Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation

Oncology Reports

Volumn 33, Issue 3, 2015, Pages 1131-1140

  Jikihara, Hiroshi ^a,b   Qi, Guangying ^a   Nozoe, Koichiro ^a   Hirokawa, Mayumi ^a   Sato, Hiromi ^a   Sugihara, Yuka ^a   Shimamoto, Fumio ^a  

^a PREFECTURAL UNIVERSITY OF HIROSHIMA   (Japan)

^b WAKUNAGA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Aged garlic extract; Cell cycle; Colorectal cancer; Cyclin B1; DMH; Rat

Indexed keywords

1,2 DIMETHYLHYDRAZINE; AGED GARLIC EXTRACT; CASPASE 3; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; GARLIC EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CARCINOGEN; PLANT EXTRACT;

ABERRANT CRYPT FOCUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BODY WEIGHT; CANCER CELL; CANCER INHIBITION; CELL CYCLE PROGRESSION; CELL PROLIFERATION; COLON CANCER; COLON CARCINOGENESIS; COLON MUCOSA; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVITY; FISCHER 344 RAT; FOOD INTAKE; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; ORGAN WEIGHT; PROTEIN EXPRESSION; RAT; ADENOCARCINOMA; ADENOMA; ANIMAL; COLON TUMOR; DRUG EFFECTS; FLOW CYTOMETRY; GARLIC; NEOPLASMS, EXPERIMENTAL; PATHOLOGY; PHYTOTHERAPY; PROCEDURES; TUMOR CELL LINE; WESTERN BLOTTING;

1,2-DIMETHYLHYDRAZINE; ADENOCARCINOMA; ADENOMA; ANIMALS; ANTICARCINOGENIC AGENTS; BLOTTING, WESTERN; CARCINOGENS; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; FLOW CYTOMETRY; GARLIC; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; NEOPLASMS, EXPERIMENTAL; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, INBRED F344;

EID: 84921670425     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3705     Document Type: Article

References (52)

