Carvacrol inhibits proliferation and induces apoptosis in human colon cancer cells

Anti-Cancer Drugs

Volumn 26, Issue 8, 2015, Pages 813-823

  Fan, Kai ^a   Li, Xiaolei ^a   Cao, Yonggang ^a   Qi, Hanping ^a   Li, Lei ^a   Zhang, Qianhui ^a   Sun, Hongli ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARVACROL; CYCLIN B1; GELATINASE A; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; ANTINEOPLASTIC AGENT; TERPENE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; DRUG MECHANISM; ENZYME PHOSPHORYLATION; G2 PHASE CELL CYCLE CHECKPOINT; HCT116 CELL LINE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; CELL MOTION; COLON TUMOR; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE; TUMOR INVASION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLONIC NEOPLASMS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; G2 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MONOTERPENES; NEOPLASM INVASIVENESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 84938839462     PISSN: 09594973     EISSN: 14735741     Source Type: Journal    
DOI: 10.1097/CAD.0000000000000263     Document Type: Article

References (36)

1. Kiskó G, Roller S. Carvacrol and p-cymene inactivate Escherichia coli O157: H7 in apple juice. BMC Microbiol 2005; 5:36.
2. Fenaroli G. Fenaroli's handbook of flavor ingredients, 4th ed. Boca Raton, Florida: CRC Press Inc.; 2002.
3. Baser KH. Biological and pharmacological activities of carvacrol and carvacrol bearing essential oils. Curr Pharm Des 2008; 14:3106-3119.
4. Zeytinoglu H, Incesu Z, Baser KH. Inhibition of DNA synthesis by carvacrol in mouse myoblast cells bearing a human N-RAS oncogene. Phytomedicine 2003; 10:292-299.
5. Karkabounas S, Kostoula OK, Daskalou T, Veltsistas P, Karamouzis M, Zelovitis I, et al. Anticarcinogenic and antiplatelet effects of carvacrol. Exp Oncol 2006; 28:121-125.
6. Jayakumar S, Madankumar A, Asokkumar S, Raghunandhakumar S, Gokula dhas K, Kamaraj S, et al. Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats. Mol Cell Biochem 2012; 360:51-60.
7. Lee SH, Ryu SY, Kim HB, Kim MY, Chun YJ. Induction of apoptosis by 3,4'-dimethoxy-5-hydroxystilbene in human promyeloid leukemic HL-60 cells. Planta Med 2002; 68:123-127.
8. Hwang HJ, Kang YJ, Hossain MA, Kim DH, Jang JY, Lee SH, et al. Novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, MHY-449, induces apoptosis and cell cycle arrest in HCT116 human colon cancer cells. Int J Oncol 2012; 41:2057-2064.
9. Liu WH, Chen YJ, Chien JH, Chang LS. Amsacrine suppresses matrix metalloproteinase-2 (MMP-2)/MMP-9 expression in human leukemia cells. J Cell Physiol 2014; 229:588-598.
10. Gao J, Ding F, Liu Q, Yao Y. Knockdown of MACC1 expression suppressed hepatocellular carcinoma cell migration and invasion and inhibited expression of MMP2 and MMP9. Mol Cell Biochem 2013; 376:21-32.
11. Wang J, Liu L, Qiu H, Zhang X, Guo W, Chen W, et al. Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells. PLoS One 2013; 8:e63872.
12. Shen Y, Lu B, Zhang S, Ma ZJ. Diterpenoid C of Radix Curcumae: an inhibitor of proliferation and inducer of apoptosis in human colon adenocarcinoma cells acting via inhibiting MAPK signaling pathway. Pharm Biol 2014; 52:1158-1165.
13. Huang XF, Chen JZ. Obesity, the PI3K/Akt signal pathway and colon cancer. Obes Rev 2009; 10:610-616.
14. Garcia-Echeverria C, Sellers WR. Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene 2008; 27:5511-5526.
