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Volumn 19, Issue 1, 2014, Pages 18-30

Thymoquinone: Fifty years of success in the battle against cancer models

Author keywords

[No Author keywords available]

Indexed keywords

NANOPARTICLE; THYMOQUINONE;

EID: 84891858462     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2013.08.021     Document Type: Review
Times cited : (190)

References (106)
  • 1
    • 33646202807 scopus 로고    scopus 로고
    • Thymoquinone: A promising anti-cancer drug from natural sources
    • H. Gali-Muhtasib et al. Thymoquinone: a promising anti-cancer drug from natural sources Int. J. Biochem. Cell Biol. 38 2006 1249 1253
    • (2006) Int. J. Biochem. Cell Biol. , vol.38 , pp. 1249-1253
    • Gali-Muhtasib, H.1
  • 2
    • 0027389096 scopus 로고
    • Thymoquinone from Eupatorium ayapana
    • N.T. Trang et al. Thymoquinone from Eupatorium ayapana Planta Med. 59 1993 99
    • (1993) Planta Med. , vol.59 , pp. 99
    • Trang, N.T.1
  • 3
    • 64549137674 scopus 로고    scopus 로고
    • Composition of essential oil compounds from different Syrian populations of Origanum syriacum L. (Lamiaceae)
    • B. Lukas et al. Composition of essential oil compounds from different Syrian populations of Origanum syriacum L. (Lamiaceae) J. Agric. Food Chem. 57 2009 1362 1365
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 1362-1365
    • Lukas, B.1
  • 4
    • 35948930977 scopus 로고    scopus 로고
    • Antimicrobial activity of extractable conifer heartwood compounds toward Phytophthora ramorum
    • D.K. Manter et al. Antimicrobial activity of extractable conifer heartwood compounds toward Phytophthora ramorum J. Chem. Ecol. 33 2007 2133 2147
    • (2007) J. Chem. Ecol. , vol.33 , pp. 2133-2147
    • Manter, D.K.1
  • 5
    • 84861089193 scopus 로고    scopus 로고
    • Evaluation of the cytotoxicity of Satureja spicigera and its main compounds
    • A.R. Gohari et al. Evaluation of the cytotoxicity of Satureja spicigera and its main compounds Sci. World J. 2012 2012 203861
    • (2012) Sci. World J. , vol.2012 , pp. 203861
    • Gohari, A.R.1
  • 6
    • 77954973717 scopus 로고    scopus 로고
    • Composition and antioxidant activity of Thymus vulgaris volatiles: Comparison between supercritical fluid extraction and hydrodistillation
    • C. Grosso et al. Composition and antioxidant activity of Thymus vulgaris volatiles: comparison between supercritical fluid extraction and hydrodistillation J. Sep. Sci. 33 2010 2211 2218
    • (2010) J. Sep. Sci. , vol.33 , pp. 2211-2218
    • Grosso, C.1
  • 7
    • 78751653788 scopus 로고    scopus 로고
    • Chemical constituents of Nepeta distans
    • J. Hussain et al. Chemical constituents of Nepeta distans Nat. Prod. Commun. 5 2010 1785 1786
    • (2010) Nat. Prod. Commun. , vol.5 , pp. 1785-1786
    • Hussain, J.1
  • 8
    • 27744476617 scopus 로고    scopus 로고
    • Immunomodulatory and therapeutic properties of the Nigella sativa L. Seed
    • M.L. Salem Immunomodulatory and therapeutic properties of the Nigella sativa L. seed Int. Immunopharmacol. 5 2005 1749 1770
    • (2005) Int. Immunopharmacol. , vol.5 , pp. 1749-1770
    • Salem, M.L.1
  • 9
    • 77958014176 scopus 로고    scopus 로고
    • Review on molecular and therapeutic potential of thymoquinone in cancer
    • S. Banerjee et al. Review on molecular and therapeutic potential of thymoquinone in cancer Nutr. Cancer 62 2010 938 946
    • (2010) Nutr. Cancer , vol.62 , pp. 938-946
    • Banerjee, S.1
  • 10
    • 84855810908 scopus 로고    scopus 로고
    • Thymoquinone: Potential cure for inflammatory disorders and cancer
    • C.C. Woo et al. Thymoquinone: potential cure for inflammatory disorders and cancer Biochem. Pharmacol. 83 2012 443 451
    • (2012) Biochem. Pharmacol. , vol.83 , pp. 443-451
    • Woo, C.C.1
  • 11
    • 78650513807 scopus 로고    scopus 로고
    • The effect of thymoquinone on intractable pediatric seizures (pilot study)
    • J. Akhondian et al. The effect of thymoquinone on intractable pediatric seizures (pilot study) Epilepsy Res. 93 2011 39 43
    • (2011) Epilepsy Res. , vol.93 , pp. 39-43
    • Akhondian, J.1
  • 12
    • 0000988920 scopus 로고
    • Studies on the chemical constitution of Egyptian N. Sativa L. Seeds
    • M. El-Dakhakhny Studies on the chemical constitution of Egyptian N. sativa L. seeds Planta Med. 11 1963 465 470
    • (1963) Planta Med. , vol.11 , pp. 465-470
    • El-Dakhakhny, M.1
  • 13
    • 0023196633 scopus 로고
    • Toward a rationalization of the sensitizing potency of substituted p-benzoquinones: Reaction of nucleophiles with p-benzoquinones
    • D. Cremer et al. Toward a rationalization of the sensitizing potency of substituted p-benzoquinones: reaction of nucleophiles with p-benzoquinones J. Med. Chem. 30 1987 1678 1681
    • (1987) J. Med. Chem. , vol.30 , pp. 1678-1681