1. Fleischauer AT, Poole C and Arab L: Garlic consumption and cancer prevention: meta-analyses of colorectal and stomach cancers. Am J Clin Nutr 72:1047-1052, 2000.
2. Gao CM, Takezaki T, Ding JH, Li MS and Tajima K: Protective effect of allium vegetables against both esophageal and stomach cancer: a simultaneous case-referent study of a high-epidemic area in Jiangsu Province, China. Jpn J Cancer Res 90:614-621, 1999.
3. Sumiyoshi H and Wargovich MJ: Chemoprevention of 1, 2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds. Cancer Res 15:5084-5087, 1990.
4. Hatono S, Jimenez A and Wargovich MJ: Chemopreventive effect of S-allylcysteine and its relationship to the detoxification enzyme glutathione S-transferase. Carcinogenesis 17:1041-1044, 1996.
5. Wang X, Jiao F, Wang QW, et al: Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo. Mol Med Rep 5:66-72, 2012.
6. Xiao D, Pinto JT, Soh JW, Deguchi A, et al: Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun. NH (2)-terminal kinase 1 activation. Cancer Res 63:6825-6837, 2003.
7. Knowles LM and Milner JA: Depressed p34 cdc2 kinase activity and G2/M phase arrest induced by diallyl disulfide in HCT-15 cells. Nutr Cancer 30:169-174, 1998.
8. Shirin H, Pinto JT, Kawabata Y, et al: Antiproliferative effects of S-allylmercaptocysteine on colon cancer cells when tested alone or in combination with sulindac sulfide. Cancer Res 61:725-731, 2001.
9. Hosono T, Fukao T, Ogihara J, Ito Y, Shiba H, Seki T and Ariga T: Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of beta-tubulin. J Biol Chem 280:41487-41493, 2005.
10. Ban JO, Yuk DY, Woo KS, et al: Inhibition of cell growth and induction of apoptosis via inactivation of NF-kappaB by a sulfurcompound isolated from garlic in human colon cancer cells. J Pharmacol Sci 104:374-383, 2007.
11. Sriram N, Kalayarasan S, Ashokkumar P, Sureshkumar A and Sudhandiran G: Diallyl sulfide induces apoptosis in Colo 320 DM human colon cancer cells: involvement of caspase-3, NF-kappaB, and ERK-2. Mol Cell Biochem 311:157-165, 2008.
12. Liang D, Qin Y, Zhao W, et al: S-allylmercaptocysteine effectively inhibits the proliferation of colorectal cancer cells under in vitro and in vivo conditions. Cancer Lett 310:69-76, 2011.
13. Dong M, Yang G, Liu H, Liu X, Lin S, Sun D and Wang Y: Aged black garlic extract inhibits HT29 colon cancer cell growth via the PI3K/Akt signaling pathway. Biomed Rep 2:250-254, 2014.
14. Soni KB, Lahiri M, Chackradeo P, Bhide SV and Kuttan R: Protective effect of food additives on aflatoxin-induced mutagenicity and hepatocarcinogenicity. Cancer Lett 115:129-133, 1997.
15. Knasmüller S, de Martin R, Domjan G and Szakmary A: Studies on the antimutagenic activities of garlic extract. Environ Mol Mutagen 13:357-365, 1989.
16. Amagase H and Milner JA: Impact of various sources of garlic and their constituents on 7, 12-dimethylbenz[a]anthracene binding to mammary cell DNA. Carcinogenesis 14:1627-1631, 1993.
17. Sparnins VL, Barany G and Wattenberg LW: Effects of organosulfur compounds from garlic and onions on benzo[a] pyrene-induced neoplasia and glutathione S-transferase activity in the mouse. Carcinogenesis 9:131-134, 1988.
18. Tadi PP, Tee RW and Lau BH: Organosulfur compounds of garlic modulate mutagenesis, metabolism, and DNA binding of aflatoxin B1. Nutr Cancer 15:87-95, 1991.
19. Perše M and Cerar A: Morphological and molecular alterations in 1, 2 dimethylhydrazine and azoxymethane induced colon carcinogenesis in rats. J Biomed Biotechnol 2011:1-14, 2011.
20. Tammariello AE and Milner JA: Mouse models for unraveling the importance of diet in colon cancer prevention. J Nutr Biochem 21:77-88, 2010.
21. Chen J and Huang XF: The signal pathways in azoxymethaneinduced colon cancer and preventive implications. Cancer Biol Ther 8:1313-1317, 2009.
22. Takahashi M and Wakabayashi K: Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents. Cancer Sci 95:475-480, 2004.
23. Lijinsky W, Saavedra JE and Reuber MD: Organ-specific carcinogenesis in rats by methyl- and ethylazoxyalkanes. Cancer Res 45:76-79, 1985.
24. Tanaka S, Haruma K, Kunihiro M, et al: Effects of aged garlic extract (AGE) on colorectal adenomas: a double-blinded study. Hiroshima J Med Sci 53:39-45, 2004.
25. Matsuura N, Miyamae Y, Yamane K, et al: Aged garlic extract inhibits angiogenesis and proliferation of colorectal carcinoma cells. J Nutr 136(Suppl 3):842-846, 2006.
26. Kyo E, Uda N, Kasuga S and Itakura Y: Immunomodulatory effects of aged garlic extract. J Nutr 131:S1075-S1079, 2006.
