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Volumn 33, Issue 2, 2014, Pages 173-180

EGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors

Author keywords

EGFR; MPNST; NF1; sarcoma; STAT3

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; JANUS KINASE 2; SHORT HAIRPIN RNA; STAT3 PROTEIN;

EID: 84891940023     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.579     Document Type: Article
Times cited : (79)

References (42)
  • 1
    • 67649388216 scopus 로고    scopus 로고
    • Current status of sporadic and neurofibromatosis type-Associated malignant peripheral nerve sheath tumors
    • Widemann BC. Current status of sporadic and neurofibromatosis type-Associated malignant peripheral nerve sheath tumors. Curr Oncol Rep 2009; 11: 322-328
    • (2009) Curr Oncol Rep , vol.11 , pp. 322-328
    • Widemann, B.C.1
  • 3
    • 0036494640 scopus 로고    scopus 로고
    • International consensus statement on malignant peripheral nerve sheath tumors in neurofibromatosis
    • Ferner RE, Gutmann DH. International consensus statement on malignant peripheral nerve sheath tumors in neurofibromatosis. Cancer Res 2002; 62: 1573-1577
    • (2002) Cancer Res , vol.62 , pp. 1573-1577
    • Ferner, R.E.1    Gutmann, D.H.2
  • 4
    • 22544487213 scopus 로고    scopus 로고
    • Association between benign and malignant peripheral nerve sheath tumors in NF1
    • Tucker T, Wolkenstein P, Revuz J, Zeller J, Friedman JM. Association between benign and malignant peripheral nerve sheath tumors in NF1. Neurology 2005; 65: 205-211
    • (2005) Neurology , vol.65 , pp. 205-211
    • Tucker, T.1    Wolkenstein, P.2    Revuz, J.3    Zeller, J.4    Friedman, J.M.5
  • 5
    • 33846319400 scopus 로고    scopus 로고
    • Neurofibromatosis 1
    • Ferner RE. Neurofibromatosis 1. Eur J Hum Genet 2007; 15: 131-138
    • (2007) Eur J Hum Genet , vol.15 , pp. 131-138
    • Ferner, R.E.1
  • 6
    • 56749139735 scopus 로고    scopus 로고
    • How does the Schwann cell lineage form tumors in NF1?
    • Carroll SL, Ratner N. How does the Schwann cell lineage form tumors in NF1? Glia 2008; 56: 1590-1605
    • (2008) Glia , vol.56 , pp. 1590-1605
    • Carroll, S.L.1    Ratner, N.2
  • 7
    • 77951761066 scopus 로고    scopus 로고
    • Malignant peripheral nerve sheath tumour (MPNST): The clinical implications of cellular signalling pathways
    • Katz D, Lazar A, Lev D. Malignant peripheral nerve sheath tumour (MPNST): The clinical implications of cellular signalling pathways. Expert Rev Mol Med 2009; 11: E30
    • (2009) Expert Rev Mol Med , vol.11
    • Katz, D.1    Lazar, A.2    Lev, D.3
  • 8
    • 75449103584 scopus 로고    scopus 로고
    • Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene
    • Miller SJ, Jessen WJ, Mehta T, Hardiman A, Sites E, Kaiser S et al. Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene. EMBO Mol Med 2009; 1: 236-248
    • (2009) EMBO Mol Med , vol.1 , pp. 236-248
    • Miller, S.J.1    Jessen, W.J.2    Mehta, T.3    Hardiman, A.4    Sites, E.5    Kaiser, S.6
  • 11
    • 38549102668 scopus 로고    scopus 로고
    • The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells
    • Joseph NM, Mosher JT, Buchstaller J, Snider P, McKeever PE, Lim M et al. The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell 2008; 13: 129-140
    • (2008) Cancer Cell , vol.13 , pp. 129-140
    • Joseph, N.M.1    Mosher, J.T.2    Buchstaller, J.3    Snider, P.4    McKeever, P.E.5    Lim, M.6
  • 12
    • 84856994155 scopus 로고    scopus 로고
    • Oncogene mutation survey in MPNST cell lines enhances the dominant role of hyperactive Ras in NF1 associated pro-survival and malignancy
    • Sun D, Tainsky MA, Haddad R. Oncogene mutation survey in MPNST cell lines enhances the dominant role of hyperactive Ras in NF1 associated pro-survival and malignancy. Transl Oncogenomics 2012; 5: 1-7
