fan, H.2    Chen, Q.S.3    Ma, G.J.4    Zhu, M.5    Zhang, X.M.6    Zhang, Y.Y.7    Yu, J.8
  • 70
    • 84923864187 scopus 로고    scopus 로고
    • Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1. Biochem
    • Guo, Y.; Shu, L.; Zhang, C.; Su, Z.; Kong, A.T. Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1. Biochem. Pharmacol. 2015, 94, 69–78.
    • (2015) Pharmacol , vol.94 , pp. 69-78
    • Guo, Y.1    Shu, L.2    Zhang, C.3    Su, Z.4    Kong, A.T.5
  • 71
    • 84924516677 scopus 로고    scopus 로고
    • Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer
    • Toden, S.; Okugawa, Y.; Jascur, T.; Wodarz, D.; Komarova, N.L.; Buhrmann, C.; Shakibaei, M.; Boland, C.R.; Goel, A. Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer. Carcinogenesis 2015, 36, 355–367.
    • (2015) Carcinogenesis , vol.36 , pp. 355-367
    • Toden, S.1    Okugawa, Y.2    Jascur, T.3    Wodarz, D.4    Komarova, N.L.5    Buhrmann, C.6    Shakibaei, M.7    Boland, C.R.8    Goel, A.9
  • 72
    • 79951601296 scopus 로고    scopus 로고
    • Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin
    • He, Z.Y.; Shi, C.B.; Wen, H.; Li, F.L.; Wang, B.L.; Wang, J. Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Cancer Investig. 2011, 29, 208–213.
    • (2011) Cancer Investig , vol.29 , pp. 208-213
    • He, Z.Y.1    Shi, C.B.2    Wen, H.3    Li, F.L.4    Wang, B.L.5    Wang, J.6
  • 73
    • 84857765620 scopus 로고    scopus 로고
    • Targeting pioneering factor and hormone receptor cooperative pathways to suppress tumor progression
    • Shah, S.; Prasad, S.; Knudsen, K.E. Targeting pioneering factor and hormone receptor cooperative pathways to suppress tumor progression. Cancer Res. 2012, 72, 1248–1259.
    • (2012) Cancer Res , vol.72 , pp. 1248-1259
    • Shah, S.1    Prasad, S.2    Knudsen, K.E.3
  • 74
    • 84896825040 scopus 로고    scopus 로고
    • Curcumin inhibits expression of inhibitor of DNA binding 1 in PC3 cells and xenografts. Asian Pac
    • Yu, X.L.; Jing, T.; Zhao, H.; Li, P.J.; Xu, W.H.; Shang, F.F. Curcumin inhibits expression of inhibitor of DNA binding 1 in PC3 cells and xenografts. Asian Pac. J. Cancer Prev. 2014, 15, 1465–1470.
    • (2014) J. Cancer Prev , vol.15 , pp. 1465-1470
    • Yu, X.L.1    Jing, T.2    Zhao, H.3    Li, P.J.4    Xu, W.H.5    Shang, F.F.6
  • 75
    • 84955491718 scopus 로고    scopus 로고
    • Combination of alpha-Tomatine and curcumin inhibits growth and induces apoptosis in human prostate cancer cells
    • Huang, H.; Chen, X.; Li, D.; He, Y.; Li, Y.; Du, Z.; Zhang, K.; DiPaola, R.; Goodin, S.; Zheng, X. Combination of alpha-Tomatine and curcumin inhibits growth and induces apoptosis in human prostate cancer cells. PLoS ONE 2015, 10, e144293.
    • (2015) Plos ONE , pp. 10
    • Huang, H.1    Chen, X.2    Li, D.3    He, Y.4    Li, Y.5    Du, Z.6    Zhang, K.7    Dipaola, R.8    Goodin, S.9    Zheng, X.10
  • 77
    • 84925224337 scopus 로고    scopus 로고
    • Curcumin promotes the apoptosis of human endometrial carcinoma cells by downregulating the expression of androgen receptor through Wnt signal pathway
    • Feng, W.; Yang, C.X.; Zhang, L.; Fang, Y.; Yan, M. Curcumin promotes the apoptosis of human endometrial carcinoma cells by downregulating the expression of androgen receptor through Wnt signal pathway. Eur. J. Gynaecol. Oncol. 2014, 35, 718–723.
    • (2014) Eur. J. Gynaecol. Oncol , vol.35 , pp. 718-723
    • Feng, W.1    Yang, C.X.2    Zhang, L.3    Fang, Y.4    Yan, M.5
  • 79
    • 84900008221 scopus 로고    scopus 로고
    • Antitumor and antiangiogenic activities of curcumin in cervical cancer xenografts in nude mice
    • Yoysungnoen-Chintana, P.; Bhattarakosol, P.; Patumraj, S. Antitumor and antiangiogenic activities of curcumin in cervical cancer xenografts in nude mice. BioMed Res. Int. 2014, 2014, 1–12.
    • (2014) Biomed Res. Int , vol.2014 , pp. 1-12
    • Yoysungnoen-Chintana, P.1    Bhattarakosol, P.2    Patumraj, S.3
  • 80
    • 80655146486 scopus 로고    scopus 로고
    • Pure curcumin inhibits exogenous Wilms’ tumor (WT1) (+/+) isoform protein via degradation pathway and protein kinase C in transfected U937 cells. Afr
    • Semsri, S.; Anuchapreeda, S.; Intasai, N.; Jomgeow, T.; Tima, S.; Sweeney, C.; Limtrakul, P. Pure curcumin inhibits exogenous Wilms’ tumor (WT1) (+/+) isoform protein via degradation pathway and protein kinase C in transfected U937 cells. Afr. J. Pharm. Pharmacol. 2011, 5, 1846–1856.
    • (2011) J. Pharm. Pharmacol , vol.5 , pp. 1846-1856
    • Semsri, S.1    Anuchapreeda, S.2    Intasai, N.3    Jomgeow, T.4    Tima, S.5    Sweeney, C.6    Limtrakul, P.7
  • 81
    • 84914669265 scopus 로고    scopus 로고
    • Role of the Wilms’ tumor 1 gene in the aberrant biological behavior of leukemic cells and the related mechanisms. Oncol
    • Li, Y.; Wang, J.; Li, X.; Jia, Y.; Huai, L.; He, K.; Yu, P.; Wang, M.; Xing, H.; Rao, Q.; et al. Role of the Wilms’ tumor 1 gene in the aberrant biological behavior of leukemic cells and the related mechanisms. Oncol. Rep. 2014, 32, 2680–2686.
    • (2014) Rep , vol.32 , pp. 2680-2686
    • Li, Y.1    Wang, J.2    Li, X.3    Jia, Y.4    Huai, L.5    He, K.6    Yu, P.7    Wang, M.8    Xing, H.9    Rao, Q.10
  • 82
    • 73849136747 scopus 로고    scopus 로고
    • Cytotoxic activity of curcumin towards CCRF-CEM leukemia cells and its effect on DNA damage
    • Kong, Y.; Ma, W.; Liu, X.; Zu, Y.; Fu, Y. Cytotoxic activity of curcumin towards CCRF-CEM leukemia cells and its effect on DNA damage. Molecules 2009, 14, 5328–5338.
    • (2009) Molecules , vol.14 , pp. 5328-5338
    • Kong, Y.1    Ma, W.2    Liu, X.3    Zu, Y.4    Fu, Y.5
  • 83
    • 79960667868 scopus 로고    scopus 로고
    • Curcumin sensitizes acute promyelocytic leukemia cells to unfolded protein response-induced apoptosis by blocking the loss of misfolded N-CoR protein. Mol
    • Ng, A.P.; Chng, W.J.; Khan, M. Curcumin sensitizes acute promyelocytic leukemia cells to unfolded protein response-induced apoptosis by blocking the loss of misfolded N-CoR protein. Mol. Cancer Res. 2011, 9, 878–888.
    • (2011) Cancer Res , vol.9 , pp. 878-888
    • Ng, A.P.1    Chng, W.J.2    Khan, M.3
  • 84
    • 84861804643 scopus 로고    scopus 로고
    • Curcumin improves the antitumor effect of X-ray irradiation by blocking the NF-kappaB pathway
    • Qiao, Q.; Jiang, Y.; Li, G. Curcumin improves the antitumor effect of X-ray irradiation by blocking the NF-kappaB pathway: An in vitro study of lymphoma. Anticancer Drugs 2012, 23, 597–605.
    • (2012) An in Vitro Study of Lymphoma. Anticancer Drugs , vol.23 , pp. 597-605
    • Qiao, Q.1    Jiang, Y.2    Li, G.3
  • 85
    • 84866079558 scopus 로고    scopus 로고
    • Oxidative stress induced by curcumin promotes the death of cutaneous T-cell lymphoma (HuT-78) by disrupting the function of several molecular targets. Mol
    • Khan, M.A.; Gahlot, S.; Majumdar, S. Oxidative stress induced by curcumin promotes the death of cutaneous T-cell lymphoma (HuT-78) by disrupting the function of several molecular targets. Mol. Cancer Ther. 2012, 11, 1873–1883.
    • (2012) Cancer Ther , vol.11 , pp. 1873-1883
    • Khan, M.A.1    Gahlot, S.2    Majumdar, S.3
  • 87
    • 84910059610 scopus 로고    scopus 로고
    • Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells. Toxicol
    • Ma, J.; Fang, B.B.; Zeng, F.P.; Pang, H.J.; Zhang, J.; Shi, Y.; Wu, X.P.; Cheng, L.; Ma, C.; Xia, J.; et al. Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells. Toxicol. Lett. 2014, 231, 82–91.
    • (2014) Lett , vol.231 , pp. 82-91
    • Ma, J.1    Fang, B.B.2    Zeng, F.P.3    Pang, H.J.4    Zhang, J.5    Shi, Y.6    Wu, X.P.7    Cheng, L.8    Ma, C.9    Xia, J.10
  • 88
    • 84875922351 scopus 로고    scopus 로고
    • Curcumin inhibits invasion and metastasis in k1 papillary thyroid cancer cells
    • Zhang, C.Y.; Zhang, L.; Yu, H.X.; Bao, J.D.; Sun, Z.; Lu, R.R. Curcumin inhibits invasion and metastasis in k1 papillary thyroid cancer cells. Food Chem. 2013, 139, 1021–1028.
    • (2013) Food Chem , vol.139 , pp. 1021-1028
    • Zhang, C.Y.1    Zhang, L.2    Yu, H.X.3    Bao, J.D.4    Sun, Z.5    Lu, R.R.6
  • 89
    • 84936980469 scopus 로고    scopus 로고
    • Curcumin inhibits hypoxia-induced migration in K1 papillary thyroid cancer cells. Exp. Biol
    • Tan, C.; Zhang, L.; Cheng, X.; Lin, X.F.; Lu, R.R.; Bao, J.D.; Yu, H.X. Curcumin inhibits hypoxia-induced migration in K1 papillary thyroid cancer cells. Exp. Biol. Med. 2015, 240, 925–935.
    • (2015) Med , vol.240 , pp. 925-935
    • Tan, C.1    Zhang, L.2    Cheng, X.3    Lin, X.F.4    Lu, R.R.5    Bao, J.D.6    Yu, H.X.7
  • 90
    • 84923776680 scopus 로고    scopus 로고
    • Induction of BCL2-Interacting killer, BIK, is mediated for Anti-Cancer activity of curcumin in human head and neck squamous cell carcinoma cells
    • Xi, Y.; Gao, H.; Callaghan, M.U.; Fribley, A.M.; Garshott, D.M.; Xu, Z.X.; Zeng, Q.H.; Li, Y.L. Induction of BCL2-Interacting killer, BIK, is mediated for Anti-Cancer activity of curcumin in human head and neck squamous cell carcinoma cells. J. Cancer 2015, 6, 327–332.
    • (2015) J. Cancer , vol.6 , pp. 327-332
    • Xi, Y.1    Gao, H.2    Callaghan, M.U.3    Fribley, A.M.4    Garshott, D.M.5    Xu, Z.X.6    Zeng, Q.H.7    Li, Y.L.8
  • 92
    • 84912072675 scopus 로고    scopus 로고
    • Curcumin inhibits oral squamous cell carcinoma proliferation and invasion via EGFR signaling pathways
    • Zhen, L.; Fan, D.; Yi, X.; Cao, X.; Chen, D.; Wang, L. Curcumin inhibits oral squamous cell carcinoma proliferation and invasion via EGFR signaling pathways. Int. J. Clin. Exp. Pathol. 2014, 7, 6438–6446.
    • (2014) Int. J. Clin. Exp. Pathol , vol.7 , pp. 6438-6446
    • Zhen, L.1    Fan, D.2    Yi, X.3    Cao, X.4    Chen, D.5    Wang, L.6
  • 93
    • 84929044434 scopus 로고    scopus 로고
    • Mechanistic perspectives on cancer chemoprevention/ chemotherapeutic effects of thymoquinone
    • Kundu, J.; Chun, K.S.; Aruoma, O.I.; Kundu, J.K. Mechanistic perspectives on cancer chemoprevention/ chemotherapeutic effects of thymoquinone. Mutat. Res.-Fundam. Mol. Mech. Mutagen. 2014, 768, 22–34.
    • (2014) Mutat. Res.-Fundam. Mol. Mech. Mutagen , vol.768 , pp. 22-34
    • Kundu, J.1    Chun, K.S.2    Aruoma, O.I.3    Kundu, J.K.4
  • 94
    • 84902158793 scopus 로고    scopus 로고
    • Therapeutic implications of black seed and its constituent thymoquinone in the prevention of cancer through inactivation and activation of molecular pathways. Evid.-Based Complement
    • Rahmani, A.H.; Alzohairy, M.A.; Khan, M.A.; Aly, S.M. Therapeutic implications of black seed and its constituent thymoquinone in the prevention of cancer through inactivation and activation of molecular pathways. Evid.-Based Complement. Altern. 2014, 2014, 724658.
