Antitumor efficacy of Piperine in the treatment of human HER2-overexpressing breast cancer cells

Food Chemistry

Volumn 141, Issue 3, 2013, Pages 2591-2599

  Do, Minh Truong ^a   Kim, Hyung Gyun ^a   Choi, Jae Ho ^a   Khanal, Tilak ^a   Park, Bong Hwan ^a   Tran, Thu Phuong ^a   Jeong, Tae Cheon ^b   Jeong, Hye Gwang ^a  

^a Chungnam National University   (South Korea)

^b Yeungnam University   (South Korea)

Author keywords

Apoptosis; FAS; HER2; Migration; MMP 9; Piperine

Indexed keywords

CELL DEATH; CELLS; CHEMICAL ACTIVATION; DISEASES; DRUG PRODUCTS; TRANSCRIPTION;

BIOACTIVE COMPONENTS; CASPASE-3 ACTIVATION; HER2; MIGRATION; MMP-9; MOLECULAR MECHANISM; PIPERINE; TRANSCRIPTIONAL LEVELS;

GENE EXPRESSION;

CASPASE 3; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FAS ANTIGEN; GELATINASE B; I KAPPA B; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PACLITAXEL; PIPERINE; PROTEIN KINASE B; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTOR AP 1;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; DRUG SENSITIZATION; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PROTEIN CLEAVAGE; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

PIPER NIGRUM;

EID: 84879244545     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2013.04.125     Document Type: Article

References (30)