    • Cremer, D.1
  • 14
    • 0034686073 scopus 로고    scopus 로고
    • Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice
    • M.A. Mansour Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice Life Sci. 66 2000 2583 2591
    • (2000) Life Sci. , vol.66 , pp. 2583-2591
    • Mansour, M.A.1
  • 15
    • 0035237915 scopus 로고    scopus 로고
    • Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis
    • O.A. Badary, and A.M. Gamal El-Din Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis Cancer Detect. Prev. 25 2001 362 368
    • (2001) Cancer Detect. Prev. , vol.25 , pp. 362-368
    • Badary, O.A.1    Gamal El-Din, A.M.2
  • 16
    • 48649088554 scopus 로고    scopus 로고
    • Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells
    • H. Gali-Muhtasib et al. Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells Cancer Res. 68 2008 5609 5618
    • (2008) Cancer Res. , vol.68 , pp. 5609-5618
    • Gali-Muhtasib, H.1
  • 17
    • 84878477104 scopus 로고    scopus 로고
    • Thymoquinone induces apoptosis in malignant T-cells via generation of ROS
    • E.M. Dergarabetian et al. Thymoquinone induces apoptosis in malignant T-cells via generation of ROS Front. Biosci. (Elite Ed.) 5 2013 706 719
    • (2013) Front. Biosci. (Elite Ed.) , vol.5 , pp. 706-719
    • Dergarabetian, E.M.1
  • 18
    • 27944477663 scopus 로고    scopus 로고
    • Modes of action of alpha-hederin and thymoquinone, active constituents of Nigella sativa, against HEp-2 cancer cells
    • S. Rooney, and M.F. Ryan Modes of action of alpha-hederin and thymoquinone, active constituents of Nigella sativa, against HEp-2 cancer cells Anticancer Res. 25 2005 4255 4259
    • (2005) Anticancer Res. , vol.25 , pp. 4255-4259
    • Rooney, S.1    Ryan, M.F.2
  • 19
    • 43149093993 scopus 로고    scopus 로고
    • Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions
    • W. Reindl et al. Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions Chem. Biol. 15 2008 459 466
    • (2008) Chem. Biol. , vol.15 , pp. 459-466
    • Reindl, W.1
  • 20
    • 34250902383 scopus 로고    scopus 로고
    • Nonenzymatic reduction of thymoquinone in physiological conditions
    • K.H. Khalife, and G. Lupidi Nonenzymatic reduction of thymoquinone in physiological conditions Free Radic. Res. 41 2007 153 161
    • (2007) Free Radic. Res. , vol.41 , pp. 153-161
    • Khalife, K.H.1    Lupidi, G.2
  • 21
    • 84874074839 scopus 로고    scopus 로고
    • Thymoquinone blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic
    • Z. Yin et al. Thymoquinone blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic ACS Chem. Biol. 8 2013 303 308
    • (2013) ACS Chem. Biol. , vol.8 , pp. 303-308
    • Yin, Z.1
  • 22
    • 80053229630 scopus 로고    scopus 로고
    • Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo
    • J. Yuan et al. Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo Am. J. Pathol. 179 2011 2091 2099
    • (2011) Am. J. Pathol. , vol.179 , pp. 2091-2099
    • Yuan, J.1
  • 23
    • 79953695947 scopus 로고    scopus 로고
    • Stability-indicating ultra-performance liquid chromatography method for the estimation of thymoquinone and its application in biopharmaceutical studies
    • S.A. Pathan et al. Stability-indicating ultra-performance liquid chromatography method for the estimation of thymoquinone and its application in biopharmaceutical studies Biomed. Chromatogr. 25 2011 613 620
    • (2011) Biomed. Chromatogr. , vol.25 , pp. 613-620
    • Pathan, S.A.1
  • 24
    • 79955966975 scopus 로고    scopus 로고
    • Cellular localisation of antitumoral 6-alkyl thymoquinones revealed by an alkyne-azide click reaction and the streptavidin-biotin system
    • K. Effenberger-Neidnicht et al. Cellular localisation of antitumoral 6-alkyl thymoquinones revealed by an alkyne-azide click reaction and the streptavidin-biotin system Chembiochem 12 2011 1237 1241
    • (2011) Chembiochem , vol.12 , pp. 1237-1241
    • Effenberger-Neidnicht, K.1
  • 25
    • 75449101581 scopus 로고    scopus 로고
    • Terpene conjugates of the Nigella sativa seed-oil constituent thymoquinone with enhanced efficacy in cancer cells
    • K. Effenberger et al. Terpene conjugates of the Nigella sativa seed-oil constituent thymoquinone with enhanced efficacy in cancer cells Chem. Biodivers. 7 2010 129 139
    • (2010) Chem. Biodivers. , vol.7 , pp. 129-139
    • Effenberger, K.1
  • 26
    • 77953180751 scopus 로고    scopus 로고
    • Structure-activity studies on therapeutic potential of thymoquinone analogs in pancreatic cancer
    • S. Banerjee et al. Structure-activity studies on therapeutic potential of thymoquinone analogs in pancreatic cancer Pharm. Res. 27 2010 1146 1158
    • (2010) Pharm. Res. , vol.27 , pp. 1146-1158
    • Banerjee, S.1
  • 27
    • 77950086914 scopus 로고    scopus 로고
