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Volumn 36, Issue 3, 2015, Pages 1763-1771

Curcumin ameliorate DENA-induced HCC via modulating TGF-β, AKT, and caspase-3 expression in experimental rat model

Author keywords

Akt; Angiogenesis; Apoptosis; Curcumin; Diethylnitrosamine; Hepatocellular carcinoma; TGF

Indexed keywords

ALANINE AMINOTRANSFERASE; CASPASE 3; CURCUMIN; DIETHYLNITROSAMINE; GLUTAMYL AMINOPEPTIDASE; PROTEIN KINASE B; TRANSFORMING GROWTH FACTOR BETA;

EID: 84930894821     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-014-2778-z     Document Type: Article
Times cited : (40)

References (60)
  • 1
    • 0037236792 scopus 로고    scopus 로고
    • Anticancer potential of curcumin: preclinical and clinical studies
    • COI: 1:CAS:528:DC%2BD3sXislaqtLo%3D, PID: 12680238
    • Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003;23:363–98.
    • (2003) Anticancer Res , vol.23 , pp. 363-398
    • Aggarwal, B.B.1    Kumar, A.2    Bharti, A.C.3
  • 2
    • 27144468987 scopus 로고    scopus 로고
    • Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice
    • COI: 1:CAS:528:DC%2BD2MXhtFartbjM, PID: 16243823
    • Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE, et al. Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res. 2005;11:7490–8.
    • (2005) Clin Cancer Res , vol.11 , pp. 7490-7498
    • Aggarwal, B.B.1    Shishodia, S.2    Takada, Y.3    Banerjee, S.4    Newman, R.A.5    Bueso-Ramos, C.E.6
  • 3
    • 0041489799 scopus 로고    scopus 로고
    • Protective effect of Rhodotorula glutinis NCIM3353 on the development of hepatic preneoplastic lesions
    • Bhosale PML, Ingle AD, Gadre RVB, Rao KV. Protective effect of Rhodotorula glutinis NCIM3353 on the development of hepatic preneoplastic lesions. Curr Sci. 2002;83:303–8.
    • (2002) Curr Sci , vol.83 , pp. 303-308
    • Bhosale, P.M.L.1    Ingle, A.D.2    Gadre, R.V.B.3    Rao, K.V.4
  • 4
    • 13244289773 scopus 로고    scopus 로고
    • Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity
    • COI: 1:CAS:528:DC%2BD2MXhsFSmuw%3D%3D, PID: 15650394
    • Biswas SK, McClure D, Jimenez LA, Megson IL, Rahman I. Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity. Antioxid Redox Signal. 2005;7:32–41.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 32-41
    • Biswas, S.K.1    McClure, D.2    Jimenez, L.A.3    Megson, I.L.4    Rahman, I.5
  • 5
    • 7044229778 scopus 로고    scopus 로고
    • Primary liver cancer: worldwide incidence and trends
    • PID: 15508102
    • Bosch FX, Ribes J, Diaz M, Cleries R. Primary liver cancer: worldwide incidence and trends. Gastroenterology. 2004;127:S5–16.
    • (2004) Gastroenterology , vol.127 , pp. 5-16
    • Bosch, F.X.1    Ribes, J.2    Diaz, M.3    Cleries, R.4
  • 6
    • 28844480321 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma
    • PID: 16250051
    • Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology. 2005;42:1208–36.
    • (2005) Hepatology , vol.42 , pp. 1208-1236
    • Bruix, J.1    Sherman, M.2
  • 7
    • 0035842333 scopus 로고    scopus 로고
    • Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53
    • COI: 1:CAS:528:DC%2BD3MXosFGhs7c%3D, PID: 11716543
    • Bush JA, Cheung Jr KJ, Li G. Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53. Exp Cell Res. 2001;271:305–14.
    • (2001) Exp Cell Res , vol.271 , pp. 305-314
    • Bush, J.A.1    Cheung, K.J.2    Li, G.3
  • 8
    • 33847025287 scopus 로고    scopus 로고
    • Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: implications in liver carcinogenesis
    • COI: 1:CAS:528:DC%2BD2sXit1Grsbw%3D, PID: 17055226
    • Caja L, Ortiz C, Bertran E, Murillo MM, Miro-Obradors MJ, Palacios E, et al. Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: implications in liver carcinogenesis. Cell Signal. 2007;19:683–94.