    • (2014) Altern , pp. 2014
    • Rahmani, A.H.1    Alzohairy, M.A.2    Khan, M.A.3    Aly, S.M.4
  • 95
    • 84891858462 scopus 로고    scopus 로고
    • Thymoquinone: Fifty years of success in the battle against cancer models. Drug Discov
    • Schneider-Stock, R.; Fakhoury, I.H.; Zaki, A.M.; El-Baba, C.O.; Gali-Muhtasib, H.U. Thymoquinone: Fifty years of success in the battle against cancer models. Drug Discov. Today 2014, 19, 18–30.
    • (2014) Today , vol.19 , pp. 18-30
    • Schneider-Stock, R.1    Fakhoury, I.H.2    Zaki, A.M.3    El-Baba, C.O.4    Gali-Muhtasib, H.U.5
  • 96
    • 81155135198 scopus 로고    scopus 로고
    • Anticancer activity of Nigella sativa (Black Seed)—A review
    • Randhawa, M.A.; Alghamdi, M.S. Anticancer activity of Nigella sativa (Black Seed)—A review. Am. J. Chin. Med. 2011, 39, 1075–1091.
    • (2011) Am. J. Chin. Med , vol.39 , pp. 1075-1091
    • Randhawa, M.A.1    Alghamdi, M.S.2
  • 97
    • 84881543265 scopus 로고    scopus 로고
    • Thymoquinone as an anticancer agent: Evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo. Fundam. Clin
    • Attoub, S.; Sperandio, O.; Raza, H.; Arafat, K.; Al-Salam, S.; Al, S.M.; Al, S.M.; Takahashi, T.; Adem, A. Thymoquinone as an anticancer agent: Evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo. Fundam. Clin. Pharmacol. 2013, 27, 557–569.
    • (2013) Pharmacol , vol.27 , pp. 557-569
    • Attoub, S.1    Sperandio, O.2    Raza, H.3    Arafat, K.4    Al-Salam, S.5    Al, S.M.6    Al, S.M.7    Takahashi, T.8    Adem, A.9
  • 99
    • 84925519301 scopus 로고    scopus 로고
    • Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathway
    • Yang, J.; Kuang, X.R.; Lv, P.T.; Yan, X.X. Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathway. Tumour Biol. 2015, 36, 259–269.
    • (2015) Tumour Biol , vol.36 , pp. 259-269
    • Yang, J.1    Kuang, X.R.2    Lv, P.T.3    Yan, X.X.4
  • 101
    • 84885132843 scopus 로고    scopus 로고
    • Thymoquinone inhibits cell proliferation through regulation of G1/S phase cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular carcinoma. Toxicol
    • Raghunandhakumar, S.; Paramasivam, A.; Senthilraja, S.; Naveenkumar, C.; Asokkumar, S.; Binuclara, J.; Jagan, S.; Anandakumar, P.; Devaki, T. Thymoquinone inhibits cell proliferation through regulation of G1/S phase cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular carcinoma. Toxicol. Lett. 2013, 223, 60–72.
    • (2013) Lett , vol.223 , pp. 60-72
    • Raghunandhakumar, S.1    Paramasivam, A.2    Senthilraja, S.3    Naveenkumar, C.4    Asokkumar, S.5    Binuclara, J.6    Jagan, S.7    Anandakumar, P.8    Devaki, T.9
  • 102
    • 84898636114 scopus 로고    scopus 로고
    • Pan, H.; et al. Thymoquinone induces G2/M arrest, inactivates PI3K/Akt and nuclear factor-kappaB pathways in human cholangiocarcinomas both in vitro and in vivo. Oncol
    • Xu, D.; Ma, Y.; Zhao, B.; Li, S.; Zhang, Y.; Pan, S.; Wu, Y.; Wang, J.; Wang, D.; Pan, H.; et al. Thymoquinone induces G2/M arrest, inactivates PI3K/Akt and nuclear factor-kappaB pathways in human cholangiocarcinomas both in vitro and in vivo. Oncol. Rep. 2014, 31, 2063–2070.
    • (2014) Rep , vol.31 , pp. 2063-2070
    • Xu, D.1    Ma, Y.2    Zhao, B.3    Li, S.4    Zhang, Y.5    Pan, S.6    Wu, Y.7    Wang, J.8    Wang, D.9
  • 103
    • 84884828296 scopus 로고    scopus 로고
    • Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: The role of p38 MAPK and ROS
    • Woo, C.C.; Hsu, A.; Kumar, A.P.; Sethi, G.; Tan, K.H. Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: The role of p38 MAPK and ROS. PLoS ONE 2013, 8, e75356.
    • (2013) Plos ONE , pp. 8
    • Woo, C.C.1    Hsu, A.2    Kumar, A.P.3    Sethi, G.4    Tan, K.H.5
  • 104
    • 84887098861 scopus 로고    scopus 로고
    • 1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells
    • 1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells. Life Sci. 2013, 93, 783–790.
    • (2013) Life Sci , vol.93 , pp. 783-790
    • Rajput, S.1    Kumar, B.N.2    Dey, K.K.3    Pal, I.4    Parekh, A.5    Mandal, M.6
  • 106
    • 84897441980 scopus 로고    scopus 로고
    • Thymoquinone, a bioactive component of black caraway seeds, causes G1 phase cell cycle arrest and apoptosis in triple-negative breast cancer cells with mutant p53. Nutr
    • Sutton, K.M.; Greenshields, A.L.; Hoskin, D.W. Thymoquinone, a bioactive component of black caraway seeds, causes G1 phase cell cycle arrest and apoptosis in triple-negative breast cancer cells with mutant p53. Nutr. Cancer 2014, 66, 408–418.
    • (2014) Cancer , vol.66 , pp. 408-418
    • Sutton, K.M.1    Greenshields, A.L.2    Hoskin, D.W.3
  • 107
    • 84934292263 scopus 로고    scopus 로고
    • Thymoquinone pretreatment overcomes the insensitivity and potentiates the antitumor effect of gemcitabine through abrogation of notch1, PI3K/Akt/mTOR regulated signaling pathways in pancreatic cancer
    • Mu, G.G.; Zhang, L.L.; Li, H.Y.; Liao, Y.; Yu, H.G. Thymoquinone pretreatment overcomes the insensitivity and potentiates the antitumor effect of gemcitabine through abrogation of notch1, PI3K/Akt/mTOR regulated signaling pathways in pancreatic cancer. Dig. Dis. Sci. 2015, 60, 1067–1080.
    • (2015) Dig. Dis. Sci. , vol.60 , pp. 1067-1080
    • Mu, G.G.1    Zhang, L.L.2    Li, H.Y.3    Liao, Y.4    Yu, H.G.5
  • 110
    • 84874945056 scopus 로고    scopus 로고
    • Effect of thymoquinone on 1,2-dimethyl-hydrazine-induced oxidative stress during initiation and promotion of colon carcinogenesis
    • Jrah-Harzallah, H.; Ben-Hadj-Khalifa, S.; Almawi, W.Y.; Maaloul, A.; Houas, Z.; Mahjoub, T. Effect of thymoquinone on 1,2-dimethyl-hydrazine-induced oxidative stress during initiation and promotion of colon carcinogenesis. Eur. J. Cancer 2013, 49, 1127–1135.
    • (2013) Eur. J. Cancer , vol.49 , pp. 1127-1135
    • Jrah-Harzallah, H.1    Ben-Hadj-Khalifa, S.2    Almawi, W.Y.3    Maaloul, A.4    Houas, Z.5    Mahjoub, T.6
  • 112
    • 84903178517 scopus 로고    scopus 로고
    • Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Srcmediated phosphorylation of EGF receptor tyrosine kinase. Oncol
    • Kundu, J.; Choi, B.Y.; Jeong, C.H.; Kundu, J.K.; Chun, K.S. Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Srcmediated phosphorylation of EGF receptor tyrosine kinase. Oncol. Rep. 2014, 32, 821–828.
    • (2014) Rep , vol.32 , pp. 821-828
    • Kundu, J.1    Choi, B.Y.2    Jeong, C.H.3    Kundu, J.K.4    Chun, K.S.5
  • 113
    • 84922666190 scopus 로고    scopus 로고
    • Thymoquinone induces caspase-independent, autophagic cell death in CPT-11-resistant lovo colon cancer via mitochondrial dysfunction and activation of JNK and p38
    • Chen, M.C.; Lee, N.H.; Hsu, H.H.; Ho, T.J.; Tu, C.C.; Hsieh, D.J.; Lin, Y.M.; Chen, L.M.; Kuo, W.W.; Huang, C.Y. Thymoquinone induces caspase-independent, autophagic cell death in CPT-11-resistant lovo colon cancer via mitochondrial dysfunction and activation of JNK and p38. J. Agric. Food Chem. 2015, 63, 1540–1546.
    • (2015) J. Agric. Food Chem , vol.63 , pp. 1540-1546
    • Chen, M.C.1    Lee, N.H.2    Hsu, H.H.3    Ho, T.J.4    Tu, C.C.5    Hsieh, D.J.6    Lin, Y.M.7    Chen, L.M.8    Kuo, W.W.9    Huang, C.Y.10
  • 116
    • 84904302664 scopus 로고    scopus 로고
    • Thymoquinone induces cell death in human squamous carcinoma cells via caspase activation-dependent apoptosis and LC3-II activation-dependent autophagy
    • Chu, S.C.; Hsieh, Y.S.; Yu, C.C.; Lai, Y.Y.; Chen, P.N. Thymoquinone induces cell death in human squamous carcinoma cells via caspase activation-dependent apoptosis and LC3-II activation-dependent autophagy. PLoS ONE 2014, 9, e101579.
    • (2014) Plos ONE , pp. 9
    • Chu, S.C.1    Hsieh, Y.S.2    Yu, C.C.3    Lai, Y.Y.4    Chen, P.N.5
  • 117
    • 84911920800 scopus 로고    scopus 로고
    • Apoptotic activities of thymoquinone, an active ingredient of black seed (Nigella sativa), in cervical cancer cell lines. Chin
    • Ichwan, S.J.; Al-Ani, I.M.; Bilal, H.G.; Suriyah, W.H.; Taher, M.; Ikeda, M.A. Apoptotic activities of thymoquinone, an active ingredient of black seed (Nigella sativa), in cervical cancer cell lines. Chin. J. Physiol. 2014, 57, 249–255.
    • (2014) J. Physiol , vol.57 , pp. 249-255
    • Ichwan, S.J.1    Al-Ani, I.M.2    Bilal, H.G.3    Suriyah, W.H.4    Taher, M.5    Ikeda, M.A.6
  • 118
    • 84875777905 scopus 로고    scopus 로고
    • Methanolic extract of Nigella sativa seed inhibits SiHa human cervical cancer cell proliferation through apoptosis. Nat. Prod
    • Hasan, T.N.; Shafi, G.; Syed, N.A.; Alfawaz, M.A.; Alsaif, M.A.; Munshi, A.; Lei, K.Y.; Alshatwi, A.A. Methanolic extract of Nigella sativa seed inhibits SiHa human cervical cancer cell proliferation through apoptosis. Nat. Prod. Commun. 2013, 8, 213–216.
    • (2013) Commun , vol.8 , pp. 213-216
    • Hasan, T.N.1    Shafi, G.2    Syed, N.A.3    Alfawaz, M.A.4    Alsaif, M.A.5    Munshi, A.6    Lei, K.Y.7    Alshatwi, A.A.8
  • 119
    • 84883648774 scopus 로고    scopus 로고
    • Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells
    • Racoma, I.O.; Meisen, W.H.; Wang, Q.E.; Kaur, B.; Wani, A.A. Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells. PLoS ONE 2013, 8, e72882.
    • (2013) Plos ONE , pp. 8
    • Racoma, I.O.1    Meisen, W.H.2    Wang, Q.E.3    Kaur, B.4    Wani, A.A.5
  • 120
    • 84877317367 scopus 로고    scopus 로고
    • Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome. Toxicol. Appl
    • Ahmad, I.; Muneer, K.M.; Tamimi, I.A.; Chang, M.E.; Ata, M.O.; Yusuf, N. Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome. Toxicol. Appl. Pharmacol. 2013, 270, 70–76.
    • (2013) Pharmacol , vol.270 , pp. 70-76
    • Ahmad, I.1    Muneer, K.M.2    Tamimi, I.A.3    Chang, M.E.4    Ata, M.O.5    Yusuf, N.6
  • 122
    • 84872774902 scopus 로고    scopus 로고
    • Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-kappaB pathway. Oncol
    • Peng, L.; Liu, A.; Shen, Y.; Xu, H.Z.; Yang, S.Z.; Ying, X.Z.; Liao, W.; Liu, H.X.; Lin, Z.Q.; Chen, Q.Y.; et al. Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-kappaB pathway. Oncol. Rep. 2013, 29, 571–578.
    • (2013) Rep , vol.29 , pp. 571-578
    • Peng, L.1    Liu, A.2    Shen, Y.3    Xu, H.Z.4    Yang, S.Z.5    Ying, X.Z.6    Liao, W.7    Liu, H.X.8    Lin, Z.Q.9    Chen, Q.Y.10
  • 124
    • 84925637452 scopus 로고    scopus 로고
    • Ginger and its constituents: Role in prevention and treatment of gastrointestinal cancer. Gastroent. Res
    • Prasad, S.; Tyagi, A.K. Ginger and its constituents: Role in prevention and treatment of gastrointestinal cancer. Gastroent. Res. Pract. 2015, 2015, 142979.
