Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and-negative breast cancer cells by modulating the EGFR/HER-2 pathway

Oncogene

Volumn 29, Issue 2, 2010, Pages 285-296

  Thoennissen, N H ^a   O'Kelly, J ^a   Lu, D ^a   Iwanski, G B ^a   La, D T ^a   Abbassi, S ^a   Leiter, A ^a   Karlan, B ^a   Mehta, R ^b   Koeffler, H P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b IIT RESEARCH INSTITUTE   (United States)

Author keywords

Apoptosis; Capsaicin; Cell cycle arrest; EGFR HER 2 pathway

Indexed keywords

CAPSAICIN; CASPASE; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CASPASE GENE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL STRAIN MCF 7; CONTROLLED STUDY; CYCLIN D1 GENE; DRUG EFFECT; DRUG POTENCY; EGFR GENE; ERK GENE; FEMALE; GENE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; ONCOGENE NEU; P27KIP1 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CAPSAICIN; CELL CYCLE; CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, NUDE; MODELS, BIOLOGICAL; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

CAPSICUM FRUTESCENS; MUS;

EID: 74449084136     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.335     Document Type: Article

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