Safranal, a Crocus sativus L constituent suppresses the growth of K-562 cells of chronic myelogenous leukemia. In silico and in vitro study

Food and Chemical Toxicology

Volumn 74, Issue , 2014, Pages 45-50

  Geromichalos, George D ^a   Papadopoulos, Theophanis ^b   Sahpazidou, Despina ^a   Sinakos, Zacharias ^c  

^a THEAGENIO CANCER HOSPITAL   (Greece)

^b Laboratory of Molecular Biology and Genetics Karyo Center   (Greece)

^c ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Bcr Abl gene expression; Cytotoxicity; In silico molecular docking; K 562 cells; XTT assay

Indexed keywords

ANTILEUKEMIC AGENT; BCR ABL PROTEIN; CROCIN; IMATINIB; PLANT MEDICINAL PRODUCT; SAFRANAL; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; CAROTENOID; CYCLOHEXENE DERIVATIVE; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TERPENE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BCR ABL GENE; CANCER GROWTH; CANCER INHIBITION; CHRONIC MYELOID LEUKEMIA; COMPUTER MODEL; CONTROLLED STUDY; CROCUS SATIVUS; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; GENE EXPRESSION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; K562 CELL LINE; MOLECULAR DOCKING; PROTEIN FUNCTION; BIOSYNTHESIS; COMPUTER SIMULATION; CROCUS; DRUG EFFECTS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; METABOLISM; TUMOR CELL LINE;

CROCUS SATIVUS;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BENZAMIDES; CAROTENOIDS; CELL LINE, TUMOR; COMPUTER SIMULATION; CROCUS; CYCLOHEXENES; FUSION PROTEINS, BCR-ABL; GENE EXPRESSION; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MOLECULAR DOCKING SIMULATION; PIPERAZINES; PYRIMIDINES; TERPENES;

EID: 84907828121     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.09.001     Document Type: Article

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