    • Pract , vol.2015 , pp. 2015
    • Prasad, S.1    Tyagi, A.K.2
  • 126
    • 80053956867 scopus 로고    scopus 로고
    • Zingiber officinale Roscoe (Ginger) as an adjuvant in cancer treatment: A review
    • Pereira, M.M.; Haniadka, R.; Chacko, P.P.; Palatty, P.L.; Baliga, M.S. Zingiber officinale Roscoe (ginger) as an adjuvant in cancer treatment: A review. J. BUON 2011, 16, 414–424.
    • (2011) J. BUON , vol.16 , pp. 414-424
    • Pereira, M.M.1    Haniadka, R.2    Chacko, P.P.3    Palatty, P.L.4    Baliga, M.S.5
  • 127
    • 84921953291 scopus 로고    scopus 로고
    • Cho, H.J.; et al. Anti-cancer activity of ginger (Zingiber officinale) leaf through the expression of activating transcription factor 3 in human colorectal cancer cells. BMC Complement. Altern
    • Park, G.H.; Park, J.H.; Song, H.M.; Eo, H.J.; Kim, M.K.; Lee, J.W.; Lee, M.H.; Cho, K.H.; Lee, J.R.; Cho, H.J.; et al. Anti-cancer activity of ginger (Zingiber officinale) leaf through the expression of activating transcription factor 3 in human colorectal cancer cells. BMC Complement. Altern. Med. 2014, 14, 408.
    • (2014) Med , vol.14 , pp. 408
    • Park, G.H.1    Park, J.H.2    Song, H.M.3    Eo, H.J.4    Kim, M.K.5    Lee, J.W.6    Lee, M.H.7    Cho, K.H.8    Lee, J.R.9
  • 128
    • 84923233589 scopus 로고    scopus 로고
    • 6-Shogaol, an active constituent of dietary ginger, impairs cancer development and lung metastasis by inhibiting the secretion of CC-chemokine ligand 2 (CCL2) in tumor-associated dendritic cells
    • Hsu, Y.L.; Hung, J.Y.; Tsai, Y.M.; Tsai, E.M.; Huang, M.S.; Hou, M.F.; Kuo, P.L. 6-Shogaol, an active constituent of dietary ginger, impairs cancer development and lung metastasis by inhibiting the secretion of CC-chemokine ligand 2 (CCL2) in tumor-associated dendritic cells. J. Agric. Food Chem. 2015, 63, 1730–1738.
    • (2015) J. Agric. Food Chem , vol.63 , pp. 1730-1738
    • Hsu, Y.L.1    Hung, J.Y.2    Tsai, Y.M.3    Tsai, E.M.4    Huang, M.S.5    Hou, M.F.6    Kuo, P.L.7
  • 129
    • 84880393750 scopus 로고    scopus 로고
    • Change in adiponectin and oxidative stress after modifiable lifestyle interventions in breast cancer cases. Asian Pac
    • Karimi, N.; Roshan, V.D. Change in adiponectin and oxidative stress after modifiable lifestyle interventions in breast cancer cases. Asian Pac. J. Cancer Prev. 2013, 14, 2845–2850.
    • (2013) J. Cancer Prev , vol.14 , pp. 2845-2850
    • Karimi, N.1    Roshan, V.D.2
  • 130
    • 84937633250 scopus 로고    scopus 로고
    • Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer. Complement. Ther
    • Lua, P.L.; Salihah, N.; Mazlan, N. Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer. Complement. Ther. Med. 2015, 23, 396–404.
    • (2015) Med , vol.23 , pp. 396-404
    • Lua, P.L.1    Salihah, N.2    Mazlan, N.3
  • 131
    • 84925616496 scopus 로고    scopus 로고
    • [6]-Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling
    • Radhakrishnan, E.K.; Bava, S.V.; Narayanan, S.S.; Nath, L.R.; Thulasidasan, A.K.; Soniya, E.V.; Anto, R.J. [6]-Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling. PLoS ONE 2014, 9, e104401.
    • (2014) Plos ONE , pp. 9
    • Radhakrishnan, E.K.1    Bava, S.V.2    Narayanan, S.S.3    Nath, L.R.4    Thulasidasan, A.K.5    Soniya, E.V.6    Anto, R.J.7
  • 132
    • 84901283331 scopus 로고    scopus 로고
    • Cysteine-conjugated metabolites of ginger components, shogaols, induce apoptosis through oxidative stress-mediated p53 pathway in human colon cancer cells
    • Fu, J.; Chen, H.; Soroka, D.N.; Warin, R.F.; Sang, S. Cysteine-conjugated metabolites of ginger components, shogaols, induce apoptosis through oxidative stress-mediated p53 pathway in human colon cancer cells. J. Agric. Food Chem. 2014, 62, 4632–4642.
    • (2014) J. Agric. Food Chem , vol.62 , pp. 4632-4642
    • Fu, J.1    Chen, H.2    Soroka, D.N.3    Warin, R.F.4    Sang, S.5
  • 133
    • 84877266971 scopus 로고    scopus 로고
    • Effects of ginger supplementation on cell-cycle biomarkers in the normal-appearing colonic mucosa of patients at increased risk for colorectal cancer: Results from a pilot, randomized, and controlled trial. Cancer Prev
    • Citronberg, J.; Bostick, R.; Ahearn, T.; Turgeon, D.K.; Ruffin, M.T.; Djuric, Z.; Sen, A.; Brenner, D.E.; Zick, S.M. Effects of ginger supplementation on cell-cycle biomarkers in the normal-appearing colonic mucosa of patients at increased risk for colorectal cancer: Results from a pilot, randomized, and controlled trial. Cancer Prev. Res. 2013, 6, 271–281.
    • (2013) Res , vol.6 , pp. 271-281
    • Citronberg, J.1    Bostick, R.2    Ahearn, T.3    Turgeon, D.K.4    Ruffin, M.T.5    Djuric, Z.6    Sen, A.7    Brenner, D.E.8    Zick, S.M.9
  • 134
    • 84882238873 scopus 로고    scopus 로고
    • Effect of ginger root on cyclooxygenase-1 and 15-hydroxyprostaglandin dehydrogenase expression in colonic mucosa of humans at normal and increased risk for colorectal cancer
    • Jiang, Y.; Turgeon, D.K.; Wright, B.D.; Sidahmed, E.; Ruffin, M.T.; Brenner, D.E.; Sen, A.; Zick, S.M. Effect of ginger root on cyclooxygenase-1 and 15-hydroxyprostaglandin dehydrogenase expression in colonic mucosa of humans at normal and increased risk for colorectal cancer. Eur. J. Cancer Prev. 2013, 22, 455–460.
    • (2013) Eur. J. Cancer Prev , vol.22 , pp. 455-460
    • Jiang, Y.1    Turgeon, D.K.2    Wright, B.D.3    Sidahmed, E.4    Ruffin, M.T.5    Brenner, D.E.6    Sen, A.7    Zick, S.M.8
  • 135
    • 84874607185 scopus 로고    scopus 로고
    • Ginger phytochemicals exhibit synergy to inhibit prostate cancer cell proliferation. Nutr
    • Brahmbhatt, M.; Gundala, S.R.; Asif, G.; Shamsi, S.A.; Aneja, R. Ginger phytochemicals exhibit synergy to inhibit prostate cancer cell proliferation. Nutr. Cancer 2013, 65, 263–272.
    • (2013) Cancer , vol.65 , pp. 263-272
    • Brahmbhatt, M.1    Gundala, S.R.2    Asif, G.3    Shamsi, S.A.4    Aneja, R.5
  • 136
    • 84903529416 scopus 로고    scopus 로고
    • 6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-kappaB signaling. Cancer Prev
    • Saha, A.; Blando, J.; Silver, E.; Beltran, L.; Sessler, J.; DiGiovanni, J. 6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-kappaB signaling. Cancer Prev. Res. 2014, 7, 627–638.
    • (2014) Res , vol.7 , pp. 627-638
    • Saha, A.1    Blando, J.2    Silver, E.3    Beltran, L.4    Sessler, J.5    Digiovanni, J.6
  • 137
    • 84880365753 scopus 로고    scopus 로고
    • Protective effects of [6]-paradol on histological lesions and immunohistochemical gene expression in DMBA induced hamster buccal pouch carcinogenesis. Asian Pac
    • Mariadoss, A.V.; Kathiresan, S.; Muthusamy, R.; Kathiresan, S. Protective effects of [6]-paradol on histological lesions and immunohistochemical gene expression in DMBA induced hamster buccal pouch carcinogenesis. Asian Pac. J. Cancer Prev. 2013, 14, 3123–3129.
    • (2013) J. Cancer Prev , vol.14 , pp. 3123-3129
    • Mariadoss, A.V.1    Kathiresan, S.2    Muthusamy, R.3    Kathiresan, S.4
  • 138
    • 84873555508 scopus 로고    scopus 로고
    • [6]-Shogaol inhibits melanogenesis in B16 mouse melanoma cells through activation of the ERK pathway. Acta Pharmacol
    • Yao, C.; Oh, J.H.; Oh, I.G.; Park, C.H.; Chung, J.H. [6]-Shogaol inhibits melanogenesis in B16 mouse melanoma cells through activation of the ERK pathway. Acta Pharmacol. Sin. 2013, 34, 289–294.
    • (2013) Sin , vol.34 , pp. 289-294
    • Yao, C.1    Oh, J.H.2    Oh, I.G.3    Park, C.H.4    Chung, J.H.5
  • 139
    • 84929051796 scopus 로고    scopus 로고
    • Effects of crude extracts from medicinal herbs Rhazya stricta and Zingiber officinale on growth and proliferation of human brain cancer cell line in vitro. BioMed Res
    • Elkady, A.I.; Hussein, R.A.; Abu-Zinadah, O.A. Effects of crude extracts from medicinal herbs Rhazya stricta and Zingiber officinale on growth and proliferation of human brain cancer cell line in vitro. BioMed Res. Int. 2014, 2014, 260210.
    • (2014) Int , pp. 2014
    • Elkady, A.I.1    Hussein, R.A.2    Abu-Zinadah, O.A.3
  • 140
    • 84928999957 scopus 로고    scopus 로고
    • Garlic consumption and colorectal cancer risk in man: A systematic review and meta-analysis
    • Chiavarini, M.; Minelli, L.; Fabiani, R. Garlic consumption and colorectal cancer risk in man: A systematic review and meta-analysis. Public Health Nutr. 2016, 19, 308–317.
    • (2016) Public Health Nutr , vol.19 , pp. 308-317
    • Chiavarini, M.1    Minelli, L.2    Fabiani, R.3
  • 141
    • 84927585622 scopus 로고    scopus 로고
    • Garlic and onions: Their cancer prevention properties. Cancer Prev
    • Nicastro, H.L.; Ross, S.A.; Milner, J.A. Garlic and onions: Their cancer prevention properties. Cancer Prev. Res. 2015, 8, 181–189.
    • (2015) Res , vol.8 , pp. 181-189
    • Nicastro, H.L.1    Ross, S.A.2    Milner, J.A.3
  • 143
    • 84911910268 scopus 로고    scopus 로고
    • Diallyl disulfide suppresses SRC/Ras/ERK signaling-mediated proliferation and metastasis in human breast cancer by up-regulating miR-34a
    • Xiao, X.; Chen, B.; Liu, X.; Liu, P.; Zheng, G.; Ye, F.; Tang, H.; Xie, X. Diallyl disulfide suppresses SRC/Ras/ERK signaling-mediated proliferation and metastasis in human breast cancer by up-regulating miR-34a. PLoS ONE 2014, 9, e112720.
    • (2014) Plos ONE , pp. 9
    • Xiao, X.1    Chen, B.2    Liu, X.3    Liu, P.4    Zheng, G.5    Ye, F.6    Tang, H.7    Xie, X.8
  • 144
    • 84908692727 scopus 로고    scopus 로고
    • Diallyl sulfide inhibits diethylstilbestrol induced DNA damage in human breast epithelial cells (MCF-10A)
    • McCaskill, M.L.; Rogan, E.; Thomas, R.D. Diallyl sulfide inhibits diethylstilbestrol induced DNA damage in human breast epithelial cells (MCF-10A). Steroids 2014, 92, 96–100.
    • (2014) Steroids , vol.92 , pp. 96-100
    • McCaskill, M.L.1    Rogan, E.2    Thomas, R.D.3
  • 145
    • 84904783611 scopus 로고    scopus 로고
    • Antitumor mechanisms of S-allyl mercaptocysteine for breast cancer therapy. BMC Complement. Altern
    • Zhang, H.; Wang, K.; Lin, G.; Zhao, Z. Antitumor mechanisms of S-allyl mercaptocysteine for breast cancer therapy. BMC Complement. Altern. Med. 2014, 14, 270.
    • (2014) Med , vol.14 , pp. 270
    • Zhang, H.1    Wang, K.2    Lin, G.3    Zhao, Z.4
  • 147
    • 84894658224 scopus 로고    scopus 로고
    • Diallyl trisulfide inhibits estrogen receptor-alpha activity in human breast cancer cells. Breast Cancer Res
    • Hahm, E.R.; Singh, S.V. Diallyl trisulfide inhibits estrogen receptor-alpha activity in human breast cancer cells. Breast Cancer Res. Treat. 2014, 144, 47–57.
    • (2014) Treat , vol.144 , pp. 47-57
    • Hahm, E.R.1    Singh, S.V.2
  • 148
    • 84904118754 scopus 로고    scopus 로고
    • Allicin enhances chemotherapeutic response and ameliorates tamoxifen-induced liver injury in experimental animals
    • Suddek, G.M. Allicin enhances chemotherapeutic response and ameliorates tamoxifen-induced liver injury in experimental animals. Pharm. Biol. 2014, 52, 1009–1014.