    • Thymoquinone poly(lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential
    • J. Ravindran et al. Thymoquinone poly(lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential Biochem. Pharmacol. 79 2010 1640 1647
    • (2010) Biochem. Pharmacol. , vol.79 , pp. 1640-1647
    • Ravindran, J.1
  • 28
    • 77954154547 scopus 로고    scopus 로고
    • Delivery of phytochemical thymoquinone using molecular micelle modified poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles
    • G.M. Ganea et al. Delivery of phytochemical thymoquinone using molecular micelle modified poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles Nanotechnology 21 2010 285104
    • (2010) Nanotechnology , vol.21 , pp. 285104
    • Ganea, G.M.1
  • 29
    • 84870189574 scopus 로고    scopus 로고
    • Thymoquinone in liposomes: A study of loading efficiency and biological activity towards breast cancer
    • F. Odeh et al. Thymoquinone in liposomes: a study of loading efficiency and biological activity towards breast cancer Drug Deliv. 19 2012 371 377
    • (2012) Drug Deliv. , vol.19 , pp. 371-377
    • Odeh, F.1
  • 30
    • 84855412382 scopus 로고    scopus 로고
    • Synthesis and characterization of PHV-block-mPEG diblock copolymer and its formation of amphiphilic nanoparticles for drug delivery
    • M. Shah et al. Synthesis and characterization of PHV-block-mPEG diblock copolymer and its formation of amphiphilic nanoparticles for drug delivery J. Nanosci. Nanotechnol. 11 2011 5702 5710
    • (2011) J. Nanosci. Nanotechnol. , vol.11 , pp. 5702-5710
    • Shah, M.1
  • 31
    • 77957671453 scopus 로고    scopus 로고
    • Amphiphilic PHA-mPEG copolymeric nanocontainers for drug delivery: Preparation, characterization and in vitro evaluation
    • M. Shah et al. Amphiphilic PHA-mPEG copolymeric nanocontainers for drug delivery: preparation, characterization and in vitro evaluation Int. J. Pharm. 400 2010 165 175
    • (2010) Int. J. Pharm. , vol.400 , pp. 165-175
    • Shah, M.1
  • 32
    • 84867772167 scopus 로고    scopus 로고
    • Nanocarrier based formulation of thymoquinone improves oral delivery: Stability assessment, in vitro and in vivo studies
    • A. Singh et al. Nanocarrier based formulation of thymoquinone improves oral delivery: stability assessment, in vitro and in vivo studies Colloids Surf. B: Biointerfaces 102 2013 822 832
    • (2013) Colloids Surf. B: Biointerfaces , vol.102 , pp. 822-832
    • Singh, A.1
  • 33
    • 84870367030 scopus 로고    scopus 로고
    • Development and evaluation of thymoquinone-encapsulated chitosan nanoparticles for nose-to-brain targeting: A pharmacoscintigraphic study
    • S. Alam et al. Development and evaluation of thymoquinone-encapsulated chitosan nanoparticles for nose-to-brain targeting: a pharmacoscintigraphic study Int. J. Nanomed. 7 2012 5705 5718
    • (2012) Int. J. Nanomed. , vol.7 , pp. 5705-5718
    • Alam, S.1
  • 34
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 35
    • 67650466020 scopus 로고    scopus 로고
    • Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer
    • S. Banerjee et al. Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer Cancer Res. 69 2009 5575 5583
    • (2009) Cancer Res. , vol.69 , pp. 5575-5583
    • Banerjee, S.1
  • 36
    • 34548015409 scopus 로고    scopus 로고
    • Androgen receptor and E2F-1 targeted thymoquinone therapy for hormone-refractory prostate cancer
    • A.O. Kaseb et al. Androgen receptor and E2F-1 targeted thymoquinone therapy for hormone-refractory prostate cancer Cancer Res. 67 2007 7782 7788
    • (2007) Cancer Res. , vol.67 , pp. 7782-7788
    • Kaseb, A.O.1
  • 37
    • 77953178795 scopus 로고    scopus 로고
    • Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: Role of reactive oxygen species
    • P.S. Koka et al. Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species Exp. Biol. Med. (Maywood) 235 2010 751 760
    • (2010) Exp. Biol. Med. (Maywood) , vol.235 , pp. 751-760
    • Koka, P.S.1
  • 38
    • 77949263613 scopus 로고    scopus 로고
    • Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling
    • N. El-Najjar et al. Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling Apoptosis 15 2010 183 195
    • (2010) Apoptosis , vol.15 , pp. 183-195
    • El-Najjar, N.1
  • 39
    • 0031878048 scopus 로고    scopus 로고
    • The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L
    • D.R. Worthen et al. The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L Anticancer Res. 18 1998 1527 1532
    • (1998) Anticancer Res. , vol.18 , pp. 1527-1532
    • Worthen, D.R.1
  • 40
    • 80052346775 scopus 로고    scopus 로고
    • Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis
    • G. Badr et al. Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis PLoS ONE 6 2011 E23741
    • (2011) PLoS ONE , vol.6 , pp. 23741
