Piperine causes G1 phase cell cycle arrest and apoptosis in melanoma cells through checkpoint kinase-1 activation

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Fofaria, Neel M ^a   Kim, Sung Hoon ^b   Srivastava, Sanjay K ^a,b  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b Kyung Hee University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

5 (3 FLUOROPHENYL) N (3 PIPERIDINYL) 3 UREIDO 2 THIOPHENECARBOXAMIDE; ATR PROTEIN; CASPASE 3; CHECKPOINT KINASE 1; CYCLIN D1; HISTONE H2AX; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PIPERINE; PROTEIN BID; PROTEIN P21; REACTIVE OXYGEN METABOLITE; RETINOBLASTOMA PROTEIN; SMALL INTERFERING RNA; TIRON; TRANSCRIPTION FACTOR E2F1; X LINKED INHIBITOR OF APOPTOSIS; 1,3 BENZODIOXOLE DERIVATIVE; ALKALOID; AMIDE; PIPERIDINE DERIVATIVE; PROTEIN KINASE;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MELANOMA CELL; PROTEIN PHOSPHORYLATION; DRUG EFFECTS; ENZYME ACTIVATION; GENETICS; MELANOMA; METABOLISM; TUMOR CELL LINE; WESTERN BLOTTING;

ALKALOIDS; APOPTOSIS; BENZODIOXOLES; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MELANOMA; PIPERIDINES; POLYUNSATURATED ALKAMIDES; PROTEIN KINASES; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING;

EID: 84900550067     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094298     Document Type: Article

References (29)

1. Markovic SN, Erickson LA, Flotte TJ, Kottschade LA, McWilliams RR, et al. (2009) Metastatic malignant melanoma. G Ital Dermatol Venereol 144: 1-26.
2. Wellbrock C, Karasarides, Marais R (2004) The RAF proteins take centre stage. Nat Rev Mol Cell Biol 5: 875-885.
3. Gray-Schopfer V, Wellbrock C, Marais R (2007) Melanoma biology and new targeted therapy. Nature 445: 851-857.
4. Bartkova J, Lukas J, Guldberg P, Alsner J, Kirkin AF, et al. (1996) The p16- cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis. Cancer Res 56: 5475-5483. (Pubitemid 27011383)
5. von Willebrand M, Zacksenhaus E, Cheng E, Glazer P, Halaban R (2003) The tyrphostin AG1024 accelerates the degradation of phosphorylated forms of retinoblastoma protein (pRb) and restores pRb tumor suppressive function in melanoma cells. Cancer Res 63: 1420-1429. (Pubitemid 36348726)
6. Halaban R, Cheng E, Smicun Y, Germino J (2000) Deregulated E2F transcriptional activity in autonomously growing melanoma cells. J Exp Med 191: 1005-1016.
7. Soengas MS, Lowe SW (2003) Apoptosis and melanoma chemoresistance. Oncogene 22: 3138-3151. (Pubitemid 36713766)
8. Bang JS, Oh da H, Choi HM, Sur BJ, Lim SJ, et al. (2009) Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models. Arthritis Res Ther 11: R49.
9. Wattanathorn J, Chonpathompikunlert P, Muchimapura S, Priprem A, Tankamnerdthai O (2008) Piperine, the potential functional food for mood and cognitive disorders. Food Chem Toxicol 46: 3106-3110.
10. Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, et al. (2002) Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 302: 645-650. (Pubitemid 34787231)
11. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, et al. (1998) Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 64: 353-356. (Pubitemid 28234275)
12. Sahu RP, Srivastava SK (2009) The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate. Journal of the National Cancer Institute 101: 176-193.
13. Kandala PK, Wright SE, Srivastava SK (2012) Blocking epidermal growth factor receptor activation by 3,3 9-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo. Journal Pharmacol Exp Ther 341: 24-32.
14. Kandala PK, Srivastava SK (2010) Activation of checkpoint kinase 2 by 3,3′-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells. Mol Pharmacol 78: 297-309.
15. Boreddy SR, Pramanik KC, Srivastava SK (2011) Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway. Clin Cancer Res 17: 1784-1795.
16. Sahu RP, Batra S, Srivastava SK (2009) Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells. Br J Cancer 100: 1425-1433.
17. Kong W, Kuester RK, Gallegos A, Sipes IG (2011) Induction of DNA damage in human urothelial cells by the brominated flame retardant 2,2-bis(bromo- methyl)-1,3-propanediol: role of oxidative stress. Toxicology 290: 271-277.
18. Cann KL, Hicks GG (2007) Regulation of the cellular DNA double-strand break response. Biochem Cell Biol 85: 663-674. (Pubitemid 351198414)
19. Norbury CJ, Zhivotovsky B (2004) DNA damage-induced apoptosis. Oncogene 23: 2797-2808. (Pubitemid 38638843)
20. Tentner AR, Lee MJ, Ostheimer GJ, Samson LD, Lauffenburger DA, et al. (2012) Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress. Mol Syst Biol 8: 568.
21. Bartek J, Lukas J, Bartkova J (2007) DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency'. Cell Cycle 6: 2344-2347. (Pubitemid 350058685)
22. Bohgaki T, Bohgaki M, Hakem R (2010) DNA double-strand break signaling and human disorders. Genome Integrity 1: 15.
23. Smith J, Tho LM, Xu N, Gillespie DA (2010) The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Advances in Cancer Research 108: 73-112.
24. Zhou BB, Elledge SJ (2000) The DNA damage response: putting checkpoints in perspective. Nature 408: 433-439.
25. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, et al. (1993) p21 is a universal inhibitor of cyclin kinases. Nature 366: 701-704. (Pubitemid 24036020)
26. Molinari M (2000) Cell cycle checkpoints and their inactivation in human cancer. Cell Prolif 33: 261-274.
27. Kastan MB, Bartek J (2004) Cell-cycle checkpoints and cancer. Nature 432: 316-323. (Pubitemid 39551659)
28. Chen CY, Hsu YL, Tsai YC, Kuo PL (2008) Kotomolide A arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and the initiation of mitochondrial system in human non-small cell lung cancer A549 cells. Food Chem Toxicol 46: 2476-2484.
29. van den Heuvel S, Dyson NJ (2008) Conserved functions of the pRB and E2F families. Nat Rev Mol Cell Biol 9: 713-724.