Anti-oncogenic perspectives of spices/herbs: A comprehensive review

EXCLI Journal

Volumn 12, Issue , 2013, Pages 1043-1065

  Butt, Masood Sadiq ^a   Naz, Ambreen ^b   Sultan, Muhammad Tauseef ^c   Qayyum, Mir Muhammad Nasir ^d  

^a UNIVERSITY OF AGRICULTURE   (Pakistan)

^b LAHORE COLLEGE FOR WOMEN UNIVERSITY   (Pakistan)

^c BAHAUDDIN ZAKARIYA UNIVERSITY   (Pakistan)

^d KARAKORAM INTERNATIONAL UNIVERSITY   (Pakistan)

Author keywords

Allicin; Cinnamic aldehyde; Dipropyle disulfides; Gingerol; Malignancy; Piperidine piperine

Indexed keywords

(6) GINGEROL; ANTINEOPLASTIC AGENT; BLACK PEPPER EXTRACT; CARDAMOM EXTRACT; CINNAMON EXTRACT; CROCIN; CURCUMIN; ESSENTIAL OIL; GINGER EXTRACT; GINGEROL; HERBACEOUS AGENT; PICROCROCIN; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; SAFRANAL; SHOGAOL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; BLACK PEPPER; CANCER GROWTH; CANCER PREVENTION; CARCINOGENESIS; CARDAMOM; CHEMOPROPHYLAXIS; CINNAMOMUM ZEYLANICUM; CROCUS SATIVUS; CURCUMA LONGA; DRUG DETERMINATION; DRUG MECHANISM; FOOD CROP; GARLIC; GINGER; HUMAN; ILLICIUM VERUM; LIVER CANCER; MELANOMA; NONHUMAN; ONION; PHYTOCHEMISTRY; PLANT TAXONOMY; REVIEW; SPICE;

ALLIUM CEPA; ALLIUM SATIVUM; CINNAMOMUM VERUM; CURCUMA LONGA; ELETTARIA CARDAMOMUM; PIPER NIGRUM; ZINGIBER OFFICINALE;

EID: 84890504920     PISSN: None     EISSN: 16112156     Source Type: Journal    
DOI: None     Document Type: Review

References (100)