    • (2007) Cell Signal , vol.19 , pp. 683-694
    • Caja, L.1    Ortiz, C.2    Bertran, E.3    Murillo, M.M.4    Miro-Obradors, M.J.5    Palacios, E.6
  • 9
    • 79959966423 scopus 로고    scopus 로고
    • Oxidative stress and ERK1/2 phosphorylation as predictors of outcome in hepatocellular carcinoma patients treated with sorafenib plus octreotide LAR
    • COI: 1:STN:280:DC%2BC3Mvnt1Gktg%3D%3D, PID: 21525937
    • Caraglia M, Giuberti G, Marra M, Addeo R, Montella L, Murolo M, et al. Oxidative stress and ERK1/2 phosphorylation as predictors of outcome in hepatocellular carcinoma patients treated with sorafenib plus octreotide LAR. Cell Death Dis. 2011;2:e150.
    • (2011) Cell Death Dis , vol.2 , pp. 150
    • Caraglia, M.1    Giuberti, G.2    Marra, M.3    Addeo, R.4    Montella, L.5    Murolo, M.6
  • 10
    • 33845678662 scopus 로고    scopus 로고
    • Carcinogen-induced early molecular events and its implication in the initiation of chemical hepatocarcinogenesis in rats: chemopreventive role of vanadium on this process
    • COI: 1:CAS:528:DC%2BD2sXht1Sqtg%3D%3D, PID: 17174075
    • Chakraborty T, Chatterjee A, Rana A, Dhachinamoorthi D, Kumar PA, Chatterjee M. Carcinogen-induced early molecular events and its implication in the initiation of chemical hepatocarcinogenesis in rats: chemopreventive role of vanadium on this process. Biochim Biophys Acta. 2007;1772:48–59.
    • (2007) Biochim Biophys Acta , vol.1772 , pp. 48-59
    • Chakraborty, T.1    Chatterjee, A.2    Rana, A.3    Dhachinamoorthi, D.4    Kumar, P.A.5    Chatterjee, M.6
  • 11
    • 1542426626 scopus 로고    scopus 로고
    • Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3
    • COI: 1:CAS:528:DC%2BD2cXhsFOht7g%3D, PID: 14985701
    • Chendil D, Ranga RS, Meigooni D, Sathishkumar S, Ahmed MM. Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3. Oncogene. 2004;23:1599–607.
    • (2004) Oncogene , vol.23 , pp. 1599-1607
    • Chendil, D.1    Ranga, R.S.2    Meigooni, D.3    Sathishkumar, S.4    Ahmed, M.M.5
  • 12
    • 0346244047 scopus 로고    scopus 로고
    • Regulation of human breast epithelial stem cells
    • COI: 1:CAS:528:DC%2BD3sXpsFChtrw%3D, PID: 14521515
    • Clarke RB, Anderson E, Howell A, Potten CS. Regulation of human breast epithelial stem cells. Cell Prolif. 2003;36 Suppl 1:45–58.
    • (2003) Cell Prolif , vol.36 , pp. 45-58
    • Clarke, R.B.1    Anderson, E.2    Howell, A.3    Potten, C.S.4
  • 14
    • 0033152165 scopus 로고    scopus 로고
    • Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN
    • COI: 1:CAS:528:DyaK1MXjs1ymsLg%3D, PID: 10363971
    • Davies MA, Koul D, Dhesi H, Berman R, McDonnell TJ, McConkey D, et al. Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. Cancer Res. 1999;59:2551–6.
    • (1999) Cancer Res , vol.59 , pp. 2551-2556
    • Davies, M.A.1    Koul, D.2    Dhesi, H.3    Berman, R.4    McDonnell, T.J.5    McConkey, D.6
  • 15
    • 84860361968 scopus 로고    scopus 로고
    • Potential chemoprevention of diethylnitrosamine-induced hepatocarcinogenesis in rats: myrrh (Commiphora molmol) vs. turmeric (Curcuma longa)
    • COI: 1:CAS:528:DC%2BC38XmtFGhtbc%3D, PID: 21871653
    • El-Shahat M, El-Abd S, Alkafafy M, El-Khatib G. Potential chemoprevention of diethylnitrosamine-induced hepatocarcinogenesis in rats: myrrh (Commiphora molmol) vs. turmeric (Curcuma longa). Acta Histochem. 2012;114:421–8.
