Enhanced oral bioavailability of piperine by self-emulsifying drug delivery systems: In vitro, in vivo and in situ intestinal permeability studies

Drug Delivery

Volumn 22, Issue 6, 2015, Pages 740-747

  Shao, Bing ^a   Cui, Chao ^a   Ji, Hongyu ^a   Tang, Jingling ^a   Wang, Zhiyong ^a   Liu, Hongmei ^a   Qin, Mengnan ^a   Li, Xin ^a   Wu, Linhua ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Bioavailability; dissolution; piperine; self emulsifying drug delivery system; single pass intestinal perfusion

Indexed keywords

DIETHYLENE GLYCOL MONOETHYL ETHER; OLEIC ACID ETHYL ESTER; PIPERINE; POLYSORBATE 80; 1,3 BENZODIOXOLE DERIVATIVE; ALKALOID; AMIDE; EMULSIFYING AGENT; EMULSION; LIPID; PIPERIDINE DERIVATIVE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CAPSULE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; INTESTINE MUCOSA PERMEABILITY; INTESTINE PERFUSION; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SELF EMULSIFYING DRUG DELIVERY SYSTEM; ANIMAL; BIOAVAILABILITY; CHEMISTRY; DOSE RESPONSE; EMULSION; MALE; MEDICINAL CHEMISTRY; ORAL DRUG ADMINISTRATION; PROCEDURES; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ALKALOIDS; ANIMALS; AREA UNDER CURVE; BENZODIOXOLES; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; EMULSIFYING AGENTS; EMULSIONS; INTESTINAL ABSORPTION; LIPIDS; MALE; PIPERIDINES; POLYUNSATURATED ALKAMIDES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84941275340     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2014.898109     Document Type: Article

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