    • (2014) Pharm. Biol , vol.52 , pp. 1009-1014
    • Suddek, G.M.1
  • 149
    • 84930177583 scopus 로고    scopus 로고
    • Diallyl disulfide inhibits growth and metastatic potential of human triple-negative breast cancer cells through inactivation of the beta-catenin signaling pathway. Mol
    • Huang, J.; Yang, B.; Xiang, T.; Peng, W.; Qiu, Z.; Wan, J.; Zhang, L.; Li, H.; Li, H.; Ren, G. Diallyl disulfide inhibits growth and metastatic potential of human triple-negative breast cancer cells through inactivation of the beta-catenin signaling pathway. Mol. Nutr. Food Res. 2015, 59, 1063–1075.
    • (2015) Nutr. Food Res , vol.59 , pp. 1063-1075
    • Huang, J.1    Yang, B.2    Xiang, T.3    Peng, W.4    Qiu, Z.5    Wan, J.6    Zhang, L.7    Li, H.8    Li, H.9    Ren, G.10
  • 150
    • 84907281139 scopus 로고    scopus 로고
    • Diallyl disulfide selectively causes checkpoint kinase-1 mediated G2/M arrest in human MGC803 gastric cancer cell line. Oncol
    • Ling, H.; Lu, L.F.; He, J.; Xiao, G.H.; Jiang, H.; Su, Q. Diallyl disulfide selectively causes checkpoint kinase-1 mediated G2/M arrest in human MGC803 gastric cancer cell line. Oncol. Rep. 2014, 32, 2274–2282.
    • (2014) Rep , vol.32 , pp. 2274-2282
    • Ling, H.1    Lu, L.F.2    He, J.3    Xiao, G.H.4    Jiang, H.5    Su, Q.6
  • 151
    • 84923068586 scopus 로고    scopus 로고
    • Diallyl disulfide induces G2/M arrest and promotes apoptosis through the p53/p21 and MEK-ERK pathways in human esophageal squamous cell carcinoma. Oncol
    • Yin, X.; Zhang, R.; Feng, C.; Zhang, J.; Liu, D.; Xu, K.; Wang, X.; Zhang, S.; Li, Z.; Liu, X.; et al. Diallyl disulfide induces G2/M arrest and promotes apoptosis through the p53/p21 and MEK-ERK pathways in human esophageal squamous cell carcinoma. Oncol. Rep. 2014, 32, 1748–1756.
    • (2014) Rep , vol.32 , pp. 1748-1756
    • Yin, X.1    Zhang, R.2    Feng, C.3    Zhang, J.4    Liu, D.5    Xu, K.6    Wang, X.7    Zhang, S.8    Li, Z.9    Liu, X.10
  • 152
    • 84904311211 scopus 로고    scopus 로고
    • DADS suppresses human esophageal xenograft tumors through RAF/MEK/ERK and mitochondria-dependent pathways
    • Yin, X.; Zhang, J.; Li, X.; Liu, D.; Feng, C.; Liang, R.; Zhuang, K.; Cai, C.; Xue, X.; Jing, F.; et al. DADS suppresses human esophageal xenograft tumors through RAF/MEK/ERK and mitochondria-dependent pathways. Int. J. Mol. Sci. 2014, 15, 12422–12441.
    • (2014) Int. J. Mol. Sci. , vol.15 , pp. 12422-12441
    • Yin, X.1    Zhang, J.2    Li, X.3    Liu, D.4    Feng, C.5    Liang, R.6    Zhuang, K.7    Cai, C.8    Xue, X.9    Jing, F.10
  • 153
    • 84921415758 scopus 로고    scopus 로고
    • Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway. Mol. Med
    • Zhang, X.; Zhu, Y.; Duan, W.; Feng, C.; He, X. Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway. Mol. Med. Rep. 2015, 11, 2755–2760.
    • (2015) Rep , vol.11 , pp. 2755-2760
    • Zhang, X.1    Zhu, Y.2    Duan, W.3    Feng, C.4    He, X.5
  • 154
    • 84920543739 scopus 로고    scopus 로고
    • Meta-analysis: Does garlic intake reduce risk of gastric cancer? Nutr
    • Kodali, R.T.; Eslick, G.D. Meta-analysis: Does garlic intake reduce risk of gastric cancer? Nutr. Cancer 2015, 67, 1–11.
    • (2015) Cancer , vol.67 , pp. 1-11
    • Kodali, R.T.1    Eslick, G.D.2
  • 155
    • 84921262580 scopus 로고    scopus 로고
    • Allium vegetable intake and gastric cancer: A case-control study and meta-analysis. Mol. Nutr
    • Turati, F.; Pelucchi, C.; Guercio, V.; La Vecchia, C.; Galeone, C. Allium vegetable intake and gastric cancer: A case-control study and meta-analysis. Mol. Nutr. Food Res. 2015, 59, 171–179.
    • (2015) Food Res , vol.59 , pp. 171-179
    • Turati, F.1    Pelucchi, C.2    Guercio, V.3    La Vecchia, C.4    Galeone, C.5
  • 156
    • 84930225800 scopus 로고    scopus 로고
    • L -selenocysteine induces apoptosis via endoplasmic reticulum stress and the death receptor pathway in human colon adenocarcinoma COLO 205 cells. J
    • L -selenocysteine induces apoptosis via endoplasmic reticulum stress and the death receptor pathway in human colon adenocarcinoma COLO 205 cells. J. Agric. Food Chem. 2015, 63, 5008–5016.
    • (2015) Agric. Food Chem , vol.63 , pp. 5008-5016
    • Tung, Y.C.1    Tsai, M.L.2    Kuo, F.L.3    Lai, C.S.4    Badmaev, V.5    Ho, C.T.6    Pan, M.H.7
  • 157
    • 84921670425 scopus 로고    scopus 로고
    • Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation. Oncol
    • Jikihara, H.; Qi, G.; Nozoe, K.; Hirokawa, M.; Sato, H.; Sugihara, Y.; Shimamoto, F. Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation. Oncol. Rep. 2015, 33, 1131–1140.
    • (2015) Rep , vol.33 , pp. 1131-1140
    • Jikihara, H.1    Qi, G.2    Nozoe, K.3    Hirokawa, M.4    Sato, H.5    Sugihara, Y.6    Shimamoto, F.7
  • 159
    • 84903198403 scopus 로고    scopus 로고
    • N-benzyl-N-methyldecan-1-amine, a phenylamine derivative isolated from garlic cloves, induces G2/M phase arrest and apoptosis in U937 human leukemia cells. Oncol
    • Jeong, J.W.; Park, S.; Park, C.; Chang, Y.C.; Moon, D.O.; Kim, S.O.; Kim, G.Y.; Cha, H.J.; Kim, H.S.; Choi, Y.W.; et al. N-benzyl-N-methyldecan-1-amine, a phenylamine derivative isolated from garlic cloves, induces G2/M phase arrest and apoptosis in U937 human leukemia cells. Oncol. Rep. 2014, 32, 373–381.
    • (2014) Rep , vol.32 , pp. 373-381
    • Jeong, J.W.1    Park, S.2    Park, C.3    Chang, Y.C.4    Moon, D.O.5    Kim, S.O.6    Kim, G.Y.7    Cha, H.J.8    Kim, H.S.9    Choi, Y.W.10
  • 160
    • 84929282576 scopus 로고    scopus 로고
    • Systemic approaches identify a garlic-derived chemical, Z-ajoene, as a glioblastoma multiforme cancer stem cell-specific targeting agent. Mol
    • Jung, Y.; Park, H.; Zhao, H.Y.; Jeon, R.; Ryu, J.H.; Kim, W.Y. Systemic approaches identify a garlic-derived chemical, Z-ajoene, as a glioblastoma multiforme cancer stem cell-specific targeting agent. Mol. Cells 2014, 37, 547–553.
    • (2014) Cells , vol.37 , pp. 547-553
    • Jung, Y.1    Park, H.2    Zhao, H.Y.3    Jeon, R.4    Ryu, J.H.5    Kim, W.Y.6
  • 162
    • 84902121662 scopus 로고    scopus 로고
    • Reversion of P-glycoprotein-mediated multidrug resistance by diallyl trisulfide in a human osteosarcoma cell line. Oncol
    • Wang, Z.; Xia, Q.; Cui, J.; Diao, Y.; Li, J. Reversion of P-glycoprotein-mediated multidrug resistance by diallyl trisulfide in a human osteosarcoma cell line. Oncol. Rep. 2014, 31, 2720–2726.
    • (2014) Rep , vol.31 , pp. 2720-2726
    • Wang, Z.1    Xia, Q.2    Cui, J.3    Diao, Y.4    Li, J.5
  • 163
    • 84891795464 scopus 로고    scopus 로고
    • Apoptotic pathway induced by diallyl trisulfide in pancreatic cancer cells. World
    • Ma, H.B.; Huang, S.; Yin, X.R.; Zhang, Y.; Di, Z.L. Apoptotic pathway induced by diallyl trisulfide in pancreatic cancer cells. World J. Gastroenterol. 2014, 20, 193–203.
    • (2014) J. Gastroenterol , vol.20 , pp. 193-203
    • Ma, H.B.1    Huang, S.2    Yin, X.R.3    Zhang, Y.4    Di, Z.L.5
  • 164
    • 84889035971 scopus 로고    scopus 로고
    • Diallyl trisulfide-induced apoptosis of bladder cancer cells is caspase-dependent and regulated by PI3K/Akt and JNK pathways. Environ. Toxicol
    • Shin, D.Y.; Kim, G.Y.; Hwang, H.J.; Kim, W.J.; Choi, Y.H. Diallyl trisulfide-induced apoptosis of bladder cancer cells is caspase-dependent and regulated by PI3K/Akt and JNK pathways. Environ. Toxicol. Pharmacol. 2014, 37, 74–83.
    • (2014) Pharmacol , vol.37 , pp. 74-83
    • Shin, D.Y.1    Kim, G.Y.2    Hwang, H.J.3    Kim, W.J.4    Choi, Y.H.5
  • 165
    • 84893630840 scopus 로고    scopus 로고
    • S-allylcysteine, a garlic derivative, suppresses proliferation and induces apoptosis in human ovarian cancer cells in vitro
    • Xu, Y.S.; Feng, J.G.; Zhang, D.; Zhang, B.; Luo, M.; Su, D.; Lin, N.M. S-allylcysteine, a garlic derivative, suppresses proliferation and induces apoptosis in human ovarian cancer cells in vitro. Acta Pharmacol. Sin. 2014, 35, 267–274.
    • (2014) Acta Pharmacol. Sin , vol.35 , pp. 267-274
    • Xu, Y.S.1    Feng, J.G.2    Zhang, D.3    Zhang, B.4    Luo, M.5    Su, D.6    Lin, N.M.7
  • 166
    • 84926427252 scopus 로고    scopus 로고
    • Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cells
    • Wu, Y.; Wu, Z.R.; Chen, P.; Yang-Li; Deng, W.R.; Wang, Y.Q.; Li, H.Y. Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cells. Bioorg. Med. Chem. Lett. 2015, 25, 1476–1478.
    • (2015) Bioorg. Med. Chem. Lett. , vol.25 , pp. 1476-1478
    • Wu, Y.1    Wu, Z.R.2    Chen, P.3    Yang-Lideng, W.R.4    Wang, Y.Q.5    Li, H.Y.6
  • 167
    • 84878201325 scopus 로고    scopus 로고
    • Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-kappaB and matrix metalloproteinase-2/-9 signaling pathways
    • Lai, W.W.; Hsu, S.C.; Chueh, F.S.; Chen, Y.Y.; Yang, J.S.; Lin, J.P.; Lien, J.C.; Tsai, C.H.; Chung, J.G. Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-kappaB and matrix metalloproteinase-2/-9 signaling pathways. Anticancer Res. 2013, 33, 1941–1950.
    • (2013) Anticancer Res , vol.33 , pp. 1941-1950
    • Lai, W.W.1    Hsu, S.C.2    Chueh, F.S.3    Chen, Y.Y.4    Yang, J.S.5    Lin, J.P.6    Lien, J.C.7    Tsai, C.H.8    Chung, J.G.9
  • 168
    • 84882737534 scopus 로고    scopus 로고
    • Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin. Anticancer Agents Med
    • Syed, D.N.; Adhami, V.M.; Khan, M.I.; Mukhtar, H. Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin. Anticancer Agents Med. Chem. 2013, 13, 995–1001.
    • (2013) Chem , vol.13 , pp. 995-1001
    • Syed, D.N.1    Adhami, V.M.2    Khan, M.I.3    Mukhtar, H.4
  • 169
    • 84879140852 scopus 로고    scopus 로고
    • Fisetin: A dietary antioxidant for health promotion. Antioxid
    • Khan, N.; Syed, D.N.; Ahmad, N.; Mukhtar, H. Fisetin: A dietary antioxidant for health promotion. Antioxid. Redox Signal. 2013, 19, 151–162.
    • (2013) Redox Signal , vol.19 , pp. 151-162
    • Khan, N.1    Syed, D.N.2    Ahmad, N.3    Mukhtar, H.4
  • 170
    • 84874587831 scopus 로고    scopus 로고
    • Reality check: There is no such thing as a miracle food. Nutr
    • Inoue-Choi, M.; Oppeneer, S.J.; Robien, K. Reality check: There is no such thing as a miracle food. Nutr. Cancer 2013, 65, 165–168.
    • (2013) Cancer , vol.65 , pp. 165-168
    • Inoue-Choi, M.1    Oppeneer, S.J.2    Robien, K.3
  • 172
    • 84866396886 scopus 로고    scopus 로고
    • Dietary administration of scallion extract effectively inhibits colorectal tumor growth: Cellular and molecular mechanisms in mice
    • Arulselvan, P.; Wen, C.C.; Lan, C.W.; Chen, Y.H.; Wei, W.C.; Yang, N.S. Dietary administration of scallion extract effectively inhibits colorectal tumor growth: Cellular and molecular mechanisms in mice. PLoS ONE 2012, 7, e44658.