    • (2012) Acta Histochem , vol.114 , pp. 421-428
    • El-Shahat, M.1    El-Abd, S.2    Alkafafy, M.3    El-Khatib, G.4
  • 16
    • 84861012202 scopus 로고    scopus 로고
    • Oxidative stress and benefits of antioxidant agents in acute and chronic hepatitis
    • PID: 22550523
    • Esrefoglu M. Oxidative stress and benefits of antioxidant agents in acute and chronic hepatitis. Hepat Mon. 2012;12:160–7.
    • (2012) Hepat Mon , vol.12 , pp. 160-167
    • Esrefoglu, M.1
  • 17
    • 34247602670 scopus 로고    scopus 로고
    • Survival and apoptosis: a dysregulated balance in liver cancer
    • COI: 1:CAS:528:DC%2BD2sXksVOksLc%3D, PID: 17311609
    • Fabregat I, Roncero C, Fernandez M. Survival and apoptosis: a dysregulated balance in liver cancer. Liver Int. 2007;27:155–62.
    • (2007) Liver Int , vol.27 , pp. 155-162
    • Fabregat, I.1    Roncero, C.2    Fernandez, M.3
  • 18
    • 0035211504 scopus 로고    scopus 로고
    • Angiogenesis-dependent diseases
    • COI: 1:STN:280:DC%2BD3MnptlOguw%3D%3D, PID: 11740806
    • Folkman J. Angiogenesis-dependent diseases. Semin Oncol. 2001;28:536–42.
    • (2001) Semin Oncol , vol.28 , pp. 536-542
    • Folkman, J.1
  • 19
    • 77958011209 scopus 로고    scopus 로고
    • Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs
    • COI: 1:CAS:528:DC%2BC3cXht1GkurbP, PID: 20924967
    • Goel A, Aggarwal BB. Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutr Cancer. 2010;62:919–30.
    • (2010) Nutr Cancer , vol.62 , pp. 919-930
    • Goel, A.1    Aggarwal, B.B.2
  • 21
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • COI: 1:CAS:528:DyaK28XltVSks7s%3D, PID: 8756718
    • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 1996;86:353–64.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 22
    • 79960716001 scopus 로고    scopus 로고
    • Akt signalling in health and disease
    • COI: 1:CAS:528:DC%2BC3MXpslaisLo%3D, PID: 21620960
    • Hers I, Vincent EE, Tavare JM. Akt signalling in health and disease. Cell Signal. 2011;23:1515–27.
    • (2011) Cell Signal , vol.23 , pp. 1515-1527
    • Hers, I.1    Vincent, E.E.2    Tavare, J.M.3
  • 23
    • 33344461738 scopus 로고    scopus 로고
    • Curcumin induces apoptosis via inhibition of PI3′-kinase/AKT pathway in acute T cell leukemias
    • COI: 1:CAS:528:DC%2BD28XhvVSrtLk%3D, PID: 16502262
    • Hussain AR, Al-Rasheed M, Manogaran PS, Al-Hussein KA, Platanias LC, Al Kuraya K, et al. Curcumin induces apoptosis via inhibition of PI3′-kinase/AKT pathway in acute T cell leukemias. Apoptosis. 2006;11:245–54.
    • (2006) Apoptosis , vol.11 , pp. 245-254
    • Hussain, A.R.1    Al-Rasheed, M.2    Manogaran, P.S.3    Al-Hussein, K.A.4    Platanias, L.C.5    Al Kuraya, K.6
  • 24
    • 84862113237 scopus 로고    scopus 로고
    • Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology
    • COI: 1:CAS:528:DC%2BC38XntF2gtrw%3D, PID: 22595785
    • Hyman BT, Yuan J. Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology. Nat Rev Neurosci. 2012;13:395–406.
    • (2012) Nat Rev Neurosci , vol.13 , pp. 395-406
    • Hyman, B.T.1    Yuan, J.2
  • 25
    • 0026406073 scopus 로고
    • Elevated levels of transforming growth factor beta messenger RNA and its polypeptide in human hepatocellular carcinoma
    • COI: 1:CAS:528:DyaK3MXltFWrsLg%3D, PID: 1649698
    • Ito N, Kawata S, Tamura S, Takaishi K, Shirai Y, Kiso S, et al. Elevated levels of transforming growth factor beta messenger RNA and its polypeptide in human hepatocellular carcinoma. Cancer Res. 1991;51:4080–3.
