Anticancer effects of crocetin in both human adenocarcinoma gastric cancer cells and rat model of gastric cancer

Biochemistry and Cell Biology

Volumn 91, Issue 6, 2013, Pages 397-403

  Bathaie, S Zahra ^a   Hoshyar, Reyhane ^a,c   Miri, Hamidreza ^b   Sadeghizadeh, Majid ^a  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b UNIVERSITY OF ZABOL   (Iran)

^c BIRJAND UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

AGS cell; anticancer property; apoptosis; Bcl 2 Bax ratio; caspase assay; flow cytometry; MNNG; MTT assay; RT RCR

Indexed keywords

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CAROTENOIDS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; CROCUS; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; L-LACTATE DEHYDROGENASE; MALE; METHYLNITRONITROSOGUANIDINE; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS;

EID: 84888260574     PISSN: 08298211     EISSN: 12086002     Source Type: Journal    
DOI: 10.1139/bcb-2013-0014     Document Type: Article

References (32)

1. Abdullaev F.I. 1994. Inhibitory effect of crocetin on intracellular nucleic acid and protein synthesis in malignant cells. Toxicol. Lett. 70: 243-251. 10.1016/0378-4274(94)90168-6. 8296327.
2. Abdullaev F.I. Espinosa-Aguirre J.J. 2004. Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Cancer Detect. Prev. 28: 426-432. 10.1016/j.cdp.2004.09.002. 15582266.
3. Abdullaev F.I. Frenkel G.D. 1992. Effect of saffron on cell colony formation and cellular nucleic acid and protein synthesis. Biofactors, 3: 201-204. 1376126.
4. Abdullaev F.I. Riveron-Negrete L. Caballero-Ortega H. Manuel Hernandez J. Perez-Lopez I. Pereda-Miranda R. Espinosa-Aguirre J.J. 2003. Use of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron (Crocus sativus L.). Toxicol. in Vitro. 17: 731-736. 10.1016/S0887-2333(03) 00098-5. 14599470.
5. Ashrafi M. Bathaie S.Z. Taghikhani M. Moosavi-Movahedi A.A. 2005. The effect of carotenoids obtained from saffron on histone H1 structure and H1-DNA interaction. Int. J. Biol. Macromol. 36: 246-252. 10.1016/j.ijbiomac.2005.05. 008. 16087230.
6. Bathaie S.Z. Mousavi S.Z. 2010. New applications and mechanisms of action of saffron and its important ingredients. Crit. Rev. Food Sci. Nutr. 50: 761-786. 10.1080/10408390902773003. 20830635.
7. Bathaie S.Z. Bolhasani A. Hoshyar R. Ranjbar B. Sabouni F. Moosavi-Movahedi A.A. 2007. Interaction of saffron carotenoids as anticancer compounds with ctDNA, Oligo (dG. dC)15, and Oligo (dA.dT)15. DNA Cell Biol. 26: 533-540. 10.1089/dna.2007.0598. 17688404.
8. Chang W.C. Lin Y.L. Lee M.J. Shiow S.J. Wang C.J. 1996. Inhibitory effect of crocetin on benzo(a)pyrene genotoxicity and neoplastic transformation in C3H10T1/2 cells. Anticancer Res. 16: 3603-3608. 9042228.
9. Chitsazan, A.B., S.Z.; Mohagheghi, M.A., and Banasadegh, S. 2006. XXXIst Symposium on Hormones and Regulation: Cancer Cell Signalling., Hostellerie du Mont Sainte-Odile, France.
10. Chryssanthi D.G. Lamari F.N. Iatrou G. Pylara A. Karamanos N.K. Cordopatis P. 2007. Inhibition of breast cancer cell proliferation by style constituents of different Crocus species. Anticancer Res. 27: 357-362. 17352254.
11. Dhar A. Mehta S. Dhar G. Dhar K. Banerjee S. Van Veldhuizen P. Campbell D.R. Banerjee S.K. 2009. Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model. Mol. Cancer Ther. 8: 315-323. 10.1158/1535-7163.MCT-08-0762. 19208826.
12. Escribano J. Alonso G.L. Coca-Prados M. Fernandez J.A. 1996. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett. 100: 23-30. 10.1016/0304-3835(95) 04067-6. 8620447.
13. Eskes R. Antonsson B. Osen-Sand A. Montessuit S. Richter C. Sadoul R. Mazzei G. Nichols A. Martinou J.C. 1998. Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions. J. Cell Biol. 143: 217-224. 10.1083/jcb.143.1.217. 9763433.
14. Ha Y.M. Park M.K. Kim H.J. Seo H.G. Lee J.H. Chang K.C. 2009. High concentrations of ascorbic acid induces apoptosis of human gastric cancer cell by p38-MAP kinase-dependent up-regulation of transferrin receptor. Cancer Lett. 277: 48-54. 10.1016/j.canlet.2008.11.020. 19108947.