    • (2012) Plos ONE , pp. 7
    • Arulselvan, P.1    Wen, C.C.2    Lan, C.W.3    Chen, Y.H.4    Wei, W.C.5    Yang, N.S.6
  • 173
    • 84879327936 scopus 로고    scopus 로고
    • Yuan, C.S. Role of saffron and its constituents on cancer chemoprevention. Pharm
    • Zhang, Z.Y.; Wang, C.Z.; Wen, X.D.; Shoyama, Y.; Yuan, C.S. Role of saffron and its constituents on cancer chemoprevention. Pharm. Biol. 2013, 51, 920–924.
    • (2013) Biol , vol.51 , pp. 920-924
    • Zhang, Z.Y.1    Wang, C.Z.2    Wen, X.D.3    Shoyama, Y.4
  • 174
    • 84855851876 scopus 로고    scopus 로고
    • Crocetin: An agent derived from saffron for prevention and therapy for cancer
    • Gutheil, W.G.; Reed, G.; Ray, A.; Anant, S.; Dhar, A. Crocetin: An agent derived from saffron for prevention and therapy for cancer. Curr. Pharm. Biotechnol. 2012, 13, 173–179.
    • (2012) Curr. Pharm. Biotechnol , vol.13 , pp. 173-179
    • Gutheil, W.G.1    Reed, G.2    Ray, A.3    Anant, S.4    Dhar, A.5
  • 175
    • 79956348262 scopus 로고    scopus 로고
    • Suppression of pulmonary tumor promotion and induction of apoptosis by crocus sativus l
    • Samarghandian, S.; Afshari, J.T.; Davoodi, S. Suppression of pulmonary tumor promotion and induction of apoptosis by crocus sativus l. Extraction. Appl. Biochem. Biotechnol. 2011, 164, 238–247.
    • (2011) Extraction. Appl. Biochem. Biotechnol. , vol.164 , pp. 238-247
    • Samarghandian, S.1    Afshari, J.T.2    Davoodi, S.3
  • 176
    • 84889063132 scopus 로고    scopus 로고
    • (Saffron) stigma aqueous extract induces apoptosis in alveolar human lung cancer cells through caspase-dependent pathways activation. BioMed Res
    • Samarghandian, S.; Borji, A.; Farahmand, S.K.; Afshari, R.; Davoodi, S. Crocus sativus L. (Saffron) stigma aqueous extract induces apoptosis in alveolar human lung cancer cells through caspase-dependent pathways activation. BioMed Res. Int. 2013, 2013, 417928.
    • (2013) Int , pp. 2013
    • Samarghandian, S.1    Borji, A.2    Farahmand, S.K.3    Afshari, R.4    Davoodi, S.5    Crocus Sativus, L.6
  • 177
    • 84888260574 scopus 로고    scopus 로고
    • Anticancer effects of crocetin in both human adenocarcinoma gastric cancer cells and rat model of gastric cancer. Biochem
    • Bathaie, S.Z.; Hoshyar, R.; Miri, H.; Sadeghizadeh, M. Anticancer effects of crocetin in both human adenocarcinoma gastric cancer cells and rat model of gastric cancer. Biochem. Cell Biol. 2013, 91, 397–403.
    • (2013) Cell Biol , vol.91 , pp. 397-403
    • Bathaie, S.Z.1    Hoshyar, R.2    Miri, H.3    Sadeghizadeh, M.4
  • 178
    • 84873048568 scopus 로고    scopus 로고
    • Crocin triggers the apoptosis through increasing the Bax/Bcl-2 ratio and caspase activation in human gastric adenocarcinoma, AGS, cells
    • Hoshyar, R.; Bathaie, S.Z.; Sadeghizadeh, M. Crocin triggers the apoptosis through increasing the Bax/Bcl-2 ratio and caspase activation in human gastric adenocarcinoma, AGS, cells. DNA Cell Biol. 2013, 32, 50–57.
    • (2013) DNA Cell Biol , vol.32 , pp. 50-57
    • Hoshyar, R.1    Bathaie, S.Z.2    Sadeghizadeh, M.3
  • 179
    • 84920969899 scopus 로고    scopus 로고
    • Defective autophagosome formation in p53-null colorectal cancer reinforces crocin-induced apoptosis
    • Amin, A.; Bajbouj, K.; Koch, A.; Gandesiri, M.; Schneider-Stock, R. Defective autophagosome formation in p53-null colorectal cancer reinforces crocin-induced apoptosis. Int. J. Mol. Sci. 2015, 16, 1544–1561.
    • (2015) Int. J. Mol. Sci , vol.16 , pp. 1544-1561
    • Amin, A.1    Bajbouj, K.2    Koch, A.3    Gandesiri, M.4    Schneider-Stock, R.5
  • 180
    • 84882374709 scopus 로고    scopus 로고
    • Crocus sativus stigma extract and its major constituent crocin possess significant antiproliferative properties against human prostate cancer. Nutr
    • D’Alessandro, A.M.; Mancini, A.; Lizzi, A.R.; De Simone, A.; Marroccella, C.E.; Gravina, G.L.; Tatone, C.; Festuccia, C. Crocus sativus stigma extract and its major constituent crocin possess significant antiproliferative properties against human prostate cancer. Nutr. Cancer 2013, 65, 930–942.
    • (2013) Cancer , vol.65 , pp. 930-942
    • D’Alessandro, A.M.1    Mancini, A.2    Lizzi, A.R.3    De Simone, A.4    Marroccella, C.E.5    Gravina, G.L.6    Tatone, C.7    Festuccia, C.8
  • 182
    • 84930986086 scopus 로고    scopus 로고
    • Ovarian cancer HO-8910 cell apoptosis induced by crocin in vitro. Nat. Prod
    • Xia, D. Ovarian cancer HO-8910 cell apoptosis induced by crocin in vitro. Nat. Prod. Commun. 2015, 10, 249–252.
    • (2015) Commun , vol.10 , pp. 249-252
    • Xia, D.1
  • 183
    • 78651485607 scopus 로고    scopus 로고
    • Crocetin inhibits invasiveness of MDA-MB-231 breast cancer cells via downregulation of matrix metalloproteinases
    • Chryssanthi, D.G.; Dedes, P.G.; Karamanos, N.K.; Cordopatis, P.; Lamari, F.N. Crocetin inhibits invasiveness of MDA-MB-231 breast cancer cells via downregulation of matrix metalloproteinases. Planta Med. 2011, 77, 146–151.
    • (2011) Planta Med , vol.77 , pp. 146-151
    • Chryssanthi, D.G.1    Dedes, P.G.2    Karamanos, N.K.3    Cordopatis, P.4    Lamari, F.N.5
  • 185
    • 84907828121 scopus 로고    scopus 로고
    • L constituent suppresses the growth of K-562 cells of chronic myelogenous leukemia: In silico and in vitro study. Food
    • L constituent suppresses the growth of K-562 cells of chronic myelogenous leukemia: In silico and in vitro study. Food Chem. Toxicol. 2014, 74, 45–50.
    • (2014) Chem. Toxicol , vol.74 , pp. 45-50
    • Geromichalos, G.D.1    Papadopoulos, T.2    Sahpazidou, D.3    Sinakos, Z.4
  • 186
    • 84881225755 scopus 로고    scopus 로고
    • Zou, C. Synergistic apoptotic effect of crocin and cisplatin on osteosarcoma cells via caspase induced apoptosis. Toxicol
    • Li, X.; Huang, T.; Jiang, G.; Gong, W.; Qian, H.; Zou, C. Synergistic apoptotic effect of crocin and cisplatin on osteosarcoma cells via caspase induced apoptosis. Toxicol. Lett. 2013, 221, 197–204.
    • (2013) Lett , vol.221 , pp. 197-204
    • Li, X.1    Huang, T.2    Jiang, G.3    Gong, W.4    Qian, H.5
  • 187
    • 84879244545 scopus 로고    scopus 로고
    • Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells
    • Do, M.T.; Kim, H.G.; Choi, J.H.; Khanal, T.; Park, B.H.; Tran, T.P.; Jeong, T.C.; Jeong, H.G. Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells. Food Chem. 2013, 141, 2591–2599.
    • (2013) Food Chem , vol.141 , pp. 2591-2599
    • Do, M.T.1    Kim, H.G.2    Choi, J.H.3    Khanal, T.4    Park, B.H.5    Tran, T.P.6    Jeong, T.C.7    Jeong, H.G.8
  • 188
    • 84902263833 scopus 로고    scopus 로고
    • Piperine enhances the efficacy of TRAIL-based therapy for triple-negative breast cancer cells
    • Abdelhamed, S.; Yokoyama, S.; Refaat, A.; Ogura, K.; Yagita, H.; Awale, S.; Saiki, I. Piperine enhances the efficacy of TRAIL-based therapy for triple-negative breast cancer cells. Anticancer Res. 2014, 34, 1893–1899.
    • (2014) Anticancer Res , vol.34 , pp. 1893-1899
    • Abdelhamed, S.1    Yokoyama, S.2    Refaat, A.3    Ogura, K.4    Yagita, H.5    Awale, S.6    Saiki, I.7
  • 191
    • 84883225880 scopus 로고    scopus 로고
    • He, X.H. Piperine inhibits the proliferation of human prostate cancer cells via induction of cell cycle arrest and autophagy. Food
    • Ouyang, D.Y.; Zeng, L.H.; Pan, H.; Xu, L.H.; Wang, Y.; Liu, K.P.; He, X.H. Piperine inhibits the proliferation of human prostate cancer cells via induction of cell cycle arrest and autophagy. Food Chem. Toxicol. 2013, 60, 424–430.
    • (2013) Chem. Toxicol , vol.60 , pp. 424-430
    • Ouyang, D.Y.1    Zeng, L.H.2    Pan, H.3    Xu, L.H.4    Wang, Y.5    Liu, K.P.6
  • 192
    • 84858753896 scopus 로고    scopus 로고
    • Co-administration of piperine and docetaxel results in improved anti-tumor efficacy via inhibition of CYP3A4 activity
    • Makhov, P.; Golovine, K.; Canter, D.; Kutikov, A.; Simhan, J.; Corlew, M.M.; Uzzo, R.G.; Kolenko, V.M. Co-administration of piperine and docetaxel results in improved anti-tumor efficacy via inhibition of CYP3A4 activity. Prostate 2012, 72, 661–667.
    • (2012) Prostate , vol.72 , pp. 661-667
    • Makhov, P.1    Golovine, K.2    Canter, D.3    Kutikov, A.4    Simhan, J.5    Corlew, M.M.6    Uzzo, R.G.7    Kolenko, V.M.8
  • 193
    • 84870875546 scopus 로고    scopus 로고
    • Piperine impairs cell cycle progression and causes reactive oxygen species-dependent apoptosis in rectal cancer cells. Exp
    • Yaffe, P.B.; Doucette, C.D.; Walsh, M.; Hoskin, D.W. Piperine impairs cell cycle progression and causes reactive oxygen species-dependent apoptosis in rectal cancer cells. Exp. Mol. Pathol. 2013, 94, 109–114.
    • (2013) Mol. Pathol , vol.94 , pp. 109-114
    • Yaffe, P.B.1    Doucette, C.D.2    Walsh, M.3    Hoskin, D.W.4
  • 194
    • 84941653158 scopus 로고    scopus 로고
    • Piperine, an alkaloid from black pepper, inhibits growth of human colon cancer cells via g1 arrest and apoptosis triggered by endoplasmic reticulum stress. Mol
    • Yaffe, P.B.; Coombs, M.; Doucette, C.D.; Walsh, M.; Hoskin, D.W. Piperine, an alkaloid from black pepper, inhibits growth of human colon cancer cells via g1 arrest and apoptosis triggered by endoplasmic reticulum stress. Mol. Carcinogen. 2015, 54, 1070–1085.
    • (2015) Carcinogen , vol.54 , pp. 1070-1085
    • Yaffe, P.B.1    Coombs, M.2    Doucette, C.D.3    Walsh, M.4    Hoskin, D.W.5
  • 195
    • 84900550067 scopus 로고    scopus 로고
    • Piperine causes G1 phase cell cycle arrest and apoptosis in melanoma cells through checkpoint kinase-1 activation
    • Fofaria, N.M.; Kim, S.H.; Srivastava, S.K. Piperine causes G1 phase cell cycle arrest and apoptosis in melanoma cells through checkpoint kinase-1 activation. PLoS ONE 2014, 9, e94298.
    • (2014) Plos ONE , pp. 9
    • Fofaria, N.M.1    Kim, S.H.2    Srivastava, S.K.3
  • 197
    • 84991585084 scopus 로고    scopus 로고
    • Anticancer properties of capsaicin against human cancer
    • Clark, R.; Lee, S.H. Anticancer properties of capsaicin against human cancer. Anticancer Res. 2016, 36, 837–843.
    • (2016) Anticancer Res , vol.36 , pp. 837-843
    • Clark, R.1    Lee, S.H.2
  • 198
    • 84902804911 scopus 로고    scopus 로고
    • Sen, A.; et al. Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis
    • Chakraborty, S.; Adhikary, A.; Mazumdar, M.; Mukherjee, S.; Bhattacharjee, P.; Guha, D.; Choudhuri, T.; Chattopadhyay, S.; Sa, G.; Sen, A.; et al. Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis. PLoS ONE 2014, 9, e99743.