    • (1991) Cancer Res , vol.51 , pp. 4080-4083
    • Ito, N.1    Kawata, S.2    Tamura, S.3    Takaishi, K.4    Shirai, Y.5    Kiso, S.6
  • 27
    • 0034652392 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
    • COI: 1:CAS:528:DC%2BD3cXhsFCrt7w%3D, PID: 10677529
    • Jiang BH, Zheng JZ, Aoki M, Vogt PK. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc Natl Acad Sci U S A. 2000;97:1749–53.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 1749-1753
    • Jiang, B.H.1    Zheng, J.Z.2    Aoki, M.3    Vogt, P.K.4
  • 29
    • 0033064548 scopus 로고    scopus 로고
    • Antitumor activity of curcumin is mediated through the induction of apoptosis in AK-5 tumor cells
    • COI: 1:CAS:528:DyaK1MXht1Ogs7w%3D, PID: 10069393
    • Khar A, Ali AM, Pardhasaradhi BV, Begum Z, Anjum R. Antitumor activity of curcumin is mediated through the induction of apoptosis in AK-5 tumor cells. FEBS Lett. 1999;445:165–8.
    • (1999) FEBS Lett , vol.445 , pp. 165-168
    • Khar, A.1    Ali, A.M.2    Pardhasaradhi, B.V.3    Begum, Z.4    Anjum, R.5
  • 30
    • 0033564103 scopus 로고    scopus 로고
    • Dead or dying: necrosis versus apoptosis in caspase-deficient human renal cell carcinoma
    • COI: 1:CAS:528:DyaK1MXktVOku78%3D, PID: 10383143
    • Kolenko V, Uzzo RG, Bukowski R, Bander NH, Novick AC, Hsi ED, et al. Dead or dying: necrosis versus apoptosis in caspase-deficient human renal cell carcinoma. Cancer Res. 1999;59:2838–42.
    • (1999) Cancer Res , vol.59 , pp. 2838-2842
    • Kolenko, V.1    Uzzo, R.G.2    Bukowski, R.3    Bander, N.H.4    Novick, A.C.5    Hsi, E.D.6
  • 31
    • 12644304864 scopus 로고    scopus 로고
    • Patterns of recurrence after initial treatment in patients with small hepatocellular carcinoma
    • COI: 1:STN:280:DyaK2s7jvVantg%3D%3D, PID: 8985270
    • Kumada T, Nakano S, Takeda I, Sugiyama K, Osada T, Kiriyama S, et al. Patterns of recurrence after initial treatment in patients with small hepatocellular carcinoma. Hepatology. 1997;25:87–92.
    • (1997) Hepatology , vol.25 , pp. 87-92
    • Kumada, T.1    Nakano, S.2    Takeda, I.3    Sugiyama, K.4    Osada, T.5    Kiriyama, S.6
  • 32
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • COI: 1:CAS:528:DC%2BD3MXlsFags7s%3D, PID: 5432063
    • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680–5.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 34
    • 84878493251 scopus 로고    scopus 로고
    • Curcumin induces apoptosis in breast cancer cell lines and delays the growth of mammary tumors in neu transgenic mice
    • COI: 1:CAS:528:DC%2BC3sXmslWhsLw%3D, PID: 23489691
    • Masuelli L, Benvenuto M, Fantini M, Marzocchella L, Sacchetti P, Di Stefano E, et al. Curcumin induces apoptosis in breast cancer cell lines and delays the growth of mammary tumors in neu transgenic mice. J Biol Regul Homeost Agents. 2013;27:105–19.
    • (2013) J Biol Regul Homeost Agents , vol.27 , pp. 105-119
    • Masuelli, L.1    Benvenuto, M.2    Fantini, M.3    Marzocchella, L.4    Sacchetti, P.5    Di Stefano, E.6
  • 35
    • 0034615942 scopus 로고    scopus 로고
    • Curcuminoids inhibit the angiogenic response stimulated by fibroblast growth factor-2, including expression of matrix metalloproteinase gelatinase B
    • COI: 1:CAS:528:DC%2BD3cXisFWjt70%3D, PID: 10744729
    • Mohan R, Sivak J, Ashton P, Russo LA, Pham BQ, Kasahara N, et al. Curcuminoids inhibit the angiogenic response stimulated by fibroblast growth factor-2, including expression of matrix metalloproteinase gelatinase B. J Biol Chem. 2000;275:10405–12.
