Carnosic acid induces autophagic cell death through inhibition of the Akt/mTOR pathway in human hepatoma cells

Journal of applied toxicology : JAT

Volumn 35, Issue 5, 2015, Pages 485-492

  Gao, Qilong ^a   Liu, Huaimin ^a   Yao, Yamin ^a   Geng, Liang ^a   Zhang, Xinfeng ^a   Jiang, Lifeng ^a   Shi, Bian ^a   Yang, Feng ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Akt; ATG; autophagy; carnosic acid; hepatoma; proliferation

Indexed keywords

3-METHYLADENINE; ABIETANE DERIVATIVE; ADENINE; BAFILOMYCIN A1; CARNOSIC ACID; CHLOROQUINE; MACROLIDE; MTOR PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLANT EXTRACT; PROTEIN KINASE B; PTEN PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; APOPTOSIS; AUTOPHAGY; CELL PROLIFERATION; DRUG EFFECTS; GENE SILENCING; HEPG2 CELL LINE; HUMAN; LIVER TUMOR; METABOLISM; PHOSPHORYLATION;

ADENINE; APOPTOSIS; AUTOPHAGY; CELL PROLIFERATION; CHLOROQUINE; DITERPENES, ABIETANE; GENE SILENCING; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MACROLIDES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; TOR SERINE-THREONINE KINASES;

EID: 85028223515     PISSN: None     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.3049     Document Type: Article

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