Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway

Molecular Medicine Reports

Volumn 11, Issue 4, 2015, Pages 2755-2760

  Zhang, Xuecheng ^a   Zhu, Yong ^b   Duan, Wei ^a   Feng, Chen ^a   He, Xuan ^a  

^a Shaanxi Provincial Corps Hospital   (China)

^b Baoji Central Hospital   (China)

Author keywords

Allicin; Apoptosis; Gastric carcinoma; P38 mitogen activated protein kinase caspase 3

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ALLICIN; CASPASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; ANTINEOPLASTIC AGENT; SULFINIC ACID DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BGC 823 CELL LINE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; GASTRIC CANCER CELL LINE; HUMAN; HUMAN CELL; MGC 803 CELL LINE; MITOSIS INHIBITION; MTT ASSAY; PROTEIN EXPRESSION; SGC 7901 CELL LINE; SIGNAL TRANSDUCTION; STAINING; STOMACH CARCINOMA; TIME TO TREATMENT; TREATMENT DURATION; WESTERN BLOTTING; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; STOMACH TUMOR; TUMOR CELL LINE;

ALLIUM SATIVUM;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; SULFINIC ACIDS;

EID: 84921415758     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.3109     Document Type: Article

References (21)

1. Zhang W, Ha M, Gong Y, Xu Y, Dong N and Yuan Y: Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways. Oncol Rep 24: 1585-1592, 2010.
2. Ha MW and Yuan Y: Allicin induced cell cycle arrest in human gastric cancer cell lines. Zhonghua Zhong Liu Za Zhi 26: 585-589, 2004 (In Chinese).
3. Park SY, Cho SJ, Kwon HC, Lee KR, Rhee DK and Pyo S: Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA. Cancer Lett 224: 123-132, 2005.
4. Zhang YW, Eom SY, Yim DH, et al: Evaluation of the relationship between dietary factors, CagA-positive Helicobacter pylori infection, and RUNX3 promoter hypermethylation in gastric cancer tissue. World J Gastroenterol 19: 1778-1787, 2013.
5. Sato T, Kikuchi Y, Saito T, Hirano S and Kouzuma T: Results of chemotherapy using new anti-cancer drugs since S-1 for advanced or recurrent gastric cancer in our institute. Gan To Kagaku Ryoho 34: 1819-1825, 2007 (In Japanese).
6. Tyagi G, Pradhan S, Srivastava T and Mehrotra R: Nucleic acid binding properties of allicin: spectroscopic analysis and estimation of anti-tumor potential. Biochim Biophys Acta 1840: 350-356, 2014.
7. Hirsch K, Danilenko M, Giat J, et al: Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation. Nutr Cancer 38: 245-254, 2000.
8. Chu YL, Ho CT, Chung JG, Rajasekaran R and Sheen LY: Allicin induces p53-mediated autophagy in Hep G2 human liver cancer cells. J Agric Food Chem 60: 8363-8371, 2012.
9. Osman M, Adnan A, Salmah Bakar N and Alashkham F: Allicin has significant effect on autoimmune anti-islet cell antibodies in type 1 diabetic rats. Pol J Pathol 63: 248-254, 2012.
10. Liang X, Yang Y, Deng C, et al: The variation of Caspase3 activity in tanshinone induced NB4 cells apoptosis. Sichuan Da Xue Xue Bao Yi Xue Ban 34: 549-551, 2003 (In Chinese).
11. Guo L, Dong F, Hou Y, Cai W, Zhou X, Huang AL, Yang M, Allen TD and Liu J: Dihydroartemisinin inhibits vascular endothelial growth factor-induced endothelial cell migration by a p38 mitogen-activated protein kinase-independent pathway. Exp Ther Med 8: 1707-1712, 2014.
12. Feidantsis K, Pörtner HO, Markou T, Lazou A and Michaelidis B: Involvement of p38 MAPK in the induction of Hsp70 during acute thermal stress in red blood cells of the gilthead sea bream, Sparus aurata. J Exp Zool A Ecol Genet Physiol 317: 303-310, 2012.
13. Franks HA, Wang Q, Lax SJ, et al: Novel function for the p38-MK2 signalling pathway in circulating CD1c+ (BDCA-1+) myeloid dendritic cells from healthy donors and advanced cancer patients; inhibition of p38 enhances IL-12 whilst suppressing IL-10. Int J Cancer 34: 575-586, 2013.
14. Jameel NM, Thirunavukkarasu C, Wu T, Watkins SC, Friedman SL and Gandhi CR: p38-MAPK- and caspase-3-mediated superoxide-induced apoptosis of rat hepatic stellate cells: reversal by retinoic acid. J Cell Physiol 218: 157-166, 2009.
15. Andualem B: Combined antibacterial activity of stingless bee (Apis mellipodae) honey and garlic (Allium sativum) extracts against standard and clinical pathogenic bacteria. Asian Pac J Trop Biomed 3: 725-731, 2013.
16. Mozaffari-Khosravi H, Hesabgar HA, Owlia MB, Hadinedoushan H, Barzegar K and Fllahzadeh MH: The effect of garlic tablet on pro-inflammatory cytokines in postmenopausal osteoporotic women: a randomized controlled clinical trial. J Diet Suppl 9: 262-271, 2012.
17. Li L, Sun T, Tian J, Yang K, Yi K and Zhang P: Garlic in clinical practice: an evidence-based overview. Crit Rev Food Sci Nutr 53: 670-681, 2013.
18. Pittler MH and Ernst E: Clinical effectiveness of garlic (Allium sativum). Mol Nutr Food Res 51: 1382-1385, 2007.
19. Zhou Y, Wang Q, Evers BM and Chung DH: Signal transduction pathways involved in oxidative stress-induced intestinal epithelial cell apoptosis. Pediatr Res 58: 1192-1197, 2005.
20. Simpson KL, Cawthorne C, Zhou C, et al: A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers. Cell Death Dis 4: e613, 2013.
21. Boosani CS, Nalabothula N, Munugalavadla V, et al: FAK and p38-MAP kinase-dependent activation of apoptosis and caspase-3 in retinal endothelial cells by alpha1 (IV) NC1. Invest Ophthalmol Vis Sci 50: 4567-4575, 2009.