    • Badr, G.1
  • 41
    • 84867567251 scopus 로고    scopus 로고
    • Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma
    • S. Das et al. Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma PLoS ONE 7 2012 E46641
    • (2012) PLoS ONE , vol.7 , pp. 46641
    • Das, S.1
  • 42
    • 51049120763 scopus 로고    scopus 로고
    • Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways
    • T. Yi et al. Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways Mol. Cancer Ther. 7 2008 1789 1796
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 1789-1796
    • Yi, T.1
  • 43
    • 78650420222 scopus 로고    scopus 로고
    • Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells
    • S.A. Arafa el et al. Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells Mutat. Res. 706 2011 28 35
    • (2011) Mutat. Res. , vol.706 , pp. 28-35
    • Arafa El, S.A.1
  • 44
    • 79952446077 scopus 로고    scopus 로고
    • Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma
    • A.R. Hussain et al. Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma Free Radic. Biol. Med. 50 2011 978 987
    • (2011) Free Radic. Biol. Med. , vol.50 , pp. 978-987
    • Hussain, A.R.1
  • 45
    • 77952140698 scopus 로고    scopus 로고
    • Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: Implications for the development of novel cancer therapies
    • M.P. Torres et al. Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies Mol. Cancer Ther. 9 2010 1419 1431
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 1419-1431
    • Torres, M.P.1
  • 46
    • 13244285843 scopus 로고    scopus 로고
    • Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism
    • H. Gali-Muhtasib et al. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism Int. J. Oncol. 25 2004 857 866
    • (2004) Int. J. Oncol. , vol.25 , pp. 857-866
    • Gali-Muhtasib, H.1
  • 47
    • 77649191011 scopus 로고    scopus 로고
    • Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1
    • M. Alhosin et al. Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1 Biochem. Pharmacol. 79 2010 1251 1260
    • (2010) Biochem. Pharmacol. , vol.79 , pp. 1251-1260
    • Alhosin, M.1
  • 48
    • 77956325713 scopus 로고    scopus 로고
    • Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway
    • F. Li et al. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway Br. J. Pharmacol. 161 2010 541 554
    • (2010) Br. J. Pharmacol. , vol.161 , pp. 541-554
    • Li, F.1
  • 49
    • 1942485326 scopus 로고    scopus 로고
    • Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes
    • H.U. Gali-Muhtasib et al. Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes Anticancer Drugs 15 2004 389 399
    • (2004) Anticancer Drugs , vol.15 , pp. 389-399
    • Gali-Muhtasib, H.U.1
  • 50
    • 77957913537 scopus 로고    scopus 로고
    • Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells
    • R.L. Gurung et al. Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells PLoS ONE 5 2010 E12124
    • (2010) PLoS ONE , vol.5 , pp. 12124
    • Gurung, R.L.1
  • 51
    • 79960929095 scopus 로고    scopus 로고
    • Anticancer activity of thymoquinone in breast cancer cells: Possible involvement of PPAR-gamma pathway
    • C.C. Woo et al. Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-gamma pathway Biochem. Pharmacol. 82 2011 464 475
    • (2011) Biochem. Pharmacol. , vol.82 , pp. 464-475
    • Woo, C.C.1
  • 52
    • 26444457920 scopus 로고    scopus 로고
    • Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells
    • M.A. El-Mahdy et al. Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells Int. J. Cancer 117 2005 409 417
    • (2005) Int. J. Cancer , vol.117 , pp. 409-417
    • El-Mahdy, M.A.1
  • 53
    • 34247362432 scopus 로고    scopus 로고
    • Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells
    • M. Roepke et al. Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells Cancer Biol. Ther. 6 2007 160 169
    • (2007) Cancer Biol. Ther. , vol.6 , pp. 160-169
    • Roepke, M.1
  • 54
    • 33746225596 scopus 로고    scopus 로고
    • Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation
    • R. El Mezayen et al. Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation Immunol. Lett. 106 2006 72 81
    • (2006) Immunol. Lett. , vol.106 , pp. 72-81
    • El Mezayen, R.1
  • 55
    • 0036277862 scopus 로고    scopus 로고
    • Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats
    • M. El-Dakhakhny et al. Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats J. Ethnopharmacol. 81 2002 161 164
    • (2002) J. Ethnopharmacol. , vol.81 , pp. 161-164
    • El-Dakhakhny, M.1
  • 56
    • 33847104142 scopus 로고    scopus 로고
    • Thymoquinone attenuates proinflammatory responses in lipopolysaccharide- activated mast cells by modulating NF-kappaB nuclear transactivation