    • (2014) Plos ONE , pp. 9
    • Chakraborty, S.1    Adhikary, A.2    Mazumdar, M.3    Mukherjee, S.4    Bhattacharjee, P.5    Guha, D.6    Choudhuri, T.7    Chattopadhyay, S.8    Sa, G.9
  • 200
    • 84896740476 scopus 로고    scopus 로고
    • Restoration of p53/miR-34a regulatory axis decreases survival advantage and ensures Bax-dependent apoptosis of non-small cell lung carcinoma cells
    • Chakraborty, S.; Mazumdar, M.; Mukherjee, S.; Bhattacharjee, P.; Adhikary, A.; Manna, A.; Chakraborty, S.; Khan, P.; Sen, A.; Das, T. Restoration of p53/miR-34a regulatory axis decreases survival advantage and ensures Bax-dependent apoptosis of non-small cell lung carcinoma cells. FEBS Lett. 2014, 588, 549–559.
    • (2014) FEBS Lett , vol.588 , pp. 549-559
    • Chakraborty, S.1    Mazumdar, M.2    Mukherjee, S.3    Bhattacharjee, P.4    Adhikary, A.5    Manna, A.6    Chakraborty, S.7    Khan, P.8    Sen, A.9    Das, T.10
  • 201
    • 77956314277 scopus 로고    scopus 로고
    • Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway
    • Brown, K.C.; Witte, T.R.; Hardman, W.E.; Luo, H.; Chen, Y.C.; Carpenter, A.B.; Lau, J.K.; Dasgupta, P. Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway. PLoS ONE 2010, 5, e10243.
    • (2010) Plos ONE , pp. 5
    • Brown, K.C.1    Witte, T.R.2    Hardman, W.E.3    Luo, H.4    Chen, Y.C.5    Carpenter, A.B.6    Lau, J.K.7    Dasgupta, P.8
  • 202
    • 84904539783 scopus 로고    scopus 로고
    • Consequences of activating the calcium-permeable ion channel TRPV1 in breast cancer cells with regulated TRPV1 expression
    • Wu, T.T.; Peters, A.A.; Tan, P.T.; Roberts-Thomson, S.J.; Monteith, G.R. Consequences of activating the calcium-permeable ion channel TRPV1 in breast cancer cells with regulated TRPV1 expression. Cell Calcium 2014, 56, 59–67.
    • (2014) Cell Calcium , vol.56 , pp. 59-67
    • Wu, T.T.1    Peters, A.A.2    Tan, P.T.3    Roberts-Thomson, S.J.4    Monteith, G.R.5
  • 203
    • 84891824913 scopus 로고    scopus 로고
    • Pepper seed extract suppresses invasion and migration of human breast cancer cells
    • Kim, H.A.; Kim, M.S.; Kim, S.H.; Kim, Y.K. Pepper seed extract suppresses invasion and migration of human breast cancer cells. Nutr. Cancer 2014, 66, 159–165.
    • (2014) Nutr. Cancer , vol.66 , pp. 159-165
    • Kim, H.A.1    Kim, M.S.2    Kim, S.H.3    Kim, Y.K.4
  • 204
    • 74449084136 scopus 로고    scopus 로고
    • Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway
    • Thoennissen, N.H.; O’Kelly, J.; Lu, D.; Iwanski, G.B.; La, D.T.; Abbassi, S.; Leiter, A.; Karlan, B.; Mehta, R.; Koeffler, H.P. Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway. Oncogene 2010, 29, 285–296.
    • (2010) Oncogene , vol.29 , pp. 285-296
    • Thoennissen, N.H.1    O’Kelly, J.2    Lu, D.3    Iwanski, G.B.4    La, D.T.5    Abbassi, S.6    Leiter, A.7    Karlan, B.8    Mehta, R.9    Koeffler, H.P.10
  • 205
    • 84905017477 scopus 로고    scopus 로고
    • Capsaicin inhibits cell proliferation by cytochrome c release in gastric cancer cells
    • Meral, O.; Alpay, M.; Kismali, G.; Kosova, F.; Cakir, D.U.; Pekcan, M.; Yigit, S.; Sel, T. Capsaicin inhibits cell proliferation by cytochrome c release in gastric cancer cells. Tumour Biol. 2014, 35, 6485–6492.
    • (2014) Tumour Biol , vol.35 , pp. 6485-6492
    • Meral, O.1    Alpay, M.2    Kismali, G.3    Kosova, F.4    Cakir, D.U.5    Pekcan, M.6    Yigit, S.7    Sel, T.8
  • 207
    • 84916929215 scopus 로고    scopus 로고
    • Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK-NF-kappaB signaling pathway. Clin. Exp
    • Lee, G.R.; Jang, S.H.; Kim, C.J.; Kim, A.R.; Yoon, D.J.; Park, N.H.; Han, I.S. Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK-NF-kappaB signaling pathway. Clin. Exp. Metastasis 2014, 31, 897–907.
    • (2014) Metastasis , vol.31 , pp. 897-907
    • Lee, G.R.1    Jang, S.H.2    Kim, C.J.3    Kim, A.R.4    Yoon, D.J.5    Park, N.H.6    Han, I.S.7
  • 209
    • 84937515507 scopus 로고    scopus 로고
    • Capsaicin reduces the metastatic burden in the transgenic adenocarcinoma of the mouse prostate model
    • Venier, N.A.; Yamamoto, T.; Sugar, L.M.; Adomat, H.; Fleshner, N.E.; Klotz, L.H.; Venkateswaran, V. Capsaicin reduces the metastatic burden in the transgenic adenocarcinoma of the mouse prostate model. Prostate 2015, 75, 1300–1311.
    • (2015) Prostate , vol.75 , pp. 1300-1311
    • Venier, N.A.1    Yamamoto, T.2    Sugar, L.M.3    Adomat, H.4    Fleshner, N.E.5    Klotz, L.H.6    Venkateswaran, V.7
  • 212
    • 84898914139 scopus 로고    scopus 로고
    • Capsaicin induced apoptosis and gene expression dysregulation of human acute lymphoblastic leukemia CCRF-CEM cells
    • Bozok, C.V.; Tezcanli, K.B.; Aktug, H.; Oltulu, F.; Taskiran, D. Capsaicin induced apoptosis and gene expression dysregulation of human acute lymphoblastic leukemia CCRF-CEM cells. J. BUON 2014, 19, 183–190.
    • (2014) J. BUON , vol.19 , pp. 183-190
    • Bozok, C.V.1    Tezcanli, K.B.2    Aktug, H.3    Oltulu, F.4    Taskiran, D.5
  • 213
    • 84896264601 scopus 로고    scopus 로고
    • CBP-mediated FOXO-1 acetylation inhibits pancreatic tumor growth by targeting SirT. Mol
    • Pramanik, K.C.; Fofaria, N.M.; Gupta, P.; Srivastava, S.K. CBP-mediated FOXO-1 acetylation inhibits pancreatic tumor growth by targeting SirT. Mol. Cancer Ther. 2014, 13, 687–698.
    • (2014) Cancer Ther , vol.13 , pp. 687-698
    • Pramanik, K.C.1    Fofaria, N.M.2    Gupta, P.3    Srivastava, S.K.4
  • 215
    • 84928910888 scopus 로고    scopus 로고
    • Synergistic Anticancer Activity of Capsaicin and 3,3 ′ -Diindolylmethane in Human Colorectal Cancer
    • Clark, R.; Lee, J.; Lee, S.H. Synergistic Anticancer Activity of Capsaicin and 3,3 ′ -Diindolylmethane in Human Colorectal Cancer. J. Agric. Food Chem. 2015, 63, 4297–4304.
    • (2015) J. Agric. Food Chem. , vol.63 , pp. 4297-4304
    • Clark, R.1    Lee, J.2    Lee, S.H.3
  • 217
    • 84939271452 scopus 로고    scopus 로고
    • Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity
    • Petiwala, S.M.; Johnson, J.J. Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity. Cancer Lett. 2015, 367, 93–102.
    • (2015) Cancer Lett , vol.367 , pp. 93-102
    • Petiwala, S.M.1    Johnson, J.J.2
  • 218
    • 84876989587 scopus 로고    scopus 로고
    • Ramirez, D.M.A. Antitumor effect of 5-fluorouracil is enhanced by rosemary extract in both drug sensitive and resistant colon cancer cells. Pharmacol
    • Gonzalez-Vallinas, M.; Molina, S.; Vicente, G.; de la Cueva, A.; Vargas, T.; Santoyo, S.; Garcia-Risco, M.R.; Fornari, T.; Reglero, G.; Ramirez, D.M.A. Antitumor effect of 5-fluorouracil is enhanced by rosemary extract in both drug sensitive and resistant colon cancer cells. Pharmacol. Res. 2013, 72, 61–68.
    • (2013) Res , vol.72 , pp. 61-68
    • Gonzalez-Vallinas, M.1    Molina, S.2    Vicente, G.3    De La Cueva, A.4    Vargas, T.5    Santoyo, S.6    Garcia-Risco, M.R.7    Fornari, T.8    Reglero, G.9
  • 220
    • 84894470103 scopus 로고    scopus 로고
    • Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells
    • Park, K.W.; Kundu, J.; Chae, I.G.; Kim, D.H.; Yu, M.H.; Kundu, J.K.; Chun, K.S. Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells. Int. J. Oncol. 2014, 44, 1309–1315.
    • (2014) Int. J. Oncol. , vol.44 , pp. 1309-1315
    • Park, K.W.1    Kundu, J.2    Chae, I.G.3    Kim, D.H.4    Yu, M.H.5    Kundu, J.K.6    Chun, K.S.7
  • 222
    • 84904479758 scopus 로고    scopus 로고
    • Carnosic acid inhibits the epithelial-mesenchymal transition in B16F10 melanoma cells: A possible mechanism for the inhibition of cell migration
    • Park, S.Y.; Song, H.; Sung, M.K.; Kang, Y.H.; Lee, K.W.; Park, J.H. Carnosic acid inhibits the epithelial-mesenchymal transition in B16F10 melanoma cells: A possible mechanism for the inhibition of cell migration. Int. J. Mol. Sci. 2014, 15, 12698–12713.
    • (2014) Int. J. Mol. Sci , vol.15 , pp. 12698-12713
    • Park, S.Y.1    Song, H.2    Sung, M.K.3    Kang, Y.H.4    Lee, K.W.5    Park, J.H.6
  • 223
    • 84922704889 scopus 로고    scopus 로고
    • Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cells
    • Jung, K.J.; Min, K.J.; Bae, J.H.; Kwon, T.K. Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cells. Oncotarget 2015, 6, 1556–1568.
    • (2015) Oncotarget , vol.6 , pp. 1556-1568
    • Jung, K.J.1    Min, K.J.2    Bae, J.H.3    Kwon, T.K.4
  • 224
    • 84897146362 scopus 로고    scopus 로고
    • Rosemary (Rosmarinus officinalis) extract modulates CHOP/GADD153 to promote androgen receptor degradation and decreases xenograft tumor growth
    • Petiwala, S.M.; Berhe, S.; Li, G.; Puthenveetil, A.G.; Rahman, O.; Nonn, L.; Johnson, J.J. Rosemary (Rosmarinus officinalis) extract modulates CHOP/GADD153 to promote androgen receptor degradation and decreases xenograft tumor growth. PLoS ONE 2014, 9, e89772.
    • (2014) Plos ONE , pp. 9
    • Petiwala, S.M.1    Berhe, S.2    Li, G.3    Puthenveetil, A.G.4    Rahman, O.5    Nonn, L.6    Johnson, J.J.7
  • 225
    • 84896978616 scopus 로고    scopus 로고
    • Carnosol, rosemary ingredient, induces apoptosis in adult T-cell leukemia/lymphoma cells via glutathione depletion: Proteomic approach using fluorescent two-dimensional differential gel electrophoresis. Hum
    • Ishida, Y.; Yamasaki, M.; Yukizaki, C.; Nishiyama, K.; Tsubouchi, H.; Okayama, A.; Kataoka, H. Carnosol, rosemary ingredient, induces apoptosis in adult T-cell leukemia/lymphoma cells via glutathione depletion: Proteomic approach using fluorescent two-dimensional differential gel electrophoresis. Hum. Cell 2014, 27, 68–77.
    • (2014) Cell , vol.27 , pp. 68-77
    • Ishida, Y.1    Yamasaki, M.2    Yukizaki, C.3    Nishiyama, K.4    Tsubouchi, H.5    Okayama, A.6    Kataoka, H.7
  • 226
    • 85028223515 scopus 로고    scopus 로고
    • Carnosic acid induces autophagic cell death through inhibition of the Akt/mTOR pathway in human hepatoma cells
    • Gao, Q.; Liu, H.; Yao, Y.; Geng, L.; Zhang, X.; Jiang, L.; Shi, B.; Yang, F. Carnosic acid induces autophagic cell death through inhibition of the Akt/mTOR pathway in human hepatoma cells. J. Appl. Toxicol. 2015, 35, 485–492.
    • (2015) J. Appl. Toxicol , vol.35 , pp. 485-492
    • Gao, Q.1    Liu, H.2    Yao, Y.3    Geng, L.4    Zhang, X.5    Jiang, L.6    Shi, B.7    Yang, F.8
  • 228
    • 84889967732 scopus 로고    scopus 로고
    • Eugenol triggers apoptosis in breast cancer cells through E2F1/survivin down-regulation
    • Al-Sharif, I.; Remmal, A.; Aboussekhra, A. Eugenol triggers apoptosis in breast cancer cells through E2F1/survivin down-regulation. BMC Cancer 2013, 13, 600.
    • (2013) BMC Cancer , vol.13 , pp. 600
    • Al-Sharif, I.1    Remmal, A.2    Aboussekhra, A.3
  • 229
    • 80054714275 scopus 로고    scopus 로고
    • Eugenol enhances the chemotherapeutic potential of gemcitabine and induces anticarcinogenic and anti-inflammatory activity in human cervical cancer cells. Cancer Biother
    • Hussain, A.; Brahmbhatt, K.; Priyani, A.; Ahmed, M.; Rizvi, T.A.; Sharma, C. Eugenol enhances the chemotherapeutic potential of gemcitabine and induces anticarcinogenic and anti-inflammatory activity in human cervical cancer cells. Cancer Biother. Radiopharm. 2011, 26, 519–527.