27. Morihara N, Sumioka I, Moriguchi T, Uda N and Kyo E: Aged garlic extract enhances production of nitric oxide. Life Sci 71:509-517, 2002.
28. Morihara N, Ushijima M, Kashimoto N, et al: Aged garlic extract ameliorates physical fatigue. Biol Pharm Bull 29:962-966, 2006.
29. Katsuki T, Hirata K, Ishikawa H, Matsuura N, Sumi S and Itoh H: Aged garlic extract has chemopreventative effects on 1, 2-dimethylhydrazine-induced colon tumors in rats. J Nutr 136(Suppl 3):847-851, 2006.
30. McLellan EA, Medline A and Bird RP: Sequential analyses of the growth and morphological characteristics of aberrant crypt foci: putative preneoplastic lesions. Cancer Res 51:5270-5274, 1991.
31. Pindborg JJ, Reichart PA, Smith CJ and Waal I: Histological typing of cancer and precancer of the oral mucosa. 2nd edition. WHO, Geneva, pp21-31, 1997.
32. Ferreira CG, Epping M, Kruyt FA and Giaccone G: Apoptosis: target of cancer therapy. Clin Cancer Res 2002 8:2024-2034, 2002.
33. Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW and Yuan J: Human ICE/CED-3 protease nomenclature. Cell 87:171, 1996.
34. Muschel RJ, Zhang HB, Iliakis G and McKenna WG: Cyclin B expression in HeLa cells during the G2 block induced by ionizing radiation. Cancer Res 51:5113-5117, 1991.
35. Metting NF and Little JB: Transient failure to dephosphorylate the cdc2-cyclin B1 complex accompanies radiation-induced G2-phase arrest in HeLa cells. Radiat Res 143:286-292, 1995.
36. Kao GD, McKenna WG, Maity A, Blank K and Muschel RJ: Cyclin B1 availability is a rate-limiting component of the radiation-induced G2 delay in HeLa cells. Cancer Res 57:753-758, 1997.
37. Azzam EI, de Toledo SM, Gooding T and Little JB: Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat Res 150:497-504, 1998.
38. Guo G, Yan-Sanders Y, Lyn-Cook BD, et al: Manganese superoxide dismutase-mediated gene expression in radiationinduced adaptive responses. Mol Cell Biol 23:2362-2378, 2003.
39. Ozeki M, Tamae D, Hou DX, Wang T, Lebon T, Spitz DR and Li JJ: Response of cyclin B1 to ionizing radiation: regulation by NF-kappaB and mitochondrial antioxidant enzyme MnSOD. Anticancer Res 24:2657-2663, 2004.
40. Herman-Antosiewicz A, Powolny AA and Singh SV: Molecular targets of cancer chemoprevention by garlic-derived organosulfides. Acta Pharmacol Sin 28:1355-1364, 2007.
41. Pretlow TP1, Cheyer C and O'Riordan MA: Aberrant crypt foci and colon tumors in F344 rats have similar increases in proliferative activity. Int J Cancer 56:599-602, 1994.
42. Hur K, Kim JR, Yoon BI, Lee JK, Choi JH, Oh GT and Kim DY: Overexpression of cyclin D1 and cyclin E in 1, 2-dimethylhydrazine dihydrochloride-induced rat colon carcinogenesis. J Vet Sci 1:121-126, 2000.
43. Janakiram NB, Mohammed A, Qian L, Choi CI, Steele VE and Rao CV: Chemopreventive effects of RXR-selective rexinoid bexarotene on intestinal neoplasia of Apc (Min/+) mice. Neoplasia 14:159-168, 2012.
44. Powolny AA and Singh SV: Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetablederived organosulfur compounds. Cancer Lett 269:305-314, 2008.
45. Pai MH, Kuo YH, Chiang EP and Tang FY: S-Allylcysteine inhibits tumour progression and the epithelial-mesenchymal transition in a mouse xenograft model of oral cancer. Br J Nutr 14:28-38, 2012.
46. Xiao D, Vogel V and Singh SV: Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak. Mol Cancer Ther 5:2931-2945, 2006.
47. Ryu DS, Kim SH and Lee DS: Anti-proliferative effect of polysaccharides from Salicornia herbacea on induction of G2/M arrest and apoptosis in human colon cancer cells. J Microbiol Biotechnol 19:1482-1489, 2009.
48. Huang S, Pettaway CA, Uehara H, Bucana CD and Fidler IJ: Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene 20:4188-4197, 2001.
49. Lee SH, Lee CW, Lee JW, et al: Induction of apoptotic cell death by 2'-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-kappaB in TNF-alpha-treated SW620 colon cancer cells. Biochem Pharmacol 70:1147-1157, 2005.
50. Saccani A, Schioppa T, Porta C, et al: p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance. Cancer Res 66:11432-11440, 2006.
51. Tang X, Liu D, Shishodia S, et al: Nuclear factor-kappaB (NF-kappaB) is frequently expressed in lung cancer and preneoplastic lesions. Cancer 107:2637-2646, 2006.
52. Hardwick JC, van den Brink GR, Offerhaus GJ, van Deventer SJ and Peppelenbosch MP: NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps. Oncogene 20:819-827, 2001.