    • (2000) J Biol Chem , vol.275 , pp. 10405-10412
    • Mohan, R.1    Sivak, J.2    Ashton, P.3    Russo, L.A.4    Pham, B.Q.5    Kasahara, N.6
  • 36
    • 0035917844 scopus 로고    scopus 로고
    • Curcumin induces the mitochondrial permeability transition pore mediated by membrane protein thiol oxidation
    • COI: 1:CAS:528:DC%2BD3MXivFegs7g%3D, PID: 11322961
    • Morin D, Barthelemy S, Zini R, Labidalle S, Tillement JP. Curcumin induces the mitochondrial permeability transition pore mediated by membrane protein thiol oxidation. FEBS Lett. 2001;495:131–6.
    • (2001) FEBS Lett , vol.495 , pp. 131-136
    • Morin, D.1    Barthelemy, S.2    Zini, R.3    Labidalle, S.4    Tillement, J.P.5
  • 38
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • COI: 1:CAS:528:DyaE1MXksFaisbk%3D, PID: 36810
    • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351–8.
    • (1979) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 39
    • 33846182255 scopus 로고    scopus 로고
    • Hepatocellular carcinoma development in cirrhosis
    • PID: 17223503
    • Okuda H. Hepatocellular carcinoma development in cirrhosis. Best Pract Res Clin Gastroenterol. 2007;21:161–73.
    • (2007) Best Pract Res Clin Gastroenterol , vol.21 , pp. 161-173
    • Okuda, H.1
  • 40
    • 33749261599 scopus 로고    scopus 로고
    • Angiogenesis and antiangiogenic therapy in hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BD28XhtVGit7rM, PID: 16564617
    • Pang R, Poon RT. Angiogenesis and antiangiogenic therapy in hepatocellular carcinoma. Cancer Lett. 2006;242:151–67.
    • (2006) Cancer Lett , vol.242 , pp. 151-167
    • Pang, R.1    Poon, R.T.2
  • 42
    • 84896553345 scopus 로고    scopus 로고
    • Molecular mechanism of TGF-beta signaling pathway in colon carcinogenesis and status of curcumin as chemopreventive strategy
    • Ramamoorthi G. & Sivalingam N. (2014) Molecular mechanism of TGF-beta signaling pathway in colon carcinogenesis and status of curcumin as chemopreventive strategy. Tumour Biol
    • (2014) Tumour Biol
    • Ramamoorthi, G.1    Sivalingam, N.2
  • 43
    • 73349094986 scopus 로고    scopus 로고
    • Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?
    • COI: 1:CAS:528:DC%2BD1MXhsFGmur7I, PID: 19590964
    • Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? Aaps J. 2009;11:495–510.
    • (2009) Aaps J , vol.11 , pp. 495-510
    • Ravindran, J.1    Prasad, S.2    Aggarwal, B.B.3
  • 44
    • 66349129125 scopus 로고
    • A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases
    • COI: 1:CAS:528:DyaG2sXpvFyiuw%3D%3D, PID: 13458125
    • Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol. 1957;28:56–63.
    • (1957) Am J Clin Pathol , vol.28 , pp. 56-63
    • Reitman, S.1    Frankel, S.2
  • 45
    • 55949108888 scopus 로고    scopus 로고
    • Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress
    • COI: 1:CAS:528:DC%2BD1cXptlalt74%3D, PID: 18705752
    • Reyes-Gordillo K, Segovia J, Shibayama M, Tsutsumi V, Vergara P, Moreno MG, et al. Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress. Fundam Clin Pharmacol. 2008;22:417–27.