1. Abdullaev FI. Cancer chemopreventive and tumor-icidal properties of saffron and medicinal phenolic substances. Exp Biol Med 2002;227:20-25.
2. Abdullaev FI, Espinosa-Aguirre JJ. Biomedical properties of saffron and its potential use in cancer therapy and chemopreventive trials. Cancer Detect Prev 2004;28:426-432.
3. Acharya A, Das I, Singh S, Saha T. Chemoprevent-ive properties of indole-3-carbinol, diindolylmethane and other constituents of cardamom against carcino-genesis. Recent Patents Food Nutr Agric 2010;2: 166-177.
4. Aggarwal BB, Shishodia S. Suppersion of the nuclear factor-κB activation pathway by spice-derived phytochemicals. Ann NY Acad Sci 2004;1030:434-441.
5. Aggarwal BB, Kunnumakkara AB, Harikumar KB, Tharakan ST, Sung B, Anand P. Potential of spice-derived phytochemicals for cancer prevention. Plan-ta Med 2008;74:1560-1569.
6. Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food Chem Toxicol 2008; 46:409-420.
7. Amagase H, Petesch BL, Matsuura H, Kasuga S, Itakura Y. Intake of garlic and its bioactive components. J Nutr 2001;131:955-962.
8. Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP. Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J Agric Food Chem 2004;52:65-70.
9. Badmaev V, Majeed M, Prakash L. Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation. J Nutr Biochem 2000;11:109-113.
10. Bakshi HA, Sam S, Feroz A, Ravesh Z, Shah GA, Sharma M. Crocin from Kashmiri saffron (Crocus sativus) induces in vitro and in vivo xenograft growth inhibition of Dalton'S lymphoma (DLA) in mice. Asian Pac J Cancer Prev 2009;10:887-890.
11. Baliga MS, Haniadka R, Pereira MM, D'Souza JJ, Pallaty PL, Bhat H et al. Update on the chemopre-ventive effects of ginger and its phytochemicals. Crit Rev Food Sci Nutr 2011;51:499-523.
12. Banerjee S, Sharma R, Kale RK, Rao AR. Influence of certain essential oils on carcinogen-metabolizing enzymes and acid-soluble sulfhydryls in mouse liver. Nutr Cancer 1994;21:263-269.
13. Bar-Sela G, Epelbaum R, Schaffer M. Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications. Curr Med Chem 2010;17:190-197.
14. Basnet P, Skalko-Basnet N. Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules 2011;16:4567-4598.
15. Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, Fromm MF. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302:645-650.
16. Bhutani M, Pathak AK, Nair AS, Kunnumakkara AB, Guha S, Sethi G et al. Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation. Clin Cancer Res 2007;13:3024-3032.
17. Block E, Gulati H, Putman D, Sha D, You N, Zhao SH. Allium chemistry: synthesis of 1-[alk (en) ylsulfinyl] propyl alk (en) yl disulfides (cepaenes), antithrombotic flavorants from homogenates of onion (Allium cepa). J Agric Food Chem 1997;45: 4414-4422.
18. nd ed. Wallingford, Oxfordshire: Cabi, 2012 (Crop Production Science in Horticulture, Book 22).
19. nd ed. Wallingford, Oxfordshire: CABI, 2008.
20. Brownlee M. The pathobiology of diabetic complications. Diabetes 2005;54:1615-1625.
21. Cerella C, Dicato M, Jacob C, Diederich M. Chemical properties and mechanisms determining the anti-cancer action of garlic-derived organic sulfur compounds. Anticancer Agents Med Chem 2011;11:267-271.
22. Chang HS, Yamato O, Yamasaki M, Ko M, Maede Y. Growth inhibitory effect of alk(en)yl thiosulfates derived from onion and garlic in human immortalized and tumor cell lines. Cancer Lett 2004;223:47-55.
23. Cheng XL, Liu Q, Peng YB, Qi L-W, Li P. Steamed ginger (Zingiber officinale): changed chemical profile and increased anticancer potential. Food Chem 2011;129:1785-1792.
24. Christensen LP, Brandt K. Bioactive polyacetylenes in food plants of the Apiaceae family: occurrence, bioactivity and analysis. J Pharm Biomed Anal 2006;41:683-693.
25. Couturier K, Batandier C, Awada M, Hininger-Favier I, Canini F, Anderson RA et al. Cinnamon improves insulin sensitivity and alters the body composition in an animal model of the metabolic syndrome. Arch Biotechnol Biophys 2010;501:158-161.
26. Dhanya K, Kizhakkayil J, Syamkumar S, Sasikumar B. Isolation and amplification of genomic DNA from recalcitrant dried berries of black pepper (Piper nigrum L.) - a medicinal spice. Mol Biotechnol 2007;37:165-168.
