Co-administration of piperine and docetaxel results in improved anti-tumor efficacy via inhibition of CYP3A4 activity

Prostate

Volumn 72, Issue 6, 2012, Pages 661-667

  Makhov, Peter ^a,b   Golovine, Konstantin ^a   Canter, Daniel ^a   Kutikov, Alexander ^a   Simhan, Jay ^a   Corlew, Melany M ^b   Uzzo, Robert G ^a   Kolenko, Vladimir M ^a,b  

^a FOX CHASE CANCER CENTER   (United States)

^b Wolfe Laboratories Inc   (United States)

Author keywords

cancer; docetaxel; piperine; prostate

Indexed keywords

CYTOCHROME P450 3A4; DOCETAXEL; PIPERINE;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CASTRATION RESISTANT PROSTATE CANCER; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFICACY; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENTIATION; DRUG TRANSPORT; DRUG USE; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INHIBITION; FLUORESCENCE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ALKALOIDS; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BENZODIOXOLES; CYTOCHROME P-450 CYP3A; DRUG INTERACTIONS; MALE; MICE; PIPERIDINES; POLYUNSATURATED ALKAMIDES; PROSTATIC NEOPLASMS; TAXOIDS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84858753896     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.21469     Document Type: Article

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