15. Chen J. Is Src the key to understanding metastasis and developing new treatments for colon cancer? Nat Clin Pract Gastroenterol Hepatol 2008; 5:306-307.
16. Morgensztern D, McLeod HL. PI3K/Akt/mTOR pathway as a target for cancer therapy. Anticancer Drugs 2005; 16:797-803.
17. Lampronti I, Saab AM, Gambari R. Antiproliferative activity of essential oils derived from plants belonging to the Magnoliophyta division. Int J Oncol 2006; 29:989-995.
18. Koparal AT, Zeytinoglu M. Effects of carvacrol on a human non-small cell lung cancer (NSCLC) cell line, A549. Cytotechnology 2003; 43:149-154.
19. Arunasree KM. Anti-proliferative effects of carvacrol on a human metastatic breast cancer cell line, MDA-MB 231. Phytomedicine 2010; 17:581-588.
20. Yin QH, Yan FX, Zu XY,Wu YH, Wu XP, Liao MC, et al. Anti-proliferative and pro-Apoptotic effect of carvacrol on human hepatocellular carcinoma cell line HepG-2. Cytotechnology 2012; 64:43-51.
21. Wu J, Wu G, Lv L, Ren YF, Zhang XJ, Xue YF, et al. MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1. Carcinogenesis 2012; 33:519-528.
22. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010; 60:277-300.
23. Hanahan D. Rethinking the war on cancer. Lancet 2014; 383:558-563.
24. Shi MD, Lin HH, Chiang TA, Tsai LY, Tsai SM, Lee YC, Chen JH. Andrographolide could inhibit human colorectal carcinoma Lovo cells migration and invasion via down-regulation of MMP-7 expression. Chem Biol Interact 2009; 180:344-352.
25. Mook OR, Frederiks WM, Van Noorden CJ. The role of gelatinases in colorectal cancer progression and metastasis. Biochim Biophys Acta 2004; 1705:69-89.
26. Pupa SM, Ménard S, Forti S, Tagliabue E. New insights into the role of extracellular matrix during tumor onset and progression. J Cell Physiol 2002; 192:259-267.
27. Yun JW, Lee WS, Kim MJ, Lu JN, Kang MH, Kim HG, et al. Characterization of a profile of the anthocyanins isolated from Vitis coignetiae Pulliat and their anti-invasive activity on HT-29 human colon cancer cells. Food Chem Toxicol 2010; 48:903-909.
28. Park MT, Lee SJ. Cell cycle and cancer. J Biochem Mol Biol 2003; 36:60-65.
29. Williams GH, Stoeber K. The cell cycle and cancer. J Pathol 2012; 226:352-364.
30. Yogosawa S, Yamada Y, Yasuda S, Sun Q, Takizawa K, Sakai T. Dehydrozingerone, a structural analogue of curcumin, induces cell-cycle arrest at the G2/M phase and accumulates intracellular ROS in HT-29 human colon cancer cells. J Nat Prod 2012; 75:2088-2093.
31. Liang WZ, Lu CH. Carvacrol-induced [Ca2+]i rise and apoptosis in human glioblastoma cells. Life Sci 2012; 90:703-711.
32. Liang WZ, Chou CT, Lu T, Chi CC, Tseng LL, Pan CC, et al. The mechanism of carvacrol-evoked [Ca2+]i rises and non-Ca2+-triggered cell death in OC2 human oral cancer cells. Toxicology 2013; 303:152-161.
33. Heath-Engel HM, Shore GC. Mitochondrial membrane dynamics, cristae remodelling and apoptosis. Biochim Biophys Acta 2006; 1763:549-560.
34. Lee ER, Kim JY, Kang YJ, Ahn JY, Kim JH, Kim BW, et al. Interplay between PI3K/Akt and MAPK signaling pathways in DNA-damaging drug-induced apoptosis. Biochim Biophys Acta 2006; 1763:958-968.
35. Xavier CP, Lima CF, Fernandes-Ferreira M, Pereira-Wilson C. Hypericum androsaemum water extract inhibits proliferation in human colorectal cancer cells through effects on MAP kinases and PI3K/Akt pathway. Food Funct 2012; 3:844-852.
36. Pan MH, Lai CS, Wu JC, Ho CT. Molecular mechanisms for chemoprevention of colorectal cancer by natural dietary compounds. Mol Nutr Food Res 2011; 55:32-45.