Cytotoxic effects of crocin on MOLT-4 human leukemia cells

Journal of Complementary and Integrative Medicine

Volumn 10, Issue 1, 2013, Pages 1-8

  Rezaee, Ramin ^a   Mahmoudi, Mahmoud ^b   Abnous, Khalil ^c   Rabe, Shahrzad Zamani Taghizadeh ^b   Tabasi, Nafiseh ^b   Hashemzaei, Mahmoud ^d   Karimi, Gholamreza ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d ZABOL UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Apoptosis; Crocin; MOLT 4; Necrosis; Reactive oxygen species

Indexed keywords

CROCIN; REACTIVE OXYGEN METABOLITE; ANTINEOPLASTIC AGENT; CAROTENOID; PLANT EXTRACT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CROCUS SATIVUS; CYTOTOXICITY; DNA FRAGMENTATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MOLT 4 CELL LINE; MTT ASSAY; NECROSIS; PERCENTAGE OF APOPTOTIC CELLS; PURIFICATION; T-CELL LEUKEMIA CELL LINE; CELL SURVIVAL; CHEMISTRY; CROCUS; DRUG EFFECTS; LEUKEMIA; METABOLISM; PHYTOTHERAPY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CAROTENOIDS; CELL LINE, TUMOR; CELL SURVIVAL; CROCUS; DNA FRAGMENTATION; HUMANS; LEUKEMIA; NECROSIS; PHYTOTHERAPY; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES;

EID: 84925028423     PISSN: None     EISSN: 15533840     Source Type: Journal    
DOI: 10.1515/jcim-2013-0011     Document Type: Article

References (31)