    • (2008) Fundam Clin Pharmacol , vol.22 , pp. 417-427
    • Reyes-Gordillo, K.1    Segovia, J.2    Shibayama, M.3    Tsutsumi, V.4    Vergara, P.5    Moreno, M.G.6
  • 46
    • 8844261849 scopus 로고    scopus 로고
    • Curcumin-induced GADD153 gene up-regulation in human colon cancer cells
    • COI: 1:CAS:528:DC%2BD2cXhtVWgs73M, PID: 15271854
    • Scott DW, Loo G. Curcumin-induced GADD153 gene up-regulation in human colon cancer cells. Carcinogenesis. 2004;25:2155–64.
    • (2004) Carcinogenesis , vol.25 , pp. 2155-2164
    • Scott, D.W.1    Loo, G.2
  • 47
    • 7244250405 scopus 로고    scopus 로고
    • Angiogenesis and hepatocellular carcinoma
    • PID: 15519663
    • Semela D, Dufour JF. Angiogenesis and hepatocellular carcinoma. J Hepatol. 2004;41:864–80.
    • (2004) J Hepatol , vol.41 , pp. 864-880
    • Semela, D.1    Dufour, J.F.2
  • 48
    • 36448981749 scopus 로고    scopus 로고
    • Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells: molecular mechanisms of apoptosis, migration and angiogenesis
    • PID: 17916240
    • Shankar S, Chen Q, Sarva K, Siddiqui I, Srivastava RK. Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells: molecular mechanisms of apoptosis, migration and angiogenesis. J Mol Signal. 2007;2:10.
    • (2007) J Mol Signal , vol.2 , pp. 10
    • Shankar, S.1    Chen, Q.2    Sarva, K.3    Siddiqui, I.4    Srivastava, R.K.5
  • 49
    • 0025965404 scopus 로고
    • Alanine aminotransferase in clinical practice. A review
    • COI: 1:STN:280:DyaK3M7ivVSguw%3D%3D, PID: 1992953
    • Sherman KE. Alanine aminotransferase in clinical practice. A review. Arch Intern Med. 1991;151:260–5.
    • (1991) Arch Intern Med , vol.151 , pp. 260-265
    • Sherman, K.E.1
  • 50
    • 0030271587 scopus 로고    scopus 로고
    • Curcumin inhibits the proliferation and cell cycle progression of human umbilical vein endothelial cell
    • COI: 1:CAS:528:DyaK28Xnt1Sktrk%3D, PID: 8913274
    • Singh AK, Sidhu GS, Deepa T, Maheshwari RK. Curcumin inhibits the proliferation and cell cycle progression of human umbilical vein endothelial cell. Cancer Lett. 1996;107:109–15.
    • (1996) Cancer Lett , vol.107 , pp. 109-115
    • Singh, A.K.1    Sidhu, G.S.2    Deepa, T.3    Maheshwari, R.K.4
  • 51
    • 33745907263 scopus 로고    scopus 로고
    • Effects of administration of embelin and curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats
    • COI: 1:CAS:528:DC%2BD28XksFGlu7c%3D, PID: 16477385
    • Sreepriya M, Bali G. Effects of administration of embelin and curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats. Mol Cell Biochem. 2006;284:49–55.
    • (2006) Mol Cell Biochem , vol.284 , pp. 49-55
    • Sreepriya, M.1    Bali, G.2
  • 52
    • 84872816700 scopus 로고    scopus 로고
    • Lifespan extension by the antioxidant curcumin in Drosophila melanogaster
    • PID: 23675008
    • Suckow BK, Suckow MA. Lifespan extension by the antioxidant curcumin in Drosophila melanogaster. Int J Biomed Sci. 2006;2:402–5.
    • (2006) Int J Biomed Sci , vol.2 , pp. 402-405
    • Suckow, B.K.1    Suckow, M.A.2
  • 53
    • 84889884073 scopus 로고    scopus 로고
    • Increased hepatic oxidative DNA damage in patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC3sXhvVWlt77L, PID: 23329365
    • Tanaka S, Miyanishi K, Kobune M, Kawano Y, Hoki T, Kubo T, et al. Increased hepatic oxidative DNA damage in patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma. J Gastroenterol. 2013;48:1249–58.
