Crocin triggers the apoptosis through increasing the Bax/Bcl-2 ratio and caspase activation in human gastric adenocarcinoma, AGS, cells

DNA and Cell Biology

Volumn 32, Issue 2, 2013, Pages 50-57

  Hoshyar, Reyhane ^a   Bathaie, S Zahra ^a   Sadeghizadeh, Majid ^a  

^a TARBIAT MODARES UNIVERSITY   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTINEOPLASTIC AGENT; CASPASE; CROCIN; PROTEIN BAX; PROTEIN BCL 2;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH ADENOCARCINOMA; WESTERN BLOTTING;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CAROTENOIDS; CASPASES; CELL LINE, TUMOR; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; FREE RADICAL SCAVENGERS; HUMANS; PROTO-ONCOGENE PROTEINS C-BCL-2; STOMACH NEOPLASMS; UP-REGULATION;

EID: 84873048568     PISSN: 10445498     EISSN: 15577430     Source Type: Journal    
DOI: 10.1089/dna.2012.1866     Document Type: Article

References (33)

1. Abdullaev, F.I., and Espinosa-Aguirre, J.J. (2004). Biomedical properties of Saffron and its potential use in cancer therapy and chemoprevention trials. Cancer Detect Prev 28, 426-432.
2. Ashrafi, M., Bathaie, S.Z., Taghikhani, M., and Moosavi-Movahedi, A.A. (2005). The effect of carotenoids obtained from saffron on histone H1 structure and H1-DNA interaction. Int J Biol Macromol 36, 246-252.
3. Aung, H.H., Wang, C.Z., Ni, M., Fishbein, A., Mehendale, S.R., Xie, J.T., Shoyama, A.Y., and Yuan, C.S. (2007). Crocin from Crocus Sativus possesses significant anti-proliferation effects on human colorectal cancer cells. Exp Oncol 29, 175-180.
4. Babaei, E., Sadeghizadeh, M., Hassan, Z.M., Hosseinpour Feizi, M.A., Najafi, F., and Hashemi S.M. (2011). Dendrosomal curcumin significantly suppresses cancer cell proliferation in vitro and in vivo. Int Immunopharmacol 12, 226-234.
5. Baell, J.B., and Huang, D.C. (2002). Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs. Biochem Pharmacol 64, 851-863.
6. Bathaie, S.Z., Hoshyar, R., Ranjbar, B., Sabouni, F., and Moosavi-Movahedi, A.A. (2007). Interaction of saffron carotenoids as anticancer compounds with ctDNA, Oligo (dG. dC) 15, and Oligo (dA. dT) 15. DNA Cell Biol 26, 533-540.
7. Bathaie, S.Z., and Mousavi, S.Z. (2010). New applications and mechanisms of action of saffron and its important ingredients. Crit Rev Food Sci Nutr 50, 761-786.
8. Bolhasani, A., Bathaie, S.Z., Yavari, I., Moosavi-Movahedi, A.A., and Ghaffari, M. (2005). Separation and purification of some components of Iranian saffron. Asian J Chem 17, 727-729.
9. Chan, S.L., and Yu, V.C. (2004). Proteins of the bcl-2 family in apoptosis signalling: From mechanistic insights to therapeutic opportunities. Clin Exp Pharmacol Physiol 31, 119-128.
10. Escribano, J.A., Alonso, G.L., Coca-Prados, M., and Fernandez, J.A. (1996). Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett 100, 23-30.
11. Fesik, S.W. (2005). Promoting apoptosis as a strategy for cancer drug discovery. Nat Rev Cancer 5, 876-885.
12. Fulda, S. (2010). Modulation of apoptosis by natural products for cancer therapy. Planta Med 76, 1075-1079.
13. Garcia-Olmo, D.C., Riese, H.H., Escribano, J., Ontanon, J., Fernandez, J.A., Atienzar. M., and Garcia-Olmo, D. (1999). Effects of long-term treatment of colon adenocarcinoma with crocin, a carotenoid from saffron (Crocus sativus L.): An experimental study in the rat. Nutr Cancer 35, 120-126.
14. Garodia, P., Ichikawa, H., Malani, N., Sethi, G., and Aggarwal, B.B. (2007). From ancient medicine to modern medicine: ayurvedic concepts of health and their role in inflammation and cancer. J Soc Integr Oncol 5, 25-37.