1. Rios JL, Recio MC, Giner RM, Manez S. An update review of saffron and its active constituents. Phytother Res 1996;10:189-93.
2. Melnyk JP, Wang S, Marcone MF. Chemical and biological properties of the world's most expensive spice: Saffron. Food Res Int 2010;43:1981-9.
3. Zargari A. Medicinal plants. Tehran: Tehran University Press, 1990:574-8.
4. Gregory MJ, Menary RC, Davies NW. Effect of drying temperature and air flow on the production and retention of secondary metabolites in saffron. J Agric Food Chem 2005;53:5969-75.
5. El-Beshbishy HA, Hassan MH, Aly HA, Doghish AS, Alghaithy AA. Crocin "saffron" protects against beryllium chloride toxicity in rats through diminution of oxidative stress and enhancing gene expression of antioxidant enzymes. Ecotoxicol Environ Saf 2012;83:47-54.
6. Naghizadeh B, Mansouri SM, Mashhadian NV. Crocin attenuates cisplatin-induced renal oxidative stress in rats. Food Chem Toxicol 2010;48:2650-5.
7. Mehri S, Abnous K, Mousavi SH, Shariaty VM, Hosseinzadeh H. Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells. Cell Mol Neurobiol 2012;32:227-35.
8. Ochiai T, Soeda S, Ohno S, Tanaka H, Shoyama Y, Shimeno H. Crocin prevents the death of PC-12 cells through sphingomyelinase- ceramide signaling by increasing glutathione synthesis. Neurochem Int 2004;44:321-30.
9. Soeda S, Ochiai T, Paopong L, Tanaka H, Shoyama Y, Shimeno H. Crocin suppresses tumor necrosis factor-α-induced cell death of neuronally differentiated PC-12 cells. Life Sci 2001;69:2887-98.
10. Zheng YQ, Liu JX, Wang JN, Xu L. Effects of crocin on reperfusioninduced oxidative/nitrative injury to cerebral microvessels after global cerebral ischemia. Brain Res 2007;1138:86-94.
11. He SY, Qian ZY, Tang FT, Wen N, Xu GL, Sheng L. Effect of crocin on experimental atherosclerosis in quails and its mechanisms. Life Sci 2005;77:907-21.
12. Asdaq SM, Inamdar MN. Potential of Crocus sativus (saffron) and its constituent, crocin, as hypolipidemic and antioxidant in rats. Appl Biochem Biotechnol 2010;162:358-72.
13. Magesh V, Singh JP, Selvendiran K, Ekambaram G, Sakthisekaran D. Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies. Mol Cell Biochem 2006;287:127-35.
14. Minowada J, Ohnuma T, Moore GE. Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus- derived lymphocytes. J Natl Cancer Inst 1972;49:891.
15. Hadizadeh F, Mohajeri SA, Seifi M. Extraction and purification of crocin from saffron stigmas employing a simple and efficient crystallization method. Pak J Biol Sci 2010;13:691-8.
16. Taghizadeh Rabe SZ, Mahmoudi M, Ahi A, Emami SA. Antiproliferative effects of extracts from Iranian Artemisia species on cancer cell lines. Pharm Biol 2011;49:962-9.
17. de Lima TM, Amarante-Mendes GP, Curi R. Docosahexaenoic acid enhances the toxic effect of imatinib on Bcr-Abl expressing HL-60 cells. Toxicol In Vitro 2007;21(8):1678-85.
18. Hosseinzadeh H, Khosravan V. Anticonvulsant effects of aqueous and ethanolic extracts of Crocus sativus L. stigmas in mice. Arch Iran Med 2002;5:44-7.
19. Imenshahidi M, Hosseinzadeh H, Javadpour Y. Hypotensive effect of aqueous saffron extract (Crocus sativus l.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother Res 2010;24:990-4.
20. Amin B, Hosseinzadeh H. Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. Fitoterapia 2012;83:888-95.
21. Abdullaev FJ. Biological effects of saffron. Biofactors 1993;4:83-6.
22. Escribano J, Alonso GL, Coca-Prados M, Fernandez JA. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett 1996;100:23-30.
23. Noureini SK, Wink M. Antiproliferative effects of crocin in HepG2 cells by telomerase inhibition and hTERT down-regulation. Asian Pac J Cancer Prev 2012;13:2305-09.
24. Hoshyar R, Bathaie SZ, Sadeghizadeh M. Crocin triggers the apoptosis through increasing the Bax/Bcl-2 ratio and caspase activation in human gastric adenocarcinoma, AGS, cells. DNA Cell Biol 2013;32:50-7.
25. Sun J, Xu XM, Ni CZ, Zhang H, Li XY, Zhang CL, et al. Crocin inhibits proliferation and nucleic acid synthesis and induces apoptosis in the human tongue squamous cell carcinoma cell line Tca8113. Asian Pac J Cancer Prev 2011;12:2679-83.
26. Bakshi H, Sam S, Rozati R, Sultan P, Islam T, Rathore B, et al. DNA fragmentation and cell cycle arrest: A hallmark of apoptosis induced by crocin from Kashmiri saffron in a human pancreatic cancer cell line. Asian Pac J Cancer Prev 2010;11:675-9.
27. Aung HH, Wang CZ, Ni M, Fishbein A, Mehendale SR, Xie JT, et al. Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells. Exp Oncol 2007;29:175-80.
28. Bhushan B, Ahuja D, Verma S, Saluja S, Siddiqui S, Kapur S. Relation of cell viability and apoptosis with clinical remission following induction chemotherapy in ALL and AML. J Exp Clin Cancer Res 2007;26:313-21.
29. Hosseinzadeh H, Sadeghnia HR, Ziaee T, Danaee A. Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. J Pharm Pharm Sci 2005;8:387-93.
30. Hosseinzadeh H, Modaghegh MH, Saffari Z. Crocus sativus L. (saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle. Evid Based Complement Alternat Med 2009;6:343-50.
31. Taghdisi SM, Lavaee P, Ramezani M, Abnous K. Reversible targeting and controlled release delivery of daunorubicin to cancer cells by aptamer-wrapped carbon nanotubes. Eur J Pharm Biopharm 2011;77:200-6.