    • (2013) J Gastroenterol , vol.48 , pp. 1249-1258
    • Tanaka, S.1    Miyanishi, K.2    Kobune, M.3    Kawano, Y.4    Hoki, T.5    Kubo, T.6
  • 54
    • 0028823210 scopus 로고
    • Plasma alpha-glutathione S-transferase assessed as a marker of liver damage in patients with chronic hepatitis C
    • Vaubourdolle M, Chazouilleres O, Briaud I, Legendre C, Serfaty L, Poupon R, Giboudeau J. Plasma alpha-glutathione S-transferase assessed as a marker of liver damage in patients with chronic hepatitis C. Clin Chem 1995;41:1716–9.
    • (1995) Clin Chem , vol.41 , pp. 1716-1719
    • Vaubourdolle, M.1    Chazouilleres, O.2    Briaud, I.3    Legendre, C.4    Serfaty, L.5    Poupon, R.6    Giboudeau, J.7
  • 55
    • 0034791087 scopus 로고    scopus 로고
    • Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling
    • COI: 1:CAS:528:DC%2BD3MXns1Wjt74%3D, PID: 11585905
    • Vinals F, Pouyssegur J. Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling. Mol Cell Biol. 2001;21:7218–30.
    • (2001) Mol Cell Biol , vol.21 , pp. 7218-7230
    • Vinals, F.1    Pouyssegur, J.2
  • 56
    • 77956627711 scopus 로고    scopus 로고
    • The role of signaling pathways in the development and treatment of hepatocellular carcinoma
    • Whittaker S, Marais R, Zhu AX. The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene. 2011;29:4989–5005.
    • (2011) Oncogene , vol.29 , pp. 4989-5005
    • Whittaker, S.1    Marais, R.2    Zhu, A.X.3
  • 57
    • 1142277821 scopus 로고    scopus 로고
    • Akt2 expression correlates with prognosis of human hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BD2cXjt1ajtw%3D%3D, PID: 14654898
    • Xu X, Sakon M, Nagano H, Hiraoka N, Yamamoto H, Hayashi N, et al. Akt2 expression correlates with prognosis of human hepatocellular carcinoma. Oncol Rep. 2004;11:25–32.
    • (2004) Oncol Rep , vol.11 , pp. 25-32
    • Xu, X.1    Sakon, M.2    Nagano, H.3    Hiraoka, N.4    Yamamoto, H.5    Hayashi, N.6
  • 58
    • 33644797877 scopus 로고    scopus 로고
    • Effects of curcumin on tumor angiogenesis and biomarkers, COX-2 and VEGF, in hepatocellular carcinoma cell-implanted nude mice
    • COI: 1:CAS:528:DC%2BD28XitVSltL4%3D, PID: 16543625
    • Yoysungnoen P, Wirachwong P, Bhattarakosol P, Niimi H, Patumraj S. Effects of curcumin on tumor angiogenesis and biomarkers, COX-2 and VEGF, in hepatocellular carcinoma cell-implanted nude mice. Clin Hemorheol Microcirc. 2006;34:109–15.
    • (2006) Clin Hemorheol Microcirc , vol.34 , pp. 109-115
    • Yoysungnoen, P.1    Wirachwong, P.2    Bhattarakosol, P.3    Niimi, H.4    Patumraj, S.5
  • 59
    • 54049128202 scopus 로고    scopus 로고
    • Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism
    • COI: 1:CAS:528:DC%2BD1cXhtFSms7jE, PID: 18790744
    • Yu S, Shen G, Khor TO, Kim JH, Kong AN. Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism. Mol Cancer Ther. 2008;7:2609–20.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2609-2620
    • Yu, S.1    Shen, G.2    Khor, T.O.3    Kim, J.H.4    Kong, A.N.5
  • 60
    • 84878928131 scopus 로고    scopus 로고
    • Curcumin inhibits the metastasis of K1 papillary thyroid cancer cells via modulating E-cadherin and matrix metalloproteinase-9 expression
    • COI: 1:CAS:528:DC%2BC3sXptFemsL8%3D, PID: 23474829
    • Zhang CY, Zhang L, Yu HX, Bao JD, Lu RR. Curcumin inhibits the metastasis of K1 papillary thyroid cancer cells via modulating E-cadherin and matrix metalloproteinase-9 expression. Biotechnol Lett. 2013;35:995–1000.
    • (2013) Biotechnol Lett , vol.35 , pp. 995-1000
    • Zhang, C.Y.1    Zhang, L.2    Yu, H.X.3    Bao, J.D.4    Lu, R.R.5


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