    • (2012) Transl Oncogenomics , vol.5 , pp. 1-7
    • Sun, D.1    Tainsky, M.A.2    Haddad, R.3
  • 13
    • 0034773992 scopus 로고    scopus 로고
    • The EGFR family and its ligands in human cancer. Signalling mechanisms and therapeutic opportunities
    • Suppl
    • Yarden Y. The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. Eur J Cancer 2001; 37(Suppl): S3-S8
    • (2001) Eur J Cancer , vol.37
    • Yarden, Y.1
  • 14
    • 0034102193 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression in neurofibromatosis type-1 related tumors and NF1 animal models
    • DeClue JE, Heffelfinger S, Benvenuto G, Ling B, Li S, Rui W et al. Epidermal growth factor receptor expression in neurofibromatosis type-1 related tumors and NF1 animal models. J Clin Invest 2000; 105: 1-10
    • (2000) J Clin Invest , vol.105 , pp. 1-10
    • DeClue, J.E.1    Heffelfinger, S.2    Benvenuto, G.3    Ling, B.4    Li, S.5    Rui, W.6
  • 15
    • 0036682199 scopus 로고    scopus 로고
    • Epidermal growth factor receptor signaling pathways are associated with tumorigenesis in the Nf1:p53 mouse tumor model
    • Li H, Velasco-Miguel S, Vass W, Parada L, DeClue J. Epidermal growth factor receptor signaling pathways are associated with tumorigenesis in the Nf1:p53 mouse tumor model. Cancer Res 2002; 62: 4507-4513
    • (2002) Cancer Res , vol.62 , pp. 4507-4513
    • Li, H.1    Velasco-Miguel, S.2    Vass, W.3    Parada, L.4    DeClue, J.5
  • 16
    • 0036330022 scopus 로고    scopus 로고
    • Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms
    • Perry A, Kunz S, Fuller C, Banerjee R, Marley E, Liapis H et al. Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms. J Neuropathol Exp Neurol 2002; 61: 702-709
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 702-709
    • Perry, A.1    Kunz, S.2    Fuller, C.3    Banerjee, R.4    Marley, E.5    Liapis, H.6
  • 17
    • 0042092519 scopus 로고    scopus 로고
    • Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line
    • Frohnert PW, Stonecypher MS, Carroll SL. Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line. Glia 2003; 43: 104-118
    • (2003) Glia , vol.43 , pp. 104-118
    • Frohnert, P.W.1    Stonecypher, M.S.2    Carroll, S.L.3
  • 18
    • 69249240322 scopus 로고    scopus 로고
    • Expression and significance of EGFR in malignant peripheral nerve sheath tumor
    • Keizman D, Issakov J, Meller I, Maimon N, Ish-Shalom M, Sher O et al. Expression and significance of EGFR in malignant peripheral nerve sheath tumor. J Neurooncol 2009; 94: 383-388
    • (2009) J Neurooncol , vol.94 , pp. 383-388
    • Keizman, D.1    Issakov, J.2    Meller, I.3    Maimon, N.4    Ish-Shalom, M.5    Sher, O.6
  • 19
    • 0028344729 scopus 로고
    • The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase
    • Luetteke N, Phillips H, Qiu T, Copeland N, Earp H, Jenkins N et al. The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev 1994; 8: 399-413
    • (1994) Genes Dev , vol.8 , pp. 399-413
    • Luetteke, N.1    Phillips, H.2    Qiu, T.3    Copeland, N.4    Earp, H.5    Jenkins, N.6
  • 20
    • 19944430338 scopus 로고    scopus 로고
    • Role for the epidermal growth factor receptor in neurofibromatosis- related peripheral nerve tumorigenesis
    • Ling B, Wu J, Miller S, Monk K, Shamekh R, Rizvi T et al. Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis. Cancer Cell 2005; 7: 65-75
    • (2005) Cancer Cell , vol.7 , pp. 65-75
    • Ling, B.1    Wu, J.2    Miller, S.3    Monk, K.4    Shamekh, R.5    Rizvi, T.6
  • 21
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: A leading role for STAT3. Nat Rev Cancer 2009; 9: 798-809