15. Gorlach, S., Wagner, W., Podsedek, A., Sosnowska, D., Dastych, J., and Koziolkiewicz, M. (2011). Polyphenols from evening primrose (oenothera paradoxa) defatted seeds induce apoptosis in human colon cancer caco-2 cells. J Agric Food Chem 59, 6985-6997.
16. Hoshyar, R., Bathaie, S.Z., and Ashrafi, M. (2008). Interaction of safranal and picrocrocin with ctDNA and their preferential mechanisms of binding to GC- and AT-rich oligonucleotides. DNA Cell Biol 27, 665-673.
17. Hoshyar, R., Bathaie, S.Z., Kyani, A., and Mousavi, M.F. (2012) Is there any interaction between telomeric DNA structures, Gquadruplex and I-motif, with saffron active metabolites? Nucleos Nucleot Nucl 31, 801-812.
18. Huang, K.C., Feng, L., Oldham, E.A., Keating, M.J., and Plunkett, W. (2000). Superoxide dismutase as a target for the selective killing of cancer cells. Nature 407, 390-395.
19. Karagozlua, M.Z., Kima, J.A., Karadeniza, F., Kong, Ch.S., and Kima, S.K. (2010). Anti-proliferative effect of aminoderivatized chitooligosaccharides on AGS human gastric cancer cells. Process Biochem 45, 1523-1528.
20. Kirkin, V., Joos, S., and Zornig, M. (2004). The role of Bcl-2 family members in tumorigenesis. Biochim Biophys Acta 1644, 229-249.
21. Anarkooli, I. (2009). Role of caspases and Bax protein in saffron-induced apoptosis in MCF-7 cells. Food Chem Toxicol 47, 1909-1913.
22. Mousavi, S.Z., and Bathaie, S.Z. (2011). Historical uses of saffron: Identifying potential new avenues for modern research. J Phytomed 1, 57-66.
23. Noureini, S.K., and Wink, M. (2012). Antiproliferative effects of crocin in Hep G2 cells by telomerase inhibition and hTERT down-regulation. Asian Pacific J Cancer Prev 13, 2305-2309.
24. Poncet, K.M., and Kroemer, G. (2002). Chemotherapy: Targeting the mitochondrial cell death pathway. Oncogene 57, 8786- 8803.
25. Sajjadi, M., Bathaie, S.Z., and Heydarzade, H. (2011). Preventing effect of crocetin on induced breast cancer in rat. 6th International Breast Cancer Congress, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Schulte-Hermann, R., Grasl-Kraupp, B., and Bursch, W. (1994
26. Tumor development and apoptosis. Int Arch Allergy Immunol 105, 363-367.
27. Soeda, S., Ochiai, T., Shimeno, H., Saito, H., Abe, K., Tanaka, H., and Shoyama, Y. (2007). Pharmacological activities of crocin in saffron. J Nat Med 61, 102-111.
28. Tarantilis, P. A., Morjani, H., Polissiou, M., and Manfait, M. (1994). Inhibition of growth and induction of differentiation of promyelocytic leukemia (HL-60) by carotenoids from Crocus sativus L. Anticancer Res 14, 1913-1918.
29. Tavakkol-Afshari, J., Brook, A., and Mousavi, S.H. (2008). Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines. Food Chem Toxicol 46, 3443-3447.
30. Thatte, U., Bagadey, S., and Dahanukar, S. (2000). Modulation of programmed cell death by medicinal plants. Cell Mol Biol 46, 199-214.
31. Watanabe, T., Kume, K., Taip, M., Shibata, M., Kubo, H., Ejiri, Y., and Otsuki, M. (2010).Gastric mucosal cancer smaller than 7mm can be treated with conventional endoscopic mucosal resection as effectively as with endoscopic submucosal dissection. Hepato-Gastroenterol 57, 668-673.
32. Zhang, A.L., Taol, L., Ruan, J., Li, W., Wu,Y., Yan, L., Zhang, F., Fan, F., Zheng, S., Wang, A., and Lu, Y. (2012). Xanthatin induces G2/M cell cycle arrest and apoptosis in human gastric carcinoma MKN-45 Cells. Planta Med 78, 890-895.
33. Zhao, P., Luo, C.L., Wu, X.H., Hu, H.B., Lv,C.F., and Ji, H.Y. (2008). Proliferation apoptotic influence of crocin on human bladder cancer T24 cell line. Zhongguo Zhong Yao Za Zhi 33, 1869-1873.