    • (2011) Radiopharm , vol.26 , pp. 519-527
    • Hussain, A.1    Brahmbhatt, K.2    Priyani, A.3    Ahmed, M.4    Rizvi, T.A.5    Sharma, C.6
  • 230
    • 84858144923 scopus 로고    scopus 로고
    • Comparative anticancer potential of clove (Syzygium aromaticum)–An Indian spice—Against cancer cell lines of various anatomical origin. Asian Pac
    • Dwivedi, V.; Shrivastava, R.; Hussain, S.; Ganguly, C.; Bharadwaj, M. Comparative anticancer potential of clove (Syzygium aromaticum)–An Indian spice—Against cancer cell lines of various anatomical origin. Asian Pac. J. Cancer Prev. 2011, 12, 1989–1993.
    • (2011) J. Cancer Prev , vol.12 , pp. 1989-1993
    • Dwivedi, V.1    Shrivastava, R.2    Hussain, S.3    Ganguly, C.4    Bharadwaj, M.5
  • 231
    • 84907542721 scopus 로고    scopus 로고
    • Wu, N.; et al. Clove extract inhibits tumor growth and promotes cell cycle arrest and apoptosis. Oncol
    • Liu, H.; Schmitz, J.C.; Wei, J.; Cao, S.; Beumer, J.H.; Strychor, S.; Cheng, L.; Liu, M.; Wang, C.; Wu, N.; et al. Clove extract inhibits tumor growth and promotes cell cycle arrest and apoptosis. Oncol. Res. 2014, 21, 247–259.
    • (2014) Res , vol.21 , pp. 247-259
    • Liu, H.1    Schmitz, J.C.2    Wei, J.3    Cao, S.4    Beumer, J.H.5    Strychor, S.6    Cheng, L.7    Liu, M.8    Wang, C.9
  • 232
    • 84894550280 scopus 로고    scopus 로고
    • Effect of dietary eugenol on xenobiotic metabolism and mediation of UDP-glucuronosyltransferase and cytochrome P450 1A1 expression in rat liver
    • Iwano, H.; Ujita, W.; Nishikawa, M.; Ishii, S.; Inoue, H.; Yokota, H. Effect of dietary eugenol on xenobiotic metabolism and mediation of UDP-glucuronosyltransferase and cytochrome P450 1A1 expression in rat liver. Int. J. Food Sci. Nutr. 2014, 65, 241–244.
    • (2014) Int. J. Food Sci. Nutr , vol.65 , pp. 241-244
    • Iwano, H.1    Ujita, W.2    Nishikawa, M.3    Ishii, S.4    Inoue, H.5    Yokota, H.6
  • 233
    • 84887353644 scopus 로고    scopus 로고
    • Galangin inhibits proliferation of hepatocellular carcinoma cells by inducing endoplasmic reticulum stress. Food
    • Su, L.; Chen, X.; Wu, J.; Lin, B.; Zhang, H.; Lan, L.; Luo, H. Galangin inhibits proliferation of hepatocellular carcinoma cells by inducing endoplasmic reticulum stress. Food Chem. Toxicol. 2013, 62, 810–816.
    • (2013) Chem. Toxicol , vol.62 , pp. 810-816
    • Su, L.1    Chen, X.2    Wu, J.3    Lin, B.4    Zhang, H.5    Lan, L.6    Luo, H.7
  • 234
    • 84908402646 scopus 로고    scopus 로고
    • Galangin suppresses HepG2 cell proliferation by activating the TGF-beta receptor/Smad pathway
    • Wang, Y.; Wu, J.; Lin, B.; Li, X.; Zhang, H.; Ding, H.; Chen, X.; Lan, L.; Luo, H. Galangin suppresses HepG2 cell proliferation by activating the TGF-beta receptor/Smad pathway. Toxicology 2014, 326, 9–17.
    • (2014) Toxicology , vol.326 , pp. 9-17
    • Wang, Y.1    Wu, J.2    Lin, B.3    Li, X.4    Zhang, H.5    Ding, H.6    Chen, X.7    Lan, L.8    Luo, H.9
  • 235
    • 84950286727 scopus 로고    scopus 로고
    • Galangin and kaempferol suppress phorbol-12-myristate-13-acetate-induced matrix metalloproteinase-9 expression in human fibrosarcoma HT-1080 cells
    • Choi, Y.J.; Lee, Y.H.; Lee, S.T. Galangin and kaempferol suppress phorbol-12-myristate-13-acetate-induced matrix metalloproteinase-9 expression in human fibrosarcoma HT-1080 cells. Mol. Cells 2015, 38, 151–155.
    • (2015) Mol. Cells , vol.38 , pp. 151-155
    • Choi, Y.J.1    Lee, Y.H.2    Lee, S.T.3
  • 236
    • 84884252482 scopus 로고    scopus 로고
    • Galangin induces human colon cancer cell death via the mitochondrial dysfunction and caspase-dependent pathway
    • Ha, T.K.; Kim, M.E.; Yoon, J.H.; Bae, S.J.; Yeom, J.; Lee, J.S. Galangin induces human colon cancer cell death via the mitochondrial dysfunction and caspase-dependent pathway. Exp. Biol. Med. 2013, 238, 1047–1054.
    • (2013) Exp. Biol. Med. , vol.238 , pp. 1047-1054
    • Ha, T.K.1    Kim, M.E.2    Yoon, J.H.3    Bae, S.J.4    Yeom, J.5    Lee, J.S.6
  • 237
    • 84869438296 scopus 로고    scopus 로고
    • Galangin inhibits tumor growth and metastasis of B16F10 melanoma. J
    • Zhang, W.; Tang, B.; Huang, Q.; Hua, Z. Galangin inhibits tumor growth and metastasis of B16F10 melanoma. J. Cell. Biochem. 2013, 114, 152–161.
    • (2013) Cell. Biochem , vol.114 , pp. 152-161
    • Zhang, W.1    Tang, B.2    Huang, Q.3    Hua, Z.4
  • 238
    • 84889792617 scopus 로고    scopus 로고
    • Antioxidant activity of Coriandrum sativum and protection against DNA damage and cancer cell migration. BMC Complement. Altern
    • Tang, E.L.; Rajarajeswaran, J.; Fung, S.Y.; Kanthimathi, M.S. Antioxidant activity of Coriandrum sativum and protection against DNA damage and cancer cell migration. BMC Complement. Altern. Med. 2013, 13, 347.
    • (2013) Med , vol.13 , pp. 347
    • Tang, E.L.1    Rajarajeswaran, J.2    Fung, S.Y.3    Kanthimathi, M.S.4
  • 239
    • 84903270561 scopus 로고    scopus 로고
    • Antitumorigenic potential of linalool is accompanied by modulation of oxidative stress: An in vivo study in sarcoma-180 solid tumor model. Nutr
    • Jana, S.; Patra, K.; Sarkar, S.; Jana, J.; Mukherjee, G.; Bhattacharjee, S.; Mandal, D.P. Antitumorigenic potential of linalool is accompanied by modulation of oxidative stress: An in vivo study in sarcoma-180 solid tumor model. Nutr. Cancer 2014, 66, 835–848.
    • (2014) Cancer , vol.66 , pp. 835-848
    • Jana, S.1    Patra, K.2    Sarkar, S.3    Jana, J.4    Mukherjee, G.5    Bhattacharjee, S.6    Mandal, D.P.7
  • 240
    • 84903316702 scopus 로고    scopus 로고
    • Wasabi-derived 6-(Methylsulfinyl)hexyl isothiocyanate induces apoptosis in human breast cancer by possible involvement of the NF-kappa b pathways. Nutr
    • Fuke, Y.; Hishinuma, M.; Namikawa, M.; Oishi, Y.; Matsuzaki, T. Wasabi-derived 6-(methylsulfinyl)hexyl isothiocyanate induces apoptosis in human breast cancer by possible involvement of the NF-kappa b pathways. Nutr. Cancer 2014, 66, 879–887.
    • (2014) Cancer , vol.66 , pp. 879-887
    • Fuke, Y.1    Hishinuma, M.2    Namikawa, M.3    Oishi, Y.4    Matsuzaki, T.5
  • 241
    • 84904723084 scopus 로고    scopus 로고
    • Research on tumorigenicity of cinnamaldehyde in melanoma cell lines and its mechanism
    • Zhou, L.; Lu, Y.; Yang, G.; Wu, J. Research on tumorigenicity of cinnamaldehyde in melanoma cell lines and its mechanism. Tumour Biol. 2014, 35, 5717–5722.
    • (2014) Tumour Biol , vol.35 , pp. 5717-5722
    • Zhou, L.1    Lu, Y.2    Yang, G.3    Wu, J.4
  • 242
    • 84898486411 scopus 로고    scopus 로고
    • Cinnamon polyphenols attenuate the hydrogen peroxide-induced down regulation of S100beta secretion by regulating sirtuin 1 in C6 rat glioma cells
    • Qin, B.; Panickar, K.S.; Anderson, R.A. Cinnamon polyphenols attenuate the hydrogen peroxide-induced down regulation of S100beta secretion by regulating sirtuin 1 in C6 rat glioma cells. Life Sci. 2014, 102, 72–79.
    • (2014) Life Sci , vol.102 , pp. 72-79
    • Qin, B.1    Panickar, K.S.2    Anderson, R.A.3
  • 243
    • 84893877683 scopus 로고    scopus 로고
    • Cinnamaldehyde/chemotherapeutic agents interaction and drug-metabolizing genes in colorectal cancer. Mol. Med
    • Yu, C.; Liu, S.L.; Qi, M.H.; Zou, X. Cinnamaldehyde/chemotherapeutic agents interaction and drug-metabolizing genes in colorectal cancer. Mol. Med. Rep. 2014, 9, 669–676.
    • (2014) Rep , vol.9 , pp. 669-676
    • Yu, C.1    Liu, S.L.2    Qi, M.H.3    Zou, X.4
  • 244
    • 84942909759 scopus 로고    scopus 로고
    • Chen, H.; et al. A novel cinnamon-related natural product with pim-1 inhibitory activity inhibits leukemia and skin cancer
    • Kim, J.E.; Son, J.E.; Jeong, H.; Kim, D.J.; Seo, S.G.; Lee, E.; Lim, T.G.; Kim, J.R.; Kimbung, Y.R.; Chen, H.; et al. A novel cinnamon-related natural product with pim-1 inhibitory activity inhibits leukemia and skin cancer. Cancer Res. 2015, 75, 2716–2728.
    • (2015) Cancer Res , vol.75 , pp. 2716-2728
    • Kim, J.E.1    Son, J.E.2    Jeong, H.3    Kim, D.J.4    Seo, S.G.5    Lee, E.6    Lim, T.G.7    Kim, J.R.8    Kimbung, Y.R.9
  • 245
    • 84923314613 scopus 로고    scopus 로고
    • Zeylanicum aqueous extract induced apoptosis in the human myelocytic leukemia cell line (THP-1)
    • Assadollahi, V.; Gholami, M.; Zendedel, A. C. Zeylanicum aqueous extract induced apoptosis in the human myelocytic leukemia cell line (THP-1). Bratisl. Med. J. 2015, 116, 132–135.
    • (2015) Bratisl. Med. J , vol.116 , pp. 132-135
    • Assadollahi, V.1    Gholami, M.2    Zendedel, A.C.3
  • 246
    • 84908316861 scopus 로고    scopus 로고
    • Beta-Caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase
    • Kim, C.; Cho, S.K.; Kapoor, S.; Kumar, A.; Vali, S.; Abbasi, T.; Kim, S.H.; Sethi, G.; Ahn, K.S. Beta-Caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase. Mol. Carcinog. 2014, 53, 793–806.
    • (2014) Mol. Carcinog , vol.53 , pp. 793-806
    • Kim, C.1    Cho, S.K.2    Kapoor, S.3    Kumar, A.4    Vali, S.5    Abbasi, T.6    Kim, S.H.7    Sethi, G.8    Ahn, K.S.9
  • 247
    • 84938839462 scopus 로고    scopus 로고
    • Carvacrol inhibits proliferation and induces apoptosis in human colon cancer cells
    • Fan, K.; Li, X.; Cao, Y.; Qi, H.; Li, L.; Zhang, Q.; Sun, H. Carvacrol inhibits proliferation and induces apoptosis in human colon cancer cells. Anticancer Drugs 2015, 26, 813–823.
    • (2015) Anticancer Drugs , vol.26 , pp. 813-823
    • Fan, K.1    Li, X.2    Cao, Y.3    Qi, H.4    Li, L.5    Zhang, Q.6    Sun, H.7
  • 248
    • 84866131393 scopus 로고    scopus 로고
    • Antioxidative effects of the spice cardamom against non-melanoma skin cancer by modulating nuclear factor erythroid-2-related factor 2 and NF-kappa B signalling pathways
    • Das, I.; Acharya, A.; Berry, D.L.; Sen, S.; Williams, E.; Permaul, E.; Sengupta, A.; Bhattacharya, S.; Saha, T. Antioxidative effects of the spice cardamom against non-melanoma skin cancer by modulating nuclear factor erythroid-2-related factor 2 and NF-kappa B signalling pathways. Br. J. Nutr. 2012, 108, 984–997.