    • M.A. El Gazzar et al. Thymoquinone attenuates proinflammatory responses in lipopolysaccharide-activated mast cells by modulating NF-kappaB nuclear transactivation Biochim. Biophys. Acta 1770 2007 556 564
    • (2007) Biochim. Biophys. Acta , vol.1770 , pp. 556-564
    • El Gazzar, M.A.1
  • 57
    • 50349098189 scopus 로고    scopus 로고
    • Targeting nuclear factor-kappa B activation pathway by thymoquinone: Role in suppression of antiapoptotic gene products and enhancement of apoptosis
    • G. Sethi et al. Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis Mol. Cancer Res. 6 2008 1059 1070
    • (2008) Mol. Cancer Res. , vol.6 , pp. 1059-1070
    • Sethi, G.1
  • 58
    • 70349528180 scopus 로고    scopus 로고
    • Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells
    • N. Chehl et al. Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells HPB (Oxford) 11 2009 373 381
    • (2009) HPB (Oxford) , vol.11 , pp. 373-381
    • Chehl, N.1
  • 59
    • 84860390247 scopus 로고    scopus 로고
    • Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein
    • W.K. Ng et al. Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein Toxicol. In Vitro 25 2011 1392 1398
    • (2011) Toxicol. in Vitro , vol.25 , pp. 1392-1398
    • Ng, W.K.1
  • 60
    • 84866935456 scopus 로고    scopus 로고
    • NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis
    • K.M. Sutton et al. NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis Biochem. Biophys. Res. Commun. 426 2012 421 426
    • (2012) Biochem. Biophys. Res. Commun. , vol.426 , pp. 421-426
    • Sutton, K.M.1
  • 61
    • 84867890420 scopus 로고    scopus 로고
    • Anti-neoplastic agent thymoquinone induces degradation of alpha and beta tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts
    • M. Alhosin et al. Anti-neoplastic agent thymoquinone induces degradation of alpha and beta tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts Invest. New Drugs 30 2012 1813 1819
    • (2012) Invest. New Drugs , vol.30 , pp. 1813-1819
    • Alhosin, M.1
  • 62
    • 77957800149 scopus 로고    scopus 로고
    • Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis
    • A. Abusnina et al. Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis Cell Signal. 23 2011 152 160
    • (2011) Cell Signal. , vol.23 , pp. 152-160
    • Abusnina, A.1
  • 63
    • 84864468084 scopus 로고    scopus 로고
    • Anti-cancer effects of thymoquinone in mouse neuroblastoma (Neuro-2a) cells through caspase-3 activation with down-regulation of XIAP
    • A. Paramasivam et al. Anti-cancer effects of thymoquinone in mouse neuroblastoma (Neuro-2a) cells through caspase-3 activation with down-regulation of XIAP Toxicol. Lett. 213 2012 151 159
    • (2012) Toxicol. Lett. , vol.213 , pp. 151-159
    • Paramasivam, A.1
  • 64
    • 77954039888 scopus 로고    scopus 로고
    • Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo
    • S.H. Jafri et al. Thymoquinone and cisplatin as a therapeutic combination in lung cancer: in vitro and in vivo J. Exp. Clin. Cancer Res. 29 2010 87
    • (2010) J. Exp. Clin. Cancer Res. , vol.29 , pp. 87
    • Jafri, S.H.1
  • 65
    • 41149137253 scopus 로고    scopus 로고
    • Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models
    • H. Gali-Muhtasib et al. Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models J. Cell Mol. Med. 12 2008 330 342
    • (2008) J. Cell Mol. Med. , vol.12 , pp. 330-342
    • Gali-Muhtasib, H.1
  • 66
    • 84875520192 scopus 로고    scopus 로고
    • Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation
    • K. Kolli-Bouhafs et al. Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation Invest. New Drugs 30 2012 2121 2131
    • (2012) Invest. New Drugs , vol.30 , pp. 2121-2131
    • Kolli-Bouhafs, K.1
  • 67
    • 80053475259 scopus 로고    scopus 로고
    • Anti-metastasis effect of thymoquinone on human pancreatic cancer
    • Z.H. Wu et al. Anti-metastasis effect of thymoquinone on human pancreatic cancer Yao Xue Xue Bao 46 2011 910 914
    • (2011) Yao Xue Xue Bao , vol.46 , pp. 910-914
    • Wu, Z.H.1
  • 68
    • 17044368705 scopus 로고    scopus 로고
    • The effects of isolated antioxidants from black seed on the cellular metabolism of A549 cells
    • N. Farah et al. The effects of isolated antioxidants from black seed on the cellular metabolism of A549 cells Biomed. Sci. Instrum. 41 2005 211 216
    • (2005) Biomed. Sci. Instrum. , vol.41 , pp. 211-216
    • Farah, N.1
  • 69
    • 70449100461 scopus 로고    scopus 로고
    • The effect of conventional and sustained delivery of thymoquinone and levodopa on SH-SY5Y human neuroblastoma cells
    • T.M. Martin et al. The effect of conventional and sustained delivery of thymoquinone and levodopa on SH-SY5Y human neuroblastoma cells Biomed. Sci. Instrum. 42 2006 332 337