15. Hoshyar R. Bathaie S.Z. Kyani A. Mousavi M.F. 2012. Is there any interaction between telomeric DNA structures, g-quadruplex and I-motif, with saffron active metabolites? Nucleosides Nucleotides Nucleic Acids, 31: 801-812. 10.1080/15257770.2012.730164. 23145950.
16. Jafarnejad A. Bathaie S.Z. Nakhjavani M. Hassan M.Z. Banasadegh S. 2008. The improvement effect of L-Lys as a chemical chaperone on STZ-induced diabetic rats, protein structure and function. Diabetes Metab. Res. Rev. 24: 64-73. 10.1002/dmrr.769. 17879961.
17. Jagadeeswaran R. Thirunavukkarasu C. Gunasekaran P. Ramamurty N. Sakthisekaran D. 2000. In vitro studies on the selective cytotoxic effect of crocetin and quercetin. Fitoterapia, 71: 395-399. 10.1016/S0367-326X(00)00138-6. 10925010.
18. Ko S.G. Koh S.H. Jun C.Y. Nam C.G. Bae H.S. Shin M.K. 2004. Induction of apoptosis by Saussurea lappa and Pharbitis nil on AGS gastric cancer cells. Biol. Pharm. Bull. 27: 1604-1610. 10.1248/bpb.27.1604. 15467204.
19. Liao M.H. Lin W.C. Wen H.C. Pu H.F. 2011. Tithonia diversifolia and its main active component tagitinin C induce survivin inhibition and G2/M arrest in human malignant glioblastoma cells. Fitoterapia, 82: 331-341. 10.1016/j.fitote.2010.11.002. 21073931.
20. Magesh V. Singh J.P. Selvendiran K. Ekambaram G. Sakthisekaran D. 2006. Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies. Mol. Cell. Biochem. 287: 127-135. 10.1007/s11010-005-9088-0. 16685462.
21. Mehrabian A. Esna-Ashari F. Zham H. Hadizadeh M. Bohlooli M. Khayamzadeh M. Akbari M. 2010. Gastric cancer prevalence, according to survival data in Iran (national study-2007). Iran J. Public Health, 39: 27-31. 23113019.
22. Miri H. Bathaie S.Z. Mohagheghi M.A. Mokhtari-Dizaji M. Shahbazfar A.A. 2011. A noninvasive method for early detection of MNNG-induced gastric cancer of male Wistar rat: ultrasonic study. Ultrasound Med. Biol. 37: 780-787. 10.1016/j.ultrasmedbio.2010.11.015. 21458142.
23. Mousavi S.Z. Bathaie S.Z. 2011. Historical uses of saffron: Identifying potential new avenues for modern research. Avicenna Journal of Phytomedicine, 1: 57-66.
24. Mousavi S.H. Tavakkol-Afshari J. Brook A. Jafari-Anarkooli I. 2009. Role of caspases and Bax protein in saffron-induced apoptosis in MCF-7 cells. Food Chem. Toxicol. 47: 1909-1913. 10.1016/j.fct.2009.05.017. 19457443.
25. Poma A. Fontecchio G. Carlucci G. Chichiricco G. 2012. Anti-inflammatory properties of drugs from saffron crocus. Antiinflamm. Antiallergy Agents Med. Chem. 11: 37-51. 10.2174/187152312803476282. 22934747.
26. Sarbia M. Bittinger F. Grabellus F. Verreet P. Dutkowski P. Willers R. Gabbert H.E. 1997. Expression of Bax, a pro-apoptotic member of the Bcl-2 family, in esophageal squamous cell carcinoma. Int. J. Cancer, 73: 508-513. 10.1002/(SICI)1097-0215(19971114)73:4<508::AID-IJC9>3.0.CO;2-3. 9389564.
27. Sedlak T.W. Oltvai Z.N. Yang E. Wang K. Boise L.H. Thompson C.B. Korsmeyer S.J. 1995. Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc. Natl. Acad. Sci. U.S.A. 92: 7834-7838. 10.1073/pnas.92.17.7834. 7644501.
28. Siu K.P. Chan J.Y. Fung K.P. 2002. Effect of arsenic trioxide on human hepatocellular carcinoma HepG2 cells: inhibition of proliferation and induction of apoptosis. Life Sci. 71: 275-285. 10.1016/S0024-3205(02)01622-3. 12034346.
29. Tarantilis P.A. Morjani H. Polissiou M. Manfait M. 1994. Inhibition of growth and induction of differentiation of promyelocytic leukemia (HL-60) by carotenoids from Crocus sativus L. Anticancer Res. 14: 1913-1918. 7847826.
30. Tseng T.H. Chu C.Y. Huang J.M. Shiow S.J. Wang C.J. 1995. Crocetin protects against oxidative damage in rat primary hepatocytes. Cancer Lett. 97: 61-67. 10.1016/0304-3835(95)03964-X. 7585479.
31. Wang C.J. Cheng T.C. Liu J.Y. Chou F.P. Kuo M.L. Lin J.K. 1996. Inhibition of protein kinase C and proto-oncogene expression by crocetin in NIH/3T3 cells. Mol. Carcinog. 17: 235-240. 10.1002/(SICI)1098-2744(199612)17: 4<235::AID-MC7>3.3.CO;2-B. 8989917.
32. Zhou X.M. Wong B.C. Fan X.M. Zhang H.B. Lin M.C. Kung H.F. Fan D.M. Lam S.K. 2001. Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak. Carcinogenesis, 22: 1393-1397. 10.1093/carcin/22.9.1393. 11532860.