27. Eberling JL, Kells AP, Pivirotto P, Beyer J, Bringas J, Federoff HJ et al. Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkey. Hum Gene Ther 2009; 20:511-518.
28. Engeland RL. Growing great garlic. Okanogan, WA: Filaree Prod., 1991.
29. Escribano J, Alonso GL, Coca-Prados M, Fernandez JA. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett 1995;100:23-30.
30. Estes JW. Staple foods: domesticated plants and animals: garlic. In: Kiple KF, Ornelas KC (eds.): The Cambridge world history of food (p 256). Cambridge: Cambridge University Press, 2000.
31. Etoh T, Simon PW. Diversity, fertility and seed production of garlic. Allium Crop Science: recent advances (pp 101-118). Wallingford, Oxfordshire: CA-BI, 2002.
32. Fleischauer AT, Arab L. Garlic and cancer: a critical review of the epidemiologic literature. J Nutr 2001; 131:1032-1040.
33. Friesen N, Fritsch RM, Blattner FR. Phylogeny and new intrageneric classification of Allium L. (Al-liaceae) based on nuclear rDNA ITS sequences. Ali-so 2006;22:372-395.
34. Fritsch RM, Friesen N. Evolution, domestication and taxonomy. Allium Crop Science: recent advances (pp 5-30). Wallingford, Oxfordshire: CABI, 2002.
35. Gohari AR, Saeidnia S, Mahmoodabadi MK. An overview on saffron, phytochemicals, and medicinal properties. Pharmacogn Rev 2013;7(13):61.
36. Gruenwald J, Freder J, Armbruester N. Cinnamon and health. Crit Rev Food Sci Nutr 2010;50:822-834.
37. Hashim S, Aboobaker VS, Madhubala R, Bhattacharya RK, Rao AR. Modulatory effects of essential oils from spices on the formation of DNA adduct by aflatoxin B1 in vitro. Nutr Cancer 1994; 21:169-175.
38. Holst B, Williamson G. Nutrients and phytochemi-cals: from bioavailability to bioefficacy beyond an-tioxidants. Curr Opin Biotechnol 2008;19:73-82.
39. Hong CH, Hur SK, Oh OJ, Kim SS, Nam KA, Lee SK. Evaluation of natural products on inhibition of indcible cycloxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J Ethnopharmacol 2002;83:153-159.
40. Hwang YP, Yun HJ, Kim HG, Han EH, Choi JH, Chung YC et al. Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKCα/ERK1/2-dependent matrix metalloproteinase-9 expression. Toxicol Lett 2011;203:9-19.
41. Jayaprakasha GK, Rao LJM. Chemistry, biogenesis, and biological activities of Cinnamomum zeylan-icum. Crit Rev Food Sci Nutr 2011;51:547-562.
42. Jung MY, Kang HJ, Moon A. Capsaicin-induced apoptosis in SK-Hep-1 hepatocarcinoma cells involves Bcl-2 downregulation and caspase-3 activation. Cancer Lett 2001;165:139-145.
43. Karsha PV, Lakshmi OB. Antibacterial activity of black pepper (Piper nigrum Linn.) with special reference to its mode of action on bacteria. Indian J Nat Prod Resour 2010;1:213-215.
44. Katiyar SK, Agarwal R, Mukhtar H. Inhibition of tumor promotion in SENCAR mouse skin by ethanol extract of Zingiber officinale rhizome. Cancer Res 1996;56:1023-1030.
45. Keum Y-S, Kim J, Lee KH, Park KK, Surh Y-J, Lee JM et al. Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells. Cancer Lett 2002;177:41-47.
46. Krishnan S, Bhosale R, Singhal RS. Microencapsu-lation of cardamom oleoresin: Evaluation of blends of gum arabic, maltodextrin and a modified starch as wall materials. Carbohydr Polym 2005;61:95-102.
47. Kuhl J, Cheung F, Yuan Q, Martin W, Zewdie Y, McCallum J et al. A unique set of 11,008 onion expressed sequence tags reveals expressed sequence and genomic differences between the monocot orders Asparagales and Poales. Plant Cell 2004;16: 114-125.
48. Kundu JK, Surh YJ. Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with anti-inflammatory phyto-chemicals. Mutat Res 2005;591:123-146.
49. Kwon HK, Hwang JS, Lee CG, So JS, Sahoo A, Im CR et al. Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells. World J Gastroenterol 2011;17:976-986.
50. Lampe JW. Spicing up a vegetarian diet: chemopre-ventive effects of phytochemicals. Am J Clin Nutr 2003;78:579S-583S.
51. Lancaster JE, Martin LS, William MR. Differential hydrolysis of alk (en) yl cysteine sulphoxides by alliinase in onion macerates: flavour implications. J Sci Food Agric 1998;78:367-372.