    • (2006) Biomed. Sci. Instrum. , vol.42 , pp. 332-337
    • Martin, T.M.1
  • 70
    • 70449089588 scopus 로고    scopus 로고
    • Comparison of potential chemotherapeutic agents, 5-fluoruracil, green tea, and thymoquinone on colon cancer cells
    • A.A. Norwood et al. Comparison of potential chemotherapeutic agents, 5-fluoruracil, green tea, and thymoquinone on colon cancer cells Biomed. Sci. Instrum. 42 2006 350 356
    • (2006) Biomed. Sci. Instrum. , vol.42 , pp. 350-356
    • Norwood, A.A.1
  • 71
    • 34247624462 scopus 로고    scopus 로고
    • Physiological responses of ES-2 ovarian cell line following administration of epigallocatechin-3-gallate (EGCG), thymoquinone (TQ), and selenium (SE)
    • F. Wilson-Simpson et al. Physiological responses of ES-2 ovarian cell line following administration of epigallocatechin-3-gallate (EGCG), thymoquinone (TQ), and selenium (SE) Biomed. Sci. Instrum. 43 2007 378 383
    • (2007) Biomed. Sci. Instrum. , vol.43 , pp. 378-383
    • Wilson-Simpson, F.1
  • 72
    • 84859845873 scopus 로고    scopus 로고
    • Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury
    • R. Ulu et al. Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury Food Chem. Toxicol. 50 2012 1675 1679
    • (2012) Food Chem. Toxicol. , vol.50 , pp. 1675-1679
    • Ulu, R.1
  • 73
    • 0033836675 scopus 로고    scopus 로고
    • Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: A possible mechanism of protection
    • M.N. Nagi, and M.A. Mansour Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: a possible mechanism of protection Pharmacol. Res. 41 2000 283 289
    • (2000) Pharmacol. Res. , vol.41 , pp. 283-289
    • Nagi, M.N.1    Mansour, M.A.2
  • 74
    • 0031841827 scopus 로고    scopus 로고
    • Thymoquinone protects against doxorubicin-induced cardiotoxicity without compromising its antitumor activity
    • O.A. al-Shabanah et al. Thymoquinone protects against doxorubicin-induced cardiotoxicity without compromising its antitumor activity J. Exp. Clin. Cancer Res. 17 1998 193 198
    • (1998) J. Exp. Clin. Cancer Res. , vol.17 , pp. 193-198
    • Al-Shabanah, O.A.1
  • 75
    • 77951556746 scopus 로고    scopus 로고
    • Protective effects of Nigella sativa oil and thymoquinone against toxicity induced by the anticancer drug cyclophosphamide
    • F.Q. Alenzi et al. Protective effects of Nigella sativa oil and thymoquinone against toxicity induced by the anticancer drug cyclophosphamide Br. J. Biomed. Sci. 67 2010 20 28
    • (2010) Br. J. Biomed. Sci. , vol.67 , pp. 20-28
    • Alenzi, F.Q.1
  • 76
    • 79958783302 scopus 로고    scopus 로고
    • Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats
    • M.N. Nagi et al. Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats J. Biochem. Mol. Toxicol. 25 2011 135 142
    • (2011) J. Biochem. Mol. Toxicol. , vol.25 , pp. 135-142
    • Nagi, M.N.1
  • 77
    • 84888361525 scopus 로고    scopus 로고
    • Thymoquinone attenuates cyclophosphamide-induced pulmonary injury in rats
    • 10.1007/s10787-012-0160-6 [Epub ahead of print]
    • G.M. Suddek et al. Thymoquinone attenuates cyclophosphamide-induced pulmonary injury in rats Inflammopharmacology 2012 1 9 10.1007/s10787-012-0160-6 [Epub ahead of print]
    • (2012) Inflammopharmacology , pp. 1-9
    • Suddek, G.M.1
  • 78
    • 0033965801 scopus 로고    scopus 로고
    • The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats
    • O.A. Badary et al. The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats Toxicology 143 2000 219 226
    • (2000) Toxicology , vol.143 , pp. 219-226
    • Badary, O.A.1
  • 79
    • 68349118245 scopus 로고    scopus 로고
    • 50 of thymoquinone, an active principle of Nigella sativa, in mice and rats
    • 50 of thymoquinone, an active principle of Nigella sativa, in mice and rats J. Ayub. Med. Coll. Abbottabad 20 2008 25 27
    • (2008) J. Ayub. Med. Coll. Abbottabad , vol.20 , pp. 25-27
    • Al-Ali, A.1
  • 80
    • 84855780158 scopus 로고    scopus 로고
    • Phase i safety and clinical activity study of thymoquinone in patients with advanced refractory malignant disease
    • A.M. Al-Amri, and A.O. Bamosa Phase I safety and clinical activity study of thymoquinone in patients with advanced refractory malignant disease Shiraz Med. J. 10 2009 107 111
    • (2009) Shiraz Med. J. , vol.10 , pp. 107-111
    • Al-Amri, A.M.1    Bamosa, A.O.2
  • 81
    • 84861455671 scopus 로고    scopus 로고
    • Cadmium-induced hepatotoxicity and its abrogation by thymoquinone
    • M.F. Zafeer et al. Cadmium-induced hepatotoxicity and its abrogation by thymoquinone J. Biochem. Mol. Toxicol. 26 2012 199 205
    • (2012) J. Biochem. Mol. Toxicol. , vol.26 , pp. 199-205
    • Zafeer, M.F.1
  • 82
    • 80054814091 scopus 로고    scopus 로고
    • Protective effect of pretreatment with thymoquinone against Aflatoxin B(1) induced liver toxicity in mice