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 22
    • 0036625960 scopus 로고    scopus 로고
    • The role of STAT3 in apoptosis
    • Battle TE, Frank DA. The role of STAT3 in apoptosis. Curr Mol Med 2002; 2: 381-392
    • (2002) Curr Mol Med , vol.2 , pp. 381-392
    • Battle, T.E.1    Frank, D.A.2
  • 23
    • 38849086135 scopus 로고    scopus 로고
    • The EGFR-STAT3 oncogenic pathway upregulates the Eme1 endonuclease to reduce DNA damage after topoisomerase I inhibition
    • Vigneron A, Gamelin E, Coqueret O. The EGFR-STAT3 oncogenic pathway upregulates the Eme1 endonuclease to reduce DNA damage after topoisomerase I inhibition. Cancer Res 2008; 68: 815-825
    • (2008) Cancer Res , vol.68 , pp. 815-825
    • Vigneron, A.1    Gamelin, E.2    Coqueret, O.3
  • 24
    • 70350212976 scopus 로고    scopus 로고
    • STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells
    • Sherry MM, Reeves A, Wu JK, Cochran BH. STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells 2009; 27: 2383-2392
    • (2009) Stem Cells , vol.27 , pp. 2383-2392
    • Sherry, M.M.1    Reeves, A.2    Wu, J.K.3    Cochran, B.H.4
  • 25
    • 76749138483 scopus 로고    scopus 로고
    • The neurofibromatosis type 1 tumor suppressor controls cell growth by regulating signal transducer and activator of transcription-3 activity in vitro and in vivo
    • Banerjee S, Byrd JN, Gianino SM, Harpstrite SE, Rodriguez FJ, Tuskan RG et al. The neurofibromatosis type 1 tumor suppressor controls cell growth by regulating signal transducer and activator of transcription-3 activity in vitro and in vivo. Cancer Res 2010; 70: 1356-1366
    • (2010) Cancer Res , vol.70 , pp. 1356-1366
    • Banerjee, S.1    Byrd, J.N.2    Gianino, S.M.3    Harpstrite, S.E.4    Rodriguez, F.J.5    Tuskan, R.G.6
  • 26
    • 77950190311 scopus 로고    scopus 로고
    • Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells
    • Lin L, Hutzen B, Zuo M, Ball S, Deangelis S, Foust E et al. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res 2010; 70: 2445-2454
    • (2010) Cancer Res , vol.70 , pp. 2445-2454
    • Lin, L.1    Hutzen, B.2    Zuo, M.3    Ball, S.4    Deangelis, S.5    Foust, E.6
  • 27
    • 38549108007 scopus 로고    scopus 로고
    • Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells
    • Wu J, Williams JP, Rizvi TA, Kordich JJ, Witte D, Meijer D et al. Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells. Cancer Cell 2008; 13: 105-116
    • (2008) Cancer Cell , vol.13 , pp. 105-116
    • Wu, J.1    Williams, J.P.2    Rizvi, T.A.3    Kordich, J.J.4    Witte, D.5    Meijer, D.6
  • 30
    • 31544475397 scopus 로고    scopus 로고
    • An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model
    • Reilly KM, Broman KW, Bronson RT, Tsang S, Loisel DA, Christy ES et al. An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model. Cancer Res 2006; 66: 62-68
    • (2006) Cancer Res , vol.66 , pp. 62-68
    • Reilly, K.M.1    Broman, K.W.2    Bronson, R.T.3    Tsang, S.4    Loisel, D.A.5    Christy, E.S.6
  • 31
    • 4444260352 scopus 로고    scopus 로고
    • Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects
    • Reilly KM, Tuskan RG, Christy E, Loisel DA, Ledger J, Bronson RT et al. Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects. Proc Natl Acad Sci USA 2004; 101: 13008-13013
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13008-13013
    • Reilly, K.M.1    Tuskan, R.G.2    Christy, E.3    Loisel, D.A.4    Ledger, J.5    Bronson, R.T.6
  • 33
    • 79959226237 scopus 로고    scopus 로고
    • Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors
    • Torres KE, Zhu QS, Bill K, Lopez G, Ghadimi MP, Xie X et al. Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors. Clin Cancer Res 2011; 17: 3943-3955
