Galangin and kaempferol suppress phorbol-12-myristate-13-acetate-induced matrix metalloproteinase-9 expression in human fibrosarcoma HT-1080 cells

Molecules and Cells

Volumn 38, Issue 2, 2015, Pages 151-155

  Choi, Yu Jung ^a   Lee, Young Hun ^a   Lee, Seung Taek ^a  

^a Yonsei University   (South Korea)

Author keywords

Flavonol; Galangin; Kaempferol; Mitogen activated protein kinase; MMP 9; NF B

Indexed keywords

ANTINEOPLASTIC AGENT; FISETIN; GALANGIN; GELATINASE B; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KAEMPFEROL; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; FLAVONOID; I KAPPA B; KAEMPFEROL DERIVATIVE; MMP9 PROTEIN, HUMAN; NF-KAPPAB INHIBITOR ALPHA; PHORBOLOL MYRISTATE ACETATE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; COMPARATIVE STUDY; CYTOTOXICITY; DRUG EFFECT; FIBROSARCOMA; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNODETECTION; LUCIFERASE ASSAY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CELL SURVIVAL; CHEMICALLY INDUCED; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; FIBROSARCOMA; FLAVONOIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; I-KAPPA B PROTEINS; KAEMPFEROLS; MATRIX METALLOPROTEINASE 9; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE;

EID: 84950286727     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.14348/molcells.2015.2229     Document Type: Article

References (31)