52. Langone P, Debata PR, Dolai S, Curcio GM, Inigo JDR, Raja K et al. Coupling to a cancer cell-specific antibody potentiates tumoricidal properties of cur-cumin. Int J Cancer 2012;131:E569-E578.
53. Lantz RC, Chen GJ, Sarihan M, Solyom AM, Jolad SD, Timmermann BN. The effect of extracts from ginger rhizome on inflammatory mediator production. Phytomedicine 2007;14:123-128.
54. Li W, Cui SW, Kakuda Y. Extraction, fractionation, structural and physical characterization of wheat b-d-glucans. Carbohydr Polym 2006;63:408-416.
55. Li SG, Wang DG, Tian W, Wang XX, Zhao JX, Liu Z et al. Characterization and anti-tumor activity of a polysaccharide from Hedysarum polybotrys Hand. Mazz. Carbohydr Polym 2008;73:344-350.
56. Li S, Lei Y, Jia Y, Li N, Wink M, Ma Y. Piperine, a piperidine alkaloid from Piper nigrum re-sensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells. Phytomedicine 2011;19:83-87.
57. Lim GP, Chu T, Yang F, Beech W, Frantschy SA, Cole GM. The curry spice curcumin reduces oxida-tive damage of amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 2001;21:8370-8377.
58. Liu LM, Guo ZD, Zhang J. Study on composition of supercritical CO2 fluid extract of Illicium verum Hook. f. J Instrumental Anal 1997:16(4):24-26.
59. Low DT. A reason to season: the therapeutic benefits of spices and culinary herbs. Explore (NY) 2006;2:446-449.
60. Majdalawieh AF, Carr RI. In vitro investigation of the potential immunomodulatory and anti-cancer activities of black pepper (Piper nigrum) and cardamom (Elettaria cardamomum). J Med Food 2010;13: 371-381.
61. Menon AN. Studies on the volatiles of cardamom (elleteria cardamomum). J Food Sci Technol 2000; 37:406-408.
62. Miyoshi N, Nakamura Y, Ueda Y, Abe M, Ozawa Y, Uchida K et al. Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in human T lymphoma jurkat cells. Cancer Lett 2003; 199:113-119.
63. Mori A, Lehmann S, O'Kelly J, Kumagai T, Desmond JC, Pervan M et al. Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells. Cancer Res 2006;66:3222-3229.
64. Moure A, Cruz JM, Franco D, Dominguez JM, Sineiro J, Dominguez H et al. Natural antioxidants from residual sources. Food Chem 2001;72:145-171.
65. Mueller M, Hobiger S, Jungbauer A. Anti-inflammatory activity of extracts from fruits, herbs and spices. Food Chem 2010;122:987-996.
66. Nair SC, Kurumboor SK, Haseqawa JH. Saffron chemoprevention in biology and medicine: a review. Cancer Biother 1995;10:257-264.
67. Omar SH, Al-Wabel NA. Organosulfur compounds and possible mechanism of garlic in cancer. Saudi Pharm J 2010;18:51-58.
68. Padmashree A, Roopa N, Semwal AD, Sharma GK, Agathian G, Bawa AS. Star-anise (Illicium verum) and black caraway (Carum nigrum) as natural anti-oxidants. Food Chem 2007;104:59-66.
69. Panickar KS, Polansky MM, Anderson RA. Cinnamon polyphenols attenuate cell swelling and mito-chondrial dysfunction following oxygen-glucose deprivation in glial cells. Exp Neurol 2009;216:420-427.
70. Parthasarathy VA, Sasikumar B, Nair RR, George KJ. Black pepper: botany and horticulture. Horticultural Reviews - Westport Then New York 2007;33: 173-266.
71. Pino JA, Borges P. Los componentes volátiles de las especias. I. Métodos de obtención y de análisis. Ali-mentaria 1999;301:39-45.
72. Qiao S, Li W, Tsubouchi R, Haneda M, Murakami K, Yoshino M. Involvement of peroxynitrite in cap-saicin-induced apoptosis of C6 glioma cells. Neuro-sci Res 2005;51:175-183.
73. Ranasinghe L, Jayawardena B, Abeywickrama K. Fungicidal activity of essential oils of Cinnamomum zeylanicum (L.) and Syzygium aromaticum (L.) Merr et LM Perry against crown rot and anthracnose pathogens isolated from banana. Lett Appl Microbi-ol 2002;35:208-211.
74. Ravindran PN, Babu KN, Shiva. Ginger: the genus Zingiber. In: Ravindran PN, Babu KN (eds.): Botany and crop improvement of ginger (pp 15-85). Boca Raton, FL: CRC Press, 2004.
75. Reyes T, Luukkanen O, Quiroz R. Small cardamom - precious for people, harmful for mountain forests: possibilities for sustainable cultivation in the East Usambaras, Tanzania. Mt Res Dev 2006;26:131-137.