    • (2011) Clin Cancer Res , vol.17 , pp. 3943-3955
    • Torres, K.E.1    Zhu, Q.S.2    Bill, K.3    Lopez, G.4    Ghadimi, M.P.5    Xie, X.6
  • 34
    • 0043175471 scopus 로고    scopus 로고
    • Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor
    • Shao H, Cheng HY, Cook RG, Tweardy DJ. Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor. Cancer Res 2003; 63: 3923-3930
    • (2003) Cancer Res , vol.63 , pp. 3923-3930
    • Shao, H.1    Cheng, H.Y.2    Cook, R.G.3    Tweardy, D.J.4
  • 35
    • 79953761842 scopus 로고    scopus 로고
    • Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression
    • Fukuda A, Wang S, Morris 4th JP, Folias A, Liou A, Kim G et al. Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression. Cancer Cell 2011; 19: 441-455
    • (2011) Cancer Cell , vol.19 , pp. 441-455
    • Fukuda, A.1    Wang, S.2    Morris IV, J.P.3    Folias, A.4    Liou, A.5    Kim, G.6
  • 36
    • 79953756112 scopus 로고    scopus 로고
    • Stat3/ Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
    • Lesina M, Kurkowski M, Ludes K, Rose-John S, Treiber M, KlÖ ppel G et al. Stat3/ Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell 2011; 19: 456-469
    • (2011) Cancer Cell , vol.19 , pp. 456-469
    • Lesina, M.1    Kurkowski, M.2    Ludes, K.3    Rose-John, S.4    Treiber, M.5    KlÖppel, G.6
  • 37
    • 79953757100 scopus 로고    scopus 로고
    • Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3
    • Guryanova O, Wu Q, Cheng L, Lathia J, Huang Z, Yang J et al. Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Cancer Cell 2011; 19: 498-511
    • (2011) Cancer Cell , vol.19 , pp. 498-511
    • Guryanova, O.1    Wu, Q.2    Cheng, L.3    Lathia, J.4    Huang, Z.5    Yang, J.6
  • 38
    • 79959956046 scopus 로고    scopus 로고
    • The JAK2/STAT3 signaling pathway is required for growth of CD44 CD24- stem cell-like breast cancer cells in human tumors
    • Marotta L, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker S et al. The JAK2/STAT3 signaling pathway is required for growth of CD44 CD24- stem cell-like breast cancer cells in human tumors. J Clin Invest 2011; 121: 2723-2735
    • (2011) J Clin Invest , vol.121 , pp. 2723-2735
    • Marotta, L.1    Almendro, V.2    Marusyk, A.3    Shipitsin, M.4    Schemme, J.5    Walker, S.6
  • 39
    • 35148832569 scopus 로고    scopus 로고
    • Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression
    • Lo HW, Hsu SC, Xia W, Cao X, Shih JY, Wei Y et al. Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Res 2007; 67: 9066-9076
    • (2007) Cancer Res , vol.67 , pp. 9066-9076
    • Lo, H.W.1    Hsu, S.C.2    Xia, W.3    Cao, X.4    Shih, J.Y.5    Wei, Y.6
  • 40
    • 33645061486 scopus 로고    scopus 로고
    • Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues
    • Miller SJ, Rangwala F, Williams J, Ackerman P, Kong S, Jegga AG et al. Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. Cancer Res 2006; 66: 2584-2591
    • (2006) Cancer Res , vol.66 , pp. 2584-2591
    • Miller, S.J.1    Rangwala, F.2    Williams, J.3    Ackerman, P.4    Kong, S.5    Jegga, A.G.6
  • 41
    • 2342570393 scopus 로고    scopus 로고
    • Genetic and phenotypic characterization of tumor cells derived from malignant peripheral nerve sheath tumors of neurofibromatosis type 1 patients
    • Frahm S, Mautner VF, Brems H, Legius E, Debiec-Rychter M, Friedrich RE et al. Genetic and phenotypic characterization of tumor cells derived from malignant peripheral nerve sheath tumors of neurofibromatosis type 1 patients. Neurobiol Dis 2004; 16: 85-91
    • (2004) Neurobiol Dis , vol.16 , pp. 85-91
    • Frahm, S.1    Mautner, V.F.2    Brems, H.3    Legius, E.4    Debiec-Rychter, M.5    Friedrich, R.E.6


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