1. Alli, P. M., Pinn, M. L., Jaffee, E. M., McFadden, J. M., & Kuhajda, F. P. (2005). Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice. Oncogene, 24, 39-46. (Pubitemid 40143863)
2. Amar, S., Moreno-Aspitia, A., & Perez, E. A. (2008). Issues and controversies in the treatment of HER2 positive metastatic breast cancer. Breast Cancer Research and Treatment, 109, 1-7. (Pubitemid 351538766)
3. Badache, A., & Goncalves, A. (2006). The ErbB2 signaling network asatarget for breast cancer therapy. Journal of Mammary Gland Biology and Neoplasia, 11, 13-25. (Pubitemid 44309186)
4. Bandyopadhyay, S., Zhan, R., Wang, Y., Pai, S. K., Hirota, S., Hosobe, S., et al. (2006). Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells. Cancer Research, 66, 5934-5940. (Pubitemid 43927149)
5. Bhardwaj, R. K., Glaeser, H., Becquemont, L., Klotz, U., Gupta, S. K., & Fromm, M. F. (2002). Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. Journal of Pharmacology and Experimental Therapeutics, 302, 645-650. (Pubitemid 34787231)
6. Clarke, M., Coates, A. S., Darby, S. C., Davies, C., Gelber, R. D., Godwin, J., et al. (2008). Adjuvant chemotherapy in oestrogen-receptor-poor breast cancer: Patientlevel meta-analysis of randomised trials. Lancet, 371, 29-40.
7. Doucette, C. D., Hilchie, A. L., Liwski, R., & Hoskin, D. W. (2013). Piperine, a dietary phytochemical, inhibits angiogenesis. Journal of Nutritional Biochemistry, 24, 231-239.
8. Early Breast Cancer Trialists' Collaborative Group. (2005). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials. Lancet, 365, 1687-1717.
9. Hwang, Y. P., Yun, H. J., Kim, H. G., Han, E. H., Choi, J. H., Chung, Y. C., et al. (2011). Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKCalpha/ERK1/2-dependent matrix metalloproteinase-9 expression. Toxicology Letters, 203, 9-19.
10. Hynes, N. E., & Lane, H. A. (2005). ERBB receptors and cancer: the complexity of targeted inhibitors. Nature Reviews Cancer, 5, 341-354. (Pubitemid 40637826)
11. Jemal, A., Siegel, R., Xu, J., & Ward, E. (2010). Cancer statistics, 2010. CA: A Cancer Journal for Clinicians, 60, 277-300.
12. Kakarala, M., Brenner, D. E., Korkaya, H., Cheng, C., Tazi, K., Ginestier, C., et al. (2010). Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast Cancer Research and Treatment, 122, 777-785.
13. Klos, K. S., Wyszomierski, S. L., Sun, M., Tan, M., Zhou, X., Li, P., et al. (2006). ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells. Cancer Research, 66, 2028-2037.
14. Kotzka, J., Muller-Wieland, D., Roth, G., Kremer, L., Munck, M., Schurmann, S., et al. (2000). Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade. Journal of Lipid Research, 41, 99-108. (Pubitemid 30051847)
15. Kumar, S., Singhal, V., Roshan, R., Sharma, A., Rembhotkar, G. W., & Ghosh, B. (2007). Piperine inhibits TNF-alpha induced adhesion of neutrophils to endothelial monolayer through suppression of NF-kappaB and IkappaB kinase activation. European Journal of Pharmacology, 575, 177-186. (Pubitemid 47576069)
16. Lai, L. H., Fu, Q. H., Liu, Y., Jiang, K., Guo, Q. M., Chen, Q. Y., et al. (2012). Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model. Acta Pharmacologica Sinica, 33, 523-530.
17. Menendez, J. A., Mehmi, I., Verma, V. A., Teng, P. K., & Lupu, R. (2004). Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation. Molecular Carcinogenesis, 41, 164-178. (Pubitemid 39435113)
18. Milgraum, L. Z., Witters, L. A., Pasternack, G. R., & Kuhajda, F. P. (1997). Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clinical Cancer Research, 3, 2115-2120. (Pubitemid 27505140)
19. Moasser, M. M. (2007). The oncogene HER2: Its signaling and transforming functions and its role in human cancer pathogenesis. Oncogene, 26, 6469-6487. (Pubitemid 47530601)
20. Moulder, S., & Hortobagyi, G. N. (2008). Advances in the treatment of breast cancer. Clinical Pharmacology & Therapeutics, 83, 26-36.
21. Pils, D., Pinter, A., Reibenwein, J., Alfanz, A., Horak, P., Schmid, B. C., et al. (2007). In ovarian cancer the prognostic influence of HER2/neu is not dependent on the CXCR4/SDF-1 signalling pathway. British Journal of Cancer, 96, 485-491. (Pubitemid 46215221)
22. Pradeep, C. R., & Kuttan, G. (2002). Effect of piperine on the inhibition of lung metastasis induced B16F-10 melanoma cells in mice. Clinical & Experimental Metastasis, 19, 703-708. (Pubitemid 36092266)
23. Roh, H., Pippin, J., & Drebin, J. A. (2000). Down-regulation of HER2/neu expression induces apoptosis in human cancer cells that overexpress HER2/neu. Cancer Research, 60, 560-565. (Pubitemid 30094551)
24. Selvendiran, K., Prince Vijeya Singh, J., & Sakthisekaran, D. (2006). In vivo effect of piperine on serum and tissue glycoprotein levels in benzo (a) pyrene induced lung carcinogenesis in Swiss albino mice. Pulmonary Pharmacology & Therapeutics, 19, 107-111. (Pubitemid 43052998)
25. Szallasi, A. (2005). Piperine: Researchers discover new flavor in an ancient spice. Trends in Pharmacological Sciences, 26, 437-439. (Pubitemid 41207873)
26. Tan, M., Yao, J., & Yu, D. (1997). Overexpression of the c-erbB-2 gene enhanced intrinsic metastasis potential in human breast cancer cells without increasing their transformation abilities. Cancer Research, 57, 1199-1205. (Pubitemid 27138623)
27. Taqvi, S. I., Shah, A. J., & Gilani, A. H. (2008). Blood pressure lowering and vasomodulator effects of piperine. Journal of Cardiovascular Pharmacology, 52, 452-458.
28. Yaffe, P. B., Doucette, C. D., Walsh, M., & Hoskin, D. W. (2013). Piperine impairs cell cycle progression and causes reactive oxygen species-dependent apoptosis in rectal cancer cells. Experimental and Molecular Pathology, 94, 109-114.
29. Yoon, S., Lee, M. Y., Park, S. W., Moon, J. S., Koh, Y. K., Ahn, Y. H., et al. (2007). Upregulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells. Journal of Biological Chemistry, 282, 26122-26131. (Pubitemid 47443806)
30. Yu, D., Jing, T., Liu, B., Yao, J., Tan, M., McDonnell, T. J., et al. (1998). Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase. Molecular Cell, 2, 581-591. (Pubitemid 128379084)