    • A. Nili-Ahmadabadi et al. Protective effect of pretreatment with thymoquinone against Aflatoxin B(1) induced liver toxicity in mice Daru 19 2011 282 287
    • (2011) Daru , vol.19 , pp. 282-287
    • Nili-Ahmadabadi, A.1
  • 83
    • 0032584004 scopus 로고    scopus 로고
    • Hepatoprotective activity of thymoquinone in isolated rat hepatocytes
    • M.H. Daba, and M.S. Abdel-Rahman Hepatoprotective activity of thymoquinone in isolated rat hepatocytes Toxicol. Lett. 95 1998 23 29
    • (1998) Toxicol. Lett. , vol.95 , pp. 23-29
    • Daba, M.H.1    Abdel-Rahman, M.S.2
  • 84
    • 77955055421 scopus 로고    scopus 로고
    • Thymoquinone supplementation reverses acetaminophen-induced oxidative stress, nitric oxide production and energy decline in mice liver
    • M.N. Nagi et al. Thymoquinone supplementation reverses acetaminophen-induced oxidative stress, nitric oxide production and energy decline in mice liver Food Chem. Toxicol. 48 2010 2361 2365
    • (2010) Food Chem. Toxicol. , vol.48 , pp. 2361-2365
    • Nagi, M.N.1
  • 85
    • 84864120336 scopus 로고    scopus 로고
    • Protective effects of thymoquinone on vancomycin-induced nephrotoxicity in rats
    • F. Basarslan et al. Protective effects of thymoquinone on vancomycin-induced nephrotoxicity in rats Hum. Exp. Toxicol. 31 2012 726 733
    • (2012) Hum. Exp. Toxicol. , vol.31 , pp. 726-733
    • Basarslan, F.1
  • 86
    • 47649095969 scopus 로고    scopus 로고
    • Thymoquinone ameliorates renal oxidative damage and proliferative response induced by mercuric chloride in rats
    • A.M. Fouda et al. Thymoquinone ameliorates renal oxidative damage and proliferative response induced by mercuric chloride in rats Basic Clin. Pharmacol. Toxicol. 103 2008 109 118
    • (2008) Basic Clin. Pharmacol. Toxicol. , vol.103 , pp. 109-118
    • Fouda, A.M.1
  • 87
    • 33947638565 scopus 로고    scopus 로고
    • Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats
    • M.M. Sayed-Ahmed, and M.N. Nagi Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats Clin. Exp. Pharmacol. Physiol. 34 2007 399 405
    • (2007) Clin. Exp. Pharmacol. Physiol. , vol.34 , pp. 399-405
    • Sayed-Ahmed, M.M.1    Nagi, M.N.2
  • 88
    • 38949116268 scopus 로고    scopus 로고
    • Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats
    • M. Kanter Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats Neurochem. Res. 33 2008 579 588
    • (2008) Neurochem. Res. , vol.33 , pp. 579-588
    • Kanter, M.1
  • 89
    • 30444448245 scopus 로고    scopus 로고
    • Gastroprotective activity of Nigella sativa L. Oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats
    • M. Kanter et al. Gastroprotective activity of Nigella sativa L. oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats World J. Gastroenterol. 11 2005 6662 6666
    • (2005) World J. Gastroenterol. , vol.11 , pp. 6662-6666
    • Kanter, M.1
  • 90
    • 55449095062 scopus 로고    scopus 로고
    • Role of Nigella sativa and a number of its antioxidant constituents towards azoxymethane-induced genotoxic effects and colon cancer in rats
    • D. Al-Johar et al. Role of Nigella sativa and a number of its antioxidant constituents towards azoxymethane-induced genotoxic effects and colon cancer in rats Phytother. Res. 22 2008 1311 1323
    • (2008) Phytother. Res. , vol.22 , pp. 1311-1323
    • Al-Johar, D.1
  • 91
    • 84861081428 scopus 로고    scopus 로고
    • Thymoquinone, the Nigella sativa bioactive compound, prevents circulatory oxidative stress caused by 1,2-dimethylhydrazine in erythrocyte during colon postinitiation carcinogenesis
    • H.J. Harzallah et al. Thymoquinone, the Nigella sativa bioactive compound, prevents circulatory oxidative stress caused by 1,2-dimethylhydrazine in erythrocyte during colon postinitiation carcinogenesis Oxid. Med. Cell Longev. 2012 2012 854065
    • (2012) Oxid. Med. Cell Longev. , vol.2012 , pp. 854065
    • Harzallah, H.J.1
  • 92
    • 79957631258 scopus 로고    scopus 로고
    • Thymoquinone attenuates lung injury induced by chronic toluene exposure in rats
    • M. Kanter Thymoquinone attenuates lung injury induced by chronic toluene exposure in rats Toxicol. Ind. Health 27 2011 387 395
    • (2011) Toxicol. Ind. Health , vol.27 , pp. 387-395
    • Kanter, M.1
  • 93
    • 79960759529 scopus 로고    scopus 로고
    • Protective effects of thymoquinone against methotrexate-induced testicular injury
    • A. Gokce et al. Protective effects of thymoquinone against methotrexate-induced testicular injury Hum. Exp. Toxicol. 30 2011 897 903
    • (2011) Hum. Exp. Toxicol. , vol.30 , pp. 897-903
    • Gokce, A.1
  • 94
    • 33750944928 scopus 로고    scopus 로고
    • The antitumor activity of thymoquinone and thymohydroquinone in vitro and in vivo