    • (2012) Br. J. Nutr. , vol.108 , pp. 984-997
    • Das, I.1    Acharya, A.2    Berry, D.L.3    Sen, S.4    Williams, E.5    Permaul, E.6    Sengupta, A.7    Bhattacharya, S.8    Saha, T.9
  • 249
    • 84932083144 scopus 로고    scopus 로고
    • Chemopreventive effect of cardamom (Elettaria cardamomum L.) against benzo(alpha)pyrene-induced forestomach papillomagenesis in Swiss Albino mice
    • Qiblawi, S.; Dhanarasu, S.; Faris, M.A. Chemopreventive effect of cardamom (Elettaria cardamomum L.) against benzo(alpha)pyrene-induced forestomach papillomagenesis in Swiss Albino mice. J. Environ. Pathol. Toxicol. Oncol. 2015, 34, 95–104.
    • (2015) J. Environ. Pathol. Toxicol. Oncol , vol.34 , pp. 95-104
    • Qiblawi, S.1    Dhanarasu, S.2    Faris, M.A.3
  • 251
    • 84863630617 scopus 로고    scopus 로고
    • Monascuspiloin enhances the radiation sensitivity of human prostate cancer cells by stimulating endoplasmic reticulum stress and inducing autophagy
    • Chiu, H.W.; Fang, W.H.; Chen, Y.L.; Wu, M.D.; Yuan, G.F.; Ho, S.Y.; Wang, Y.J. Monascuspiloin enhances the radiation sensitivity of human prostate cancer cells by stimulating endoplasmic reticulum stress and inducing autophagy. PLoS ONE 2012, 7, e40462.
    • (2012) Plos ONE , pp. 7
    • Chiu, H.W.1    Fang, W.H.2    Chen, Y.L.3    Wu, M.D.4    Yuan, G.F.5    Ho, S.Y.6    Wang, Y.J.7
  • 252
    • 84891396722 scopus 로고    scopus 로고
    • Dichamanetin inhibits cancer cell growth by affecting ROS-related signaling components through mitochondrial-mediated apoptosis
    • Yong, Y.; Matthew, S.; Wittwer, J.; Pan, L.; Shen, Q.; Kinghorn, A.D.; Swanson, S.M.; de Blanco, E. Dichamanetin inhibits cancer cell growth by affecting ROS-related signaling components through mitochondrial-mediated apoptosis. Anticancer Res. 2013, 33, 5349–5355.
    • (2013) Anticancer Res , vol.33 , pp. 5349-5355
    • Yong, Y.1    Matthew, S.2    Wittwer, J.3    Pan, L.4    Shen, Q.5    Kinghorn, A.D.6    Swanson, S.M.7    De Blanco, E.8
  • 253
    • 84941315899 scopus 로고    scopus 로고
    • Chemopreventive and immunomodulatory effects of Murraya koenigii aqueous extract on 4T1 breast cancer cell-challenged mice. BMC Complement
    • Yeap, S.K.; Abu, N.; Mohamad, N.E.; Beh, B.K.; Ho, W.Y.; Ebrahimi, S.; Yusof, H.M.; Ky, H.; Tan, S.W.; Alitheen, N.B. Chemopreventive and immunomodulatory effects of Murraya koenigii aqueous extract on 4T1 breast cancer cell-challenged mice. BMC Complement. Altern. Med. 2015, 15, 306.
    • (2015) Altern. Med , vol.15 , pp. 306
    • Yeap, S.K.1    Abu, N.2    Mohamad, N.E.3    Beh, B.K.4    Ho, W.Y.5    Ebrahimi, S.6    Yusof, H.M.7    Ky, H.8    Tan, S.W.9    Alitheen, N.B.10
  • 255
    • 84893973489 scopus 로고    scopus 로고
    • Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: The golden pigment from golden spice. Cancer Res
    • Prasad, S.; Tyagi, A.K.; Aggarwal, B.B. Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: The golden pigment from golden spice. Cancer Res. Treat. 2014, 46, 2–18.
    • (2014) Treat , vol.46 , pp. 2-18
    • Prasad, S.1    Tyagi, A.K.2    Aggarwal, B.B.3
  • 256
    • 84940584013 scopus 로고    scopus 로고
    • Pharmacokinetic plasma behaviors of intravenous and oral bioavailability of thymoquinone in a rabbit model
    • Alkharfy, K.M.; Ahmad, A.; Khan, R.; Al-Shagha, W.M. Pharmacokinetic plasma behaviors of intravenous and oral bioavailability of thymoquinone in a rabbit model. J. Drug Metab. 2015, 40, 319–323.
    • (2015) J. Drug Metab , vol.40 , pp. 319-323
    • Alkharfy, K.M.1    Ahmad, A.2    Khan, R.3    Al-Shagha, W.M.4
  • 257
    • 84959010432 scopus 로고    scopus 로고
    • How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies. Sci
    • Shen, L.; Liu, C.C.; An, C.Y.; Ji, H.F. How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies. Sci. Rep. 2016, 6, 20872.
    • (2016) Rep , vol.6 , pp. 20872
    • Shen, L.1    Liu, C.C.2    An, C.Y.3    Ji, H.F.4
  • 258
    • 84948468486 scopus 로고    scopus 로고
    • Molecular complexation of curcumin with pH sensitive cationic copolymer enhances the aqueous solubility, stability and bioavailability of curcumin
    • Kumar, S.; Kesharwani, S.S.; Mathur, H.; Tyagi, M.; Bhat, G.J.; Tummala, H. Molecular complexation of curcumin with pH sensitive cationic copolymer enhances the aqueous solubility, stability and bioavailability of curcumin. Eur. J. Pharm. Sci. 2016, 82, 86–96.
    • (2016) Eur. J. Pharm. Sci. , vol.82 , pp. 86-96
    • Kumar, S.1    Kesharwani, S.S.2    Mathur, H.3    Tyagi, M.4    Bhat, G.J.5    Tummala, H.6
  • 259
    • 84954316669 scopus 로고    scopus 로고
    • Curcumin-loaded lipid nanocarrier for improving bioavailability, stability and cytotoxicity against malignant glioma cells
    • Kumar, A.; Ahuja, A.; Ali, J.; Baboota, S. Curcumin-loaded lipid nanocarrier for improving bioavailability, stability and cytotoxicity against malignant glioma cells. Drug Deliv. 2016, 23, 214–229.
    • (2016) Drug Deliv , vol.23 , pp. 214-229
    • Kumar, A.1    Ahuja, A.2    Ali, J.3    Baboota, S.4
  • 260
    • 84930340065 scopus 로고    scopus 로고
    • Microparticles containing curcumin solid dispersion: Stability, bioavailability and anti-Inflammatory activity
    • Teixeira, C.; Mendonca, L.M.; Bergamaschi, M.M.; Queiroz, R.; Souza, G.; Antunes, L.; Freitas, L. Microparticles containing curcumin solid dispersion: Stability, bioavailability and anti-Inflammatory activity. AAPS PharmSciTech 2016, 17, 252–261.
    • (2016) AAPS Pharmscitech , vol.17 , pp. 252-261
    • Teixeira, C.1    Mendonca, L.M.2    Bergamaschi, M.M.3    Queiroz, R.4    Souza, G.5    Antunes, L.6    Freitas, L.7
  • 261
    • 84982277715 scopus 로고    scopus 로고
    • Evidence for anti-tumor activity and improved bioavailability of a novel curcumin analog-CDF against pancreatic tumors in vivo
    • Banerjee, S.; Ali, S.; Wang, Z.; Azmi, A.; Ahmad, A.; Padhye, S.; Sarkar, F.H. Evidence for anti-tumor activity and improved bioavailability of a novel curcumin analog-CDF against pancreatic tumors in vivo. Pancreas 2010, 39, 1309–1310.
    • (2010) Pancreas , vol.39 , pp. 1309-1310
    • Banerjee, S.1    Ali, S.2    Wang, Z.3    Azmi, A.4    Ahmad, A.5    Padhye, S.6    Sarkar, F.H.7
  • 262
    • 84982277711 scopus 로고    scopus 로고
    • Novel analogs of dietary thymoquinone with superior bioavailability and anti-tumor activity against GI cancers
    • Azmi, A.S.; Padhye, S.; Banerjee, S.; Aboukameel, A.; Sarkar, F.H.; Mohammad, R.M. Novel analogs of dietary thymoquinone with superior bioavailability and anti-tumor activity against GI cancers. Cancer Res. 2011, 7, 3706.
    • (2011) Cancer Res , vol.7 , pp. 3706
    • Azmi, A.S.1    Padhye, S.2    Banerjee, S.3    Aboukameel, A.4    Sarkar, F.H.5    Mohammad, R.M.6
  • 263
    • 84885672996 scopus 로고    scopus 로고
    • Improving the therapeutic efficiency of ginger extract for treatment of colon cancer using a suitably designed multiparticulate system
    • Deol, P.K.; Kaur, I.P. Improving the therapeutic efficiency of ginger extract for treatment of colon cancer using a suitably designed multiparticulate system. J. Drug Target. 2013, 21, 855–865.
    • (2013) J. Drug Target , vol.21 , pp. 855-865
    • Deol, P.K.1    Kaur, I.P.2
  • 266
    • 84926482859 scopus 로고    scopus 로고
    • Improved oral bioavailability of capsaicin via liposomal nanoformulation: Preparation, in vitro drug release and pharmacokinetics in rats
    • Zhu, Y.; Wang, M.M.; Zhang, J.J.; Peng, W.; Firempong, C.K.; Deng, W.W.; Wang, Q.L.; Wang, S.C.; Shi, F.; Yu, J.N.; et al. Improved oral bioavailability of capsaicin via liposomal nanoformulation: Preparation, in vitro drug release and pharmacokinetics in rats. Arch. Pharm. Res. 2015, 38, 512–521.
    • (2015) Arch. Pharm. Res. , vol.38 , pp. 512-521
    • Zhu, Y.1    Wang, M.M.2    Zhang, J.J.3    Peng, W.4    Firempong, C.K.5    Deng, W.W.6    Wang, Q.L.7    Wang, S.C.8    Shi, F.9    Yu, J.N.10
  • 267
    • 84899969642 scopus 로고    scopus 로고
    • Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: Preparation, in vitro and in vivo evaluation
    • Zhu, Y.; Peng, W.; Zhang, J.J.; Wang, M.M.; Firempong, C.K.; Feng, C.L.; Liu, H.F.; Xu, X.M.; Yu, J.N. Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: Preparation, in vitro and in vivo evaluation. J. Funct. Foods 2014, 8, 358–366.
    • (2014) J. Funct. Foods , vol.8 , pp. 358-366
    • Zhu, Y.1    Peng, W.2    Zhang, J.J.3    Wang, M.M.4    Firempong, C.K.5    Feng, C.L.6    Liu, H.F.7    Xu, X.M.8    Yu, J.N.9
  • 268
    • 84941275340 scopus 로고    scopus 로고
    • Enhanced oral bioavailability of piperine by self-emulsifying drug delivery systems: In vitro, in vivo and in situ intestinal permeability studies
    • Shao, B.; Cui, C.; Ji, H.Y.; Tang, J.L.; Wang, Z.Y.; Liu, H.M.; Qin, M.N.; Li, X.; Wu, L.H. Enhanced oral bioavailability of piperine by self-emulsifying drug delivery systems: In vitro, in vivo and in situ intestinal permeability studies. Drug Deliv. 2015, 22, 740–747.
    • (2015) Drug Deliv , vol.22 , pp. 740-747
    • Shao, B.1    Cui, C.2    Ji, H.Y.3    Tang, J.L.4    Wang, Z.Y.5    Liu, H.M.6    Qin, M.N.7    Li, X.8    Wu, L.H.9
  • 269
    • 53449094405 scopus 로고    scopus 로고
    • Anticancer and carcinogenic properties of curcumin: Considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent. Mol. Nutr
    • Lopez-Lazaro, M. Anticancer and carcinogenic properties of curcumin: Considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent. Mol. Nutr. Food Res. 2008, 52 (Suppl. 1), S103–S127.
    • (2008) Food Res , vol.52 , pp. S103-S127
    • Lopez-Lazaro, M.1
  • 270
    • 0032512698 scopus 로고    scopus 로고
    • Strand scission in DNA induced by curcumin in the presence of Cu(II)
    • Ahsan, H.; Hadi, S.M. Strand scission in DNA induced by curcumin in the presence of Cu(II). Cancer Lett. 1998, 124, 23–30.
    • (1998) Cancer Lett , vol.124 , pp. 23-30
    • Ahsan, H.1    Hadi, S.M.2
  • 272
    • 1842784609 scopus 로고    scopus 로고
    • Degradation of the natural mutagenic compound safrole in spices by cooking and irradiation
    • Farag, S.E.; Abo-Zeid, M. Degradation of the natural mutagenic compound safrole in spices by cooking and irradiation. Nahrung 1997, 41, 359–361.
    • (1997) Nahrung , vol.41 , pp. 359-361
    • Farag, S.E.1    Abo-Zeid, M.2
  • 274
    • 0030978825 scopus 로고    scopus 로고
    • Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot
    • Bordia, A.; Verma, S.K.; Srivastava, K.C. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot. Essent. 1997, 56, 379–384.
    • (1997) Essent , vol.56 , pp. 379-384
    • Bordia, A.1    Verma, S.K.2    Srivastava, K.C.3
  • 275
    • 0025312180 scopus 로고
    • Spontaneous spinal epidural hematoma with associated platelet dysfunction from excessive garlic ingestion
    • Rose, K.D.; Croissant, P.D.; Parliament, C.F.; Levin, M.B. Spontaneous spinal epidural hematoma with associated platelet dysfunction from excessive garlic ingestion: A case report. Neurosurgery 1990, 26, 880–882.
    • (1990) A Case Report. Neurosurgery , vol.26 , pp. 880-882
    • Rose, K.D.1    Croissant, P.D.2    Parliament, C.F.3    Levin, M.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.