76. Ross SA, Finley JW, Milner JA. Allyl sulfur compounds from garlic modulte aberrant crypt formation. J Nutr 2006;136:852-854.
77. Saxena RB. Botany, taxonomy and cytology of Crocus sativus series. Ayu 2010;31:374.
78. Schaffer M, Schaffer PM, Zidan J, Sela GB. Curcuma as a functional food in the control of cancer and inflammation. Curr Opin Clin Nutr Metabol Care 2011;14:588-597.
79. Schoene NW, Kelly MA, Polansky MM, Anderson RA. Water-soluble polymeric polyphenols from cinnamon inhibit proliferation and alter cell cycle distribution patterns of hematologic tumor cell lines. Cancer Lett 2005;230:134-140.
80. Sengupta A, Ghosh S, Bhattacharjee S, Das S. Indian food ingredients and cancer prevention-an experimental evaluation of anticarcinogenic effects of garlic in rats colon. Asian Pac J Cancer Prev 2004; 5:126-132.
81. Sengupta A, Ghosh S, Bhattacharjee S. Dietary cardamom inhibits the formation of azoxymethane-induced aberrant crypt foci in mice and reduces COX-2 and iNOS expression in the colon. Asian Pac J Cancer Prev 2005;6:118-122.
82. Shon MY, Choi SD, Kahng GG, Nam SH, Sung NJ. Antimutagenic, antioxidant and free radical activity of ethyl acetate extracts from white, yellow and red onions. Food Chem Toxicol 2004;42:659-666.
83. Shu X, Liu X, Fu C, Liang Q. Extraction, characterization and antitumor effect of the polysaccharides from star anise (illicium verum Hook. f.). J Med Plants Res 2010;4:2666-2673.
84. Shukla Y, Kalra N. Cancer chemoprevention with garlic and its constituents. Cancer Lett 2007;247: 167-181.
85. Shukla Y, Singh M. Cancer preventive properties of ginger: a brief review. Food Chem Toxicol 2007;45: 683-690.
86. Sindhu S, Chempakam B, Leela NK, Bhai RS. Chemoprevention by essential oil of turmeric leaves (Curcuma longa) on the growth of Aspergillus flavus and aflatoxin production. Food Chem Toxicol 2011; 49:1188-1192.
87. Skrzypczak-Jankun E, Zhou K, McCabe NP, Selman SH, Jankun J. Structure of curcumin in complex with lipoxygenase and its significance in cancer. Int J Mol Med 2003;12:17-24.
88. Srinivasan K. Role of spices beyond food flavoring: nutraceuticals with multiple health effects. Food Rev Int 2005;21:167-188.
89. Surh YJ, Na HK, Lee JY, Keum YS. Molecular mechanisms underlying anti-tumor promoting activities of heat-processed Panax ginseng C.A. Meyer. J Korean Med Sci 2001;16(Suppl):S38-S41.
90. Tache S, Ladam A, Corpet DE. Chemoprevention of aberrant foci in the colon of rats by dietary onion. Eur J Cancer 2006;43:454-458.
91. Thapliyal R, Deshpande SS, Maru GB. Mecha-nism(s) of turmeric-mediated protective effects against benzo(a)pyrene-derived DNA adducts. Cancer Lett 2002;175:79-88.
92. Thomas-Eapen NE. Turmeric: the intriguing yellow spice with medicinal properties. Explore 2009;5: 114-115.
93. Thomson M, Ali M. Garlic (Allium sativum): a review of its potential use as an anti-cancer agent. Curr Cancer Drug Targets 2003;3:67-81.
94. Wang GW, Hu WT, Huang BK, Qin LP. Illicium verum: A review on its botany, traditional use, chemistry and pharmacology. J Ethnopharmacol 2011;136:10-20.
95. Wei QY, Ma JP, Cai YJ, Yang L, Liu ZL. Cytotoxic and apoptotic activities of diarylhepatanoids and gingerol-related compounds from the rhizome of Chinese ginger. J Ethnopharmacol 2005;102:177-184.
96. Yadav AS, Bhatnagar D. Chemo-preventive effect of star anise in N-nitrosodiethylamine initiated and Phenobarbital promoted hepato-carcinogenesis. Chem Biol Interact 2007;169:207-214.
97. Yang RY, Lin S, Kuo G. Content and distribution of flavonoids among 91 edible plant species. Asian Pac J Cancer Prev 2008;17(Suppl 1):275-279.
98. Yanishlieva-Maslarova NN, Heinonen M. Sources of natural antioxidants. In: Pokorny J, Yanishlieva N, Gordon M (eds.): Antioxidants in food (pp 210-249). Boca Raton, FL: CRC Press, 2001.
99. Yong-xiu SU, Zheng LI. Study of climatic division approach for Illicium verum planting based on GIS in Guangxi [J]. J Fujian College Forestry 2006;4: 014.
100. Yoon JH, Baek SJ. Molecular targets of dietary pol-yphenols with anti-inflammatory properties. Yonsei Med J 2005;46:585-596.