    • S. Ivankovic et al. The antitumor activity of thymoquinone and thymohydroquinone in vitro and in vivo Exp. Oncol. 28 2006 220 224
    • (2006) Exp. Oncol. , vol.28 , pp. 220-224
    • Ivankovic, S.1
  • 95
    • 84871475402 scopus 로고    scopus 로고
    • Inhibitory effects of thymoquinone on human pancreatic carcinoma orthotopically implanted in nude mice
    • Y.M. Wang Inhibitory effects of thymoquinone on human pancreatic carcinoma orthotopically implanted in nude mice Zhonghua Yi Xue Za Zhi 91 2011 3111 3114
    • (2011) Zhonghua Yi Xue Za Zhi , vol.91 , pp. 3111-3114
    • Wang, Y.M.1
  • 96
    • 84867845569 scopus 로고    scopus 로고
    • Role of NF-kappaB in the anti-tumor effect of thymoquinone on bladder cancer
    • H.Q. Mu et al. Role of NF-kappaB in the anti-tumor effect of thymoquinone on bladder cancer Zhonghua Yi Xue Za Zhi 92 2012 392 396
    • (2012) Zhonghua Yi Xue Za Zhi , vol.92 , pp. 392-396
    • Mu, H.Q.1
  • 97
    • 70449107828 scopus 로고    scopus 로고
    • Effects of (-)epigallocatechin gallate and thymoquinone on proliferation of a PANC-1 cell line in culture
    • M. Tan et al. Effects of (-)epigallocatechin gallate and thymoquinone on proliferation of a PANC-1 cell line in culture Biomed. Sci. Instrum. 42 2006 363 371
    • (2006) Biomed. Sci. Instrum. , vol.42 , pp. 363-371
    • Tan, M.1
  • 98
    • 34247643071 scopus 로고    scopus 로고
    • LNCaP cells exposed to ceramic drug delivery treatment with epigallocatechin-3-gallate, thymoquinone, and tannic acid
    • L.R. Richards et al. LNCaP cells exposed to ceramic drug delivery treatment with epigallocatechin-3-gallate, thymoquinone, and tannic acid Biomed. Sci. Instrum. 43 2007 242 247
    • (2007) Biomed. Sci. Instrum. , vol.43 , pp. 242-247
    • Richards, L.R.1
  • 99
    • 84866377073 scopus 로고    scopus 로고
    • Thymoquinone prevents and ameliorates dextran sulfate sodium-induced colitis in mice
    • X. Lei et al. Thymoquinone prevents and ameliorates dextran sulfate sodium-induced colitis in mice Dig. Dis. Sci. 57 2012 2296 2303
    • (2012) Dig. Dis. Sci. , vol.57 , pp. 2296-2303
    • Lei, X.1
  • 100
    • 0032876393 scopus 로고    scopus 로고
    • Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice
    • O.A. Badary Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice J. Ethnopharmacol. 67 1999 135 142
    • (1999) J. Ethnopharmacol. , vol.67 , pp. 135-142
    • Badary, O.A.1
  • 101
    • 0033379794 scopus 로고    scopus 로고
    • Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone
    • O.A. Badary et al. Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone Eur. J. Cancer Prev. 8 1999 435 440
    • (1999) Eur. J. Cancer Prev. , vol.8 , pp. 435-440
    • Badary, O.A.1
  • 102
    • 33745199857 scopus 로고    scopus 로고
    • Effects of thymoquinone, lycopene, and selenomethione in the presence of estrogen on the viability of SiHa cells in vitro
    • J. Brewer et al. Effects of thymoquinone, lycopene, and selenomethione in the presence of estrogen on the viability of SiHa cells in vitro Biomed. Sci. Instrum. 42 2006 37 41
    • (2006) Biomed. Sci. Instrum. , vol.42 , pp. 37-41
    • Brewer, J.1
  • 103
    • 65749120709 scopus 로고    scopus 로고
    • The role of estrogen, testosterone, and parathyroid hormones in combination with conventional and sustained antioxidant treatment on lncap cells - Biomed 2009
    • L. Ross Richards et al. The role of estrogen, testosterone, and parathyroid hormones in combination with conventional and sustained antioxidant treatment on lncap cells - biomed 2009 Biomed. Sci. Instrum. 45 2009 268 273
    • (2009) Biomed. Sci. Instrum. , vol.45 , pp. 268-273
    • Ross Richards, L.1
  • 104
    • 80054968162 scopus 로고    scopus 로고
    • Radiosensitization in human breast carcinoma cells by thymoquinone: Role of cell cycle and apoptosis
    • R. Velho-Pereira et al. Radiosensitization in human breast carcinoma cells by thymoquinone: role of cell cycle and apoptosis Cell Biol. Int. 35 2011 1025 1029
    • (2011) Cell Biol. Int. , vol.35 , pp. 1025-1029
    • Velho-Pereira, R.1
  • 105
    • 79960562089 scopus 로고    scopus 로고
    • Impact of protein binding on the analytical detectability and anticancer activity of thymoquinone
    • N. El-Najjar et al. Impact of protein binding on the analytical detectability and anticancer activity of thymoquinone J. Chem. Biol. 4 2011 97 107
    • (2011) J. Chem. Biol. , vol.4 , pp. 97-107
    • El-Najjar, N.1
  • 106
    • 77954604842 scopus 로고    scopus 로고
    • Nanoparticle formulation for hydrophilic & hydrophobic drugs
    • V.K. Gupta et al. Nanoparticle formulation for hydrophilic & hydrophobic drugs Int. J. Res. Pharm. Sci. 1 2010 163 169
    • (2010) Int. J. Res. Pharm. Sci. , vol.1 , pp. 163-169
    • Gupta, V.K.1


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