1. Bond, M., Fabunmi, R.P., Baker, A.H., and Newby, A.C. (1998). Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-kappa B. FEBS Lett. 435, 29-34.
2. Chen, H.J., Lin, C.M., Lee, C.Y., Shih, N.C., Peng, S.F., Tsuzuki, M., Amagaya, S., Huang, W.W., and Yang, J.S. (2013). Kaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in U-2 OS human osteosarcoma cells. Oncol. Rep. 30, 925-932.
3. Coussens, L.M., Fingleton, B., and Matrisian, L.M. (2002). Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 295, 2387-2392.
4. Gum, R., Wang, H., Lengyel, E., Juarez, J., and Boyd, D. (1997). Regulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades. Oncogene 14, 1481-1493.
5. Hah, N., and Lee, S.T. (2003). An absolute role of the PKCdependent NF-kappaB activation for induction of MMP-9 in hepatocellular carcinoma cells. Biochem. Biophys. Res. Commun. 305, 428-433.
6. Hanneken, A., Lin, F.F., Johnson, J., and Maher, P. (2006). Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death. Invest. Ophthalmol. Vis. Sci. 47, 3164-3177.
7. Kim, H.I., Saldova, R., Park, J.H., Lee, Y.H., Harvey, D.J., Wormald, M.R., Wynne, K., Elia, G., Kim, H.-J., Rudd, P.M., and Lee, S.-T. (2013) The presence of outer arm fucose residues on the Nglycans of tissue inhibitor of metalloproteinases-1 reduces its activity. J. Proteome Res. 12, 3547-3560.
8. Knekt, P., Kumpulainen, J., Jarvinen, R., Rissanen, H., Heliovaara, M., Reunanen, A., Hakulinen, T., and Aromaa, A. (2002). Flavonoid intake and risk of chronic diseases. Am. J. Clin. Nutr. 76, 560-568.
9. Lee, D.E., Chung, M.Y., Lim, T.G., Huh, W.B., Lee, H.J., and Lee, K.W. (2013). Quercetin suppresses intracellular ROS formation, MMP activation, and cell motility in human fibrosarcoma cells. J. Food Sci. 78, 1464-1469.
10. Lee, S.U., Ahn, K.S., Sung M.H., Park, J.W., Ryu, H.W., Lee, H.J., Hong, S.T., and Oh, S.R. (2014). Indacaterol inhibits tumor cell invasiveness and MMP-9 expression by suppressing IKK/NF-κB activation. Mol. Cells 37, 585-591.
11. Lianxu, C., Hongti, J., and Changlong, Y. (2006). NF-kappaBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1beta-induced and TNF-alpha-induced chondrocytes. Osteoarthritis Cartilage 14, 367-376.
12. Lin, C.W., Shen, S.C., Chien, C.C., Yang, L.Y., Shia, L.T., and Chen, Y.C. (2010). 12-O-tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB-dependent MMP-9 expression. J. Cell Physiol. 225, 472-481.
13. Lin, C.W., Chen, P.N., Chen, M.K., Yang, W.E., Tang, C.H., Yang, S.F., and Hsieh, Y.S. (2013). Kaempferol reduces matrix metalloproteinase-2 expression by down-regulating ERK1/2 and the activator protein-1 signaling pathways in oral cancer cells. PLoS One 8, e80883.
14. Liotta, L.A., Steeg, P.S., and Stetler-Stevenson, W.G. (1991). Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64, 327-336.
15. Lv, Z., Yang, D., Li, J., Hu, M., Luo, M., Zhan, X., Song, P., Liu, C., Bai, H., Li, B., et al. (2013). Bone morphogenetic protein 9 overexpression reduces osteosarcoma cell migration and invasion. Mol. Cells 36, 119-126
16. Nam, Y.H., Ryu, E., Lee, D., Shim, H.J., Lee, Y.C., and Lee, S.T. (2011). CagA phosphorylation-dependent MMP-9 expression in gastric epithelial cells. Helicobacter 16, 276-283.
17. Nelson, A.R., Fingleton, B., Rothenberg, M.L., and Matrisian, L.M. (2000). Matrix metalloproteinases: biologic activity and clinical implications. J. Clin. Oncol. 18, 1135-1149.
18. Park, J.H., Jang, Y.J., Choi, Y.J., Jang, J.W., Kim, J.H., Rho, Y.K., Kim, I.J., Kim, H.J., Leem, M.J., and Lee, S.T. (2013). Fisetin inhibits matrix metalloproteinases and reduces tumor cell invasiveness and endothelial cell tube formation. Nutr. Cancer 65, 1192-1199.
19. Phromnoi, K., Yodkeeree, S., Anuchapreeda, S., and Limtrakul, P. (2009). Inhibition of MMP-3 activity and invasion of the MDAMB-231 human invasive breast carcinoma cell line by bioflavonoids. Acta Pharmacol. Sin. 30, 1169-1176.
20. Sartor, L., Pezzato, E., Dell'Aica, I., Caniato, R., Biggin, S., and Garbisa, S. (2002). Inhibition of matrix-proteases by polyphenols: chemical insights for anti-inflammatory and anti-invasion drug design. Biochem. Pharmacol. 64, 229-237.
21. Sato, H., and Seiki, M. (1993). Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells. Oncogene 8, 395-405.
22. Sato, H., Kita, M., and Seiki, M. (1993). v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines. J. Biol. Chem. 268, 23460-23468.
23. Scalbert, A., Manach, C., Morand, C., Remesy, C., and Jimenez, L. (2005). Dietary polyphenols and the prevention of diseases. Crit. Rev. Food Sci. Nutr. 45, 287-306.
24. Shin, M., Yan, C., and Boyd, D. (2002). An inhibitor of c-jun aminoterminal kinase (SP600125) represses c-Jun activation, DNAbinding and PMA-inducible 92-kDa type IV collagenase expression. Biochim. Biophys. Acta 1589, 311-316.
25. Shin, W.S., Maeng, Y.S., Jung, J.W., Min, J.K., Kwon, Y.G., and Lee, S.T. (2008). Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis. Biochem. Biophys. Res. Commun. 371, 793-798.
26. Sivaramakrishnan, V., and Niranjali Devaraj, S. (2009). Morin regulates the expression of NF-kappaB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. Chem. Biol. Interact 180, 353-359.
27. Visse, R., and Nagase, H. (2003). Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ. Res. 92, 827-839.
28. Watanabe, H., Nakanishi, I., Yamashita, K., Hayakawa, T., and Okada, Y. (1993). Matrix metalloproteinase-9 (92 kDa gelatinase/type IV collagenase) from U937 monoblastoid cells: correlation with cellular invasion. J. Cell Sci. 104 (Pt 4), 991-999.
29. Yan, C., and Boyd, D.D. (2007). Regulation of matrix metalloproteinase gene expression. J. Cell Physiol. 211, 19-26.
30. Yi, L., Chen, C.Y., Jin, X., Zhang, T., Zhou, Y., Zhang, Q.Y., Zhu, J.D., and Mi, M.T. (2012). Differential suppression of intracellular reactive oxygen species-mediated signaling pathway in vascular endothelial cells by several subclasses of flavonoids. Biochimie 94, 2035-2044.
31. Zheng, H., Takahashi, H., Murai, Y., Cui, Z., Nomoto, K., Niwa, H., Tsuneyama, K., and Takano, Y. (2006). Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth, invasion, metastasis and angiogenesis of gastric carcinoma. Anticancer Res. 26, 3579-3583.